Determinants of right ventricular afterload (2013 Grover Conference series).

abstract：:Many dyspneic patients who undergo computerized tomographic pulmonary angiography (CTPA) for presumed acute pulmonary embolism (PE) have no identified cause for their dyspnea yet have persistent symptoms, leading to more CTPA scanning. Right ventricular (RV) dysfunction or overload can signal treatable causes of dyspn...

journal_title：Pulmonary circulation

authors： Kline JA,Russell FM,Lahm T,Mastouri RA

更新日期：2015-03-01 00:00:00

abstract：:Right-ventricular function is a good indicator of pulmonary arterial hypertension (PAH) prognosis; however, how the right ventricle (RV) adapts to the pressure overload is not well understood. Here, we aimed at characterizing the time course of RV early remodeling and discriminate the contribution of ventricular geome...

journal_title：Pulmonary circulation

authors： Vélez-Rendón D,Zhang X,Gerringer J,Valdez-Jasso D

更新日期：2018-10-01 00:00:00

abstract：:Obesity is causally linked to a number of comorbidities, including cardiovascular disease, diabetes, renal dysfunction, and cancer. Obesity has also been linked to pulmonary disorders, including pulmonary arterial hypertension (PAH). It was long believed that obesity-related PAH was the result of hypoventilation and h...

journal_title：Pulmonary circulation

authors： Irwin DC,Garat CV,Crossno JT Jr,MacLean PS,Sullivan TM,Erickson PF,Jackman MR,Harral JW,Reusch JE,Klemm DJ

更新日期：2014-12-01 00:00:00

abstract：:Rapid access to lung-derived cells from stable subjects is a major challenge in the pulmonary hypertension field, given the relative contraindication of lung biopsy. In these studies, we sought to demonstrate the importance of evaluating a cell type that actively participates in disease processes, as well as the poten...

journal_title：Pulmonary circulation

authors： Gaskill C,Marriott S,Pratap S,Menon S,Hedges LK,Fessel JP,Kropski JA,Ames D,Wheeler L,Loyd JE,Hemnes AR,Roop DR,Klemm DJ,Austin ED,Majka SM

更新日期：2016-12-01 00:00:00

abstract：:[This corrects the article DOI: 10.1086/688060.]. ...

journal_title：Pulmonary circulation

authors：

更新日期：2016-12-01 00:00:00

abstract：:Pulmonary embolism is associated with high rates of mortality and morbidity. It is important to understand direct comparisons of current interventions to differentiate favorable outcomes and complications. The objective of this study was to compare ultrasound-accelerated thrombolysis versus systemic thrombolysis versu...

journal_title：Pulmonary circulation

authors： Antoine D,Chuich T,Mylvaganam R,Malaisrie C,Freed B,Cuttica M,Schimmel D Jr

更新日期：2020-09-28 00:00:00

abstract：:Pulmonary tumor thrombotic microangiopathy (PTTM) is a fatal disease process in which pulmonary hypertension (PH) develops in the setting of malignancy. The purpose of this study is to present a detailed analysis of cases of PTTM reported in literature in the hopes of achieving more ante-mortem diagnoses. We conducted...

journal_title：Pulmonary circulation

authors： Godbole RH,Saggar R,Kamangar N

更新日期：2019-04-01 00:00:00

abstract：:Levels of the cAMP-responsive transcription factor, CREB, are reduced in medial smooth muscle cells in remodeled pulmonary arteries from hypertensive calves and rats with chronic hypoxia-induced pulmonary hypertension. Here, we show that chronic hypoxia fails to promote CREB depletion in pulmonary artery smooth muscle...

journal_title：Pulmonary circulation

authors： Garat CV,Majka SM,Sullivan TM,Crossno JT Jr,Reusch JEB,Klemm DJ

更新日期：2020-04-14 00:00:00

abstract：:Radiotherapy as a primary treatment for thoracic malignancies induces deleterious effects, such as acute or subacute radiation-induced lung injury (RILI). Although the molecular etiology of RILI is controversial and likely multifactorial, a potentially important cellular target is the lung endothelial cytoskeleton tha...

journal_title：Pulmonary circulation

authors： Wang T,Mathew B,Wu X,Shimizu Y,Rizzo AN,Dudek SM,Weichselbaum RR,Jacobson JR,Hecker L,Garcia JG

更新日期：2016-06-01 00:00:00

abstract：:Oral treprostinil (TRE) is a prostacylin that is approved for the treatment of patients with pulmonary arterial hypertension (PAH). Dosing is approved for two or three times daily (t.i.d.); however, adverse effects, including gastrointestinal-related symptoms, may limit the ability to reach optimal doses. We report ou...

journal_title：Pulmonary circulation

authors： Coons JC,Bunner C,Ishizawar DC,Risbano MG,Rivera-Lebron B,Mathier MA,Chan SY,Simon MA

更新日期：2018-01-01 00:00:00

abstract：:Uncorrected atrial septal defect undergoes right ventricle chronic volume overload which may lead to pulmonary hypertension and Eisenmenger Syndrome. The soluble suppression of tumorigenicity-2 is a left ventricle strain biomarker; however, its role in right ventricle strain is unclear. This study aimed to investigate...

