abstract：:To shed light on how acute exercise affects blood glucose (BG) concentrations in nondiabetic subjects, we develop a physiological pharmacokinetic/pharmacodynamic model of postprandial glucose dynamics during exercise. We unify several concepts of exercise physiology to derive a multiscale model that includes three imp...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Frank S,Jbaily A,Hinshaw L,Basu R,Basu A,Szeri AJ

更新日期：2021-01-04 00:00:00

abstract：:HER2-positive breast cancer (BC) is a rapidly growing and aggressive BC subtype that predominantly affects younger women. Despite improvements in patient outcomes with anti-HER2 therapy, primary and/or acquired resistance remain a major clinical challenge. Here, we sought to use a quantitative systems pharmacological ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Franco YL,Ramakrishnan V,Vaidya TR,Mody H,Perez L,Ait-Oudhia S

更新日期：2021-01-03 00:00:00

abstract：:A modeling and simulation approach was used for quantitative comparison of a new generation HER2 antibody drug conjugate (ADC, PF-06804103) with trastuzumab-DM1 (T-DM1). To compare preclinical efficacy, the pharmacokinetic (PK)/pharmacodynamic (PD) relationship of PF-06804103 and T-DM1 was determined across a range of...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Betts A,Clark T,Jasper P,Tolsma J,van der Graaf PH,Graziani EI,Rosfjord E,Sung M,Ma D,Barletta F

更新日期：2020-10-01 00:00:00

abstract：:Neutropenia is a common side-effect of oncology drugs. We aimed to study the impact of exposure and dosing schedule on neutropenia to guide selection of dosing schedules that minimize neutropenia potential while maintaining the desired minimum concentration (Cmin) required for target engagement. Dose, frequency and PK...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Guo Y,Haddish-Berhane N,Xie H,Ouellet D

更新日期：2020-02-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a chronic obstructive disease of the airways. An exacerbation of COPD is defined as shortness of breath, cough, and sputum production. New therapies for COPD exacerbations are examined in clinical trials frequently based on the number of exacerbations that implies long-t...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Largajolli A,Beerahee M,Yang S

更新日期：2019-08-01 00:00:00

abstract：:Stepwise covariate modeling (SCM) is a widely used tool in pharmacometric analyses to identify covariates that explain between-subject variability (BSV) in exposure and exposure-response relationships. However, this approach has several potential weaknesses, including over-estimated covariate effect and incorrect sele...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Ahamadi M,Largajolli A,Diderichsen PM,de Greef R,Kerbusch T,Witjes H,Chawla A,Davis CB,Gheyas F

更新日期：2019-06-01 00:00:00

abstract：:Bridging fundamental approaches to model optimization for pharmacometricians, systems pharmacologists and statisticians is a critical issue. These fields rely primarily on Maximum Likelihood and Extended Least Squares metrics with iterative estimation of parameters. Our research combines adaptive chaos synchronization...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Pillai N,Schwartz SL,Ho T,Dokoumetzidis A,Bies R,Freedman I

更新日期：2019-04-01 00:00:00

abstract：:Ordinary differential equation models often contain a large number of parameters that must be determined from measurements by estimation procedure. For an estimation to be successful there must be a unique set of parameters that can have produced the measured data. This is not the case if a model is not structurally i...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Iliadis A

更新日期：2019-04-01 00:00:00

abstract：:Regulatory authorities introduced procedures in the last decade for evaluating the bioequivalence (BE) for highly variable drugs. These approaches are similar in principle but differ in details. For example, the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) recommend differing regulatory c...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Endrenyi L,Tothfalusi L

更新日期：2019-04-01 00:00:00

abstract：:Multiple classes of antihypertensive drugs inhibit components of the renin-angiotensin-aldosterone system (RAAS). The primary physiological effector of the RAAS is angiotensin II (AngII) bound to the AT1 receptor (AT1-bound AngII). There is a strong non-linear feedback from AT1-bound AngII on renin secretion. Since AT...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Gebremichael Y,Lahu G,Vakilynejad M,Hallow KM

