Dysregulation of ubiquitin-proteasome pathway and apolipoprotein A metabolism in sickle cell disease-related pulmonary arterial hypertension.

abstract：:Pulmonary hypertension (PH) comprises a group of pathophysiological syndromes characterized by elevated pulmonary artery pressure and pulmonary vascular resistance, which lead to right ventricular overload, and even right heart failure. PH has a poor prognosis and severely leads to a decline in quality of life. Histor...

journal_title：Pulmonary circulation

authors： Zhang X,Xu D

更新日期：2020-07-07 00:00:00

abstract：:Right ventricular (RV) afterload consists of both resistive and capacitive (pulsatile) components. Total afterload can be measured directly with pulmonary artery input impedance spectra or estimated, either with lumped-parameter modeling or by pressure-volume analysis. However, the inverse, hyperbolic relationship bet...

journal_title：Pulmonary circulation

authors： Tedford RJ

更新日期：2014-06-01 00:00:00

abstract：:PH occurs alone or in association with many disorders. Many patients with transthoracic echocardiography (TTE) findings suggesting PH never receive additional evaluation. Patient characteristics and echocardiographic data associated with increased recognition of PH have not been fully evaluated. We evaluated TTE repor...

journal_title：Pulmonary circulation

authors： Kingrey JF,Panos RJ,Ying J,Meganathan K,Vandivier R,Elwing JM

更新日期：2013-04-01 00:00:00

abstract：:Many dyspneic patients who undergo computerized tomographic pulmonary angiography (CTPA) for presumed acute pulmonary embolism (PE) have no identified cause for their dyspnea yet have persistent symptoms, leading to more CTPA scanning. Right ventricular (RV) dysfunction or overload can signal treatable causes of dyspn...

journal_title：Pulmonary circulation

authors： Kline JA,Russell FM,Lahm T,Mastouri RA

更新日期：2015-03-01 00:00:00

abstract：:Hypereosinophilic syndrome is a myeloproliferative disorder characterized by persistent eosinophilia with involvement of multiple organs. The occurrence of severe pulmonary hypertension (PH) in the setting of hypereosinophilic syndrome is very uncommon. A 43-year-old man with documented idiopathic hypereosinophlic syn...

journal_title：Pulmonary circulation

authors： Zhang L,Peng X,Adhikari BK,Li B,Liu Q,Mikeladze J,Zhang W

更新日期：2019-01-01 00:00:00

abstract：:South America is a territory of 17,819,100 km(2), where ∼388 million people live in 13 countries. In the region, access to medical assistance (e.g., for treatment of cardiovascular disorders) is relatively easy in metropolitan areas but difficult in remote places such as the Andes and the Amazon. Altitudes up to ∼6,70...

journal_title：Pulmonary circulation

authors： Lopes AA,Flores PC,Diaz GF,Mesquita SM

更新日期：2014-09-01 00:00:00

abstract：:With the advancement of computed tomography pulmonary angiography, differentiating between acute and chronic thrombus in pulmonary embolism has become more feasible. However, whether pulmonary embolism with chronic thrombus contributes to a higher mortality than pulmonary embolism with acute thrombus remains undetermi...

journal_title：Pulmonary circulation

authors： Chang HY,Chang WT,Chen PW,Lin CC,Hsu CH

更新日期：2020-05-01 00:00:00

abstract：:Inhaled treprostinil (Tyvaso) has been shown to be a safe and effective addition to pulmonary arterial hypertension (PAH) oral therapies; however, the respiratory-related safety profile of inhaled treprostinil required further elucidation in the setting of routine clinical care. The objectives of this study were to ch...

journal_title：Pulmonary circulation

authors： Zamanian RT,Levine DJ,Bourge RC,De Souza SA,Rosenzweig EB,Alnuaimat H,Burger C,Mathai SC,Leedom N,DeAngelis K,Lim A,De Marco T

更新日期：2016-09-01 00:00:00

abstract：:Pharmacokinetic studies with oral treprostinil demonstrate that three times daily (TID) dosing reduces peak-to-trough plasma trepostinil fluctuations compared with twice daily (BID) dosing. TID dosing may allow for faster titration, higher total daily doses, and potentially improve the tolerability of oral trepostinil...

journal_title：Pulmonary circulation

authors： Balasubramanian VP,Messick CR,Broderick M,Nelsen AC

更新日期：2018-04-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) patients have distinct disease courses and responses to treatment, but current diagnostic and treatment schemes provide limited insight. We aimed to see if cluster analysis could distinguish clinical phenotypes in PAH. An unbiased cluster analysis was performed on 17 baseline clin...

