Abstract:
AIM:Hemoglobin is reported to be positively associated with hypertension. However, the underlying mechanism of this association is unknown. Recently, bone marrow-derived CD34-positive cells have been reported to play an important role in endothelial repair in conjunction with platelets. As the association between hypertension and endothelial dysfunction is bidirectional, the influence of endothelial repair also might strongly influence the association between hemoglobin and hypertension. METHODS:To clarify the clinical importance of the hematological parameter on endothelial maintenance in older men, we carried out a cross-sectional study of 222 Japanese men aged 60-69 years undergoing a general health checkup. RESULTS:For participants with a lower platelet count (≤21.0/μL), hemoglobin was significantly positively associated with hypertension, but not for participants with a higher platelet count (>21.0/μL). The classical cardiovascular risk factor adjusted odds ratio of hypertension for 1-standard deviation increment of hemoglobin (1.0 g/dL) was 2.09 (95% CI: 1.26, 3.48) for participants with a lower platelet count, and 1.07 (95% CI: 0.68, 1.67) for participants with a higher platelet count. We also found that although there was no significant correlation between hemoglobin and circulating CD34-positive cells for participants with a lower platelet count (β = -0.06, P = 0.603), a significant positive correlation was seen for participants with a higher platelet count (β = 0.29, P = 0.004). CONCLUSIONS:The positive association between hemoglobin and hypertension was limited to participants with a lower platelet count as a result of insufficient endothelial repair. These results represent an efficient tool for clarifying the mechanism of endothelial maintenance that correlates with hypertension. Geriatr Gerontol Int 2017; 17: 2586-2592.
journal_name
Geriatr Gerontol Intjournal_title
Geriatrics & gerontology internationalauthors
Shimizu Y,Sato S,Koyamatsu J,Yamanashi H,Nagayoshi M,Kadota K,Kawashiri SY,Maeda Tdoi
10.1111/ggi.13068subject
Has Abstractpub_date
2017-12-01 00:00:00pages
2586-2592issue
12eissn
1444-1586issn
1447-0594journal_volume
17pub_type
杂志文章abstract:AIM:The present study aimed to examine the associations among behavioral and psychological symptoms of dementia (BPSD) of persons with dementia (PWD), care burden and family-to-work conflict (FWC) of employed family caregivers. METHOD:A cross-sectional study was carried out with employed adult daughter or son (or in-l...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13556
更新日期:2019-01-01 00:00:00
abstract:AIM:To evaluate the prevalence of potentially inappropriate prescribing (PIP), as defined by the internationally validated Screening Tool of Older Person's Prescriptions (STOPP) criteria, in 12 months before and after initiation of medicines for dementia. METHODS:A retrospective cohort study was carried out involving ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13686
更新日期:2019-07-01 00:00:00
abstract:AIM:A nested case-control study was carried out to examine relationships of a fall-risk score and the use of single medications and polypharmacy with falls among hospitalized patients aged 50 years and older in Taiwan. METHODS:There were 83 patients who experienced a fall during hospitalization in an acute-care hospit...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12359
更新日期:2015-07-01 00:00:00
abstract:AIM:Malnutrition is common in older patients and is associated with adverse outcomes. The Geriatric Nutritional Risk Index (GNRI) has been developed as an objective index to assess nutritional risk in these patients. However, there is limited evidence regarding the association between GNRI and postoperative delirium (P...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13963
更新日期:2020-08-01 00:00:00
abstract::Now that the number of elderly people has increased and the number of dementia patients is rapidly increasing, dementia might be regarded as a common disease. Under these circumstances, the establishment of systems to support the elderly with dementia from the early stages, and to provide primary care doctors and care...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,评审
doi:10.1111/ggi.12248
更新日期:2014-04-01 00:00:00
abstract:AIM:In the present study, we analyzed the severity of white matter hyperintensities detected on magnetic resonance imaging of the brain in older Japanese adults who were aged in their mid 80s, and examined its relationships with the clinical parameters. METHODS:To identify factors related to the severity of white matt...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12671
更新日期:2015-12-01 00:00:00
abstract:AIM:Population aging is a global phenomenon, and East Asian countries are no exception. However, the use of advance care planning (ACP) and advance directives (ADs) are not widespread in East Asia. This study aimed to examine the awareness of ACP/ADs and its related factors among community-dwelling older persons in Jap...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.14086