journal_title：Pulmonary circulation

authors： Pratama RS,Hartopo AB,Anggrahini DW,Dewanto VC,Dinarti LK

更新日期：2020-05-26 00:00:00

abstract：:South America is a territory of 17,819,100 km(2), where ∼388 million people live in 13 countries. In the region, access to medical assistance (e.g., for treatment of cardiovascular disorders) is relatively easy in metropolitan areas but difficult in remote places such as the Andes and the Amazon. Altitudes up to ∼6,70...

journal_title：Pulmonary circulation

authors： Lopes AA,Flores PC,Diaz GF,Mesquita SM

更新日期：2014-09-01 00:00:00

abstract：:Right ventricular failure (RVF) is the most important prognostic factor for both morbidity and mortality in pulmonary arterial hypertension (PAH), but also occurs in numerous other common diseases and conditions, including left ventricle dysfunction. RVF remains understudied compared with left ventricular failure (LVF...

journal_title：Pulmonary circulation

authors： Samson N,Paulin R

更新日期：2017-07-01 00:00:00

abstract：:Transforming growth factor-β (TGF-β) inhibition is an investigational therapy for pulmonary arterial hypertension with promising results in experimental studies. The present work compared this approach with endothelin-receptor blockade and evaluated the effects of combined administration. Pulmonary arterial hypertensi...

journal_title：Pulmonary circulation

authors： Megalou AJ,Glava C,Vilaeti AD,Oikonomidis DL,Baltogiannis GG,Papalois A,Vlahos AP,Kolettis TM

更新日期：2012-10-01 00:00:00

abstract：:Pulmonary arterial dilatation associated with pulmonary hypertension may result in significant compression of local structures. Left main coronary artery and left recurrent laryngeal nerve compression have been described. Tracheobronchial compression from pulmonary arterial dilatation is rare in adults, and there are ...

journal_title：Pulmonary circulation

authors： Jaijee SK,Ariff B,Howard L,O'Regan DP,Gin-Sing W,Davies R,Gibbs JS

更新日期：2015-12-01 00:00:00

abstract：:Chronic lung disease (CLD), including pulmonary fibrosis (PF) and chronic obstructive pulmonary disease (COPD), is the fourth leading cause of mortality worldwide. Both are debilitating pathologies that impede overall tissue function. A common co-morbidity in CLD is vasculopathy, characterized by deregulated angiogene...

journal_title：Pulmonary circulation

authors： Kropski JA,Richmond BW,Gaskill CF,Foronjy RF,Majka SM

更新日期：2018-01-01 00:00:00

abstract：:Despite the discovery more than 15 years ago that patients with hereditary pulmonary arterial hypertension (HPAH) inherit BMP type 2 receptor ( BMPR2) mutations, it is still unclear how these mutations cause disease. In part, this is attributable to the rarity of HPAH and difficulty obtaining tissue samples from patie...

journal_title：Pulmonary circulation

authors： Frump A,Prewitt A,de Caestecker MP

更新日期：2018-04-01 00:00:00

abstract：:While it is well established that the haemodynamic cause of hypoxic pulmonary hypertension is increased pulmonary vascular resistance, the molecular pathogenesis of the increased resistance remains incompletely understood. Macrophage migration inhibitory factor is a pleiotropic cytokine with endogenous tautomerase enz...

journal_title：Pulmonary circulation

authors： Li L,Xu M,Rowan SC,Howell K,Russell-Hallinan A,Donnelly SC,McLoughlin P,Baugh JA

更新日期：2020-10-26 00:00:00

abstract：:Inhaled iloprost is an effective therapy for patients with pulmonary arterial hypertension (PAH); however, some patients experience extended inhalation times when using the V10 formulation (10.0 µg/mL) to deliver a 5 -µg dose (at mouthpiece) and are at risk of incomplete inhalations and reduced inhalation frequency. V...

journal_title：Pulmonary circulation

authors： Richter MJ,Stollfuß B,Roitenberg A,Kleinjung F,Graeff V,Berghaus S,Müller C,Ghofrani HA

更新日期：2018-10-01 00:00:00

abstract：:Quantifying metabolic derangements in pulmonary hypertension (PH) by plasma metabolomics could identify biomarkers useful for diagnosis and treatment. The objective of this paper is to test the hypotheses that circulating metabolites are differentially expressed in PH patients compared with controls and among differen...

journal_title：Pulmonary circulation

authors： Luo N,Craig D,Ilkayeva O,Muehlbauer M,Kraus WE,Newgard CB,Shah SH,Rajagopal S

更新日期：2017-02-01 00:00:00

abstract：:In 301 treatment-naïve patients with pulmonary arterial hypertension stratified by the European Society of Cardiology/European Respiratory Society risk score, further stratification of intermediate-risk patients based on six-minute walk distance and the tricuspid annular plane systolic excursion/systolic pulmonary art...

