Implementation of the Xpert MTB/RIF assay for tuberculosis in Mongolia: a qualitative exploration of barriers and enablers.

Abstract:

OBJECTIVE:The aim of our study was to identify barriers and enablers to implementation of the Xpert MTB/RIF test within Mongolia's National Tuberculosis Program. METHODS:Twenty-foursemi-structured interviews were conducted between June and September 2015 with laboratory staff and tuberculosis physicians in Mongolia's capital Ulaanbaatar and regional towns where Xpert MTB/RIF testing had been implemented. Interviews were recorded, transcribed, translated and analysed thematically using NVIVO qualitative analysis software. RESULTS:Eight laboratory staff (five from the National Tuberculosis Reference Laboratory in Ulaanbaatar and three from provincial laboratories) and sixteen tuberculosis physicians (five from the Mongolian National Center for Communicable Diseases in Ulaanbaatar, four from district tuberculosis clinics in Ulaanbaatar and seven from provincial tuberculosis clinics) were interviewed. Major barriers to Xpert MTB/RIF implementation identified were: lack of awareness of program guidelines; inadequate staffing arrangements; problems with cartridge supply management; lack of local repair options for the Xpert machines; lack of regular formal training; paper based system; delayed treatment initiation due to consensus meeting and poor sample quality. Enablers to Xpert MTB/RIF implementation included availability of guidelines in the local language; provision of extra laboratory staff, shift working arrangements and additional modules; capacity for troubleshooting internally; access to experts; opportunities for peer learning; common understanding of diagnostic algorithms and decentralised testing. CONCLUSION:Our study identified a number of barriers and enablers to implementation of Xpert MTB/RIF in the Mongolian National Tuberculosis Program. Lessons learned from this study can help to facilitate implementation of Xpert MTB/RIF in other Mongolian locations as well as other low-and middle-income countries.

journal_name

PeerJ

journal_title

PeerJ

authors

Rendell NL,Bekhbat S,Ganbaatar G,Dorjravdan M,Pai M,Dobler CC

doi

10.7717/peerj.3567

subject

Has Abstract

pub_date

2017-07-14 00:00:00

pages

e3567

issn

2167-8359

pii

3567

journal_volume

5

pub_type

杂志文章

相关文献

PeerJ文献大全
  • Application of a high-quality, high-volume trap-neuter-return model of community cats in Seoul, Korea.

    abstract:Background:This study was performed to determine the characteristics of community cats that were admitted to trap-neuter-return(TNR) programs and the feasibility of the high-quality, high-volume spay/neuter (HQHVSN) model in Seoul, Korea. Methods:TNR programs were performed eight times from 2017 to 2018, and a total o...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.8711

    authors: Cho Y,Kim K,Kim MS,Lee I

    更新日期:2020-03-05 00:00:00

  • SECAPR-a bioinformatics pipeline for the rapid and user-friendly processing of targeted enriched Illumina sequences, from raw reads to alignments.

    abstract::Evolutionary biology has entered an era of unprecedented amounts of DNA sequence data, as new sequencing technologies such as Massive Parallel Sequencing (MPS) can generate billions of nucleotides within less than a day. The current bottleneck is how to efficiently handle, process, and analyze such large amounts of da...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.5175

    authors: Andermann T,Cano Á,Zizka A,Bacon C,Antonelli A

    更新日期:2018-07-13 00:00:00

  • The efficacy of IL-6 inhibitor Tocilizumab in reducing severe COVID-19 mortality: a systematic review.

    abstract:Background:In the absence of highly effective antiviral therapies against SARS-CoV-2, it is crucial to counter the known pathophysiological causes of severe COVID-19. Evaluating the efficacy existing drugs may expedite the development of such therapeutics. Severe COVID-19 is largely the result of a dysregulated immune ...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.10322

    authors: Kaye AG,Siegel R

    更新日期:2020-11-02 00:00:00

  • Mountain colonisation, miniaturisation and ecological evolution in a radiation of direct-developing New Guinea Frogs (Choerophryne, Microhylidae).

    abstract:AIMS:Mountain ranges in the tropics are characterised by high levels of localised endemism, often-aberrant evolutionary trajectories, and some of the world's most diverse regional biotas. Here we investigate the evolution of montane endemism, ecology and body size in a clade of direct-developing frogs (Choerophryne, Mi...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.3077

    authors: Oliver PM,Iannella A,Richards SJ,Lee MS

    更新日期:2017-03-30 00:00:00

  • Factors that influence the beta-diversity of spider communities in northwestern Argentinean Grasslands.

