Significant intrapulmonary Schistosoma egg antigens are not present in schistosomiasis-associated pulmonary hypertension.

abstract：:Pulmonary arterial hypertension (PAH) patients have distinct disease courses and responses to treatment, but current diagnostic and treatment schemes provide limited insight. We aimed to see if cluster analysis could distinguish clinical phenotypes in PAH. An unbiased cluster analysis was performed on 17 baseline clin...

journal_title：Pulmonary circulation

authors： Parikh KS,Rao Y,Ahmad T,Shen K,Felker GM,Rajagopal S

更新日期：2017-04-01 00:00:00

abstract：:Echocardiography, a non-invasive and cost-effective method for monitoring cardiac function, is commonly used for evaluation and pre-clinical diagnostics of pulmonary hypertension (PH). Previous echocardiographic studies in experimental models of PH are fragmentary in terms of the evaluation of right ventricle (RV) fun...

journal_title：Pulmonary circulation

authors： Zhu Z,Godana D,Li A,Rodriguez B,Gu C,Tang H,Minshall RD,Huang W,Chen J

更新日期：2019-04-01 00:00:00

abstract：:Radiotherapy as a primary treatment for thoracic malignancies induces deleterious effects, such as acute or subacute radiation-induced lung injury (RILI). Although the molecular etiology of RILI is controversial and likely multifactorial, a potentially important cellular target is the lung endothelial cytoskeleton tha...

journal_title：Pulmonary circulation

authors： Wang T,Mathew B,Wu X,Shimizu Y,Rizzo AN,Dudek SM,Weichselbaum RR,Jacobson JR,Hecker L,Garcia JG

更新日期：2016-06-01 00:00:00

abstract：:We aimed to evaluate the association between the presence of histologic chorioamnionitis (HC) and development of pulmonary hypertension (PH) during neonatal intensive care unit (NICU) stay. Data of preterm infants born at 32 weeks of gestation or less were reviewed. The development of PH and other respiratory outcomes...

journal_title：Pulmonary circulation

authors： Yum SK,Kim MS,Kwun Y,Moon CJ,Youn YA,Sung IK

更新日期：2018-04-01 00:00:00

abstract：:Pregnancy is not advised for patients with Pulmonary hypertension (PH) because of high risk of PH crisis. However, some patients have undiagnosed idiopathic pulmonary arterial hypertension (IPAH) before pregnancy. Upfront combination therapy has high efficacy for patients with IPAH. However, some patients are unable t...

journal_title：Pulmonary circulation

authors： Adachi S,Shimokata S,Yoshida M,Imai R,Nakano Y,Okumura N,Suzuki S,Murohara T,Kondo T

更新日期：2020-02-28 00:00:00

abstract：:Obesity is causally linked to a number of comorbidities, including cardiovascular disease, diabetes, renal dysfunction, and cancer. Obesity has also been linked to pulmonary disorders, including pulmonary arterial hypertension (PAH). It was long believed that obesity-related PAH was the result of hypoventilation and h...

journal_title：Pulmonary circulation

authors： Irwin DC,Garat CV,Crossno JT Jr,MacLean PS,Sullivan TM,Erickson PF,Jackman MR,Harral JW,Reusch JE,Klemm DJ

更新日期：2014-12-01 00:00:00

abstract：:Riociguat is approved for the treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. Some patients have difficulty swallowing tablets; therefore, 2 randomized, nonblinded, crossover studies compared the relative bioavailability of riociguat oral suspensions and immediate-releas...

journal_title：Pulmonary circulation

authors： Saleh S,Frey R,Becker C,Unger S,Wensing G,Mück W

更新日期：2016-03-01 00:00:00

abstract：:The biological mechanisms behind the development of pulmonary hypertension in the setting of left heart failure (HF-PH), including combined pre- and post-capillary pulmonary hypertension (Cpc-PH), remains unclear. This study aimed to use candidate polymorphisms in nitric oxide synthase (NOS) genes to explore the role ...

journal_title：Pulmonary circulation

authors： Duarte JD,Kansal M,Desai AA,Riden K,Arwood MJ,Yacob AA,Stamos TD,Cavallari LH,Zamanian RT,Shah SJ,Machado RF

更新日期：2018-04-01 00:00:00

abstract：:Oral treprostinil (TRE) is a prostacylin that is approved for the treatment of patients with pulmonary arterial hypertension (PAH). Dosing is approved for two or three times daily (t.i.d.); however, adverse effects, including gastrointestinal-related symptoms, may limit the ability to reach optimal doses. We report ou...

journal_title：Pulmonary circulation

authors： Coons JC,Bunner C,Ishizawar DC,Risbano MG,Rivera-Lebron B,Mathier MA,Chan SY,Simon MA

更新日期：2018-01-01 00:00:00

abstract：:Endothelial dysfunction plays an important role in the pathogenesis of pulmonary arterial hypertension (PAH) in sickle cell disease (SCD). A variety of evidence suggests that circulating endothelial progenitor cells (EPCs) play an integral role in vascular repair. We hypothesized that SCD patients with PAH are deficie...

