A high-yield isolation and enrichment strategy for human lung microvascular endothelial cells.

abstract：:Current evidence suggests that exercise training is beneficial in pulmonary arterial hypertension (PAH). Unfortunately, the standard supervised, hospital-based programs limit patient accessibility to this important intervention. Our proof-of-concept study aimed to provide insight into the usefulness of a prescribed wa...

journal_title：Pulmonary circulation

authors： Brown MB,Kempf A,Collins CM,Long GM,Owens M,Gupta S,Hellman Y,Wong V,Farber M,Lahm T

更新日期：2018-01-01 00:00:00

abstract：:Carboxyl terminus of Hsc70-interacting protein (CHIP) is a 35-kDa cytoplasmic protein expressed in human striated muscle, brain, aortic smooth muscle, endothelial cells, and other tissues. Studies have confirmed that CHIP regulates cell growth, apoptosis, cell phenotype, metabolism, neurodegeneration, etc. However, wh...

journal_title：Pulmonary circulation

authors： Dong F,Zhang J

更新日期：2019-09-09 00:00:00

abstract：:Infection, thrombosis, and catheter dislodgment are well-recognized potential complications of chronic intravenous prostanoid therapy for pulmonary arterial hypertension. As long-term outcomes of pulmonary hypertension patients improve, novel adverse events are likely to arise. We describe the sudden development of un...

journal_title：Pulmonary circulation

authors： LeVarge BL,Law AC,Murphy B

更新日期：2018-01-01 00:00:00

abstract：:Schistosomiasis-associated pulmonary arterial hypertension (PAH) is one of the most common causes of pulmonary hypertension worldwide. A potential contributing mechanism to the pathogenesis of this disease is a localized immune reaction to retained and persistent parasite-derived antigens. We sought to identify Schist...

journal_title：Pulmonary circulation

authors： Graham BB,Chabon J,Bandeira A,Espinheira L,Butrous G,Tuder RM

更新日期：2011-10-01 00:00:00

abstract：:Chronic thromboembolic pulmonary hypertension (CTEPH) is a complication of unresolved organised pulmonary emboli/thrombi obstructing the major pulmonary arteries. The aim of this study was to estimate the incidence and risk factors of CTEPH in a cohort with first venous thromboembolism (VTE). This was a population-bas...

journal_title：Pulmonary circulation

authors： Martinez C,Wallenhorst C,Teal S,Cohen AT,Peacock AJ

更新日期：2018-07-01 00:00:00

abstract：:Scleroderma-associated pulmonary arterial hypertension (SSc-PAH) is associated with worse outcome than idiopathic pulmonary arterial hypertension (IPAH), potentially due to worse right ventricular adaptation to load as suggested by pressure-volume loop analysis. The value of non-invasive load-adaptability metrics has ...

journal_title：Pulmonary circulation

authors： French S,Amsallem M,Ouazani N,Li S,Kudelko K,Zamanian RT,Haddad F,Chung L

更新日期：2018-07-01 00:00:00

abstract：:Limited data about the long-term prognosis and response to therapy in pulmonary arterial hypertension patients with World Health Organization functional class I/II symptoms are available. PubMed and Embase were searched for publications of observational registries and randomized, controlled trials in pulmonary arteria...

journal_title：Pulmonary circulation

authors： Kim NH,Fisher M,Poch D,Zhao C,Shah M,Bartolome S

更新日期：2020-11-25 00:00:00

abstract：:Andeans and Tibetans have less altitude reduction in birth weight than do shorter-resident groups, but only Tibetans are protected from pulmonary hypertension and chronic mountain sickness (CMS). We hypothesized that differences in neonatal oxygenation were involved, with arterial O2 saturation (SaO2) being highest in...

journal_title：Pulmonary circulation

authors： Niermeyer S,Andrade-M MP,Vargas E,Moore LG

更新日期：2015-03-01 00:00:00

abstract：:Increased peripheral resistance of small distal pulmonary arteries is a hallmark signature of pulmonary hypertension (PH) and is believed to be the consequence of enhanced vasoconstriction to agonists, thickening of the arterial wall due to remodeling, and increased thrombosis. The elevation in arterial tone in PH is ...

journal_title：Pulmonary circulation

authors： Leblanc N,Forrest AS,Ayon RJ,Wiwchar M,Angermann JE,Pritchard HA,Singer CA,Valencik ML,Britton F,Greenwood IA

更新日期：2015-06-01 00:00:00

abstract：:There are few data on the epidemiology of pulmonary hypertension (PH)-related hospitalizations in children in the United States. Our aim was to determine hospital mortality, length of hospitalization, and hospital charges pertaining to PH-related hospitalizations and also the effects of codiagnoses and comorbidities. ...