更新日期：2019-02-01 00:00:00

abstract：:This study developed an integrated model of severity scores of migraine headache and the incidence of nausea, photophobia, and phonophobia to predict the natural time course of migraine symptoms, which are likely to occur by a common disease progression mechanism. Data were acquired from two phase 3 clinical trials co...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Chae D,Park K

更新日期：2018-10-01 00:00:00

abstract：:The physiologically based pharmacokinetic (PBPK) models allow for predictive assessment of variability in population of interest. One of the future application of PBPK modeling is in the field of precision dosing and personalized medicine. The aim of the study was to develop PBPK model for amitriptyline given orally, ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Tylutki Z,Mendyk A,Polak S

更新日期：2018-10-01 00:00:00

abstract：:The objective was to develop a physiologically-based pharmacokinetic (PBPK) model to characterize the whole-body disposition of paclitaxel (formulated in Cremophor EL and ethanol-Taxol®) in mice and to evaluate the utility of this model for predicting pharmacokinetics in other species. Published studies that reported ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Zang X,Kagan L

更新日期：2018-08-01 00:00:00

abstract：:Guselkumab, a human IgG1 monoclonal antibody that blocks interleukin-23, has been evaluated in one Phase 2 and two Phase 3 trials in patients with moderate-to-severe psoriasis, in which disease severity was assessed using Psoriasis Area and Severity Index (PASI) and Investigator's Global Assessment (IGA) scores. Throu...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Hu C,Yao Z,Chen Y,Randazzo B,Zhang L,Xu Z,Sharma A,Zhou H

更新日期：2018-08-01 00:00:00

abstract：:Drugs can affect the cardiovascular (CV) system either as an intended treatment or as an unwanted side effect. In both cases, drug-induced cardiotoxicities such as arrhythmia and unfavourable hemodynamic effects can occur, and be described using mathematical models; such a model informed approach can provide valuable ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Cheung SYA,Parkinson J,Wählby-Hamrén U,Dota CD,Kragh ÅM,Bergenholm L,Vik T,Collins T,Arfvidsson C,Pollard CE,Tomkinson HK,Hamrén B

更新日期：2018-06-01 00:00:00

abstract：:The distributed delay model has been introduced that replaces the transit compartments in the classic model of chemotherapy-induced myelosuppression with a convolution integral. The maturation of granulocyte precursors in the bone marrow is described by the gamma probability density function with the shape parameter (...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Krzyzanski W,Hu S,Dunlavey M

更新日期：2018-04-01 00:00:00

abstract：:The aim of this study was to develop a population in vitro-in vivo pharmacokinetic model that simultaneously describe the absorption and accumulation kinetics of itraconazole (ICZ) and hydroxy-itraconazole (HICZ) in healthy subjects. The model integrated meta-models of gastrointestinal pH and gastrointestinal transit ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Abuhelwa AY,Mudge S,Upton RN,Foster DJR

更新日期：2018-04-01 00:00:00

abstract：:This study was designed to investigate ethnic differences in the pharmacokinetics (PKs) of moxifloxacin and its metabolites, M1 (sulfo conjugate) and M2 (acyl-glucuronate), among Japanese, Chinese, and Korean populations, following oral administration. We used a population PK modeling approach using data from a clinic...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Kaneko M,Aoyama T,Ishida Y,Miyamoto A,Saito Y,Tohkin M,Kawai S,Matsumoto Y

更新日期：2018-04-01 00:00:00

abstract：:The emerging discipline of mathematical pharmacology occupies the space between advanced pharmacometrics and systems biology. A characteristic feature of the approach is application of advance mathematical methods to study the behavior of biological systems as described by mathematical (most often differential) equati...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Gibiansky L,Gibiansky E

更新日期：2018-02-01 00:00:00

abstract：:Structural identifiability is an often overlooked, but essential, prerequisite to the experiment design stage. The application of structural identifiability analysis to models of myelosuppression is used to demonstrate the importance of its considerations. It is shown that, under certain assumptions, these models are ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Evans ND,Cheung SYA,Yates JWT

