Abstract:
AIM:Werner syndrome (WS) is an autosomal recessive disorder of progeroid symptoms and signs. It is caused by mutations in the WRN gene, which encodes a RecQ DNA helicase. The aim of this study was to revise the diagnostic criteria for Japanese Werner syndrome. METHODS:A nationwide epidemiological study was carried out from 2009 to 2011, involving 6921 surveys sent to hospitals with more than 200 beds to assess existing WS diagnostic criteria, as well as additional signs of high incidence on the basis of clinical experience with WS. RESULTS:The existing diagnostic criteria were reviewed, and signs with >90% incidence were listed as cardinal signs. Several criteria were added, including genetic testing and calcification of the Achilles tendon, whereas criteria that are practically difficult to obtain, such as measurement of urinary hyaluronic acid, were omitted. CONCLUSION:The 26-year-old diagnostic criteria for WS were revised on the basis of the results of a nationwide epidemiological study. The proposed revised criteria will facilitate simpler, faster and more robust diagnosis of WS in the Japanese population.
journal_name
Geriatr Gerontol Intjournal_title
Geriatrics & gerontology internationalauthors
Takemoto M,Mori S,Kuzuya M,Yoshimoto S,Shimamoto A,Igarashi M,Tanaka Y,Miki T,Yokote Kdoi
10.1111/j.1447-0594.2012.00913.xsubject
Has Abstractpub_date
2013-04-01 00:00:00pages
475-81issue
2eissn
1444-1586issn
1447-0594journal_volume
13pub_type
杂志文章abstract:AIM:To measure illuminance in the home lives of elderly people to clarify the current state of affairs and concurrently investigate quantification methods for this purpose. METHODS:Illuminance and the physical and mental health of 24 elderly people living, with some assistance, in their homes in a prefecture in the Ho...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12021
更新日期:2013-07-01 00:00:00
abstract:AIM:Increases in oxidative stress and advanced glycation end-products (AGE) formation play an important role in the pathogenesis of aging. Carnosine (CAR; β-alanyl-L-histidine) has anti-oxidant and antiglycating properties. We investigated the effect of CAR supplementation on AGE levels, and protein and lipid oxidation...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13126
更新日期:2017-12-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12078
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1447-0594.2011.00714.x
更新日期:2012-01-01 00:00:00
abstract:AIM:Skeletal muscle loss is a common feature of aging, and is associated with unfavorable outcomes. Although several indexes of skeletal muscle mass measurement have been developed, the most optimal index for sarcopenia diagnosis among Asian populations has remained unclear. The present study aimed to evaluate the rela...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12040
更新日期:2013-10-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13882
更新日期:2021-01-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,多中心研究
doi:10.1111/ggi.12872
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abstract:AIM:This cross-sectional study examined whether sleep duration and excessive daytime sleepiness (EDS) were associated with social frailty in community-dwelling older people. METHODS:A total of 4427 community-dwelling older people (51.4% women, mean age 71.9 years) who met the entry criteria were included in this study...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13734
更新日期:2019-09-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,多中心研究
doi:10.1111/ggi.12165
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12254
更新日期:2015-02-01 00:00:00
abstract:AIM:To analyze the hierarchical structure of activities of daily living (ADL) among vestibular older adults, according to its power to discriminate disability. METHODS:An exploratory cross-sectional study was conducted comprising 235 elderly, aged 65 years and older, with chronic vestibular dysfunction. Functional cap...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2010.00633.x
更新日期:2011-01-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13209
更新日期:2018-03-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13503
更新日期:2018-10-01 00:00:00
abstract:AIM:To identify and evaluate the causes and characteristics of road traffic accidents (RTA) and to analyze injury patterns in elderly road traffic victims in order to apply appropriate measures for the prevention of RTA in the elderly. METHODS:Two hundred and fifty-eight elderly road traffic victims admitted to the Em...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2009.00535.x
更新日期:2009-09-01 00:00:00
abstract:AIM:The present study assessed the effect of family social capital on self-rated health and family life satisfaction among older adults aged ≥50 years. METHODS:A logistic regression model was used to analyze the longitudinal data of 1243 older adults from the Panel Study of Family Dynamics in Taiwan. RESULTS:The find...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13599
更新日期:2019-03-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2010.00685.x
更新日期:2011-07-01 00:00:00
abstract:AIM:Atrial fibrillation (AF) is the most common underlying cause of cardiogenic cerebral embolism. To prevent cardiogenic cerebral embolism, it is important to determine the level of awareness of AF in Japan. METHODS:We used survey monitor attribute data to sample 172 824 Japanese adults aged ≥50 years from all 47 Jap...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13318
