Abstract：
:The remarkable improvement of the outcome of HIV infection came with the price of substantial toxicity of some antiretrovirals. The first molecules used to treat HIV included an important nephrotoxicity. Zalcitabine, stavudine and didanosine can induce severe lactic acidosis. Lactate production is enhanced and the renal capacity to regulate pH is overwhelmed. However, this side effect is not due to a direct dysfunction of the kidneys. Zalcitabine was withdrawn from the market because of this risk. Indinavir, a protease inhibitor, is soluble only in very acidic solutions. Consequently, the small fraction that is excreted in the urine precipitates and can be responsible for uro-nephrolithiasis, leukocyturia, cristalluria, obstructive acute kidney failure, and acute or chronic interstitial nephritis. This is the reason why indinavir is almost not prescribed nowadays, even if it is still marketed. In addition to the direct nephrotoxicity of some antiretrovirals, anti-HIV treatment also includes a toxicity which pathophysiology is not completely elucidated. This nephrotoxicity is the consequence of organ accelerated ageing and of an increased vascular risk. Kidney vascularization (from renal arteries to capillaries) is essential to kidney function and all cardiovascular risks are also renal risks. It is now clearly established that combined antiretroviral treatment increases the vascular risk. A better comprehension of the links between HIV infection, its treatment and very long-term kidney risk is needed to improve the complex management of patients who have now cumulated several decades of HIV infection and treatment with various toxicities.
journal_name
Nephrol Therjournal_title
Nephrologie & therapeutiqueauthors
Loens C,Amet S,Isnard-Bagnis C,Deray G,Tourret Jdoi
10.1016/j.nephro.2017.12.001subject
Has Abstractpub_date
2018-02-01 00:00:00pages
55-66issue
1eissn
1769-7255issn
1872-9177pii
S1769-7255(17)30635-1journal_volume
14pub_type
杂志文章abstract：INTRODUCTION:The FIND-CKD study has validated the use of ferric carboxymaltose (FCM) injection with a target of ferritin level between 400 and 600ng/mL to treat iron deficiency anemia in non-dialysis-dependent chronic kidney disease (ND-CKD) patients. In order to assess this strategy in clinical practice, we constitute...
journal_title：Nephrologie & therapeutique
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更新日期：2019-04-01 00:00:00
abstract：:Buerger's disease or thombo-angiitis obliterans disease is a small vessel's vasculitis, frequently observed in young and smoker's males. Diagnosis is based on both clinical and radiological arguments. There is no specific treatment designed for this disease. We report the case of 43 years old patient presenting with a...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2017.10.006
更新日期：2018-05-01 00:00:00
abstract：:In France, 1 adult out of 3 is affected by hypertension and only 1 hypertensive out of 4 achieves blood pressure targets (<140/90mmHg). This proportion is significantly better in similar countries (e.g. England, Germany, the USA). Nephrologists are particularly concerned since although more than 90 % of Chronic Kidney...
journal_title：Nephrologie & therapeutique
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doi：10.1016/j.nephro.2020.10.001
更新日期：2020-11-01 00:00:00
abstract：INTRODUCTION:Morocco stays far behind other countries in the domain of organ donation and transplantation. Improving the knowledge of Moroccan students, about organ donation and transplantation, can be a key factor in the development of transplant activity. The aim of this study is to evaluate the knowledge, attitudes ...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2015.02.003
更新日期：2015-07-01 00:00:00
abstract：:In 2006, 6,509 patients with end-stage renal disease living in 16 regions covering 48(M) inhabitants (79% of the French population), started renal replacement therapy (dialysis or preemptive graft): median age was 71 years; 3% had a preemptive graft. The overall crude annual incidence rate of renal replacement therapy...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：
更新日期：2008-07-01 00:00:00
abstract：:This chapter provides indicators to describe the specificity of End Stage Renal Disease in children in France and to study these patients'outcome and the choices of treatment modalities. In 2011, the incidence and the prevalence of ESRD among patients under 20 years old remained stable at 8 and 53 pmp respectively. Th...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章,多中心研究
doi：10.1016/S1769-7255(13)70044-0
更新日期：2013-09-01 00:00:00
abstract：:Ischemia-reperfusion injury is an inescapable phenomenon in kidney transplantation. It combines lesional processes of biochemical origin associated with oxydative stress and of immunological origin in connection with the recruitment and activation of innate immunity cells. Histological lesions associate acute tubular ...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2020.05.001
