Abstract:
:Mycophenolate mofetil is a prodrug widely used in renal transplantation to prevent organ rejection. It is hydrolyzed to its active compound mycophenolic acid (MPA). MPA area under the curve (AUC0-12h) is considered the best pharmacokinetic parameter for the estimation of MPA exposition and for prediction of rejection. MPA-AUC requires several blood samples, making it impractical for clinical practice. Therefore, development of a limited sampling strategy (LSS) to estimate MPA AUC0-12h using three blood samples is very helpful for MPA individual dose adjustment. Results of LSS differ according to the patient background and to the drug formulation. Therefore, the purpose of this study was to develop a LSS for the estimation of MPA AUC0-12h in Tunisian renal transplant patients treated with the generic formulation of mycophenolate mofetil (MMF®, MEDIS). The best correlation was achieved by a profile based on three time points C0.5h, C1.5h, and C4h after drug intake: AUC0-12h = 0.414 + 1.210 × C0.5 + 2.256 × C1.5 + 4.134 × C4 (mei = 1.65% and rmse = 5.81%). The correlation between full AUC0-12h and abbreviated AUC0-12h was 0.917. In conclusion, this model provides a reliable and simple equation to estimate MPA AUC0-12h for the generic formulation of mycophenolate mofetil (MMF®).
journal_name
Nephrol Therjournal_title
Nephrologie & therapeutiqueauthors
Gaies E,Ben Sassi M,El Jebari H,Jebabli N,Charfi R,Chokri I,Salouage I,Klouz A,Trabelsi Sdoi
10.1016/j.nephro.2017.02.010subject
Has Abstractpub_date
2017-11-01 00:00:00pages
460-462issue
6eissn
1769-7255issn
1872-9177pii
S1769-7255(17)30171-2journal_volume
13pub_type
杂志文章abstract:AIM:To investigate risk factors of renal complications in glycogen storage disease type I, in order to identify practical implications for renal preservation. METHODS:A retrospective study of 38 patients with glycogen storage disease type I. RESULTS:The patients studied were 8.6 years old in average (1.5 to 22 years)...
journal_title:Nephrologie & therapeutique
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abstract::Salt consumption has substantially increased these last years in our modern societies and far exceeds our needs. It has a great impact on cardiovascular and renal disease and represents a major issue in public health. The present work is a review of observational and interventional studies exploring the relationship b...
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abstract::For ten years, an increase in the number of elderly patients on renal transplant waiting lists has occured. In an attempt to close the widening gap between supply and demand and because the demand for kidneys for younger patients already surpasses the supply, transplant physicians nowadays accept organs from older don...
journal_title:Nephrologie & therapeutique
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journal_title:Nephrologie & therapeutique
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journal_title:Nephrologie & therapeutique
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journal_title:Nephrologie & therapeutique
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abstract::Due to a national theoretical training provided to all resident for many years and the ongoing discussions to change the organization of the resident training of specialized study diploma (SSD) of nephrology, a survey was done to assess the perception of skills acquired in the management of different clinical situatio...
journal_title:Nephrologie & therapeutique
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doi:10.1016/j.nephro.2017.01.026
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journal_title:Nephrologie & therapeutique
pub_type: 杂志文章,评审
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journal_title:Nephrologie & therapeutique
pub_type: 杂志文章
doi:10.1016/j.nephro.2014.08.004
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journal_title:Nephrologie & therapeutique
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journal_title:Nephrologie & therapeutique
pub_type: 杂志文章
doi:10.1016/j.nephro.2007.05.005
更新日期:2007-10-01 00:00:00
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journal_title:Nephrologie & therapeutique
pub_type: 杂志文章
doi:10.1016/j.nephro.2017.10.006
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journal_title:Nephrologie & therapeutique
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journal_title:Nephrologie & therapeutique
pub_type: 杂志文章,评审
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更新日期:2006-01-01 00:00:00
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journal_title:Nephrologie & therapeutique
pub_type: 杂志文章
doi:10.1016/j.nephro.2014.04.003
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abstract::The primitive peritonitis (PP) is one of the rare but severe complications of the nephrotic syndrome. Through a series of 25 children who suffer from a primitive peritonitis complicating or revealing a nephritic syndrome, we tried to analyse the epidemiological and bacteriological aspects of these peritonitis. The mea...
journal_title:Nephrologie & therapeutique
pub_type: 杂志文章
doi:10.1016/j.nephro.2005.01.010
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journal_title:Nephrologie & therapeutique
pub_type: 杂志文章
doi:10.1016/j.nephro.2018.02.006
更新日期:2018-04-01 00:00:00
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journal_title:Nephrologie & therapeutique
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journal_title:Nephrologie & therapeutique
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doi:
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journal_title:Nephrologie & therapeutique
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journal_title:Nephrologie & therapeutique
pub_type: 杂志文章
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更新日期:2006-11-01 00:00:00
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journal_title:Nephrologie & therapeutique
pub_type: 杂志文章
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更新日期:2014-02-01 00:00:00
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journal_title:Nephrologie & therapeutique
pub_type: 杂志文章
doi:10.1016/j.nephro.2009.12.004
更新日期:2010-04-01 00:00:00
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journal_title:Nephrologie & therapeutique
pub_type: 杂志文章
doi:10.1016/j.nephro.2018.10.006
更新日期:2019-04-01 00:00:00