更新日期:2021-01-01 00:00:00
abstract:AIM:To validate and standardize the Brazilian version of the Medication Regimen Complexity Index (MRCI) for older adults in primary healthcare. METHODS:A cross-sectional methodological study was carried out with elderly patients attending primary healthcare centers in southeastern Brazil. Convergent validity was teste...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13261
更新日期:2018-06-01 00:00:00
abstract:AIM:Older adults often present with several comorbidities, including sarcopenia. However, the prevalence of sarcopenia and its associations with other comorbidities in hospitalized older adults are unknown. The present study aimed to determine the prevalence of sarcopenia, and its associations with other comorbidities ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12825
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the intensity of pain and levels of disability at different times through the day in patients with burning mouth syndrome (BMS) over a 14-day period. METHODS:This was a prospective clinical study of 30 patients with BMS, 26 of whom completed the study. The parameters studied were pain intensity (...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12303
更新日期:2015-04-01 00:00:00
abstract:AIM:In Japan, many elderly patients are managed at home, and fever is a common problem. This study examined the incidence of fever events in elderly patients on home medical management, and underlying disorders from the pragmatic standpoint. This study also investigated whether the care-need level determined at the sta...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12024
更新日期:2013-10-01 00:00:00
abstract:AIM:To investigate the frequency of calcification in the basal ganglia and the dentate nuclei in the cerebellum, and compare the difference in age and area, we examined the brain computed tomography (CT) images of all patients in two representative university hospitals in Japan. METHODS:We examined the brain CT images...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12004
更新日期:2013-07-01 00:00:00
abstract:AIM:Chronic diseases are frequent in older adults, particularly hypertension and diabetes. The relationship between frailty and these two conditions is still unclear. The aim of the present analyses was to explore the association between frailty with diabetes and hypertension in Mexican older adults. METHODS:Analyses ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12805
更新日期:2017-06-01 00:00:00
abstract:AIM:To establish the validity of the Norwegian General Motor Function (NGMF) assessment scale. METHOD:To establish construct and criteria validity, Spearman's rank correlation coefficients were calculated for the NGMF, and age, sex, medical conditions, history of falls and to four functional tests. Content validity wa...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12491
更新日期:2016-04-01 00:00:00
abstract:AIM:The number of hemodialysis (HD) patients is increasing along with their mean age in Japan. The assessment of their psychosocial status and quality of life (QOL) is therefore becoming more and more important along with laboratory data or comorbidities. METHODS:We examined the psychosocial status of 211 HD patients ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2011.00731.x
更新日期:2012-01-01 00:00:00
abstract:AIM:The effectiveness of resistance training in improving cognitive function in older adults is well demonstrated. In particular, unconventional high-speed resistance training can improve muscle power development. In the present study, the effectiveness of 12 weeks of elastic band-based high-speed power training (HSPT)...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,随机对照试验
doi:10.1111/ggi.12784
更新日期:2017-05-01 00:00:00
abstract:AIM:The Community Commitment Scale was developed in Japan to measure communities' ability to prevent older adults' social isolation, including socializing and belonging in the community. We translated the scale into Korean (the Community Commitment Scale-Korean version [CCS-K]), and determined its internal consistency,...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13249
更新日期:2018-05-01 00:00:00
abstract::The number of older adults is increasing worldwide, including in Asian countries. Various problems associated with medical care for older adults are being highlighted in aging societies. As the number of chronic diseases increases with age, older adults are more likely to have multiple chronic diseases simultaneously ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,评审
doi:10.1111/ggi.13742
更新日期:2019-08-01 00:00:00
