Abstract：
BACKGROUND:Scleroderma is a chronic connective tissue disease of unknown etiology. Vitamin D and parathyroid hormone (PTH) that play particular functions in calcium and phosphate homeostasis may be involved in the etiology of this disorder. Klotho, the co-receptor of the fibroblast growth factor 23 (FGF-23), can interfere with calcium and phosphate metabolism. The purpose of this study was to evaluate serum Klotho, FGF-23, intact PTH (iPTH) and vitamin D levels in scleroderma patients compared with the healthy controls. METHODS:The study was performed in Biotechnology Research Center, Tabriz University of Medical Sciences (TUMS) from 2014-2015. Sixty scleroderma patients based on the classification criteria of systemic sclerosis and 30 age- and sex-matched healthy controls were included in this study. Serum Klotho, FGF-23, 25-hydroxy vitamin D (25-OH Vit D), and iPTH levels were analyzed using ELISA. RESULTS:Serum levels of Klotho and 25-OH Vit D in the scleroderma patients were lower than those in the healthy controls (P<0.001). In addition, scleroderma patients had higher serum iPTH levels than the controls (P<0.001). There was no significant difference in serum FGF-23 levels between the patients and controls (P=0.202). CONCLUSION:The decreased serum Klotho, 25-OH Vit D, and increased iPTH levels in the scleroderma patients may be associated with the pathogenesis of this disease and could be considered a future therapeutic target.
journal_name
Iran J Public Healthjournal_title
Iranian journal of public healthauthors
Ahmadi R,Hajialilo M,Ghorbanihaghjo A,Mota A,Raeisi S,Bargahi N,Valilo M,Askarian Fsubject
Has Abstractpub_date
2017-04-01 00:00:00pages
530-536issue
4eissn
2251-6085issn
2251-6093journal_volume
46pub_type
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journal_title：Iranian journal of public health
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journal_title：Iranian journal of public health
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abstract：BACKGROUND:HIV and AIDS have many different epidemiological, social and political aspects. The aim of this study was to determine the research priorities according to the necessary aspects of HIV and AIDS in Iran. METHODS:The national and international databases were searched to obtain the published articles regarding...
journal_title：Iranian journal of public health
pub_type： 杂志文章,评审
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journal_title：Iranian journal of public health
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journal_title：Iranian journal of public health
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journal_title：Iranian journal of public health
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journal_title：Iranian journal of public health
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journal_title：Iranian journal of public health
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journal_title：Iranian journal of public health
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journal_title：Iranian journal of public health
pub_type： 杂志文章
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journal_title：Iranian journal of public health
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journal_title：Iranian journal of public health
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doi：
更新日期：2019-07-01 00:00:00
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journal_title：Iranian journal of public health
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doi：
更新日期：2016-06-01 00:00:00
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journal_title：Iranian journal of public health
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更新日期：2018-07-01 00:00:00
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journal_title：Iranian journal of public health
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doi：
更新日期：2016-12-01 00:00:00
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journal_title：Iranian journal of public health
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journal_title：Iranian journal of public health
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doi：
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journal_title：Iranian journal of public health
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更新日期：2013-08-01 00:00:00
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2015-05-01 00:00:00
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更新日期：2010-01-01 00:00:00
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journal_title：Iranian journal of public health
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doi：
更新日期：2018-02-01 00:00:00
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journal_title：Iranian journal of public health
pub_type： 杂志文章
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更新日期：2013-01-01 00:00:00
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2014-12-01 00:00:00
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
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journal_title：Iranian journal of public health
pub_type： 杂志文章,评审
doi：
更新日期：2019-01-01 00:00:00
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2013-03-01 00:00:00
