Abstract：
ETHNOPHARMACOLOGICAL RELEVANCE:Herb-drug interactions are of great concern in health practices. Curcumin is a natural polyphenol extracted from turmeric, a spice widely used all over the world. Curcumin is clinically used due to its acceptable safety profile and therapeutic efficacy. AIM OF THE STUDY:Current paper aims to highlight the effect of curcumin on concomitantly used drugs. METHODS:Electronic databases including PubMed, Scopus and Science Direct were searched with the keywords "curcumin" in the title/abstract and "drug interaction," "drug metabolism," "cytochrome," "P-glycoprotein" and "P450" in the whole text. RESULTS:Curcumin can induce pharmacokinetic alterations such as changes in Cmax and AUC when concomitantly used with pharmacological agents like cardiovascular drugs, antidepressants, anticoagulants, antibiotics, chemotherapeutic agents, and antihistamines. The underlying mechanisms of these interactions include inhibition of cytochrome (CYP) isoenzymes and P-glycoprotein. There is only one clinical trial which proved a significant alteration of conventional drugs in concomitant use with curcumin indicating the need for further human studies. CONCLUSIONS:Although in vitro and in vivo studies do not provide enough evidence to judge the clinical drug interactions of curcumin, physicians must remain cautious and avoid drug combinations which may lead to curcumin-drug interactions.
journal_name
J Ethnopharmacoljournal_title
Journal of ethnopharmacologyauthors
Bahramsoltani R,Rahimi R,Farzaei MHdoi
10.1016/j.jep.2017.07.022subject
Has Abstractpub_date
2017-09-14 00:00:00pages
1-12eissn
0378-8741issn
1872-7573pii
S0378-8741(16)32525-9journal_volume
209pub_type
杂志文章,评审abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Arogyavardhini vati, an Ayurvedic polyherbal formulation has been used for liver and skin disorders in the Ayurvedic system of medicine. However, toxicity due to the presence of heavy metals in this traditional medicine is a matter of concern. AIM OF THE STUDY:To evaluate the safety of A...
journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Polygonum capitatum is a well-known Miao medicinal plant that has been used for many years for its unique therapeutic effects on various urological disorders, including urinary calculus and urinary tract infections. To investigate the effect of Polygonum capitatum on cytochrome P450 (CYP)...
journal_title：Journal of ethnopharmacology
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abstract：:The usage and indications of possible therapeutic and harmful effects of 96 plants reported to be used for headaches in traditional Zulu, Xhosa and Sotho medicine are reviewed. Although few pharmacological studies have been undertaken on the plants used, related usage by other ethnic groups and known properties in rel...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
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abstract：:Aloe barbadensis Mill. Syn. Aloe vera Tourn. ex Linn.(Liliaceae) has been used in variety of diseases in traditional Indian system of medicine in India and its use for hepatic ailments is also documented. In the present study an attempt has been made to validate its hepatoprotective activity. The shade dried aerial pa...
journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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abstract：AIM OF THE STUDY:Rhizoma Coptidis (Huanglian) is a widely used Traditional Chinese Medicine. However, it causes human as well as animal toxicities. In this study, we aimed to ascertain the toxic constituents in Rhizoma Coptidis. MATERIALS AND METHODS:The acute toxicity of both the total extract and the alkaloid-rich e...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2010-03-24 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
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更新日期：2013-06-21 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:Lignosus rhinocerus (Tiger Milk mushroom) is distributed in South China, Thailand, Malaysia, Indonesia, Philippines and Papua New Guinea. In Malaysia, it is the most popular medicinal mushroom used by the indigenous communities to relieve fever, cough, asthma, cancer, food poisoning and a...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2013-05-02 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
doi：10.1016/j.jep.2012.12.051
更新日期：2013-03-27 00:00:00
abstract：:Extracts of Schefflera bodinieri and S. delavayi (Araliaceae), Celastrus angulatus and C. orbiculatus (Celastraceae), Clerodendrum mandarinorum and C. bungei (Verbenaceae), Periploca callophylla and P. forrestii (Asclepiadaceae), Alangium platanifolium (Alangiaceae) and Uncaria rhynchophylla (Rubiaceae) were assessed ...
journal_title：Journal of ethnopharmacology
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更新日期：1996-11-01 00:00:00
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journal_title：Journal of ethnopharmacology
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更新日期：2021-03-01 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2003.06.001
更新日期：2004-01-01 00:00:00
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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journal_title：Journal of ethnopharmacology
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更新日期：2015-03-13 00:00:00
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journal_title：Journal of ethnopharmacology
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更新日期：2008-06-19 00:00:00
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journal_title：Journal of ethnopharmacology
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更新日期：2020-07-15 00:00:00
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journal_title：Journal of ethnopharmacology
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更新日期：2017-07-12 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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更新日期：2011-09-02 00:00:00
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
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journal_title：Journal of ethnopharmacology
pub_type： 杂志文章,评审
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更新日期：2014-12-02 00:00:00
abstract：ETHNOPHARMACOLOGICAL RELEVANCE:The majority of the Ethiopian people, including the Meinit ethnic group, are highly dependent on medicinal plants for their day-to-day public healthcare and veterinary needs. The existence of medicinal plants and the associated knowledge is, however, currently being threatened mainly due ...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2009.05.009
更新日期：2009-07-30 00:00:00
abstract：:Adiantum Linn. of Adiantaceae family is one of the most common and widely distributed species. Ethnomedicinally, the genus is important and popularly known as "Hansraj" in Ayurvedic System of Medicine. It has been used in cold, tumors of spleen, liver and other viscera, skin diseases, bronchitis and inflammatory disea...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2007.09.018
更新日期：2008-01-17 00:00:00
abstract：AIM OF THE STUDY:In African traditional medicine, different parts of Phyllanthus amarus Schum. and Thonn. (family: Euphorbiaceae) are highly valued for the treatment of array of human diseases including hepatic and urolithic and/or other renal diseases. In the present study, single oral 100-400mg/kg/day of the leaf and...
journal_title：Journal of ethnopharmacology
pub_type： 杂志文章
doi：10.1016/j.jep.2008.04.025
更新日期：2008-07-23 00:00:00