更新日期：2020-11-01 00:00:00
abstract：:The dramatic occurrence, during haemodialysis sessions, of hemodynamic and cerebral symptoms in a 53-year-old haemodialysed woman with a history of aortocoronary bypass leads to discovery and treatment by percutaneous angioplasty and stenting of a significant stenosis of proximal subclavian artery, ipsilateral to the ...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2009.06.002
更新日期：2009-12-01 00:00:00
abstract：:African-Americans exhibit an excess risk for chronic and end-stage kidney disease compared to the non-African populations. Two APOL1 genetic variants were shown to account for the majority of this racial disparity in glomerulopathies and other non-diabetic kidney disease. The high-risk genotype has only been reported ...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2019.03.007
更新日期：2019-04-01 00:00:00
abstract：:When seen, some habits of calcium oxalate monohydrate crystals (whewellite) are so typical of ethylene glycol intoxication that they may be helpful for its diagnosis when circumstances are not clearly established. ...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2014.04.003
更新日期：2014-11-01 00:00:00
abstract：:The haemodialysis has considerably transformed the evolution of chronic renal failure which usually has a precarious evolution. However, this palliative treatment disturbed in several manners the universe of the patient. Our purposes were to evaluate the quality of life of patient on haemodialysis and to identify the ...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章,多中心研究
doi：10.1016/j.nephro.2007.07.008
更新日期：2008-02-01 00:00:00
abstract：:Cytomegalovirus infection in kidney transplantation is associated with increased morbidity and mortality through direct and indirect effects. International guidelines had been recently updated, focusing on diagnostic, prevention strategies and curative treatment. Cytomegalovirus-specific immune response plays also an ...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章,评审
doi：10.1016/j.nephro.2015.03.005
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:Self-care education can play an important role in improving the quality of life in hemodialysis patients. PURPOSE:The purpose of this study was to determine the effect of self-care education with teach back method on the quality of life in hemodialysis patients. METHODS:In this pre- and post-test clinical ...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2020.01.002
更新日期：2020-07-01 00:00:00
abstract：:Extracellular content in magnesium represents about 1% of total body content, of which plasma magnesium is thus a poor reflect. Hypomagnesaemia is defined by a value lesser than 0.65mmol/L. Its incidence in hospitalized patients ranges between 10 and 15%. Identification of the physiopathology of hypomagnesaemia relies...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2012.09.002
更新日期：2012-11-01 00:00:00
abstract：:While the CKD-EPI (for Chronic Kidney Disease Epidemiology) equation is now implemented worldwide, utilization of the Cockcroft formula is still advocated by some physicians for drug dosage adjustment. Justifications for this recommendation are that the Cockcroft formula was preferentially used to determine dose adjus...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2015.07.472
更新日期：2016-02-01 00:00:00
abstract：:Post-transplantation lymphoproliferative disorder (PTLD) is a well-know complication after organ transplantation. We report a case of a patient who developed an extramedullary plasmacytoma-like PTLD around his transplanted kidney treated with standard multiple myeloma chemotherapy. Three years after benefiting of a de...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2018.07.404
更新日期：2018-12-01 00:00:00
abstract：:IgA vasculitis is a systemic vasculitis affecting small vessels. IgA vasculitis usually affect children whereas it is rare in adults (150 to 200 for 1) in which the disease is often more serious with more frequent and severe nephritis. Prevalence of adult IgA vasculitis is unknown and its annual incidence is 1 in 1 mi...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2019.02.001
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:The end-stage renal disease (ESRD) in children has special features in terms of etiologies, therapeutic modalities and access to renal transplantation. In Tunisia, there are no data on the epidemiology of ESRD in children. The aim of our study was to describe epidemiology of ESRD among Tunisian children. ME...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章,多中心研究
doi：10.1016/j.nephro.2015.09.001
更新日期：2016-06-01 00:00:00
abstract：:End-stage renal disease has an important impact on the patients' daily life, which can be measured by quality of life questionnaires. The objective of this work was to adapt the Kidney Disease Quality of Life questionnaire (KDQoL) into French and to determine its basic psychometric properties, i.e. validity and reliab...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2007.05.005
