Abstract:
INTRODUCTION:Dengue fever, caused by any of the four dengue viruses (DENV1-4), is endemic in more than 100 countries around the world. Each year, up to 400 million people get infected with dengue virus. It is one of the most important arthropod-borne viral diseases. Dengue's global presence poses a medical threat to deploying military personnel and their dependents. An accurate diagnosis followed by attentive supportive care can improve outcomes in patients with severe dengue disease. Dengue diagnostic tests based on PCR and ELISA platforms have been developed and cleared by the U.S. FDA. However, these diagnostic assays are laborious and usually require highly trained personnel and specialized equipment, which presents a significant challenge when conducting operations in austere and resource-constrained areas. InBios International, Inc. (Seattle, WA) has developed two rapid and instrument-free immunochromatographic test prototype devices (multiplex and traditional formats) for dengue diagnosis. MATERIALS AND METHODS:To determine the performance of the InBios immunochromatographic tests, 183 clinical samples were tested on both prototype devices. Both assays were performed without any instruments and the results were read in 20 minutes. RESULTS:The traditional format had better overall performance (sensitivity: 97.4%; specificity: 90%) than the multiplex format (sensitivity: 86.9%; specificity: 63.3%). The traditional format was superior in serotype-specific detection with 100% overall sensitivity for DENV1, DENV3, and DENV4 and 93.3% sensitivity for DENV2 compared to the multiplex format (91.7%, 78.3%, 83.3%, and 96.3% for DENV1, 2, 3, and 4, respectively). The traditional format was easier to read than the multiplex format. The multiplex format was simpler and faster to set up than the traditional format. CONCLUSIONS:The InBios traditional format had a better overall performance and readability profile than the multiplex format, while the multiplex format was easier to set up. Both formats were highly sensitive and specific, were easy to perform, and did not require sophisticated equipment. They are ideal for use in resource-limited settings where dengue is endemic. Based on our overall assessment, the traditional format should be considered for further development and used in the upcoming multicenter clinical trial toward FDA clearance.
journal_name
Mil Medjournal_title
Military medicineauthors
Chen HW,Maldonado TD,Lee CR,Williams M,Defang GN,Ellison DW,Van De Wyngaerde M,Rooney CM,Wu SLdoi
10.1093/milmed/usaa553subject
Has Abstractpub_date
2021-01-11 00:00:00eissn
0026-4075issn
1930-613Xpii
6080202pub_type
杂志文章abstract::One hundred six astronaut applicants who had passed initial screening were evaluated for Axis I and Axis II DSM-III-R diagnoses using a structured psychiatric interview. Nine of 106 candidates (8.5%) met diagnostic criteria for six Axis I (including V-code), or Axis II disorders. The use of the NASA structured intervi...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::Very little data are available to commanders regarding gynecological problems encountered by a large female population in a combat zone for extended periods of time. The 312th Evacuation Hospital supported Operation Desert Storm, treating over 12,000 patients. Of these, 577 were treated by the gynecological service. O...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1992-05-01 00:00:00
abstract::A survey of 600 Army and Navy physicians deployed to the Persian Gulf during Operation Desert Storm was conducted to ascertain their concerns pertaining to the ethics of combat medicine and note any similarities with common ethical concerns in the peacetime practice of medicine. Despite expressed familiarity with the ...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-16-00022
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:Determine the short-term effects of creatine supplementation on performance of military tasks, thermoregulation, and health risks. METHODS:Male military personnel were randomly assigned to a creatine (CR; N = 8) or a placebo (CON; N = 8) supplementation group. Testing was conducted at baseline, after a 6-day l...
journal_title:Military medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2001-11-01 00:00:00
abstract::Ethylene glycol is an inexpensive, readily available substance that may be associated with accidental or intentional toxicity. Toxicity from this substance may be encountered in the military and civilian populations. Because it is highly toxic and can result in death if not treated appropriately, it is imperative to r...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed.169.8.660
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journal_title:Military medicine
pub_type: 杂志文章
doi:10.1093/milmed/usx050
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journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
abstract::Previous research has found that individual characteristics play an important role in psychological wellbeing and perception of stress. Although the Five Factor Model of personality has been found to consistently predict psychological well-being in the general population and among military personnel, hardiness has als...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed-d-10-00359
更新日期:2011-04-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:10.1093/milmed/usz327
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journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-13-00423
更新日期:2014-04-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章,多中心研究
doi:10.1093/milmed/usy153
更新日期:2019-03-01 00:00:00
abstract:INTRODUCTION:Upon injury, skeletal muscle undergoes a multiphase process beginning with degeneration of the damaged tissue, which is accompanied by inflammation and finally regeneration. One consequence of an injured microenvironment is excessive production of reactive oxygen species, which results in attenuated regene...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.1093/milmed/usz232
更新日期:2020-01-07 00:00:00
abstract::Spontaneous pneumomediastinum (SPM) with associated subcutaneous emphysema is an uncommon and generally benign condition. We describe an occurrence of SPM that occurred from yelling in a U.S. Marine Corps Drill Instructor. The patient describes yelling at Marine recruits the day prior when he felt a pop "behind his no...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed-d-12-00243
更新日期:2012-11-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:2002-06-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-12-00322
更新日期:2013-04-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed-d-00-4309
更新日期:2009-11-01 00:00:00
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journal_title:Military medicine
pub_type:
doi:
更新日期:2001-12-01 00:00:00
abstract:Introduction:This review summarizes the research conducted on botulinum toxin (BoTx) from 1943 to 1956 by a small group of Camp Detrick investigators and their staff. A systematic, cross-disciplinary approach was used to develop effective vaccines against this biological warfare threat agent. In response to the potenti...
journal_title:Military medicine
pub_type: 历史文章,杂志文章,评审
doi:10.1093/milmed/usx047
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:To describe the development of the Combat Casualty Critical Care Database, a comprehensive database of critically injured combat casualties to identify potentially modifiable risk factors for morbidity and mortality in this population. METHODS:The Department of Defense's Joint Theater Trauma Registry was que...
journal_title:Military medicine
pub_type: 杂志文章,评审
doi:10.7205/MILMED-D-13-00393
更新日期:2014-04-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1989-09-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-16-00018
更新日期:2016-11-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed.171.4.288
更新日期:2006-04-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-14-00080
更新日期:2014-11-01 00:00:00
abstract::Of 782 Army families with children that were surveyed, over 10% reported one or more member with health problems or handicapping conditions requiring special ongoing treatment. However, less than half of these were enrolled in the Exceptional Family Member Program. Families with illnesses/handicaps that were enrolled ...
journal_title:Military medicine
pub_type: 杂志文章
doi:
更新日期:1992-02-01 00:00:00
abstract::This retrospective study examined spinal-related hospitalizations of U.S. Army soldiers deployed to Afghanistan and Iraq. Spinal cord injuries (SCI) and vertebral column injuries (VCI) were identified using International Classification of Disease, 9th Revision, Clinical Modification diagnosis codes. In our study, spin...
journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-14-00061
更新日期:2015-02-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:10.1093/milmed/usz068
更新日期:2019-12-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/milmed.173.3.328
更新日期:2008-03-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:10.7205/MILMED-D-14-00635
更新日期:2015-07-01 00:00:00
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journal_title:Military medicine
pub_type: 杂志文章
doi:10.1093/milmed/usaa110
更新日期:2020-09-18 00:00:00