journal_title：Pulmonary circulation

authors： Parikh KS,Rao Y,Ahmad T,Shen K,Felker GM,Rajagopal S

更新日期：2017-04-01 00:00:00

abstract：:Pulmonary capillary hemangiomatosis (PCH) is a rare form of pulmonary arterial hypertension (PAH) characterized by pulmonary capillary proliferation and pseudoinvasion of collagenous septal structures. PCH is often accompanied by veno-occlusive changes and pulmonary hypertensive arterial remodeling. The clinical and p...

journal_title：Pulmonary circulation

authors： DuBrock HM,Kradin RL,Rodriguez-Lopez JM,Channick RN

更新日期：2015-09-01 00:00:00

abstract：:Chronic thromboembolic pulmonary hypertension (CTEPH) is a complication of unresolved organised pulmonary emboli/thrombi obstructing the major pulmonary arteries. The aim of this study was to estimate the incidence and risk factors of CTEPH in a cohort with first venous thromboembolism (VTE). This was a population-bas...

journal_title：Pulmonary circulation

authors： Martinez C,Wallenhorst C,Teal S,Cohen AT,Peacock AJ

更新日期：2018-07-01 00:00:00

abstract：:Low-grade albuminuria, determined by the urinary albumin to creatinine ratio, has been linked to systemic vascular dysfunction and is associated with cardiovascular mortality. Pulmonary arterial hypertension is related to mutations in the bone morphogenetic protein receptor type 2, pulmonary vascular dysfunction and i...

journal_title：Pulmonary circulation

authors： Nickel NP,de Jesus Perez VA,Zamanian RT,Fessel JP,Cogan JD,Hamid R,West JD,de Caestecker MP,Yang H,Austin ED

更新日期：2019-04-01 00:00:00

abstract：:The biological mechanisms behind the development of pulmonary hypertension in the setting of left heart failure (HF-PH), including combined pre- and post-capillary pulmonary hypertension (Cpc-PH), remains unclear. This study aimed to use candidate polymorphisms in nitric oxide synthase (NOS) genes to explore the role ...

journal_title：Pulmonary circulation

authors： Duarte JD,Kansal M,Desai AA,Riden K,Arwood MJ,Yacob AA,Stamos TD,Cavallari LH,Zamanian RT,Shah SJ,Machado RF

更新日期：2018-04-01 00:00:00

abstract：:Pulmonary hypertension currently has minimal guidelines for outpatient disease management. Congestive heart failure studies, however, have shown effectiveness of disease management plans in reducing all-cause mortality and all-cause and congestive heart failure-related hospital readmissions. Heart failure exacerbation...

journal_title：Pulmonary circulation

authors： Dolan J,Mandras S,Mehta JP,Navas V,Tarver J,Chakinala M,Rahaghi F

更新日期：2020-12-07 00:00:00

abstract：:In pulmonary hypertension, as in many other diseases, there is a need for a smarter approach to evaluating new treatments. The traditional randomized controlled trial has served medical science well, but constrains the development of treatments for rare diseases. A workshop was established to consider alternative clin...

journal_title：Pulmonary circulation

authors： Grieve AP,Chow SC,Curram J,Dawe S,Harnisch LO,Henig NR,Hung HM,Ivy DD,Kawut SM,Rahbar MH,Xiao S,Wilkins MR

更新日期：2013-01-01 00:00:00

abstract：:Two oral medications targeting the prostacyclin pathway are available to treat pulmonary arterial hypertension in the United States: oral treprostinil and selexipag. We compared real-world hospitalization in patients receiving these medications. A retrospective administrative claims study was conducted using the Optum...

journal_title：Pulmonary circulation

authors： McConnell JW,Tsang Y,Pruett J,Iii WD

更新日期：2020-11-10 00:00:00

abstract：:Cardiac magnetic resonance-derived ventricular variables are predictive of mortality in pulmonary arterial hypertension. Rodent models which emphasize ventricular function, allowing serial monitoring, are needed to identify pathophysiological features and novel therapies for pulmonary arterial hypertension. We investi...

journal_title：Pulmonary circulation

authors： Jayasekera G,Wilson KS,Buist H,Woodward R,Uckan A,Hughes C,Nilsen M,Church AC,Johnson MK,Gallagher L,Mullin J,MacLean MR,Holmes WM,Peacock AJ,Welsh DJ

更新日期：2020-02-10 00:00:00

abstract：:Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening condition characterized by single or recurrent pulmonary thromboemboli, which promote pulmonary vascular remodeling. MicroRNA (miRNA), is a small, noncoding RNA that is involved in multiple cell processes and functions and may partici...

journal_title：Pulmonary circulation

authors： Wang L,Guo LJ,Liu J,Wang W,Yuan JX,Zhao L,Wang J,Wang C

更新日期：2013-09-01 00:00:00

abstract：:Oral treprostinil (TRE) is a prostacylin that is approved for the treatment of patients with pulmonary arterial hypertension (PAH). Dosing is approved for two or three times daily (t.i.d.); however, adverse effects, including gastrointestinal-related symptoms, may limit the ability to reach optimal doses. We report ou...

