Abstract：
:Human chorionic gonadotropin (hCG) is no longer a single, omnipotent ovulation triggering option. Gonadotropin releasing hormone (GnRH) agonist, initially presented as a substitute for hCG, has led to a new era of administering GnRH agonist followed by hCG triggering. According to this new concept, GnRH agonist enables successful ovum maturation, while hCG supports the luteal phase and pregnancy until placental shift.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Hershko Klement A,Shulman Adoi
10.3390/ijms18051075subject
Has Abstractpub_date
2017-05-17 00:00:00issue
5issn
1422-0067pii
ijms18051075journal_volume
18pub_type
杂志文章,评审abstract：:Glial cell line-derived neurotrophic factor (GDNF) was encapsulated into liposomes in order to protect it from enzyme degradation in vivo and promote its permeability across the blood-brain barrier (BBB). In this study, GDNF conventional liposomes (GDNF-L) and GDNF target sterically stabilized liposomes (GDNF-SSL-T) w...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15033612
更新日期：2014-02-27 00:00:00
abstract：:Mature mRNA is generated by the 3' end cleavage and polyadenylation of its precursor pre-mRNA. Eukaryotic genes frequently have multiple polyadenylation sites, resulting in mRNA isoforms with different 3'-UTR lengths that often encode different C-terminal amino acid sequences. It is well-known that this form of post-t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21186460
更新日期：2020-09-04 00:00:00
abstract：:The concept of "Sweet Immunity" postulates that sugar metabolism and signaling influence plant immune networks. In this study, we tested the potential of commercially available inulin-type fructans to limit disease symptoms caused by Botrytis cinerea in lettuce. Spraying mature lettuce leaves, with inulin-type fructan...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20051052
更新日期：2019-02-28 00:00:00
abstract：:Malignant gliomas are primary brain tumors with poor prognoses. These tumors are infiltrated by brain intrinsic microglia and peripheral monocytes which promote glioma cell invasion. In our previous studies, we discovered that the activation of Toll-like receptor 2 (TLR2) on microglia/brain macrophages converts them i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21082959
更新日期：2020-04-22 00:00:00
abstract：:Understanding disease pathology often does not require an overall proteomic analysis of clinical samples but rather the analysis of different, often rare, subpopulations of cells in a heterogeneous mixture of cell types. For the isolation of pre-specified cellular subtypes, fluorescence activated cell sorting (FACS) i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21186557
更新日期：2020-09-08 00:00:00
abstract：:According to recent estimates, 2%-15% of couples are sterile, and approximately half of the infertility cases are attributed to male reproductive factors. However, the reasons remain undefined in approximately 25% of male infertility cases, and most infertility cases exhibit spermatogenic defects. Numerous genes invol...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18010097
更新日期：2017-01-05 00:00:00
abstract：:Reproductive dysfunction and malignancies related to the male gender represent a serious health concern, whose incidence has significantly risen over the past years. Prior to treatment, testicular or prostate cancer patients often display poor semen characteristics similar to subfertile or infertile patients. This fac...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms16047230
更新日期：2015-03-31 00:00:00
abstract：:Molecular characterization of Circulating Tumor Cells (CTCs) is still challenging, despite attempts to minimize the drawbacks of Whole Genome Amplification (WGA). In this paper, we propose a Next-Generation Sequencing (NGS) optimized protocol based on molecular tagging technology, in order to detect CTCs mutations whi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21124364
更新日期：2020-06-19 00:00:00
abstract：:A detailed understanding of the mechanism of unfolding, aggregation, and associated rheological changes is developed in this study for β-Lactoglobulin at different pH values through concomitant measurements utilizing dynamic light scattering (DLS), optical microrheology, Raman spectroscopy, and differential scanning c...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160817719
更新日期：2015-08-03 00:00:00
abstract：:The treatment of memory impairments associated with the central nervous system diseases remains an unmet medical need with social and economic implications. Here we show, that a multi-target ligand of aminergic G protein-coupled receptors with antipsychotic activity in vivo (D2AAK1) stimulates neuron growth and surviv...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21228849
更新日期：2020-11-23 00:00:00
abstract：:Alzheimer's disease (AD) is the leading cause of dementia worldwide. It involves progressive impairment of cognitive function. A growing number of neuroprotective compounds have been identified with potential anti-AD properties through in vitro and in vivo models of AD. Quercetin, a natural flavonoid contained in a wi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21020493
更新日期：2020-01-13 00:00:00
abstract：:To uncover mechanisms and explore novel biomarkers of obesity, type 2 diabetes (T2DM) and nonalcoholic steatohepatitis (NASH)-associated hepatocarcinogenesis, cellular and molecular alterations in the liver, and hepatocellular carcinomas (HCCs) were investigated in NASH model 60-week-old Tsumura, Suzuki, Obese Diabeti...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21207746
更新日期：2020-10-20 00:00:00
abstract：:Pigeon pea (Cajanus cajan (L.) Millspaugh) is cultivated widely in semiarid agricultural regions in over 90 countries around the world. This important legume can enter into symbiotic associations with a wide range of rhizobia including Bradyrhizobium and fast-growing rhizobia. In comparison with other major legumes su...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20051091
更新日期：2019-03-03 00:00:00
abstract：:The extracellular signal-regulated kinases (ERKs) comprise a particular branch of the mitogen-activated protein kinase cascades (MAPK) that transmits extracellular signals into the intracellular environment to trigger cellular growth responses. Similar to other MAPK cascades, the MAPK-ERK pathway signals through three...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20143427
更新日期：2019-07-12 00:00:00
