Efficacy of Botox versus Placebo for Treatment of Patients with Major Depression.

Abstract:

BACKGROUND:Treatment of major depression is crucial to decrease the burden of disease. Hence, in this study, the efficacy of Botox was compared with placebo for treatment of patients with major depression. METHODS:In this randomized clinical trial, 28 consecutive patients with major depression were enrolled. The patients were randomly assigned to receive either Botox or placebo and the scores of Beck Depression Inventory were determined and compared at baseline and after two and six weeks in the groups and between the groups. In addition, the drug adverse effects were compared between groups. This study had been registered in TCTR with TCTR20170409001 code. RESULTS:There was a statistically significant difference two group for 6th week Beck Score (P=0.004), but at baseline and after two weeks, there was no significant difference (P>0.05). None of the patients experienced side effects. CONCLUSION:Finally, Botox is effective for treatment of patients with major depression and it has a high safety.

journal_name

Iran J Public Health

authors

Zamanian A,Ghanbari Jolfaei A,Mehran G,Azizian Z

subject

Has Abstract

pub_date

2017-07-01 00:00:00

pages

982-984

issue

7

eissn

2251-6085

issn

2251-6093

journal_volume

46

pub_type

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