Inspiratory capacity is not altered in operable chronic thromboembolic pulmonary hypertension.

abstract：:Pulmonary hypertension currently has minimal guidelines for outpatient disease management. Congestive heart failure studies, however, have shown effectiveness of disease management plans in reducing all-cause mortality and all-cause and congestive heart failure-related hospital readmissions. Heart failure exacerbation...

journal_title：Pulmonary circulation

authors： Dolan J,Mandras S,Mehta JP,Navas V,Tarver J,Chakinala M,Rahaghi F

更新日期：2020-12-07 00:00:00

abstract：:Carboxyl terminus of Hsc70-interacting protein (CHIP) is a 35-kDa cytoplasmic protein expressed in human striated muscle, brain, aortic smooth muscle, endothelial cells, and other tissues. Studies have confirmed that CHIP regulates cell growth, apoptosis, cell phenotype, metabolism, neurodegeneration, etc. However, wh...

journal_title：Pulmonary circulation

authors： Dong F,Zhang J

更新日期：2019-09-09 00:00:00

abstract：:Abstract Changes in voltage-gated K(+) (Kv) channel function contribute to the pathogenesis of pulmonary hypertension. Yet the mechanisms underlying Kv channel impairments in the pulmonary circulation remain unclear. We tested the hypothesis that reactive oxygen species (ROSs) contribute to the Kv channel dysfunction ...

journal_title：Pulmonary circulation

authors： Fike CD,Aschner JL,Kaplowitz MR,Zhang Y,Madden JA

更新日期：2013-09-01 00:00:00

abstract：:Schistosomiasis-associated pulmonary arterial hypertension (PAH) is one of the most common causes of pulmonary hypertension worldwide. A potential contributing mechanism to the pathogenesis of this disease is a localized immune reaction to retained and persistent parasite-derived antigens. We sought to identify Schist...

journal_title：Pulmonary circulation

authors： Graham BB,Chabon J,Bandeira A,Espinheira L,Butrous G,Tuder RM

更新日期：2011-10-01 00:00:00

abstract：:In pulmonary hypertension, as in many other diseases, there is a need for a smarter approach to evaluating new treatments. The traditional randomized controlled trial has served medical science well, but constrains the development of treatments for rare diseases. A workshop was established to consider alternative clin...

journal_title：Pulmonary circulation

authors： Grieve AP,Chow SC,Curram J,Dawe S,Harnisch LO,Henig NR,Hung HM,Ivy DD,Kawut SM,Rahbar MH,Xiao S,Wilkins MR

更新日期：2013-01-01 00:00:00

abstract：:While it is well established that the haemodynamic cause of hypoxic pulmonary hypertension is increased pulmonary vascular resistance, the molecular pathogenesis of the increased resistance remains incompletely understood. Macrophage migration inhibitory factor is a pleiotropic cytokine with endogenous tautomerase enz...

journal_title：Pulmonary circulation

authors： Li L,Xu M,Rowan SC,Howell K,Russell-Hallinan A,Donnelly SC,McLoughlin P,Baugh JA

更新日期：2020-10-26 00:00:00

abstract：:Inappropriate mechanical ventilation may induce hemodynamic alterations through cardiopulmonary interactions. The aim of this study was to explore the relationship between airway pressure and central venous pressure during the first 72 h of mechanical ventilation and its relevance to patient outcomes. We conducted a r...

journal_title：Pulmonary circulation

authors： Mao JY,Li DK,Ding X,Zhang HM,Long Y,Wang XT,Liu DW

更新日期：2020-11-25 00:00:00

abstract：:Cardiac magnetic resonance-derived ventricular variables are predictive of mortality in pulmonary arterial hypertension. Rodent models which emphasize ventricular function, allowing serial monitoring, are needed to identify pathophysiological features and novel therapies for pulmonary arterial hypertension. We investi...

journal_title：Pulmonary circulation

authors： Jayasekera G,Wilson KS,Buist H,Woodward R,Uckan A,Hughes C,Nilsen M,Church AC,Johnson MK,Gallagher L,Mullin J,MacLean MR,Holmes WM,Peacock AJ,Welsh DJ

更新日期：2020-02-10 00:00:00

abstract：:Low-grade albuminuria, determined by the urinary albumin to creatinine ratio, has been linked to systemic vascular dysfunction and is associated with cardiovascular mortality. Pulmonary arterial hypertension is related to mutations in the bone morphogenetic protein receptor type 2, pulmonary vascular dysfunction and i...

journal_title：Pulmonary circulation

authors： Nickel NP,de Jesus Perez VA,Zamanian RT,Fessel JP,Cogan JD,Hamid R,West JD,de Caestecker MP,Yang H,Austin ED

更新日期：2019-04-01 00:00:00

abstract：:Vasculopathies, characterized by the formation of fragile and abnormal microvessels, are associated with the severity of many chronic lung diseases, including pulmonary fibrosis, emphysema/chronic obstructive pulmonary disease, systemic sclerosis, and hypertension. However, the study of human lung vasculature has been...

