Understanding the linked kinetics of benzo(a)pyrene and 3-hydroxybenzo(a)pyrene biomarker of exposure using physiologically-based pharmacokinetic modelling in rats.

abstract：:The physiologically based pharmacokinetic (PBPK) models allow for predictive assessment of variability in population of interest. One of the future application of PBPK modeling is in the field of precision dosing and personalized medicine. The aim of the study was to develop PBPK model for amitriptyline given orally, ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Tylutki Z,Mendyk A,Polak S

更新日期：2018-10-01 00:00:00

abstract：:The utilisation of physiologically-based pharmacokinetic models for the analysis of population data is an approach with progressively increasing impact. However, as we move from empirical to complex mechanistic model structures, incorporation of stochastic variability in model parameters can be challenging due to the ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Tsamandouras N,Wendling T,Rostami-Hodjegan A,Galetin A,Aarons L

更新日期：2015-08-01 00:00:00

abstract：:The distributed delay model has been introduced that replaces the transit compartments in the classic model of chemotherapy-induced myelosuppression with a convolution integral. The maturation of granulocyte precursors in the bone marrow is described by the gamma probability density function with the shape parameter (...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Krzyzanski W,Hu S,Dunlavey M

更新日期：2018-04-01 00:00:00

abstract：:We explored the type I error rate (false positive rate) associated with exposure-response (ER) analyses for two compounds in a fixed-dose combination product through simulations. In the simulations, at least one compound was assumed to be inactive, whereas the active compound followed E(max) model at different concent...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Zhu H,Wang Y

更新日期：2011-12-01 00:00:00

abstract：:Intravenous acetaminophen is a commonly used analgesic following surgery. The aims of this study were to determine the population pharmacokinetic profile of intravenous acetaminophen and its metabolites in adult surgical patients and to identify patient characteristics associated with acetaminophen metabolism in the p...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Owens KH,Murphy PG,Medlicott NJ,Kennedy J,Zacharias M,Curran N,Sreebhavan S,Thompson-Fawcett M,Reith DM

更新日期：2014-06-01 00:00:00

abstract：:Monoclonal antibodies (mAbs) represent a therapeutic strategy that has been increasingly used in different diseases. mAbs are highly specific for their targets leading to induce specific effector functions. Despite their therapeutic benefits, the presence of immunogenic reactions is of growing concern. The immunogenic...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Gómez-Mantilla JD,Trocóniz IF,Parra-Guillén Z,Garrido MJ

更新日期：2014-10-01 00:00:00

abstract：:This study was designed to investigate ethnic differences in the pharmacokinetics (PKs) of moxifloxacin and its metabolites, M1 (sulfo conjugate) and M2 (acyl-glucuronate), among Japanese, Chinese, and Korean populations, following oral administration. We used a population PK modeling approach using data from a clinic...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Kaneko M,Aoyama T,Ishida Y,Miyamoto A,Saito Y,Tohkin M,Kawai S,Matsumoto Y

更新日期：2018-04-01 00:00:00

abstract：:We investigated the propagation of population pharmacokinetic information across clinical studies by applying Bayesian techniques. The aim was to summarize the population pharmacokinetic estimates of a study in appropriate statistical distributions in order to use them as Bayesian priors in consequent population pharm...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Dokoumetzidis A,Aarons L

更新日期：2005-08-01 00:00:00

abstract：:The volume of distribution at steady state (Vss) of therapeutic proteins is usually assessed by non-compartmental or compartmental pharmacokinetic (PK) analysis wherein errors may arise due to the elimination of therapeutic proteins from peripheral tissues that are not in rapid equilibrium with the sampling compartmen...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Richter WF,Grimm HP,Theil FP

更新日期：2011-10-01 00:00:00

abstract：:The population approach to estimating mixed effects model parameters of interest in pharmacokinetic (PK) studies has been demonstrated to be an effective method in quantifying relevant population drug properties. The information available for each individual is usually sparse. As such, care should be taken to ensure t...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Dodds MG,Hooker AC,Vicini P