journal_title：Pulmonary circulation

authors： Frank DB,Crystal MA,Morales DL,Gerald K,Hanna BD,Mallory GB Jr,Rossano JW

更新日期：2015-06-01 00:00:00

abstract：:N-terminal pro B-type natriuretic peptide (NT-proBNP) is a product of cleavage of the cardiac prohormone pro B-type natriuretic peptide into its active form. It has proven to be a useful biomarker in left heart failure. However, studies examining the utility of serial measurements of NT-proBNP in pulmonary arterial hy...

journal_title：Pulmonary circulation

authors： Soon E,Doughty NJ,Treacy CM,Ross RM,Toshner M,Upton PD,Sheares K,Morrell NW,Pepke-Zaba J

更新日期：2011-04-01 00:00:00

abstract：:The diagnosis of pulmonary vascular disease (PVD) is usually based on hemodynamic and/or clinical criteria. Noninvasive imaging of the heart and proximal vasculature can also provide useful information. An alternate approach to such criteria in the diagnosis of PVD is to image the vascular abnormalities in the lungs t...

journal_title：Pulmonary circulation

authors： Dahhan T,Kaushik SS,He M,Mammarappallil JG,Tapson VF,McAdams HP,Sporn TA,Driehuys B,Rajagopal S

更新日期：2016-03-01 00:00:00

abstract：:Most subtypes of pulmonary arterial hypertension (PAH) are characterized by a greater susceptibility to disease among females, although females with PAH appear to live longer after diagnosis. While this "estrogen paradoxȍ of enhanced female survival despite increased female susceptibility remains a mystery, recent pro...

journal_title：Pulmonary circulation

authors： Austin ED,Lahm T,West J,Tofovic SP,Johansen AK,Maclean MR,Alzoubi A,Oka M

更新日期：2013-04-01 00:00:00

abstract：:Pharmacokinetic studies with oral treprostinil demonstrate that three times daily (TID) dosing reduces peak-to-trough plasma trepostinil fluctuations compared with twice daily (BID) dosing. TID dosing may allow for faster titration, higher total daily doses, and potentially improve the tolerability of oral trepostinil...

journal_title：Pulmonary circulation

authors： Balasubramanian VP,Messick CR,Broderick M,Nelsen AC

更新日期：2018-04-01 00:00:00

abstract：:Pathological alterations of inspiratory capacity (IC) have been observed in pulmonary hypertension. However, the clinical significance of IC in operable chronic thromboembolic pulmonary hypertension (CTEPH) without other pulmonary diseases remains unknown. CTEPH patients scheduled for pulmonary endarterectomy were pro...

journal_title：Pulmonary circulation

authors： Richter MJ,Gall H,Wittkämper G,Seeger W,Mayer E,Ghofrani HA,Guth S,Reichenberger F

更新日期：2017-04-01 00:00:00

abstract：:South America is a territory of 17,819,100 km(2), where ∼388 million people live in 13 countries. In the region, access to medical assistance (e.g., for treatment of cardiovascular disorders) is relatively easy in metropolitan areas but difficult in remote places such as the Andes and the Amazon. Altitudes up to ∼6,70...

journal_title：Pulmonary circulation

authors： Lopes AA,Flores PC,Diaz GF,Mesquita SM

更新日期：2014-09-01 00:00:00

abstract：:[This corrects the article DOI: 10.1086/688060.]. ...

journal_title：Pulmonary circulation

authors：

更新日期：2016-12-01 00:00:00

abstract：:Late-onset pulmonary arterial hypertension (PAH) is a rare but fatal complication in patients with childhood surgical repair of dextro-transposition of great arteries (D-TGA), especially with the Mustard and Senning procedures. The pathogenic mechanisms of PAH in patients with repaired D-TGA are not well understood an...

journal_title：Pulmonary circulation

authors： Baskaran J,March KS,Thenappan T

更新日期：2017-04-01 00:00:00

abstract：:Obesity is causally linked to a number of comorbidities, including cardiovascular disease, diabetes, renal dysfunction, and cancer. Obesity has also been linked to pulmonary disorders, including pulmonary arterial hypertension (PAH). It was long believed that obesity-related PAH was the result of hypoventilation and h...

journal_title：Pulmonary circulation

authors： Irwin DC,Garat CV,Crossno JT Jr,MacLean PS,Sullivan TM,Erickson PF,Jackman MR,Harral JW,Reusch JE,Klemm DJ

更新日期：2014-12-01 00:00:00

abstract：:To shed light on the efficacy of oxygen therapy in pulmonary arterial hypertension (PAH) when hypoxemia is not present, we report seven years of observational data for a female patient recorded between February 2012 and February 2019 when she was aged 7.8-14.8 years. The patient was born with an atrial septal defect (...