更新日期:2018-07-01 00:00:00
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journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12732
更新日期:2017-03-01 00:00:00
abstract:AIM:Sarcopenia causes a decline in physical performance and decreased quality of life. However, there is little evidence for effective treatments. Because of the similarities between osteoporosis and sarcopenia, alfacalcidol used for osteoporosis might be beneficial for low muscle mass. Therefore, we investigated the e...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12222
更新日期:2014-02-01 00:00:00
abstract:AIM:The present study aimed to evaluate the relationship between the change of carotid intima-media thickness (CIMT) and clinical characteristics in Japanese patients without a history of cardiovascular disease. METHODS:The study participants were 149 Japanese patients without a history of cardiovascular disease treat...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12402
更新日期:2015-08-01 00:00:00
abstract:AIM:Impaired attention is a core diagnostic feature for delirium. The present study examined the discriminating properties for patients with delirium versus those with dementia and/or no neurocognitive disorder of four objective tests of attention: digit span, vigilance "A" test, serial 7s subtraction and months of the...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12592
更新日期:2016-09-01 00:00:00
abstract:AIM:To evaluate the safety, tolerability and pharmacokinetic profile of bapineuzumab after a single intravenous injection in Japanese patients with mild to moderate Alzheimer's disease. METHODS:Participants received either a placebo (n = 8), or bapineuzumab 0.15 (n = 6), 0.5 (n = 6), 1.0 (n = 6) or 2.0 (n = 6) mg/kg. ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/ggi.12516
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Long-term care (LTC) insurance was introduced in Japan in 2000. Herein, we describe the trends in demand for LTC, using age-standardized and level-specific rates of entitlement and utilization of LTC at national and prefectural levels. METHODS:We analyzed LTC data from 2002-2005 to examine: (i) the influenc...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2008.00466.x
更新日期:2008-09-01 00:00:00
abstract:AIMS:The aim of the present study was to evaluate whether there was an inflammation-mediated link between Alzheimer's disease (AD) and type 2 diabetes mellitus (DM) status. METHODS:An age-matched control group and patient groups designated as AD without treatment (AD); AD under cholinesterase inhibitors (AD-CEI); DM w...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12602
更新日期:2016-10-01 00:00:00
abstract:AIM:To investigate the frequency of calcification in the basal ganglia and the dentate nuclei in the cerebellum, and compare the difference in age and area, we examined the brain computed tomography (CT) images of all patients in two representative university hospitals in Japan. METHODS:We examined the brain CT images...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.12004
更新日期:2013-07-01 00:00:00
abstract::A series of our studies on the development of the Dementia Assessment Sheet for Community-based Integrated Care System 21-items (DASC-21) were reviewed. Study 1: to examine the distribution of scores and internal reliability of DASC-21, trained nurses and researchers visited the homes of 1341 participants aged 65 year...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,评审
doi:10.1111/ggi.12727
更新日期:2016-03-01 00:00:00
abstract:AIM:There is little data regarding the prevalence and associated comorbidities of anemia in Chinese nursing home older adults. The objective of this study was to investigate the prevalence and associated comorbidities of anemia in Chinese nursing home older adults. METHODS:We carried out a retrospective cross-sectiona...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1447-0594.2012.00942.x
更新日期:2013-07-01 00:00:00
abstract::We report here on an elderly patient, aged 88 years, who developed acquired hemophilia, with a high titer of factor VIII inhibitors and severe hemorrhage, in the absence of a detectable cause. Marked and prolonged efficacy was observed after rituximab. ...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/j.1447-0594.2008.00491.x
更新日期:2009-06-01 00:00:00
abstract:AIM:Malnutrition is common in older patients and is associated with adverse outcomes. The Geriatric Nutritional Risk Index (GNRI) has been developed as an objective index to assess nutritional risk in these patients. However, there is limited evidence regarding the association between GNRI and postoperative delirium (P...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章
doi:10.1111/ggi.13963
更新日期:2020-08-01 00:00:00
abstract:AIMS:We aimed to investigate whether older age leads to limitations in the starting dose of imatinib in daily treatment of chronic myeloid leukemia, and to determine the compliance of elderly patients with tyrosine kinase inhibitors (TKI) therapy. METHODS:Data including the clinical characteristics, therapeutic outcom...
journal_title:Geriatrics & gerontology international
pub_type: 杂志文章,多中心研究
doi:10.1111/ggi.12341
更新日期:2015-06-01 00:00:00