更新日期：2018-02-01 00:00:00

abstract：:A hazard model of fracture was developed using individual patient data (IPD) from the NHANES (2005-2008) database and summary-level data from an aggregate dataset (AD). The AD was built by performing a comprehensive and systematic literature search of clinical studies published from 1995 to 2015, recording fracture ra...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Eudy-Byrne RJ,Gillespie W,Riggs MM,Gastonguay MR

更新日期：2017-12-01 00:00:00

abstract：:Age-structured cell population model was introduced to describe cell survival. The impact of the environment on the cell population is represented by drug plasma concentration. A key model variable is the hazard of cell removal that is a subject to the environment effect. The model is capable of describing cohort and ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Krzyzanski W,Wiczling P,Gebre A

更新日期：2017-08-01 00:00:00

abstract：:Optimizing designs using robust (global) optimality criteria has been shown to be a more flexible approach compared to using local optimality criteria. Additionally, model based adaptive optimal design (MBAOD) may be less sensitive to misspecification in the prior information available at the design stage. In this wor...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Strömberg EA,Hooker AC

更新日期：2017-08-01 00:00:00

abstract：:The purpose of this study was to develop a whole-body physiologically based pharmacokinetic (WB-PBPK) model for ciprofloxacin for ICU patients, based on only plasma concentration data. In a next step, tissue and organ concentration time profiles in patients were predicted using the developed model. The WB-PBPK model w...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Sadiq MW,Nielsen EI,Khachman D,Conil JM,Georges B,Houin G,Laffont CM,Karlsson MO,Friberg LE

更新日期：2017-04-01 00:00:00

abstract：:The citalopram for Alzheimer's disease trial evaluated citalopram for the management for agitation in Alzheimer's disease patients. Sparse data was available from this elderly patient population. A nonlinear mixed effects population pharmacokinetic modeling approach was used to describe the pharmacokinetics of R- and ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Akil A,Bies RR,Pollock BG,Avramopoulos D,Devanand DP,Mintzer JE,Porsteinsson AP,Schneider LS,Weintraub D,Yesavage J,Shade DM,Lyketsos CG

更新日期：2016-02-01 00:00:00

abstract：:Development of novel therapies for bone diseases can benefit from mathematical models that predict drug effect on bone remodeling biomarkers. Therefore, a bone cycle model (BCM) was developed that takes into consideration the concept of the basic multicellular unit and the dynamic equilibrium of bone remodeling. The m...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： van Schaick E,Zheng J,Perez Ruixo JJ,Gieschke R,Jacqmin P

更新日期：2015-08-01 00:00:00

abstract：:The utilisation of physiologically-based pharmacokinetic models for the analysis of population data is an approach with progressively increasing impact. However, as we move from empirical to complex mechanistic model structures, incorporation of stochastic variability in model parameters can be challenging due to the ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Tsamandouras N,Wendling T,Rostami-Hodjegan A,Galetin A,Aarons L

更新日期：2015-08-01 00:00:00

abstract：:There have been no pharmacokinetic parameters and blood-brain equilibration rate constant (k e0) of propofol obtained in a single population of children, by which propofol can be administered using a target effect-site concentration controlled infusion. Thirty-nine, American Society of Anesthesiologists Physical Statu...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Choi BM,Lee HG,Byon HJ,Lee SH,Lee EK,Kim HS,Noh GJ

更新日期：2015-04-01 00:00:00

abstract：:Minimal physiologically based pharmacokinetic (mPBPK) models provide a simple and sensible approach that incorporates physiological elements into pharmacokinetic (PK) analysis when only plasma data are available. With this modeling concept, a second-generation mPBPK model was further developed with specific accommodat...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Cao Y,Jusko WJ

更新日期：2014-12-01 00:00:00

abstract：:This study aimed to characterize pharmacodynamic interaction between propofol and aminophylline. Nine beagle dogs were randomly allocated at the propofol rates of 0.75 (group A), 1.00 (group B), and 1.25 (group C) mg/kg/min. During period 1, propofol only was infused, while during period 2, aminophylline only, at the ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Lee SH,Kang HJ,Jin SJ,Park DY,Choi YJ,Choi BM,Lee EK,Noh GJ

