Abstract:
INTRODUCTION:This pilot study was conducted to examine, for the first time, the ongoing systems biology research and development projects within the laboratories and centers of the U.S. Army Medical Research and Materiel Command (USAMRMC). The analysis has provided an understanding of the breadth of systems biology activities, resources, and collaborations across all USAMRMC subordinate laboratories. METHODS:The Systems Biology Collaboration Center at USAMRMC issued a survey regarding systems biology research projects to the eight U.S.-based USAMRMC laboratories and centers in August 2016. This survey included a data call worksheet to gather self-identified project and programmatic information. The general topics focused on the investigators and their projects, on the project's research areas, on omics and other large data types being collected and stored, on the analytical or computational tools being used, and on identifying intramural (i.e., USAMRMC) and extramural collaborations. RESULTS:Among seven of the eight laboratories, 62 unique systems biology studies were funded and active during the final quarter of fiscal year 2016. Of 29 preselected medical Research Task Areas, 20 were associated with these studies, some of which were applicable to two or more Research Task Areas. Overall, studies were categorized among six general types of objectives: biological mechanisms of disease, risk of/susceptibility to injury or disease, innate mechanisms of healing, diagnostic and prognostic biomarkers, and host/patient responses to vaccines, and therapeutic strategies including host responses to therapies. We identified eight types of omics studies and four types of study subjects. Studies were categorized on a scale of increasing complexity from single study subject/single omics technology studies (23/62) to studies integrating results across two study subject types and two or more omics technologies (13/62). Investigators at seven USAMRMC laboratories had collaborations with systems biology experts from 18 extramural organizations and three other USAMRMC laboratories. Collaborators from six USAMRMC laboratories and 58 extramural organizations were identified who provided additional research expertise to these systems biology studies. CONCLUSIONS:At the end of fiscal year 2016, USAMRMC laboratories self-reported 66 systems biology/computational biology studies (62 of which were unique) with 25 intramural and 81 extramural collaborators. Nearly two-thirds were led by or in collaboration with the U.S. Army Telemedicine and Advanced Technology Research Center/Department of Defense Biotechnology High-Performance Computing Software Applications Institute and U.S. Army Center for Environmental Health Research. The most common study objective addressed biological mechanisms of disease. The most common types of Research Task Areas addressed infectious diseases (viral and bacterial) and chemical agents (environmental toxicant exposures, and traditional and emerging chemical threats). More than 40% of the studies (27/62) involved collaborations between the reporting USAMRMC laboratory and one other organization. Nearly half of the studies (30/62) involved collaborations between the reporting USAMRMC laboratory and at least two other organizations. These survey results indicate that USAMRMC laboratories are compliant with data-centric policy and guidance documents whose goals are to prevent redundancy and promote collaborations by sharing data and leveraging capabilities. These results also serve as a foundation to make recommendations for future systems biology research efforts.
journal_name
Mil Medjournal_title
Military medicineauthors
Zalatoris JJ,Scheerer JB,Lebeda FJdoi
10.7205/MILMED-D-16-00446subject
Has Abstractpub_date
2017-09-01 00:00:00pages
e1802-e1809issue
9eissn
0026-4075issn
1930-613Xjournal_volume
182pub_type
杂志文章abstract:OBJECTIVE:The goal was to show the epidemiological characteristics and clinical manifestations of Lyme borreliosis in Croatia. METHODS:Data on registered Lyme borreliosis cases were analyzed and the most common clinical manifestations of the disease, based on meta-analysis of the data collected, are described. RESULT...
journal_title:Military medicine
pub_type: 杂志文章,meta分析
doi:10.7205/milmed.171.11.1105
更新日期:2006-11-01 00:00:00
abstract::This case report examines a vesiculopustular reaction which occurred in a young Marine 9 d after receiving the smallpox vaccination. Review of the CDC guidelines, ACAM2000 package insert, and literature surrounding the smallpox vaccine reveals several well-established adverse cutaneous reactions associated with vaccin...