    abstract::Beta-diversity, defined as spatial replacement in species composition, is crucial to the understanding of how local communities assemble. These changes can be driven by environmental or geographic factors (such as geographic distance), or a combination of the two. Spiders have been shown to be good indicators of envir...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.1946

    authors: Rodriguez-Artigas SM,Ballester R,Corronca JA

    更新日期:2016-04-21 00:00:00

  • Transcriptomic profiling of purple broccoli reveals light-induced anthocyanin biosynthetic signaling and structural genes.

    abstract::Purple Broccoli (Brassica oleracea L. var italica) attracts growing attention as a functional food. Its purple coloration is due to high anthocyanin amounts. Light represents a critical parameter affecting anthocyanins biosynthesis. In this study, 'Purple Broccoli', a light-responding pigmentation cultivar, was assess...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.8870

    authors: Liu C,Yao X,Li G,Huang L,Xie Z

    更新日期:2020-05-05 00:00:00

  • Inventory statistics meet big data: complications for estimating numbers of species.

    abstract::We point out complications inherent in biodiversity inventory metrics when applied to large-scale datasets. The number of units of inventory effort (e.g., days of inventory effort) in which a species is detected saturates, such that crucial numbers of detections of rare species approach zero. Any rare errors can then ...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.8872

    authors: Khalighifar A,Jiménez L,Nuñez-Penichet C,Freeman B,Ingenloff K,Jiménez-García D,Peterson T

    更新日期:2020-05-13 00:00:00

  • Breakdown of coevolution between symbiotic bacteria Wolbachia and their filarial hosts.

    abstract::Wolbachia is an alpha-proteobacterial symbiont widely distributed in arthropods. Since the identification of Wolbachia in certain animal-parasitic nematodes (the Onchocercidae or filariae), the relationship between arthropod and nematode Wolbachia has attracted great interest. The obligate symbiosis in filariae, which...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.1840

    authors: Lefoulon E,Bain O,Makepeace BL,d'Haese C,Uni S,Martin C,Gavotte L

    更新日期:2016-03-28 00:00:00

  • Genome analysis of quorum sensing Cedecea neteri SSMD04 leads to identification of its novel signaling synthase (cneI), cognate receptor (cneR) and an orphan receptor.

    abstract::Cedecea neteri is a very rare human pathogen. We have isolated a strain of C. neteri SSMD04 from pickled mackerel sashimi identified using molecular and phenotypics approaches. Using the biosensor Chromobacterium violaceum CV026, we have demonstrated the presence of short chain N-acyl-homoserine lactone (AHL) type quo...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.1216

    authors: Tan KH,Tan JY,Yin WF,Chan KG

    更新日期:2015-09-01 00:00:00

  • The smell of success: the amount of prey consumed by predators determines the strength and range of cascading non-consumptive effects.

    abstract::We examined whether chemically mediated risk perception by prey and the effects of changes in prey behavior on basal resources vary as a function of the amount of prey biomass consumed by the predator. We studied these issues using a tritrophic system composed of blue crabs, Callinectes sapidus (top predator), mud cra...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.1426

    authors: Weissburg M,Beauvais J

    更新日期:2015-11-19 00:00:00

  • Blood serum and BSA, but neither red blood cells nor hemoglobin can support vitellogenesis and egg production in the dengue vector Aedes aegypti.

    abstract::Aedes aegypti is the major vector of dengue, yellow fever and chikungunya viruses that put millions of people in endemic countries at risk. Mass rearing of this mosquito is crucial for strategies that use modified insects to reduce vector populations and transmission of pathogens, such as sterile insect technique or p...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.938

    authors: Gonzales KK,Tsujimoto H,Hansen IA

    更新日期:2015-05-05 00:00:00

  • Multielement analysis of plant extracts with potential use in the treatment of peptic ulcers by synchrotron radiation total reflection X-ray fluorescence.

    abstract::Some plants popularly employed for the treatment of peptic ulcers have proved to be attractive sources of new drugs. Despite extensive research, the pharmacological and toxicological potentials of these plants are not fully understood. In this context, the aim of this work was to analyze the multielemental composition...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.5375

    authors: Vieira LD,da Silva KT,Giarola RS,Inocente GF,Kushima H,Hiruma Lima CA,Hormaza JM

    更新日期:2018-09-12 00:00:00

  • Estimating the incidence and diagnosed proportion of HIV infections in Japan: a statistical modeling study.

    abstract:Background:Epidemiological surveillance of HIV infection in Japan involves two technical problems for directly applying a classical backcalculation method, i.e., (i) all AIDS cases are not counted over time and (ii) people diagnosed with HIV have received antiretroviral therapy, extending the incubation period. The pre...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.6275

    authors: Nishiura H

    更新日期:2019-01-15 00:00:00

  • Co-father relationships among the Suruí (Paiter) of Brazil.

