Abstract：
:Quantitative systems pharmacology (QSP) is a recent addition to the modeling and simulation toolbox for drug discovery and development and is based upon mathematical modeling of biophysical realistic biological processes in the disease area of interest. The combination of preclinical neurophysiology information with clinical data on pathology, imaging and clinical scales makes it a real translational tool. We will discuss the specific characteristics of QSP and where it differs from PK/PD modeling, such as the ability to provide support in target validation, clinical candidate selection and multi-target MedChem projects. In clinical development the approach can provide additional and unique evaluation of the effect of comedications, genotypes and disease states (patient populations) even before the initiation of actual trials. A powerful property is the ability to perform failure analysis. By giving examples from the CNS R&D field in schizophrenia and Alzheimer's disease, we will illustrate how this approach can make a difference for CNS R&D projects.
journal_name
J Pharmacokinet Pharmacodynjournal_title
Journal of pharmacokinetics and pharmacodynamicsauthors
Geerts H,Spiros A,Roberts P,Carr Rdoi
10.1007/s10928-013-9297-1subject
Has Abstractpub_date
2013-06-01 00:00:00pages
257-65issue
3eissn
1567-567Xissn
1573-8744journal_volume
40pub_type
杂志文章abstract：:This study aimed to characterize pharmacodynamic interaction between propofol and aminophylline. Nine beagle dogs were randomly allocated at the propofol rates of 0.75 (group A), 1.00 (group B), and 1.25 (group C) mg/kg/min. During period 1, propofol only was infused, while during period 2, aminophylline only, at the ...
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abstract：:Guselkumab, a human IgG1 monoclonal antibody that blocks interleukin-23, has been evaluated in one Phase 2 and two Phase 3 trials in patients with moderate-to-severe psoriasis, in which disease severity was assessed using Psoriasis Area and Severity Index (PASI) and Investigator's Global Assessment (IGA) scores. Throu...
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pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：Journal of pharmacokinetics and pharmacodynamics
pub_type： 杂志文章
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更新日期：2018-06-01 00:00:00
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journal_title：Journal of pharmacokinetics and pharmacodynamics
pub_type： 杂志文章
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章
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更新日期：2021-01-03 00:00:00
