Abstract:
AIM:To investigate risk factors of renal complications in glycogen storage disease type I, in order to identify practical implications for renal preservation. METHODS:A retrospective study of 38 patients with glycogen storage disease type I. RESULTS:The patients studied were 8.6 years old in average (1.5 to 22 years) and were followed during 7.4 ± 4.5 years. Hypercalciuria was detected in 23 patients and was related to acidosis (P=0.028), higher lactate levels (5.9 ± 3.5 versus 3.7 ± 1.7 mmol/L; P=0.013) and smaller height (-2.1 ± 1.5 SD versus -0.8 ± 1.5 SD; P=0.026). Urolithiasis was diagnosed in 7 cases. Glomerular disease (19/38) was more frequent in cases with severe hypertriglyceridemia (P=0.042) and occurred at an older age (P=0.007). Microalbuminuria occurred in 15/31 cases; ACE inhibitors were prescribed in only 8 cases. The frequency of renal complications did not differ according to the diet group (continuous enteral feeding or uncooked starch). Logistic regression concluded as risk factors: lactic acidosis for tubular disease and age>10 years for glomerular disease. CONCLUSIONS:Renal involvement is common in glycogen storage disease type I patients. Tubular abnormalities are precocious, related to lactic acidosis and may be detected by monitoring of urinary calcium. Glomerular hyperfiltration is the first stage of a progressive glomerular disease and is related to age. Practical implications for renal preservation are discussed based on our results and literature.
journal_name
Nephrol Therjournal_title
Nephrologie & therapeutiqueauthors
Ben Chehida A,Bensmaïl T,Ben Rehouma F,Ben Abdelaziz R,Azzouz H,Boudabbous H,Slim Abdelmoula M,Abdelhak S,Kaabachi N,Ben Turkia H,Tebib Ndoi
10.1016/j.nephro.2014.12.007subject
Has Abstractpub_date
2015-07-01 00:00:00pages
240-5issue
4eissn
1769-7255issn
1872-9177pii
S1769-7255(15)00062-0journal_volume
11pub_type
杂志文章abstract::Definition and classification of acute renal failure evolved in recent years. The acronym "Acute Kidney Injury" replaces "Acute Renal Failure". The RIFLE classification spreads the AKI in three degrees of severity, and two degrees of disease duration. The group Acute Kidney Injury Network refines this classification i...
journal_title:Nephrologie & therapeutique
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journal_title:Nephrologie & therapeutique
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journal_title:Nephrologie & therapeutique
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journal_title:Nephrologie & therapeutique
pub_type: 杂志文章,评审
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journal_title:Nephrologie & therapeutique
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journal_title:Nephrologie & therapeutique
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journal_title:Nephrologie & therapeutique
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journal_title:Nephrologie & therapeutique
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,多中心研究
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journal_title:Nephrologie & therapeutique
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journal_title:Nephrologie & therapeutique
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journal_title:Nephrologie & therapeutique
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journal_title:Nephrologie & therapeutique
pub_type: 历史文章,杂志文章
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journal_title:Nephrologie & therapeutique
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journal_title:Nephrologie & therapeutique
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journal_title:Nephrologie & therapeutique
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doi:10.1016/j.nephro.2012.10.004
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journal_title:Nephrologie & therapeutique
pub_type: 杂志文章
doi:10.1016/j.nephro.2016.12.002
更新日期:2017-02-01 00:00:00
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journal_title:Nephrologie & therapeutique
pub_type: 杂志文章
doi:10.1016/j.nephro.2018.02.006
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journal_title:Nephrologie & therapeutique
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journal_title:Nephrologie & therapeutique
pub_type: 杂志文章
doi:10.1016/j.nephro.2017.01.026
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journal_title:Nephrologie & therapeutique
pub_type: 杂志文章
doi:10.1016/j.nephro.2020.09.007
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