abstract:AIM:To re-evaluate the suitability of calf circumference as a surrogate marker of low muscle mass measured by both bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DXA). We also examined the effects of obesity and age on low muscle mass screening using calf circumference. METHODS:In total, ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.14025
更新日期:2020-10-01 00:00:00
abstract:AIM:Our aim was to study the outcome and the predictors of in-hospital cardiopulmonary resuscitation (CPR) among elderly patients admitted to Ain Shams University Hospitals, Egypt. METHODS:We carried out a cross-sectional study for all elderly patients (age ≥60 years) who underwent CPR after cardiac arrest at Ain Sham...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,收录出版
doi:10.1111/ggi.12099
更新日期:2014-04-01 00:00:00
abstract:AIM:The enteric nervous system degenerates gradually with age, and α-synuclein (α-syn) is a suitable marker of enteric nervous system degeneration, which is intimately related with endoplasmic reticulum stress and unfolded protein response (UPRER ). Saponins from Panax japonicus (SPJ) have obvious protective effects on...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13882
更新日期:2021-01-01 00:00:00
abstract:AIM:The aim of this study was to develop the Korean Anticholinergic Burden Scale through assessment of previously developed tools, a literature review and a modified Delphi process. METHODS:We carried out a systematic review to identify previously published anticholinergic burden tools. A composite medication list was...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13680
更新日期:2019-07-01 00:00:00
abstract:AIM:Calf circumference, which is a known simple indicator of muscle mass, increases during edema. However, the extent to which edema increases calf circumference in older adults is unclear. METHODS:This retrospective cross-sectional study included patients aged ≥65 years whose nutritional status was assessed by nutrit...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13756
更新日期:2019-10-01 00:00:00
abstract:AIM:Skeletal muscle loss is a common feature of aging, and is associated with unfavorable outcomes. Although several indexes of skeletal muscle mass measurement have been developed, the most optimal index for sarcopenia diagnosis among Asian populations has remained unclear. The present study aimed to evaluate the rela...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12040
更新日期:2013-10-01 00:00:00
abstract:AIM:Postoperative cognitive dysfunction is often observed in older patients. Previous reports described the link between postoperative cognitive dysfunction and general anesthetics, such as sevoflurane, but the exact mechanism remains unclear. We therefore sought to characterize the effects of sevoflurane on hippocampa...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13619
更新日期:2019-04-01 00:00:00
abstract:AIM:Nutrition is the focus of a new treatment target in older hospitalized cardiac patients. However, little is known about the differences in nutritional status in relation to physical performance in these inpatients. We determined the differences in physical performance based on the Geriatric Nutritional Risk Index (...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12257
更新日期:2015-02-01 00:00:00
abstract:AIM:The role of preoperative frailty assessment in patients with gastrointestinal (GI) disease remains unclear. This study aimed to clarify the relationship between frailty and postoperative outcomes in patients with GI disease. METHODS:This study investigated 42 patients (aged ≥65 years) with GI disease who underwent...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.14134
更新日期:2021-01-27 00:00:00
abstract:AIM:Werner syndrome (WS) is an autosomal recessive disorder of progeroid symptoms and signs. It is caused by mutations in the WRN gene, which encodes a RecQ DNA helicase. The aim of this study was to revise the diagnostic criteria for Japanese Werner syndrome. METHODS:A nationwide epidemiological study was carried out...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2012.00913.x
更新日期:2013-04-01 00:00:00
abstract:AIM:The present study examined the association between vision, fear of falling and fear-related activity restriction, and assessed the effect of vision on the relationship between fear of falling and mobility, using data from a nationally representative sample of community-dwelling adults aged ≥ 50 years. METHODS:Part...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12174
更新日期:2014-10-01 00:00:00
abstract:AIM:To assess the nutritional status, and its association with sociodemographic factors, health and functional status of community-dwelling older adults living in the Greater Beirut area. METHODS:This was a cross-sectional study involving 905 randomly selected community dwelling older adults aged ≥65 years living in G...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12732
更新日期:2017-03-01 00:00:00