journal_title：Pulmonary circulation

authors： Gaskill C,Majka SM

更新日期：2017-03-27 00:00:00

abstract：:Retinal vessel diameters have been associated with left ventricular morphology and function but their relationship with the right ventricle (RV) has not been studied. We hypothesized that wider retinal venules and narrower retinal arterioles are associated with RV morphology and function. RV end-diastolic mass (RVEDM)...

journal_title：Pulmonary circulation

authors： Chyou AC,Klein BEK,Klein R,Barr RG,Cotch MF,Praestgaard A,Wong TY,Lima J,Bluemke DA,Kawut S

更新日期：2018-12-03 00:00:00

abstract：:Current knowledge gaps pertaining to diagnosis and management of neonatal chronic pulmonary hypertension (cPH) may result in significant variability in clinical practice. The objective of the study is to understand cPH management practices in neonatal intensive care units affiliated with the Canadian Neonatal Network ...

journal_title：Pulmonary circulation

authors： Baczynski M,Bell EF,Finan E,McNamara PJ,Jain A

更新日期：2020-07-16 00:00:00

abstract：:Inhaled iloprost is an effective therapy for patients with pulmonary arterial hypertension (PAH); however, some patients experience extended inhalation times when using the V10 formulation (10.0 µg/mL) to deliver a 5 -µg dose (at mouthpiece) and are at risk of incomplete inhalations and reduced inhalation frequency. V...

journal_title：Pulmonary circulation

authors： Richter MJ,Stollfuß B,Roitenberg A,Kleinjung F,Graeff V,Berghaus S,Müller C,Ghofrani HA

更新日期：2018-10-01 00:00:00

abstract：:African Americans (AA) have a higher incidence of pulmonary hypertension (PH) risk factors. Few studies have examined the racial differences in the prevalence and etiology of PH and direct comparison of invasive hemodynamics between AAs and Caucasians has rarely been reported. In this study, we examined whether racial...

journal_title：Pulmonary circulation

authors： Yang BQ,Assad TR,O'Leary JM,Xu M,Halliday SJ,D'Amico RW,Farber-Eger EH,Wells QS,Hemnes AR,Brittain EL

更新日期：2018-04-01 00:00:00

abstract：:Endothelial dysfunction plays an important role in the pathogenesis of pulmonary arterial hypertension (PAH) in sickle cell disease (SCD). A variety of evidence suggests that circulating endothelial progenitor cells (EPCs) play an integral role in vascular repair. We hypothesized that SCD patients with PAH are deficie...

journal_title：Pulmonary circulation

authors： Anjum F,Lazar J,Zein J,Jamaleddine G,Demetis S,Wadgaonkar R

更新日期：2012-01-01 00:00:00

abstract：:This manuscript on endpoints incorporates the broad experience of members of Pulmonary Vascular Research Institute's Innovative Drug Development Initiative as an open debate platform for academia, the pharmaceutical industry and regulatory experts surrounding the future design of clinical trials in pulmonary hypertens...

journal_title：Pulmonary circulation

authors： Sitbon O,Nikkho S,Benza R,Cq Deng C,W Farber H,Gomberg-Maitland M,Hassoun P,Meier C,Pepke-Zaba J,Prasad K,Seeger W,Corris PA

更新日期：2020-11-18 00:00:00

abstract：:Clinical guidelines for pulmonary hypertension recommend evaluating treatment response through various methods; however, electrocardiography (ECG) is not included as one of the methods of choice. We aimed to identify ECG parameters that correlated with prognosis in patients with pulmonary arterial hypertension (PAH). ...

journal_title：Pulmonary circulation

authors： Sato S,Ogawa A,Matsubara H

更新日期：2018-04-01 00:00:00

abstract：:Echocardiography, a non-invasive and cost-effective method for monitoring cardiac function, is commonly used for evaluation and pre-clinical diagnostics of pulmonary hypertension (PH). Previous echocardiographic studies in experimental models of PH are fragmentary in terms of the evaluation of right ventricle (RV) fun...

journal_title：Pulmonary circulation

authors： Zhu Z,Godana D,Li A,Rodriguez B,Gu C,Tang H,Minshall RD,Huang W,Chen J

更新日期：2019-04-01 00:00:00

abstract：:The diagnosis of pulmonary vascular disease (PVD) is usually based on hemodynamic and/or clinical criteria. Noninvasive imaging of the heart and proximal vasculature can also provide useful information. An alternate approach to such criteria in the diagnosis of PVD is to image the vascular abnormalities in the lungs t...

journal_title：Pulmonary circulation

authors： Dahhan T,Kaushik SS,He M,Mammarappallil JG,Tapson VF,McAdams HP,Sporn TA,Driehuys B,Rajagopal S

