Regulation of geminin by neuropeptide Y in vascular smooth muscle cell proliferation : A current review.

Abstract:

:Geminin, a key regulator of DNA replication licensing in the cell cycle, plays an essential role in determining the fate of cells via suppression of cell proliferation and cellular differentiation. Neuropeptide Y (NPY) intensifies the proliferation of vascular smooth muscle cells (VSMCs) directly by binding with Y1 receptors. In vitro experiments have shown that stimulation of NPY on VSMCs via regulation of geminin is a double-edged sword. Given that the proliferation and the phenotypic transformation of VSMCs increase the risk for progression of atherosclerosis, we focus on the role of geminin interference in determining the fate of VSMCs. Furthermore, we discuss the therapeutic potential of peripheral neurotransmitter interference, thus pointing toward future research directions in the treatment of atherosclerosis.

journal_name

Herz

journal_title

Herz

authors

Liang SY,Zhou YL,Shu MQ,Lin S

doi

10.1007/s00059-018-4721-3

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

712-716

issue

8

eissn

0340-9937

issn

1615-6692

pii

10.1007/s00059-018-4721-3

journal_volume

44

pub_type

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