Abstract:
AIM:The enteric nervous system degenerates gradually with age, and α-synuclein (α-syn) is a suitable marker of enteric nervous system degeneration, which is intimately related with endoplasmic reticulum stress and unfolded protein response (UPRER ). Saponins from Panax japonicus (SPJ) have obvious protective effects on neurons in several degenerative disease models. Here, the study was designed to investigate whether SPJ could reverse the neuron degeneration through regulating the UPRER in the colon myenteric plexus of aging rats. METHODS:Aging rats had been treated with SPJ for 6 months since they were aged 18 months. Then, the colon samples were collected and neuron morphology in the myenteric plexus was observed. Immunohistochemistry staining was used to detect the expressions of NeuN, α-syn, GRP78 and three different UPRER branches. Double immunofluorescence was used to determine the co-localization of α-syn and NeuN, GRP78 and NeuN. RESULTS:Neurons degenerated in the colon myenteric plexus of aging rats, but co-localization of α-syn and NeuN increased. In addition, both the expressions of GRP78 and three UPRER branch signaling pathway proteins decreased in the colon myenteric plexus of aging rats. Treatment of SPJ almost alleviated the above effects in aging rats, except for ATF6. CONCLUSIONS:SPJ could reverse the neuron loss caused by accumulation of α-syn in the myenteric plexus of colon in aging rats, which is potentially associated with increased GRP78 and most URPER changes. Geriatr Gerontol Int 2021; 21: 85-93.
journal_name
Geriatr Gerontol Intjournal_title
Geriatrics & gerontology internationalauthors
Guo Y,Cheng Z,Liu J,He Y,Xiong Z,Yuan D,Dun Y,Zhang Cdoi
10.1111/ggi.13882subject
Has Abstractpub_date
2021-01-01 00:00:00pages
85-93issue
1eissn
1444-1586issn
1447-0594journal_volume
21pub_type
杂志文章abstract:AIM:An association between body mass index (BMI) and stroke outcome have been reported, but the results are controversial. The aim of the present study was to evaluate whether BMI is associated with ischemic stroke outcome. METHODS:Consecutive Japanese acute ischemic stroke patients were analyzed. BMI was categorized ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12713
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Long-term care (LTC) insurance was introduced in Japan in 2000. Herein, we describe the trends in demand for LTC, using age-standardized and level-specific rates of entitlement and utilization of LTC at national and prefectural levels. METHODS:We analyzed LTC data from 2002-2005 to examine: (i) the influenc...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2008.00466.x
更新日期:2008-09-01 00:00:00
abstract:AIM:To determine whether elderly subjects with distinct histories of falls presented differences concerning the influence of sensory interaction on balance. METHODS:Cross-sectional research. Ninety-six community-dwelling elderly subjects were divided into three groups, according to the history of falls within the past...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2009.00516.x
更新日期:2009-06-01 00:00:00
abstract:AIM:Postoperative cognitive dysfunction is often observed in older patients. Previous reports described the link between postoperative cognitive dysfunction and general anesthetics, such as sevoflurane, but the exact mechanism remains unclear. We therefore sought to characterize the effects of sevoflurane on hippocampa...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13619
更新日期:2019-04-01 00:00:00
abstract:AIM:This study analyzed the trend of gender gaps in life expectancy (GGLE) in Japan between 1947 and 2010, and explored the correlations of GGLE with gender mortality ratio and social development indices. METHODS:Using GGLE and social indices data collected from the official websites, we carried out trends analysis of...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12001
更新日期:2013-07-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13492
更新日期:2018-09-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,评审
doi:10.1111/j.1447-0594.2009.00579.x
更新日期:2010-04-01 00:00:00
abstract:AIM:As the Japanese population ages, the number of older patients with chronic obstructive pulmonary disease (COPD) is expected to increase, but the prevalence of COPD in patients aged ≥80 years remains unclear. The purpose of the present study was to determine the prevalence of COPD in independent community-dwelling o...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13091
更新日期:2017-12-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12805
更新日期:2017-06-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12764
更新日期:2017-04-01 00:00:00
abstract:AIM:To determine if hospital treatment in residential care facilities, led by a geriatric team, might be a viable alternative to inpatient admission for selected patients. METHODS:Case series with a new intervention were compared with historical controls receiving the conventional treatment. Treatment in residential c...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2012.00910.x
更新日期:2013-04-01 00:00:00
abstract:AIM:Low alanine aminotransferase (ALT) level is associated with frailty in the older adult population. We investigated the usefulness of ALT in predicting low muscle strength among older patients with diabetes. METHODS:We included 550 men aged ≥50 years and 525 postmenopausal women. All participants had diabetes, and ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13868