更新日期：2014-12-01 00:00:00

abstract：:Monoclonal antibodies (mAbs) represent a therapeutic strategy that has been increasingly used in different diseases. mAbs are highly specific for their targets leading to induce specific effector functions. Despite their therapeutic benefits, the presence of immunogenic reactions is of growing concern. The immunogenic...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Gómez-Mantilla JD,Trocóniz IF,Parra-Guillén Z,Garrido MJ

更新日期：2014-10-01 00:00:00

abstract：:Cancer therapies that harness the actions of the immune response, such as targeted monoclonal antibody treatments and therapeutic vaccines, are relatively new and promising in the landscape of cancer treatment options. Mathematical modeling and simulation of immune-modifying therapies can help to offset the costs of d...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： dePillis LG,Eladdadi A,Radunskaya AE

更新日期：2014-10-01 00:00:00

abstract：:T cell responses are a crucial part of the adaptive immune system in the fight against infections. This article discusses the use of mathematical models for understanding the dynamics of cytotoxic T lymphocyte (CTL) responses against viral infections. Complementing experimental research, mathematical models have been ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Wodarz D

更新日期：2014-10-01 00:00:00

abstract：:We used a previously developed physiologically based kinetic (PBK) model to analyze the effect of individual variations in metabolism and transport of cholesterol on pravastatin response. The PBK model is based on kinetic expressions for 21 reactions that interconnect eight different body cholesterol pools including p...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： van de Pas NC,Rullmann JA,Woutersen RA,van Ommen B,Rietjens IM,de Graaf AA

更新日期：2014-08-01 00:00:00

abstract：:Intravenous acetaminophen is a commonly used analgesic following surgery. The aims of this study were to determine the population pharmacokinetic profile of intravenous acetaminophen and its metabolites in adult surgical patients and to identify patient characteristics associated with acetaminophen metabolism in the p...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Owens KH,Murphy PG,Medlicott NJ,Kennedy J,Zacharias M,Curran N,Sreebhavan S,Thompson-Fawcett M,Reith DM

更新日期：2014-06-01 00:00:00

abstract：:A population pharmacokinetic analysis was conducted to characterize the pharmacokinetics of fexofenadine in Japanese pediatric patients (6 months through 16 years) with perennial allergic rhinitis or atopic dermatitis. The dataset was composed of 515 patients (including 109 adults), for a total of 1,080 concentration-...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Martinez JM,Khier S,Morita S,Rauch C,Fabre D

更新日期：2014-04-01 00:00:00

abstract：:Bootstrap methods are used in many disciplines to estimate the uncertainty of parameters, including multi-level or linear mixed-effects models. Residual-based bootstrap methods which resample both random effects and residuals are an alternative approach to case bootstrap, which resamples the individuals. Most PKPD app...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Thai HT,Mentré F,Holford NH,Veyrat-Follet C,Comets E

更新日期：2014-02-01 00:00:00

abstract：:3-hydroxybenzo(a)pyrene (3-OHBaP) in urine has been proposed as a biomarker of occupational exposure to polycyclic aromatic hydrocarbons. However, to reconstruct exposure doses in workers from biomarker measurements, a thorough knowledge of the kinetics of the benzo(a)pyrene (BaP) and 3-OHBaP given different routes of...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Heredia-Ortiz R,Bouchard M

更新日期：2013-12-01 00:00:00

abstract：:Previously, we developed a feedback model to describe the tolerance and oscillatory rebound of non-esterified fatty acid (NEFA) plasma concentrations in male Sprague Dawley rats after intravenous infusions of nicotinic acid (NiAc). This study challenges that model, using the following regimens of intravenous and oral ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Ahlström C,Peletier LA,Gabrielsson J

更新日期：2013-08-01 00:00:00

abstract：:Several reviews on specific topics related to positron emission tomography (PET) ranging in complexity from introductory to highly technical have already been published. This introduction to the analysis of PET data was written as a simple guide of the different phases of analysis of a given PET dataset, from acquisit...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Tomasi G,Aboagye EO

更新日期：2013-08-01 00:00:00