更新日期：2016-03-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is characterized by obstruction of pre-capillary pulmonary arteries, which leads to sustained elevation of pulmonary arterial pressure. Identifying those at risk through early interventions, such as genetic testing, may mitigate disease course. Current practice guidelines recommen...

journal_title：Pulmonary circulation

authors： Jacher JE,Martin LJ,Chung WK,Loyd JE,Nichols WC

更新日期：2017-04-01 00:00:00

abstract：:Pharmacokinetic studies with oral treprostinil demonstrate that three times daily (TID) dosing reduces peak-to-trough plasma trepostinil fluctuations compared with twice daily (BID) dosing. TID dosing may allow for faster titration, higher total daily doses, and potentially improve the tolerability of oral trepostinil...

journal_title：Pulmonary circulation

authors： Balasubramanian VP,Messick CR,Broderick M,Nelsen AC

更新日期：2018-04-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) patients have distinct disease courses and responses to treatment, but current diagnostic and treatment schemes provide limited insight. We aimed to see if cluster analysis could distinguish clinical phenotypes in PAH. An unbiased cluster analysis was performed on 17 baseline clin...

journal_title：Pulmonary circulation

authors： Parikh KS,Rao Y,Ahmad T,Shen K,Felker GM,Rajagopal S

更新日期：2017-04-01 00:00:00

abstract：:Pulmonary endarterectomy (PEA) is the standard therapy for chronic thromboembolic pulmonary hypertension (CTEPH). Balloon pulmonary angioplasty (BPA) is an alternative therapy for such patients. Here we report the case of a 60-year-old woman who presented with severe CTEPH resulting in low cardiac output and liver fai...

journal_title：Pulmonary circulation

authors： Tsuji A,Ogo T,Demachi J,Ono Y,Sanda Y,Morita Y,Fukuda T,Nakanishi N

更新日期：2014-03-01 00:00:00

abstract：:Limited data about the long-term prognosis and response to therapy in pulmonary arterial hypertension patients with World Health Organization functional class I/II symptoms are available. PubMed and Embase were searched for publications of observational registries and randomized, controlled trials in pulmonary arteria...

journal_title：Pulmonary circulation

authors： Kim NH,Fisher M,Poch D,Zhao C,Shah M,Bartolome S

更新日期：2020-11-25 00:00:00

abstract：:The maintenance of endothelial barrier integrity is absolutely essential to prevent the vascular leak associated with pneumonia, pulmonary edema resulting from inhalation of toxins, acute elevation to high altitude, traumatic and septic lung injury, acute lung injury (ALI), and its life-threatening complication, acute...

journal_title：Pulmonary circulation

authors： Karki P,Birukova AA

更新日期：2018-04-01 00:00:00

abstract：:Pulmonary capillary hemangiomatosis (PCH) is a rare form of pulmonary arterial hypertension (PAH) characterized by pulmonary capillary proliferation and pseudoinvasion of collagenous septal structures. PCH is often accompanied by veno-occlusive changes and pulmonary hypertensive arterial remodeling. The clinical and p...

journal_title：Pulmonary circulation

authors： DuBrock HM,Kradin RL,Rodriguez-Lopez JM,Channick RN

更新日期：2015-09-01 00:00:00

abstract：:Despite the discovery more than 15 years ago that patients with hereditary pulmonary arterial hypertension (HPAH) inherit BMP type 2 receptor ( BMPR2) mutations, it is still unclear how these mutations cause disease. In part, this is attributable to the rarity of HPAH and difficulty obtaining tissue samples from patie...

journal_title：Pulmonary circulation

authors： Frump A,Prewitt A,de Caestecker MP

更新日期：2018-04-01 00:00:00

abstract：:Pulmonary embolism is associated with high rates of mortality and morbidity. It is important to understand direct comparisons of current interventions to differentiate favorable outcomes and complications. The objective of this study was to compare ultrasound-accelerated thrombolysis versus systemic thrombolysis versu...

journal_title：Pulmonary circulation

authors： Antoine D,Chuich T,Mylvaganam R,Malaisrie C,Freed B,Cuttica M,Schimmel D Jr

更新日期：2020-09-28 00:00:00

abstract：:Pregnancy is not advised for patients with Pulmonary hypertension (PH) because of high risk of PH crisis. However, some patients have undiagnosed idiopathic pulmonary arterial hypertension (IPAH) before pregnancy. Upfront combination therapy has high efficacy for patients with IPAH. However, some patients are unable t...

journal_title：Pulmonary circulation

authors： Adachi S,Shimokata S,Yoshida M,Imai R,Nakano Y,Okumura N,Suzuki S,Murohara T,Kondo T

更新日期：2020-02-28 00:00:00

abstract：:[This corrects the article DOI: 10.1086/688060.]. ...

journal_title：Pulmonary circulation

authors：

更新日期：2016-12-01 00:00:00