更新日期：2005-02-01 00:00:00

abstract：:Mixture models are applied in population pharmacometrics to characterize underlying population distributions that are not adequately approximated by a single normal or lognormal distribution. In addition to obtaining individualized maximum a posteriori Bayesian post hoc parameter estimates, the subpopulation to which ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Kaila N,Straka RJ,Brundage RC

更新日期：2007-04-01 00:00:00

abstract：:This study developed an integrated model of severity scores of migraine headache and the incidence of nausea, photophobia, and phonophobia to predict the natural time course of migraine symptoms, which are likely to occur by a common disease progression mechanism. Data were acquired from two phase 3 clinical trials co...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Chae D,Park K

更新日期：2018-10-01 00:00:00

abstract：:We used a previously developed physiologically based kinetic (PBK) model to analyze the effect of individual variations in metabolism and transport of cholesterol on pravastatin response. The PBK model is based on kinetic expressions for 21 reactions that interconnect eight different body cholesterol pools including p...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： van de Pas NC,Rullmann JA,Woutersen RA,van Ommen B,Rietjens IM,de Graaf AA

更新日期：2014-08-01 00:00:00

abstract：:Long term therapy with antiretroviral agents in HIV-infected patients often result in failure to suppress the virus load. Imperfect adherence to prescribed antiviral drugs is an important factor explaining the resurgence of virus. A better understanding of the factors responsible for the virological failure is importa...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Labbé L,Verotta D

更新日期：2006-08-01 00:00:00

abstract：:Guselkumab, a human IgG1 monoclonal antibody that blocks interleukin-23, has been evaluated in one Phase 2 and two Phase 3 trials in patients with moderate-to-severe psoriasis, in which disease severity was assessed using Psoriasis Area and Severity Index (PASI) and Investigator's Global Assessment (IGA) scores. Throu...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Hu C,Yao Z,Chen Y,Randazzo B,Zhang L,Xu Z,Sharma A,Zhou H

更新日期：2018-08-01 00:00:00

abstract：:Development of novel therapies for bone diseases can benefit from mathematical models that predict drug effect on bone remodeling biomarkers. Therefore, a bone cycle model (BCM) was developed that takes into consideration the concept of the basic multicellular unit and the dynamic equilibrium of bone remodeling. The m...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： van Schaick E,Zheng J,Perez Ruixo JJ,Gieschke R,Jacqmin P

更新日期：2015-08-01 00:00:00

abstract：:Bridging fundamental approaches to model optimization for pharmacometricians, systems pharmacologists and statisticians is a critical issue. These fields rely primarily on Maximum Likelihood and Extended Least Squares metrics with iterative estimation of parameters. Our research combines adaptive chaos synchronization...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Pillai N,Schwartz SL,Ho T,Dokoumetzidis A,Bies R,Freedman I

更新日期：2019-04-01 00:00:00

abstract：:Age-structured cell population model was introduced to describe cell survival. The impact of the environment on the cell population is represented by drug plasma concentration. A key model variable is the hazard of cell removal that is a subject to the environment effect. The model is capable of describing cohort and ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Krzyzanski W,Wiczling P,Gebre A

更新日期：2017-08-01 00:00:00

abstract：:The purpose of this study was to develop a whole-body physiologically based pharmacokinetic (WB-PBPK) model for ciprofloxacin for ICU patients, based on only plasma concentration data. In a next step, tissue and organ concentration time profiles in patients were predicted using the developed model. The WB-PBPK model w...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Sadiq MW,Nielsen EI,Khachman D,Conil JM,Georges B,Houin G,Laffont CM,Karlsson MO,Friberg LE

更新日期：2017-04-01 00:00:00

abstract：:Drugs that bind with high affinity and to a significant extent (relative to dose) to a pharmacologic target such as an enzyme, receptor, or transporter may exhibit nonlinear pharmacokinetic (PK) behavior. Processes such as receptor-mediated endocytosis may result in drug elimination. A general PK model for characteriz...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Mager DE,Jusko WJ