journal_title：Pulmonary circulation

authors： Anjum F,Lazar J,Zein J,Jamaleddine G,Demetis S,Wadgaonkar R

更新日期：2012-01-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a progressive and debilitating condition. Despite promoting vasodilation, current drugs have a therapeutic window within which they are limited by systemic side effects. Nanomedicine uses nanoparticles to improve drug delivery and/or reduce side effects. We hypothesize that thi...

journal_title：Pulmonary circulation

authors： Mohamed NA,Davies RP,Lickiss PD,Ahmetaj-Shala B,Reed DM,Gashaw HH,Saleem H,Freeman GR,George PM,Wort SJ,Morales-Cano D,Barreira B,Tetley TD,Chester AH,Yacoub MH,Kirkby NS,Moreno L,Mitchell JA

更新日期：2017-07-01 00:00:00

abstract：:Increased peripheral resistance of small distal pulmonary arteries is a hallmark signature of pulmonary hypertension (PH) and is believed to be the consequence of enhanced vasoconstriction to agonists, thickening of the arterial wall due to remodeling, and increased thrombosis. The elevation in arterial tone in PH is ...

journal_title：Pulmonary circulation

authors： Leblanc N,Forrest AS,Ayon RJ,Wiwchar M,Angermann JE,Pritchard HA,Singer CA,Valencik ML,Britton F,Greenwood IA

更新日期：2015-06-01 00:00:00

abstract：:Pulmonary hypertension (PH) comprises a group of pathophysiological syndromes characterized by elevated pulmonary artery pressure and pulmonary vascular resistance, which lead to right ventricular overload, and even right heart failure. PH has a poor prognosis and severely leads to a decline in quality of life. Histor...

journal_title：Pulmonary circulation

authors： Zhang X,Xu D

更新日期：2020-07-07 00:00:00

abstract：:Insulin resistance is highly prevalent in pulmonary arterial hypertension (PAH) patients. However, the long-term impact of diabetes mellitus (DM) on survival in PAH is unclear. Insulin resistance and DM are associated with left ventricular steatosis and dysfunction, but whether the right ventricle (RV) might be affect...

journal_title：Pulmonary circulation

authors： Benson L,Brittain EL,Pugh ME,Austin ED,Fox K,Wheeler L,Robbins IM,Hemnes AR

更新日期：2014-06-01 00:00:00

abstract：:Vasculopathies, characterized by the formation of fragile and abnormal microvessels, are associated with the severity of many chronic lung diseases, including pulmonary fibrosis, emphysema/chronic obstructive pulmonary disease, systemic sclerosis, and hypertension. However, the study of human lung vasculature has been...

journal_title：Pulmonary circulation

authors： Gaskill C,Majka SM

更新日期：2017-03-27 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a major complication of sickle cell disease (SCD). Low levels of apolipoprotein A1 (Apo-A1) have been implicated in the development of PAH in SCD. We speculate that lower levels of Apo-A1 are related to dysregulation of the ubiquitin-proteasome pathway (UPP). Of 36 recruited pa...

journal_title：Pulmonary circulation

authors： Anjum F,Lazar J,Soh J,Albitar M,Gowda S,Hussain MM,Wadgaonkar R

更新日期：2013-12-01 00:00:00

abstract：:A loss of K+ efflux in pulmonary arterial smooth muscle cells (PASMCs) contributes to abnormal vasoconstriction and PASMC proliferation during pulmonary hypertension (PH). Activation of high-conductance Ca2+-activated (BK) channels represents a therapeutic strategy to restore K+ efflux to the affected PASMCs. However,...

journal_title：Pulmonary circulation

authors： Detweiler ND,Song L,McClenahan SJ,Versluis RJ,Kharade SV,Kurten RC,Rhee SW,Rusch NJ

更新日期：2016-12-01 00:00:00

abstract：:Current evidence suggests that exercise training is beneficial in pulmonary arterial hypertension (PAH). Unfortunately, the standard supervised, hospital-based programs limit patient accessibility to this important intervention. Our proof-of-concept study aimed to provide insight into the usefulness of a prescribed wa...

journal_title：Pulmonary circulation

authors： Brown MB,Kempf A,Collins CM,Long GM,Owens M,Gupta S,Hellman Y,Wong V,Farber M,Lahm T

更新日期：2018-01-01 00:00:00

abstract：:Adherence to therapy for pulmonary arterial hypertension is essential to optimize patient outcomes, but data on real-world adherence to different pulmonary arterial hypertension drug classes are limited. This retrospective database analysis evaluated relationships between adherence, hospitalization, and healthcare cos...

journal_title：Pulmonary circulation

authors： Frantz RP,Hill JW,Lickert CA,Wade RL,Cole MR,Tsang Y,Drake W 3rd

更新日期：2020-03-18 00:00:00

abstract：:Most subtypes of pulmonary arterial hypertension (PAH) are characterized by a greater susceptibility to disease among females, although females with PAH appear to live longer after diagnosis. While this "estrogen paradoxȍ of enhanced female survival despite increased female susceptibility remains a mystery, recent pro...