更新日期：2007-10-01 00:00:00
abstract：:Kakimoto and Akazawa, first isolated and identified asymmetric dimethylarginine (ADMA) from human urine in 1970. They speculated that ADMA, and its structural isomer symmetrical dimethylarginine (SDMA), "may be important for the study of various pathological states". It took 22 years before this hypothesis materialize...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章,评审
doi：10.1016/j.nephro.2007.02.002
更新日期：2007-04-01 00:00:00
abstract：:The optimal method to assess the adequacy of peritoneal dialysis therapies is controversial. Today, the adequacy must not be considered as a number or a concept assessed only by two parameters (total KT/V urea and total solute clearance) but defined by many more items. In the absence of data, based on theoretical cons...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2013.05.005
更新日期：2013-11-01 00:00:00
abstract：AIM:The aim of the study is to analyse haemodialysis patients' prescriptions accordance with legal registrations in 64 chronic haemodialysis patients during a one-month follow-up period. RESULTS:Patients are taking 9.6+/-3 different drugs. A mean of 2.4+/-1.3 prescriptions per patient disagree with the recommended dru...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章,多中心研究
doi：10.1016/j.nephro.2005.08.002
更新日期：2005-10-01 00:00:00
abstract：:Primary hyperoxalurias are rare recessive inherited inborn errors of glyoxylate metabolism. They are responsible for progressive renal involvement, which further lead to systemic oxalate deposition, which can even occur in infants. Primary hyperoxaluria type 1 is the most common form in Europe and is due to alanine-gl...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2011.03.004
更新日期：2011-07-01 00:00:00
abstract：:A 21-year-old man ingested 75g of pure caffeine, in an attempt to commit suicide. This represents 7.5 times the minimal lethal dose. Caffeine, 1,3,7-trimethylxanthine, is the most widely consumed psychoactive compound worldwide. It is mostly found in coffee, tea, energizing drinks and in some drugs. However, it has be...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2016.10.005
更新日期：2017-05-01 00:00:00
abstract：:High blood pressure during renal disease is highly prevalent and an important risk factor for cardiovascular disease and renal progression. Its optimal management is therefore necessary to improve the prognosis of patients. Several trials concerning the blood pressure target in patients with chronic non-diabetic kidne...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章,评审
doi：10.1016/j.nephro.2018.01.001
更新日期：2018-11-01 00:00:00
abstract：:The renal transplantation is nowadays the reference treatment of ESRD. Living donor kidney transplantation is less often performed in France than in other countries. Nevertheless, numerous French and international surveys have evidenced that it provides the recipients a longer life expectancy and a better quality of l...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章,多中心研究
doi：10.1016/S1769-7255(11)70007-4
更新日期：2011-07-01 00:00:00
abstract：BACKGROUND:Due to technical requirements and cost, hemodiafiltration (HDF) is not widely used in pediatrics. We have been using online HDF (oHDF) since 2009 and we observed low parathyroid hormone (PTH) levels despite the accurate management of CKD-MBD. METHODS:We reviewed the medical charts and parameters of mineral ...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2013.09.003
更新日期：2014-02-01 00:00:00
abstract：:Beta cell replacement by pancreas or Langerhans islets transplantation is the only way to restore glucose homeostasis in type 1 diabetic patients. The counterpart is the need for long-term immunosuppression. These transplantations are therefore mainly indicated for patients candidates for kidney transplantation and fo...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2018.02.006
更新日期：2018-04-01 00:00:00
abstract：:Calcium and phosphate play a key role in bone mineralization but have also many other physiological functions. The control of serum phosphate concentration is mandatory to avoid the occurrence of severe metabolic disorders, but is less tightly regulated than serum ionized calcium concentration, which is maintained in ...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2010.12.004
更新日期：2011-04-01 00:00:00
abstract：:Continuous renal replacement therapy (CRRT) with a high cutoff (HCO) membrane is proposed for septic shock as a blood purification technique. The aim of this therapy is to modulate the immune response through the increase of the clearances of the inflammatory mediators as compared to standard CRRT. The use of HCO memb...
journal_title：Nephrologie & therapeutique
pub_type： 杂志文章
doi：10.1016/j.nephro.2013.07.370
更新日期：2013-12-01 00:00:00