journal_title:Military medicine
pub_type: 杂志文章
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abstract::The study determines the extent to which payment thresholds for reporting malpractice claims to the National Practitioner Data Bank identifies substandard health care delivery in the Department of Defense. Relevant data were available on 2,291 of 2,576 medical malpractice claims reported to the closed medical malpract...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1997-04-01 00:00:00
abstract::Civilian emergency response personnel who assist at chemical or biological disaster scenes are likely to be novices at functioning in chemical-biological (C-B) protective clothing (CBC) meant for use on contaminated battlefields. Such teams must be aware that CBC imposes numerous physiological, psychophysiological, an...
journal_title:Military medicine
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doi:
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abstract::Individual fitness, an important component of combat readiness, has been found to be deficient in some Reserve Component units of the United States Army. We evaluated a program of monthly physical training in an environment of increasing emphasis on unit physical fitness in an effort to determine the effect on unit pe...
journal_title:Military medicine
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doi:
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abstract::A case of fly larva infestation of the eye (ophthalmomyiasis) is reported in an American soldier serving in Operation Desert Shield. Background information, prognosis, and treatment are discussed. ...
journal_title:Military medicine
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doi:
更新日期:1991-08-01 00:00:00
abstract:INTRODUCTION:The aims of this study were as follows: first to quantify and review the types of surgical procedures performed by military surgeons assigned to a Forward Surgical Team (FST) providing medical support to the population (MSP) in the Ivory Coast (IC), and second to analyze how this MSP was achieved. METHODS...
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journal_title:Military medicine
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abstract::The U.S. Army Special Forces Medic, Military Occupational Specialty 18D, is a unique, enlisted, medical asset. The training of the 18D is demanding, lengthy, and selective. The 18D is trained to independently assess, and provide acute and long-term medical care for, a variety of medical conditions in support of the Sp...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1992-02-01 00:00:00
abstract::Four cases of splenic infarction/sequestration in sickle cell trait (SCT) patients are presented. All four patients were undergoing moderate exercise at elevations ranging from 5,500 to 12,000 feet. The patients include two African-American males, a Hispanic male, and a white female. All four presented with the acute ...
journal_title:Military medicine
pub_type: 杂志文章,评审
doi:
更新日期:1999-03-01 00:00:00
abstract:PURPOSE:Evaluate the effectiveness of a 2-day, 3-night outdoor recreation intervention involving fly-fishing in reducing the psychological concomitants of stress among 74 veterans (M = 47.27, SD = 14.55 years) with post-traumatic stress disorder (PTSD). METHODS:Participants completed repeated assessments of attentiven...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-12-00308
更新日期:2013-03-01 00:00:00
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journal_title:Military medicine
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journal_title:Military medicine
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doi:10.7205/MILMED-D-14-00647
更新日期:2015-07-01 00:00:00
abstract::Sternal wound complications after sternotomy carry significant morbidity and mortality rates. Sternal fractures attributable to blunt trauma may cause incapacitating pain or may be plagued by symptoms resulting from chronic nonunion. A sternal fixation system has been developed and used successfully for the management...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed.172.10.1125
更新日期:2007-10-01 00:00:00
abstract::A duplication cyst of the ileum was initially observed in a fetus at 26 weeks gestation on prenatal ultrasonography. Repeated spontaneous resolution of the cyst by decompression into the adjacent bowel lumen delayed diagnosis and management until the child was 9 months of age. The child experienced two episodes of hem...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1989-11-01 00:00:00
abstract::U.S. military researchers have made major contributions to the discovery, diagnosis, treatment, and prevention of a number of parasitic diseases. We review the paramount U.S. military contributions to the understanding of leishmaniasis, filariasis, schistosomiasis, trypanosomiasis, gastrointestinal parasites, intestin...
journal_title:Military medicine
pub_type: 历史文章,杂志文章,评审
doi:10.7205/milmed.170.4s.17
更新日期:2005-04-01 00:00:00
abstract::The purpose of this study was to assess changes in alcohol, tobacco, and other drug use after the terrorist attacks of September 11 among a cohort of young military personnel consisting of 661 active duty Navy personnel, including 164 women. Paired sample t tests were computed to assess mean differences in substance u...