更新日期：2001-12-01 00:00:00

abstract：:Pegylated liposomal formulations contain lipid conjugated to polyethylene glycol. The disposition of encapsulated drug is dictated by the composition of the liposome, thus altering the pharmacokinetic (PK) profile of the drug. Allometric scaling is based on a power-log relationship between body weight (W) and drug cle...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Caron WP,Clewell H,Dedrick R,Ramanathan RK,Davis WL,Yu N,Tonda M,Schellens JH,Beijnen JH,Zamboni WC

更新日期：2011-10-01 00:00:00

abstract：:Population pharmacokinetic-pharmacodynamic analysis involves nonlinear hierarchical modelling where the mean response in a population and the variability in response from different sources are studied. It generally consists of two model hierarchies: a model for residual error and a model for heterogeneity termed betwe...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Lagishetty CV,Vajjah P,Duffull SB

更新日期：2012-08-01 00:00:00

abstract：:Mixture modeling within the context of pharmacokinetic (PK)/pharmacodynamic (PD) mixed effects modeling is a useful tool to explore a population for the presence of two or more subpopulations, not explained by evaluated covariates. At present, statistical tests for the existence of mixed populations have not been deve...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Frame B,Miller R,Lalonde RL

更新日期：2003-06-01 00:00:00

abstract：:T cell responses are a crucial part of the adaptive immune system in the fight against infections. This article discusses the use of mathematical models for understanding the dynamics of cytotoxic T lymphocyte (CTL) responses against viral infections. Complementing experimental research, mathematical models have been ...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Wodarz D

更新日期：2014-10-01 00:00:00

abstract：:The aim of this simulation study was to present a system-approach method for adjustment of continuous drug infusions at time-varying rates, aimed at achieving and then maintaining required drug concentration-time profiles in patients. The method presented can be used for safe and cost-effective individualization of dr...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Durisová M,Dedík L

更新日期：2002-12-01 00:00:00

abstract：:There have been no pharmacokinetic parameters and blood-brain equilibration rate constant (k e0) of propofol obtained in a single population of children, by which propofol can be administered using a target effect-site concentration controlled infusion. Thirty-nine, American Society of Anesthesiologists Physical Statu...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Choi BM,Lee HG,Byon HJ,Lee SH,Lee EK,Kim HS,Noh GJ

更新日期：2015-04-01 00:00:00

abstract：:We propose an efficient algorithm for screening covariates in population model building using Wald's approximation to the likelihood ratio test (LRT) statistic in conjunction with Schwarz's Bayesian criterion. The algorithm can be applied to a full model fit of k covariate parameters to calculate the approximate LRT f...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Kowalski KG,Hutmacher MM

更新日期：2001-06-01 00:00:00

abstract：:Bootstrap methods are used in many disciplines to estimate the uncertainty of parameters, including multi-level or linear mixed-effects models. Residual-based bootstrap methods which resample both random effects and residuals are an alternative approach to case bootstrap, which resamples the individuals. Most PKPD app...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Thai HT,Mentré F,Holford NH,Veyrat-Follet C,Comets E

更新日期：2014-02-01 00:00:00

abstract：:Mathematical modeling of drug effects maximizes the information gained from an experiment, provides further insight into the mechanisms of drug effects, and allows for simulations in order to design studies or even to derive clinical treatment strategies. We reviewed modeling of antimicrobial drug effects and show tha...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Czock D,Keller F

更新日期：2007-12-01 00:00:00

abstract：:Although selective 5-HT reuptake inhibitors (SSRIs) block monoamine uptake within hours of administration to patients, their full clinical effect does not appear until 2-4 weeks after treatment onset. Pindolol, a betablocker with weak partial 5-HT1A receptor agonist activity has been shown to produce a more rapid onse...

journal_title：Journal of pharmacokinetics and pharmacodynamics

authors： Gruwez B,Dauphin A,Tod M

更新日期：2005-12-01 00:00:00