journal_title：Pulmonary circulation

authors： Austin ED,Lahm T,West J,Tofovic SP,Johansen AK,Maclean MR,Alzoubi A,Oka M

更新日期：2013-04-01 00:00:00

abstract：:Increased exposure to ambient particulate matter (PM) is associated with elevated morbidity and mortality in patients with cardiopulmonary diseases and cancer. We and others have shown that PM induces lung microvascular barrier dysfunction which potentially enhances the systemic toxicity of PM. However, the mechanisms...

journal_title：Pulmonary circulation

authors： Wang T,Shimizu Y,Wu X,Kelly GT,Xu X,Wang L,Qian Z,Chen Y,Garcia JGN

更新日期：2017-07-01 00:00:00

abstract：:With the advancement of computed tomography pulmonary angiography, differentiating between acute and chronic thrombus in pulmonary embolism has become more feasible. However, whether pulmonary embolism with chronic thrombus contributes to a higher mortality than pulmonary embolism with acute thrombus remains undetermi...

journal_title：Pulmonary circulation

authors： Chang HY,Chang WT,Chen PW,Lin CC,Hsu CH

更新日期：2020-05-01 00:00:00

abstract：:Uncorrected atrial septal defect undergoes right ventricle chronic volume overload which may lead to pulmonary hypertension and Eisenmenger Syndrome. The soluble suppression of tumorigenicity-2 is a left ventricle strain biomarker; however, its role in right ventricle strain is unclear. This study aimed to investigate...

journal_title：Pulmonary circulation

authors： Pratama RS,Hartopo AB,Anggrahini DW,Dewanto VC,Dinarti LK

更新日期：2020-05-26 00:00:00

abstract：:Hypereosinophilic syndrome is a myeloproliferative disorder characterized by persistent eosinophilia with involvement of multiple organs. The occurrence of severe pulmonary hypertension (PH) in the setting of hypereosinophilic syndrome is very uncommon. A 43-year-old man with documented idiopathic hypereosinophlic syn...

journal_title：Pulmonary circulation

authors： Zhang L,Peng X,Adhikari BK,Li B,Liu Q,Mikeladze J,Zhang W

更新日期：2019-01-01 00:00:00

abstract：:Two oral medications targeting the prostacyclin pathway are available to treat pulmonary arterial hypertension in the United States: oral treprostinil and selexipag. We compared real-world hospitalization in patients receiving these medications. A retrospective administrative claims study was conducted using the Optum...

journal_title：Pulmonary circulation

authors： McConnell JW,Tsang Y,Pruett J,Iii WD

更新日期：2020-11-10 00:00:00

abstract：:Inhaled treprostinil (Tyvaso) has been shown to be a safe and effective addition to pulmonary arterial hypertension (PAH) oral therapies; however, the respiratory-related safety profile of inhaled treprostinil required further elucidation in the setting of routine clinical care. The objectives of this study were to ch...

journal_title：Pulmonary circulation

authors： Zamanian RT,Levine DJ,Bourge RC,De Souza SA,Rosenzweig EB,Alnuaimat H,Burger C,Mathai SC,Leedom N,DeAngelis K,Lim A,De Marco T

更新日期：2016-09-01 00:00:00

abstract：:Pulmonary capillary hemangiomatosis (PCH) is a rare form of pulmonary arterial hypertension (PAH) characterized by pulmonary capillary proliferation and pseudoinvasion of collagenous septal structures. PCH is often accompanied by veno-occlusive changes and pulmonary hypertensive arterial remodeling. The clinical and p...

journal_title：Pulmonary circulation

authors： DuBrock HM,Kradin RL,Rodriguez-Lopez JM,Channick RN

更新日期：2015-09-01 00:00:00

abstract：:Adults with sickle cell disease can develop pulmonary hypertension from a multitude of etiologies. Classified as WHO Group 5, there are no therapies approved for the treatment of sickle cell disease-pulmonary hypertension. Thromboembolic disease is prevalent in sickle cell disease and can lead to pulmonary hypertensio...

journal_title：Pulmonary circulation

authors： Weir NA,Conrey A,Lewis D,Mehari A

更新日期：2018-10-01 00:00:00

abstract：:Pathological alterations of inspiratory capacity (IC) have been observed in pulmonary hypertension. However, the clinical significance of IC in operable chronic thromboembolic pulmonary hypertension (CTEPH) without other pulmonary diseases remains unknown. CTEPH patients scheduled for pulmonary endarterectomy were pro...

journal_title：Pulmonary circulation

authors： Richter MJ,Gall H,Wittkämper G,Seeger W,Mayer E,Ghofrani HA,Guth S,Reichenberger F

更新日期：2017-04-01 00:00:00

abstract：: ...

journal_title：Pulmonary circulation

authors： Liu BY,Wu WC,Zeng QX,Liu ZH,Tian Y,Niu LL,Cheng XL,Luo Q,Zhao Z,An CH,Huang L,Wang H,He J,Xiong CM

更新日期：2019-07-03 00:00:00