journal_title：Pulmonary circulation

authors： Yogeswaran A,Richter MJ,Sommer N,Ghofrani HA,Seeger W,Tello K,Gall H

更新日期：2020-10-07 00:00:00

abstract：:Adherence to therapy for pulmonary arterial hypertension is essential to optimize patient outcomes, but data on real-world adherence to different pulmonary arterial hypertension drug classes are limited. This retrospective database analysis evaluated relationships between adherence, hospitalization, and healthcare cos...

journal_title：Pulmonary circulation

authors： Frantz RP,Hill JW,Lickert CA,Wade RL,Cole MR,Tsang Y,Drake W 3rd

更新日期：2020-03-18 00:00:00

abstract：:Optimal pulmonary hypertension (PH) management relies on a timely, accurate diagnosis and follow-up in specialized clinics by multidisciplinary teams that have clearly defined responsibilities and protocols. Internationally agreed criteria for expert center staff are lacking, particularly with respect to nurses, who o...

journal_title：Pulmonary circulation

authors： Doyle-Cox C,Nicholson G,Stewart T,Gin-Sing W

更新日期：2019-04-01 00:00:00

abstract：:Patients with chronic thromboembolic pulmonary hypertension (CTEPH) require lifelong anticoagulation therapy. However, the bleeding risk and recurrence of venous thromboembolism (VTE) in CTEPH patients who are administered warfarin have not been adequately evaluated. The purpose of this study was to evaluate the risk ...

journal_title：Pulmonary circulation

authors： Jujo-Sanada T,Tanabe N,Sakao S,Sugiura T,Sekine A,Nishimura R,Suda R,Naito A,Miwa H,Yamamoto K,Sasaki A,Matsumura A,Ema R,Kasai H,Kato F,Tatsumi K

更新日期：2017-07-01 00:00:00

abstract：:Cardiac magnetic resonance-derived ventricular variables are predictive of mortality in pulmonary arterial hypertension. Rodent models which emphasize ventricular function, allowing serial monitoring, are needed to identify pathophysiological features and novel therapies for pulmonary arterial hypertension. We investi...

journal_title：Pulmonary circulation

authors： Jayasekera G,Wilson KS,Buist H,Woodward R,Uckan A,Hughes C,Nilsen M,Church AC,Johnson MK,Gallagher L,Mullin J,MacLean MR,Holmes WM,Peacock AJ,Welsh DJ

更新日期：2020-02-10 00:00:00

abstract：:Pulmonary capillary hemangiomatosis (PCH) is a rare form of pulmonary arterial hypertension (PAH) characterized by pulmonary capillary proliferation and pseudoinvasion of collagenous septal structures. PCH is often accompanied by veno-occlusive changes and pulmonary hypertensive arterial remodeling. The clinical and p...

journal_title：Pulmonary circulation

authors： DuBrock HM,Kradin RL,Rodriguez-Lopez JM,Channick RN

更新日期：2015-09-01 00:00:00

abstract：:The aim of this study was to investigate whether a dual endothelin receptor antagonist bosentan modulates the kinetics of bone marrow-derived stem cells in inhibiting the development of pulmonary hypertension. Bone marrow chimeric mice, transplanted with enhanced green fluorescent protein (eGFP)-positive bone marrow m...

journal_title：Pulmonary circulation

authors： Kato T,Mitani Y,Masuya M,Maruyama J,Sawada H,Ohashi H,Ikeyama Y,Otsuki S,Yodoya N,Shinohara T,Miyata E,Zhang E,Katayama N,Shimpo H,Maruyama K,Komada Y,Hirayama M

更新日期：2020-05-14 00:00:00

abstract：:There are few data on the epidemiology of pulmonary hypertension (PH)-related hospitalizations in children in the United States. Our aim was to determine hospital mortality, length of hospitalization, and hospital charges pertaining to PH-related hospitalizations and also the effects of codiagnoses and comorbidities. ...

journal_title：Pulmonary circulation

authors： Frank DB,Crystal MA,Morales DL,Gerald K,Hanna BD,Mallory GB Jr,Rossano JW

更新日期：2015-06-01 00:00:00

abstract：:This study aimed to identify receptors mediating sphingosine-1-phosphate (S1P)-induced vasoconstriction in the normotensive and chronic hypoxia-induced hypertensive rat pulmonary circulation. In isolated perfused lungs from normoxic rats, infusion of S1P caused a sustained vasoconstriction, which was not reduced by co...

journal_title：Pulmonary circulation

authors： Ota H,Beutz MA,Ito M,Abe K,Oka M,McMurtry IF

更新日期：2011-07-01 00:00:00

abstract：:Echocardiography, a non-invasive and cost-effective method for monitoring cardiac function, is commonly used for evaluation and pre-clinical diagnostics of pulmonary hypertension (PH). Previous echocardiographic studies in experimental models of PH are fragmentary in terms of the evaluation of right ventricle (RV) fun...

journal_title：Pulmonary circulation

authors： Zhu Z,Godana D,Li A,Rodriguez B,Gu C,Tang H,Minshall RD,Huang W,Chen J

更新日期：2019-04-01 00:00:00