更新日期:2020-04-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13816
更新日期:2020-01-01 00:00:00
abstract:AIM:To examine the effects of a multifactorial intervention on frailty and functional health among community-dwelling older adults, a 6-month randomized, controlled, cross-over trial was carried out within the Hatoyama Cohort Study. METHODS:A total of 77 pre-frail or frail older adults (mean age 74.6 years) were rando...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,随机对照试验
doi:10.1111/ggi.13016
更新日期:2017-11-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12732
更新日期:2017-03-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12210
更新日期:2014-02-01 00:00:00
abstract::A series of our studies on the development of the Dementia Assessment Sheet for Community-based Integrated Care System 21-items (DASC-21) were reviewed. Study 1: to examine the distribution of scores and internal reliability of DASC-21, trained nurses and researchers visited the homes of 1341 participants aged 65 year...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,评审
doi:10.1111/ggi.12727
更新日期:2016-03-01 00:00:00
abstract:AIM:We propose a simple method to measure knee extensor muscle strength using a single-legged vertical squat. The purpose of the present study was to assess the validity of this method in comparison with standard methods of measurement. METHODS:A total of 30 healthy adults (mean age 22 years) and 28 healthy older indi...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13299
更新日期:2018-07-01 00:00:00
abstract:AIM:To investigate whether positive affect independently predicts a lower risk of functional decline among community-dwelling older Japanese. METHODS:A 2-year prospective study was carried out among 505 residents of Tosa Town aged 65 years and older without disability in carrying out basic activities of daily living (...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12008
更新日期:2013-10-01 00:00:00
abstract:AIM:In Japan, many elderly patients are managed at home, and fever is a common problem. This study examined the incidence of fever events in elderly patients on home medical management, and underlying disorders from the pragmatic standpoint. This study also investigated whether the care-need level determined at the sta...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12024
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abstract:AIM:The study aimed to study the prevalence, etiologies, clinical profile and outcome of delirium in hospitalized elderly in medicine wards. METHODS: Four hundred elderly patients of more than 60years of age admitted with delirium in the emergency and medicine wards of Sir Sunderlal Hospital Varanasi, India, were eva...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2011.00710.x
更新日期:2011-10-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13577
更新日期:2019-02-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/ggi.12516
更新日期:2016-05-01 00:00:00
abstract:AIM:Sarcopenia causes a decline in physical performance and decreased quality of life. However, there is little evidence for effective treatments. Because of the similarities between osteoporosis and sarcopenia, alfacalcidol used for osteoporosis might be beneficial for low muscle mass. Therefore, we investigated the e...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12222
更新日期:2014-02-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.14086
更新日期:2021-01-01 00:00:00
abstract:AIM:Due to demographic change, the number of geriatric patients is still rising. Although hip fractures are the subject of current research, little is known about the remaining geriatric trauma entities. The aim of this study was to collect data of the age-related traumatological intensive care unit (ICU) population, i...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.14053
更新日期:2020-12-01 00:00:00
abstract:AIM:The aim of this study was to develop the Korean Anticholinergic Burden Scale through assessment of previously developed tools, a literature review and a modified Delphi process. METHODS:We carried out a systematic review to identify previously published anticholinergic burden tools. A composite medication list was...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13680
更新日期:2019-07-01 00:00:00
abstract:AIM:We aimed to compare the level of physical function (PF) and habitual exercise between older Japanese and Korean adults. METHODS:A comparative study was carried out on 1069 community-dwelling older Japanese and Korean adults (mean age 73.9 ± 5.2 years). The participants were asked to complete a self-reported questi...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13218
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVES:The aim of the present study was to analyze geriatric oral health predicaments in India. Specifically, to assess the oral health status and treatment needs among the geriatric population attending health camps in New Delhi, Northern India. METHODS:The sample size for the cross-sectional study comprised of 2...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12434
更新日期:2016-01-01 00:00:00
abstract:AIM:The Community Commitment Scale was developed in Japan to measure communities' ability to prevent older adults' social isolation, including socializing and belonging in the community. We translated the scale into Korean (the Community Commitment Scale-Korean version [CCS-K]), and determined its internal consistency,...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13249
更新日期:2018-05-01 00:00:00