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pub_type: 杂志文章
doi:10.7205/milmed.169.10.829
更新日期:2004-10-01 00:00:00
abstract::Ethylene glycol is an inexpensive, readily available substance that may be associated with accidental or intentional toxicity. Toxicity from this substance may be encountered in the military and civilian populations. Because it is highly toxic and can result in death if not treated appropriately, it is imperative to r...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed.169.8.660
更新日期:2004-08-01 00:00:00
abstract::Appropriate and consistent use of condom remains an effective approach to human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) intervention. We analyzed the baseline data gathered for a situationally based HIV/AIDS intervention to assess the potential predictors of condom use among the Uniforme...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed.171.10.1027
更新日期:2006-10-01 00:00:00
abstract::Shoulder pain is a common musculoskeletal complaint. Patients with shoulder pain who are seeking care in a military tertiary setting in the United States have not been previously described. This study describes the clinical features of 55 patients (47 men, 8 women) undergoing shoulder surgery at a tertiary care milita...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed-d-01-3607
更新日期:2009-06-01 00:00:00
abstract::In June 1988, the armed forces of the United States began testing prospective candidates for military service for alcohol, marijuana metabolite (THC-COOH), and cocaine metabolite (benzoylecgonine) through the Military Entrance Processing Station (MEPS) program. Comparison of the confirmed positive drug rates for pre-i...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract:INTRODUCTION:The role of the Emergency Medicine (EM) physician in the U.S. military continues to expand, and current Accreditation Council for Graduate Medical Education general training requirements do not optimally prepare military EM graduates to be successful in postresidency operational assignments. To address thi...
journal_title:Military medicine
pub_type: 杂志文章
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更新日期:2020-01-07 00:00:00
abstract::Administrative and clinical considerations for the establishment of an ophthalmic laser program at a VA Outpatient Clinic are discussed. Outcomes of the first 320 patients treated over a 3-year period of time are presented. The program is evaluated from the perspectives of patient care, safety, maintenance, education,...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1995-08-01 00:00:00
abstract::Occupational upper-extremity disorders have been associated with prolonged pain and work disability. Using the U.S. Army Physical Disability Agency database, the present case-control studies (n = 434 and n = 342) investigated the contribution of demographic, physical, occupational psychosocial, and individual psychoso...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract:INTRODUCTION:Dengue fever, caused by any of the four dengue viruses (DENV1-4), is endemic in more than 100 countries around the world. Each year, up to 400 million people get infected with dengue virus. It is one of the most important arthropod-borne viral diseases. Dengue's global presence poses a medical threat to de...
journal_title:Military medicine
pub_type: 杂志文章
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更新日期:2021-01-11 00:00:00
abstract::Advanced practice nurses (APN) who practice in the surgical subspecialty areas may have the opportunity to expand their scope of practice to include first assistant at surgery. Surgical APNs who practice as registered nurse first assistants (RNFA) should seek credentialing and apply for institutional privileges to ass...
journal_title:Military medicine
pub_type: 历史文章,杂志文章
doi:10.7205/milmed.171.9.875
更新日期:2006-09-01 00:00:00
abstract::Air National Guard (ANG) medical units perform 2 weeks of active duty training each year to develop and maintain essential medical skills. Providing meaningful training is, however, a great challenge to both the Guard unit and its active duty counterpart. Too often, annual training is not a relevant learning experienc...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1991-11-01 00:00:00
abstract::Twenty-four pilots (age 20-32 years) were monitored with a Holter monitor during 26 hours including a high-Gz flight in order to evaluate heart rate (HR) and cardiac rhythm. Flight experience did not predict the mean in-flight HR (range 69-121 beats/minute), which decreased with increasing age and correlated to the ma...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract::Trauma disclosure is the initial step toward healing trauma-related distress. This study used qualitative methods to better understand factors facilitating and inhibiting change in the disclosure process. Fifty-six veterans were interviewed about their disclosure experiences between August 2004 and 2005. Emerging them...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed-d-10-00054
更新日期:2010-10-01 00:00:00
abstract:INTRODUCTION:Given the role of perceived stress in disability and suicidality in the military, intervening early before service members become at risk for severe injuries, hospitalizations, and chronic disability could improve health outcomes. The purpose of this study was to explore the feasibility and acceptability o...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.1093/milmed/usz132
更新日期:2020-02-13 00:00:00