Abstract:
:Low-grade albuminuria, determined by the urinary albumin to creatinine ratio, has been linked to systemic vascular dysfunction and is associated with cardiovascular mortality. Pulmonary arterial hypertension is related to mutations in the bone morphogenetic protein receptor type 2, pulmonary vascular dysfunction and is increasingly recognized as a systemic disease. In a total of 283 patients (two independent cohorts) diagnosed with pulmonary arterial hypertension, 18 unaffected BMPR2 mutation carriers and 68 healthy controls, spot urinary albumin to creatinine ratio and its relationship to demographic, functional, hemodynamic and outcome data were analyzed. Pulmonary arterial hypertension patients and unaffected BMPR2 mutation carriers had significantly elevated urinary albumin to creatinine ratios compared with healthy controls ( P < 0.01; P = 0.04). In pulmonary arterial hypertension patients, the urinary albumin to creatinine ratio was associated with older age, lower six-minute walking distance, elevated levels of C-reactive protein and hemoglobin A1c, but there was no correlation between the urinary albumin to creatinine ratio and hemodynamic variables. Pulmonary arterial hypertension patients with a urinary albumin to creatinine ratio above 10 µg/mg had significantly higher rates of poor outcome ( P < 0.001). This study shows that low-grade albuminuria is prevalent in pulmonary arterial hypertension patients and is associated with poor outcome. This study shows that albuminuria in pulmonary arterial hypertension is associated with systemic inflammation and insulin resistance.
journal_name
Pulm Circjournal_title
Pulmonary circulationauthors
Nickel NP,de Jesus Perez VA,Zamanian RT,Fessel JP,Cogan JD,Hamid R,West JD,de Caestecker MP,Yang H,Austin EDdoi
10.1177/2045894018824564subject
Has Abstractpub_date
2019-04-01 00:00:00pages
2045894018824564issue
2eissn
2045-8932issn
2045-8940journal_volume
9pub_type
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journal_title:Pulmonary circulation
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doi:10.1086/675643
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journal_title:Pulmonary circulation
pub_type: 杂志文章
doi:10.1177/2045894019875343
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abstract::[This corrects the article DOI: 10.1086/688060.]. ...
journal_title:Pulmonary circulation
pub_type: 已发布勘误
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pub_type: 杂志文章
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abstract:: ...
journal_title:Pulmonary circulation
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journal_title:Pulmonary circulation
pub_type: 杂志文章
doi:10.1177/2045894018776496
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journal_title:Pulmonary circulation
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2012-07-01 00:00:00
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journal_title:Pulmonary circulation
pub_type: 杂志文章
doi:10.4103/2045-8932.94834
更新日期:2012-01-01 00:00:00
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journal_title:Pulmonary circulation
pub_type: 杂志文章,评审
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更新日期:2014-09-01 00:00:00
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journal_title:Pulmonary circulation
pub_type: 杂志文章
doi:10.1086/686491
更新日期:2016-06-01 00:00:00
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journal_title:Pulmonary circulation
pub_type: 杂志文章
doi:10.1086/678510
更新日期:2014-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1086/689906
更新日期:2017-07-01 00:00:00
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journal_title:Pulmonary circulation
pub_type: 杂志文章
doi:10.1086/685549
更新日期:2016-06-01 00:00:00
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doi:10.1177/2045894020961739
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pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2020-07-07 00:00:00
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journal_title:Pulmonary circulation
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