[Genetic testing in polygenic diseases : Atrial fibrillation, arterial hypertension and coronary artery disease].

Abstract:

:Genetic testing plays an increasing role in cardiovascular medicine. Advances in technology and the development of novel and more affordable (high throughput) methods have led to the identification of genetic risk factors in research and clinical practice. Also, this progress has simplified the screening of patients and individuals at risk. In case of rare monogenic diseases, diagnostics, risk stratification, and, in some cases, treatment decisions have become easier. For common, polygenic cardiovascular diseases, the situation is more complex due to interaction of modifiable external risk factors and nonmodifiable factors like genetic predisposition. Over the last few years, it has been shown that multiple genes are involved in the pathophysiology of these cardiovascular diseases rather than one single gene. In the following article, we give an overview of the genetic risk factors in polygenic cardiovascular diseases as atrial fibrillation, arterial hypertension and coronary artery disease. Furthermore, we aim to illustrate in which cases genetic testing is recommended in these diseases.

journal_name

Herz

journal_title

Herz

authors

Trenkwalder T,Kessler T,Schunkert H

doi

10.1007/s00059-017-4576-z

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

440-448

issue

5

eissn

0340-9937

issn

1615-6692

pii

10.1007/s00059-017-4576-z

journal_volume

42

pub_type

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