Abstract:
:Genetic testing plays an increasing role in cardiovascular medicine. Advances in technology and the development of novel and more affordable (high throughput) methods have led to the identification of genetic risk factors in research and clinical practice. Also, this progress has simplified the screening of patients and individuals at risk. In case of rare monogenic diseases, diagnostics, risk stratification, and, in some cases, treatment decisions have become easier. For common, polygenic cardiovascular diseases, the situation is more complex due to interaction of modifiable external risk factors and nonmodifiable factors like genetic predisposition. Over the last few years, it has been shown that multiple genes are involved in the pathophysiology of these cardiovascular diseases rather than one single gene. In the following article, we give an overview of the genetic risk factors in polygenic cardiovascular diseases as atrial fibrillation, arterial hypertension and coronary artery disease. Furthermore, we aim to illustrate in which cases genetic testing is recommended in these diseases.
journal_name
Herzjournal_title
Herzauthors
Trenkwalder T,Kessler T,Schunkert Hdoi
10.1007/s00059-017-4576-zsubject
Has Abstractpub_date
2017-08-01 00:00:00pages
440-448issue
5eissn
0340-9937issn
1615-6692pii
10.1007/s00059-017-4576-zjournal_volume
42pub_type
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