journal_title：Pulmonary circulation

authors： Coons JC,Bunner C,Ishizawar DC,Risbano MG,Rivera-Lebron B,Mathier MA,Chan SY,Simon MA

更新日期：2018-01-01 00:00:00

abstract：:Current knowledge gaps pertaining to diagnosis and management of neonatal chronic pulmonary hypertension (cPH) may result in significant variability in clinical practice. The objective of the study is to understand cPH management practices in neonatal intensive care units affiliated with the Canadian Neonatal Network ...

journal_title：Pulmonary circulation

authors： Baczynski M,Bell EF,Finan E,McNamara PJ,Jain A

更新日期：2020-07-16 00:00:00

abstract：:Atrial arrhythmias are common during episodes of acute respiratory failure in patients with chronic lung disease-associated pulmonary hypertension. Expert opinion suggests that management of atrial arrhythmias in patients with pulmonary hypertension should aim to restore sinus rhythm. This is clinically challenging in...

journal_title：Pulmonary circulation

authors： Vahdatpour CA,Luebbert JJ,Palevsky HI

更新日期：2020-03-09 00:00:00

abstract：:African Americans (AA) have a higher incidence of pulmonary hypertension (PH) risk factors. Few studies have examined the racial differences in the prevalence and etiology of PH and direct comparison of invasive hemodynamics between AAs and Caucasians has rarely been reported. In this study, we examined whether racial...

journal_title：Pulmonary circulation

authors： Yang BQ,Assad TR,O'Leary JM,Xu M,Halliday SJ,D'Amico RW,Farber-Eger EH,Wells QS,Hemnes AR,Brittain EL

更新日期：2018-04-01 00:00:00

abstract：:Pulmonary arterial hypertension can be associated with exposure to certain drugs or toxins. However, only a few cases of drug-induced pulmonary arterial hypertension have been previously reported. Anagrelide is an oral imidazoquinazoline agent that is prescribed for reducing elevated platelet counts in patients with m...

journal_title：Pulmonary circulation

authors： Sumimoto K,Taniguchi Y,Matsuoka Y,Onishi H,Emoto N,Hirata KI

更新日期：2019-12-27 00:00:00

abstract：:Andeans and Tibetans have less altitude reduction in birth weight than do shorter-resident groups, but only Tibetans are protected from pulmonary hypertension and chronic mountain sickness (CMS). We hypothesized that differences in neonatal oxygenation were involved, with arterial O2 saturation (SaO2) being highest in...

journal_title：Pulmonary circulation

authors： Niermeyer S,Andrade-M MP,Vargas E,Moore LG

更新日期：2015-03-01 00:00:00

abstract：:Pulmonary embolism is associated with high rates of mortality and morbidity. It is important to understand direct comparisons of current interventions to differentiate favorable outcomes and complications. The objective of this study was to compare ultrasound-accelerated thrombolysis versus systemic thrombolysis versu...

journal_title：Pulmonary circulation

authors： Antoine D,Chuich T,Mylvaganam R,Malaisrie C,Freed B,Cuttica M,Schimmel D Jr

更新日期：2020-09-28 00:00:00

abstract：:[This corrects the article DOI: 10.1086/688060.]. ...

journal_title：Pulmonary circulation

authors：

更新日期：2016-12-01 00:00:00

abstract：:Riociguat is approved for the treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. Some patients have difficulty swallowing tablets; therefore, 2 randomized, nonblinded, crossover studies compared the relative bioavailability of riociguat oral suspensions and immediate-releas...

journal_title：Pulmonary circulation

authors： Saleh S,Frey R,Becker C,Unger S,Wensing G,Mück W

更新日期：2016-03-01 00:00:00

abstract：:Increased peripheral resistance of small distal pulmonary arteries is a hallmark signature of pulmonary hypertension (PH) and is believed to be the consequence of enhanced vasoconstriction to agonists, thickening of the arterial wall due to remodeling, and increased thrombosis. The elevation in arterial tone in PH is ...

journal_title：Pulmonary circulation

authors： Leblanc N,Forrest AS,Ayon RJ,Wiwchar M,Angermann JE,Pritchard HA,Singer CA,Valencik ML,Britton F,Greenwood IA

更新日期：2015-06-01 00:00:00

abstract：:Transforming growth factor-β (TGF-β) inhibition is an investigational therapy for pulmonary arterial hypertension with promising results in experimental studies. The present work compared this approach with endothelin-receptor blockade and evaluated the effects of combined administration. Pulmonary arterial hypertensi...

journal_title：Pulmonary circulation

authors： Megalou AJ,Glava C,Vilaeti AD,Oikonomidis DL,Baltogiannis GG,Papalois A,Vlahos AP,Kolettis TM

更新日期：2012-10-01 00:00:00