    abstract::Partible paternity refers to the conception belief that children can have multiple fathers ("co-fathers") and is common to indigenous cultures of lowland South America. The nature of social relationships observed between co-fathers reveals information about the reproductive strategies underlying partible paternity. He...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.899

    authors: Walker RS,Yvinec C,Ellsworth RM,Bailey DH

    更新日期:2015-04-14 00:00:00

  • Ontogenetic foraging activity and feeding selectivity of the Brazilian endemic parrotfish Scarus zelindae.

    abstract::Parrotfish are fundamental species in controlling algal phase-shifts and ensuring the resilience of coral reefs. Nevertheless, little is known on their ecological role in the south-western Atlantic Ocean. The present study analysed the ontogenetic foraging activity and feeding selectivity of the Brazilian endemic parr...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.2536

    authors: Pereira PH,Santos M,Lippi DL,Silva P

    更新日期:2016-10-12 00:00:00

  • Differential roles of prostaglandin E-type receptors in activation of hypoxia-inducible factor 1 by prostaglandin E1 in vascular-derived cells under non-hypoxic conditions.

    abstract::Prostaglandin E1 (PGE1), known pharmaceutically as alprostadil, has vasodilatory properties and is used widely in various clinical settings. In addition to acute vasodilatory properties, PGE1 may exert beneficial effects by altering protein expression of vascular cells. PGE1 is reported to be a potent stimulator of an...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.220

    authors: Suzuki K,Nishi K,Takabuchi S,Kai S,Matsuyama T,Kurosawa S,Adachi T,Maruyama T,Fukuda K,Hirota K

    更新日期:2013-11-28 00:00:00

  • L1 and L2 reading skills in Dutch adolescents with a familial risk of dyslexia.

    abstract:BACKGROUND:The present study investigated differences in reading and spelling outcomes in Dutch and English as a second language (ESL) in adolescents with a high familial risk of dyslexia, of whom some have developed dyslexia (HRDys) while others have not (HRnonDys), in comparison to a low familial risk control group w...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.3895

    authors: van Setten ERH,Tops W,Hakvoort BE,van der Leij A,Maurits NM,Maassen BAM

    更新日期:2017-10-16 00:00:00

  • The European and Japanese outbreaks of H5N8 derive from a single source population providing evidence for the dispersal along the long distance bird migratory flyways.

    abstract::The origin of recent parallel outbreaks of the high pathogenicity H5N8 avian flu virus in Europe and in Japan can be traced to a single source population, which has most likely been spread by migratory birds. By using Bayesian coalescent methods to analyze the DNA sequences of the virus to find the times for divergenc...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.934

    authors: Dalby AR,Iqbal M

    更新日期:2015-04-30 00:00:00

  • Integrative taxonomy of the ornamental 'peppermint' shrimp public market and population genetics of Lysmata boggessi, the most heavily traded species worldwide.

    abstract::The ornamental trade is a worldwide industry worth >15 billion USD with a problem of rampant product misidentification. Minimizing misidentification is critical in the face of overexploitation of species in the trade. We surveyed the peppermint shrimp ornamental marketplace in the southeastern USA, the most intense ma...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.3786

    authors: Baeza JA,Behringer DC

    更新日期:2017-09-18 00:00:00

  • Antimicrobial activity of Tachyplesin 1 against Burkholderia pseudomallei: an in vitro and in silico approach.

    abstract::Burkholderia pseudomallei, the causative agent of melioidosis, is intrinsically resistant to many conventional antibiotics. Therefore, alternative antimicrobial agents such as antimicrobial peptides (AMPs) are extensively studied to combat this issue. Our study aims to identify and understand the mode of action of the...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.2468

    authors: Lee LF,Mariappan V,Vellasamy KM,Lee VS,Vadivelu J

    更新日期:2016-10-25 00:00:00

  • Effects of a blend of green tea and curcuma extract supplementation on lipopolysaccharide-induced inflammation in horses and ponies.

    abstract:Background:In horses and ponies numerous medical conditions are known to be linked with inflammation in different tissues, especially in the liver. Besides affecting other metabolic pathways such as the expression of certain interleukins (IL), inflammation is associated with stress of the endoplasmic reticulum (ER). In...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.8053

    authors: Starzonek J,Roscher K,Blüher M,Blaue D,Schedlbauer C,Hirz M,Raila J,Vervuert I

    更新日期:2019-11-12 00:00:00

  • Continuum beliefs in the stigma process regarding persons with schizophrenia and depression: results of path analyses.