journal_title：Pulmonary circulation

authors： Green S,Stuart D

更新日期：2019-04-01 00:00:00

abstract：:Oral treprostinil (TRE) is a prostacylin that is approved for the treatment of patients with pulmonary arterial hypertension (PAH). Dosing is approved for two or three times daily (t.i.d.); however, adverse effects, including gastrointestinal-related symptoms, may limit the ability to reach optimal doses. We report ou...

journal_title：Pulmonary circulation

authors： Coons JC,Bunner C,Ishizawar DC,Risbano MG,Rivera-Lebron B,Mathier MA,Chan SY,Simon MA

更新日期：2018-01-01 00:00:00

abstract：:Pulmonary arterial hypertension can be associated with exposure to certain drugs or toxins. However, only a few cases of drug-induced pulmonary arterial hypertension have been previously reported. Anagrelide is an oral imidazoquinazoline agent that is prescribed for reducing elevated platelet counts in patients with m...

journal_title：Pulmonary circulation

authors： Sumimoto K,Taniguchi Y,Matsuoka Y,Onishi H,Emoto N,Hirata KI

更新日期：2019-12-27 00:00:00

abstract：:Riociguat is approved for the treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. Some patients have difficulty swallowing tablets; therefore, 2 randomized, nonblinded, crossover studies compared the relative bioavailability of riociguat oral suspensions and immediate-releas...

journal_title：Pulmonary circulation

authors： Saleh S,Frey R,Becker C,Unger S,Wensing G,Mück W

更新日期：2016-03-01 00:00:00

abstract：:Patients with pulmonary hypertension are more sedentary than the general population, but attitudes and experiences that may influence their exercise behaviour remain poorly understood. This study identified patterns of behaviour, attitudes towards exercise, barriers and enablers of exercise for people living with pulm...

journal_title：Pulmonary circulation

authors： Chia KSW,Brown K,Kotlyar E,Wong PKK,Faux SG,Shiner CT

更新日期：2020-11-16 00:00:00

abstract：:Hypereosinophilic syndrome is a myeloproliferative disorder characterized by persistent eosinophilia with involvement of multiple organs. The occurrence of severe pulmonary hypertension (PH) in the setting of hypereosinophilic syndrome is very uncommon. A 43-year-old man with documented idiopathic hypereosinophlic syn...

journal_title：Pulmonary circulation

authors： Zhang L,Peng X,Adhikari BK,Li B,Liu Q,Mikeladze J,Zhang W

更新日期：2019-01-01 00:00:00

abstract：:Pulmonary hypertension is a multifactorial disease with a high morbidity and mortality. Right ventricular function is the most important predictor of morbidity and mortality in patients suffering from pulmonary hypertension, but currently there are no approved treatments directly supporting the failing right ventricle...

journal_title：Pulmonary circulation

authors： Hansen MS,Andersen A,Nielsen-Kudsk JE

更新日期：2018-07-01 00:00:00

abstract：:Adherence to therapy for pulmonary arterial hypertension is essential to optimize patient outcomes, but data on real-world adherence to different pulmonary arterial hypertension drug classes are limited. This retrospective database analysis evaluated relationships between adherence, hospitalization, and healthcare cos...

journal_title：Pulmonary circulation

authors： Frantz RP,Hill JW,Lickert CA,Wade RL,Cole MR,Tsang Y,Drake W 3rd

更新日期：2020-03-18 00:00:00

abstract：:The present study aimed to propose the pulmonary hypertension for predicting left ventricular dysfunction in adults after patent ductus arteriosus closure. A total of 183 patients (age ≥18 years) after patent ductus arteriosus occlusion were retrospectively collected in this study. In brief, pre-, post-procedure and s...

journal_title：Pulmonary circulation

authors： Chen PY,Luo DL,Li HZ,Fei HW,Huang T,Huang YG,Chen JM,Zhuang J,He PC,Zhang CJ

更新日期：2019-11-15 00:00:00

abstract：:Pulmonary capillary hemangiomatosis (PCH) is a rare form of pulmonary arterial hypertension (PAH) characterized by pulmonary capillary proliferation and pseudoinvasion of collagenous septal structures. PCH is often accompanied by veno-occlusive changes and pulmonary hypertensive arterial remodeling. The clinical and p...

journal_title：Pulmonary circulation

authors： DuBrock HM,Kradin RL,Rodriguez-Lopez JM,Channick RN

更新日期：2015-09-01 00:00:00

abstract：:There are limited data on the management of pulmonary arterial hypertension (PAH) in the elderly; therefore, this analysis compared the safety and efficacy of tadalafil between patients ≥65 and <65 years old. This was a post hoc analysis of the randomized, double-blind, placebo-controlled phase 3 Pulmonary Arterial Hy...

journal_title：Pulmonary circulation

authors： Berman-Rosenzweig E,Arneson C,Klinger JR

更新日期：2014-03-01 00:00:00