abstract：:The influenza A virus (IAV), a member of the Orthomyxoviridae family, is a highly transmissible respiratory pathogen and represents a continued threat to global health with considerable economic and social impact. IAV is a zoonotic virus that comprises a plethora of strains with different pathogenic profiles. The diff...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18081673
更新日期：2017-08-01 00:00:00
abstract：:Human papillomavirus (HPV)(+) and HPV(-) head and neck cancer (HNC) cells' interactions with the host immune system are poorly understood. Recently, we identified molecular and functional differences in exosomes produced by HPV(+) vs. HPV(-) cells, suggesting that genetic cargos of exosomes might identify novel biomar...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21228570
更新日期：2020-11-13 00:00:00
abstract：:Cisplatin is ranked as one of the most powerful and commonly prescribed anti-tumor chemotherapeutic agents which improve survival in many solid tumors including non-small cell lung cancer. However, the treatment of advanced lung cancer is restricted due to chemotherapy resistance. Here, we developed and investigated s...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20051125
更新日期：2019-03-05 00:00:00
abstract：:Antimicrobial lipids such as fatty acids and monoglycerides are promising antibacterial agents that destabilize bacterial cell membranes, causing a wide range of direct and indirect inhibitory effects. The goal of this review is to introduce the latest experimental approaches for characterizing how antimicrobial lipid...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19041114
更新日期：2018-04-08 00:00:00
abstract：:Esophageal adenocarcinoma (EAC) is a highly lethal cancer type with an overall poor survival rate. Twenty to thirty percent of EAC overexpress the human epidermal growth factor receptor 2 (Her2), a transmembrane receptor tyrosine kinase promoting cell growth and proliferation. Patients with Her2 overexpressing breast ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19103069
更新日期：2018-10-08 00:00:00
abstract：:The interactions between chiral molecules and cell membranes have attracted more and more attention in recent decades, due to their importance in molecular science and medical applications. It is observed that some peptides composed of different chiral amino acids may have distinct interactions with a membrane. How do...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20194760
更新日期：2019-09-25 00:00:00
abstract：:Rett syndrome (RTT) is an early-onset neurodevelopmental disorder that primarily affects females, resulting in severe cognitive and physical disabilities, and is one of the most prevalent causes of intellectual disability in females. More than fifty years after the first publication on Rett syndrome, and almost two de...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20163925
更新日期：2019-08-12 00:00:00
abstract：:To decrease the cost of bioethanol production, biomass recalcitrance needs to be overcome so that the conversion of biomass to bioethanol becomes more efficient. CO(2) laser irradiation can disrupt the lignocellulosic physical structure and reduce the average size of fiber. Analyses with Fourier transform infrared spe...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13044141
更新日期：2012-01-01 00:00:00
abstract：:Molecular imprinted polymers (MIP) are considered one of the most promising selective and novel separation methods for removal phenolic compound in wastewater treatment. MIP are crosslinked polymeric materials that exhibit high binding capacity and selectivity towards a target molecule (template), purposely present du...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms10010354
更新日期：2009-01-01 00:00:00
abstract：:Two mesenchymal zinc transporters, ZIP7 and ZIP13, play critical roles in dermal development. ZIP7 and ZIP13 are the closest among the conserved mammalian zinc transporters. However, whether their functions are complementary remains a controversial issue. In the present study, we found that the expression of ZIP13, bu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20163941
更新日期：2019-08-13 00:00:00
abstract：:Ginsenoside Rd (GSRd), one of the main active monomer compounds from the medical plant Panax ginseng, has been shown to promote neuronal survival in models of ischemic cerebral damage. As an extending study, here we examined whether GSRd could exert a beneficial effect in an experimental Parkinson disease (PD) model i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160714395
更新日期：2015-06-24 00:00:00
abstract：:Heme oxygenase-1 (HO-1) is an intracellular enzyme that catalyzes the oxidation of heme to generate ferrous iron, carbon monoxide (CO), and biliverdin, which is subsequently converted to bilirubin. These products have anti-inflammatory, anti-oxidant, anti-apoptotic, and anti-thrombotic properties. Although HO-1 is exp...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20153628
更新日期：2019-07-24 00:00:00
abstract：:Class I and II histone deacetylases (HDAC) are considered important regulators of immunity and inflammation. Modulation of HDAC expression and activity is associated with altered inflammatory responses but reports are controversial and the specific impact of single HDACs is not clear. We examined class I and II HDACs ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21238943
更新日期：2020-11-25 00:00:00
abstract：:Flowering plants have evolved different flowering habits to sustain long-term reproduction. Most woody trees experience dormancy and then bloom in the warm spring, but loquat blooms in the cold autumn and winter. To explore its mechanism of flowering regulation, we cloned two SHORT VEGETATIVE PHASE (SVP) homologous ge...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20235933
更新日期：2019-11-26 00:00:00
abstract：:Mitochondrial dysfunction plays a central role in the neuropathology associated with status epilepticus (SE) and is implicated in the development of epilepsy. While excitotoxic mechanisms are well-known mediators affecting mitochondrial health following SE, whether hyperactivation of poly(ADP-ribose) polymerase-1 (PAR...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18071502
更新日期：2017-07-12 00:00:00
abstract：:3,3'-Diindolylmethane (DIM) is a bioactive compound found in Cruciferous vegetables that possesses health benefits such as antioxidant, anticancer, and anti-inflammatory effects. However, hydrophobicity and photolabile limit its pharmaceutical applications. This study aims to prepare and characterize DIM-encapsulated ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20163917
更新日期：2019-08-12 00:00:00