    abstract:BACKGROUND:Individuals with mental illness often experience stigmatization and encounter stereotypes such as being dangerous or unpredictable. To further improve measures against psychiatric stigma, it is of importance to understand its components. In this study, we attend to the step of separation between "us" and "th...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.2360

    authors: Makowski AC,Mnich EE,Angermeyer MC,von dem Knesebeck O

    更新日期:2016-09-27 00:00:00

  • Predicting disease occurrence of cabbage Verticillium wilt in monoculture using species distribution modeling.

    abstract:Background:Although integrated pest management (IPM) is essential for conservation agriculture, this method can be inadequate for severely infected fields. The ability to predict the potential occurrence of severe infestation of soil-borne disease would enable farmers to adopt suitable methods for high-risk areas, such...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.10290

    authors: Ikeda K,Osawa T

    更新日期:2020-11-17 00:00:00

  • Stable isotope analyses of web-spinning spider assemblages along a headwater stream in Puerto Rico.

    abstract::Web-spinning spiders that inhabit stream channels are considered specialists of aquatic ecosystems and are major consumers of emerging aquatic insects, while other spider taxa are more commonly found in riparian forests and as a result may consume more terrestrial insects. To determine if there was a difference in spi...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.1324

    authors: Kelly SP,Cuevas E,Ramírez A

    更新日期:2015-10-15 00:00:00

  • IOCBIO Sparks detection and analysis software.

    abstract::Analysis of calcium sparks in cardiomyocytes can provide valuable information about functional changes of calcium handling in health and disease. As a part of the calcium sparks analysis, sparks detection and characterization is necessary. Here, we describe a new open-source platform for automatic calcium sparks detec...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.6652

    authors: Laasmaa M,Karro N,Birkedal R,Vendelin M

    更新日期:2019-03-29 00:00:00

  • Serum metabolite profiling of a 4-Nitroquinoline-1-oxide-induced experimental oral carcinogenesis model using gas chromatography-mass spectrometry.

    abstract:Background:Oral cancer progresses from hyperplastic epithelial lesions through dysplasia to invasive carcinoma. The critical needs in oral cancer treatment are expanding our knowledge of malignant tumour progression and the development of useful approaches to prevent dysplastic lesions. This study was designed to gain ...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.10619

    authors: Ge S,Zhou H,Zhou Z,Liu L,Lou J

    更新日期:2021-01-04 00:00:00

  • Novel polymeric micelles for insect pest control: encapsulation of essential oil monoterpenes inside a triblock copolymer shell for head lice control.

    abstract:BACKGROUND:Essential oil components (EOCs) are molecules with interesting application in pest control, these have been evaluated against different insect pest from more than 100 years, but their practical use is rather limited. Thus, the enhancement of their bioavailability and manageability due to their dispersion in ...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.3171

    authors: Lucia A,Toloza AC,Guzmán E,Ortega F,Rubio RG

    更新日期:2017-04-20 00:00:00

  • The R2R3-MYB transcription factor family in Taxus chinensis: identification, characterization, expression profiling and posttranscriptional regulation analysis.

    abstract::The MYB transcription factor family is one of the largest gene families playing regulatory roles in plant growth and development. The MYB family has been studied in a variety of plant species but has not been reported in Taxus chinensis. Here we identified 72 putative R2R3-MYB genes in T. chinensis using a comprehensi...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.8473

    authors: Hu X,Zhang L,Wilson I,Shao F,Qiu D

    更新日期:2020-02-17 00:00:00

  • The tetrapod fauna of the upper Permian Naobaogou Formation of China: 3. Jiufengia jiai gen. et sp. nov., a large akidnognathid therocephalian.

    abstract::Recent field trips to Member III of the Naobaogou Formation, Nei Mongol, China yielded new fossil discoveries, increasing our knowledge of the late Permian continental fauna from China. We present here a new large therocephalian, Jiufengia jiai gen. et sp. nov., represented by a partial skull with mandibles and part o...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.6463

    authors: Liu J,Abdala F

    更新日期:2019-02-22 00:00:00

  • Honey bee viruses in Serbian colonies of different strength.

    abstract::Protection of honey bees is of great economic importance because of their role in pollination. Crucial steps towards this goal are epidemiological surveys of pathogens connected with honey bee losses. In this study deformed wing virus (DWV), chronic bee paralysis virus (CBPV), acute bee paralysis virus (ABPV) and sacb...

    journal_title:PeerJ

    pub_type: 杂志文章

    doi:10.7717/peerj.5887

    authors: Cirkovic D,Stevanovic J,Glavinic U,Aleksic N,Djuric S,Aleksic J,Stanimirovic Z

    更新日期:2018-11-14 00:00:00