Levosimendan in pulmonary hypertension and right heart failure.

Abstract:

:Pulmonary hypertension is a multifactorial disease with a high morbidity and mortality. Right ventricular function is the most important predictor of morbidity and mortality in patients suffering from pulmonary hypertension, but currently there are no approved treatments directly supporting the failing right ventricle. Levosimendan is a calcium sensitizing agent with inotropic, pulmonary vasodilatory, and cardioprotective properties. Given its pharmacodynamic profile, levosimendan could be a potential novel agent for the treatment of right ventricular failure caused by pulmonary hypertension. The aim of this review is to provide an overview of the current knowledge on the effects of levosimendan in pulmonary hypertension and right heart failure.

journal_name

Pulm Circ

journal_title

Pulmonary circulation

authors

Hansen MS,Andersen A,Nielsen-Kudsk JE

doi

10.1177/2045894018790905

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

2045894018790905

issue

3

eissn

2045-8932

issn

2045-8940

journal_volume

8

pub_type

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