Significantly higher faecal counts of the yeasts candida and saccharomyces identified in people with coeliac disease.


BACKGROUND:Coeliac disease is an autoimmune disorder resulting from an interaction between diet, genome and immunity. The treatment of CoeD is lifelong adherence to a gluten free diet, which is associated with clinical and histological improvements. However, a substantive number of individuals report only partial symptom improvement despite both compliance with a strict gluten free diet and improvements in serological and histological biomarkers of disease activity. The role of the intestinal microbiota is an area of interest in this sub-group. AIMS:To investigate the role of yeasts and parasites in individuals reporting persistent symptoms of Coeliac disease (CoeD). METHODS:Forty-five people who met the ESPGHAN diagnostic criteria for CoeD were recruited via the Australian Coeliac Association. The faecal measures of the DNA of yeasts and parasites from the CoeD group were compared to data obtained from the medical records of non-coeliac controls with gastrointestinal symptoms from other causes. RESULTS:Candida sp. was detected in 33% of the CoeD group compared 0% of the control group (p = 0.000) and Saccharomyces sp. was detected in 33% of the CoeD group compared to 10% of the control group (p = 0.026). There were no differences in the presence of any of the parasite species measured. CONCLUSION:Further research is required to understand the significance of Candida and Saccharomyces species in both the aetiology of CoeD and of persistent symptoms in this sub-group. Trial Registration Clinical Trial Registration-ANZCTR Number: 12610000630011.


Gut Pathog


Gut pathogens


Harnett J,Myers SP,Rolfe M




Has Abstract


2017-05-05 00:00:00










  • Gut microbiome of native Arab Kuwaitis.

    abstract:Background:The human gut microbiome has an important role in health and disease. There is extensive geographical variation in the composition of the gut microbiome, however, little is known about the gut microbiome composition of people from the Arabian Peninsula. In this study, we describe the gut microbiome of Arab K...

    journal_title:Gut pathogens

    pub_type: 杂志文章


    authors: Plummer E,Bulach D,Carter G,Albert MJ

    更新日期:2020-02-26 00:00:00

  • Effects of Escherichia coli Nissle 1917 and Ciprofloxacin on small intestinal epithelial cell mRNA expression in the neonatal piglet model of human rotavirus infection.

    abstract::We evaluated the effects of the probiotic Escherichia coli Nissle 1917 (EcN) and the antibiotic Ciprofloxacin (Cipro) on mRNA expression of intestinal epithelial cells (IEC) in gnotobiotic (Gn) piglets colonized with a defined commensal microflora (DMF) and inoculated with human rotavirus (HRV) that infects IECs. We a...

    journal_title:Gut pathogens



    authors: Paim FC,Langel SN,Fischer DD,Kandasamy S,Shao L,Alhamo MA,Huang HC,Kumar A,Rajashekara G,Saif LJ,Vlasova AN

    更新日期:2016-12-13 00:00:00

  • Stool and sputum microbiome during quinolone prophylaxis of spontaneous bacterial peritonitis: an exploratory study.

    abstract:Introduction:Quinolone prophylaxis is recommended for patients with advanced cirrhosis at high risk of spontaneous bacterial peritonitis (SBP) or with prior SBP. Yet, the impact of long-term antibiotic prophylaxis on the microbiome of these patients is poorly characterized. Methods:Patients with liver cirrhosis receiv...

    journal_title:Gut pathogens

    pub_type: 杂志文章


    authors: Mücke MM,Rüschenbaum S,Mayer A,Mücke VT,Schwarzkopf KM,Zeuzem S,Kehrmann J,Scholtysik R,Lange CM

    更新日期:2020-10-30 00:00:00

  • Characterisation of Campylobacter jejuni genes potentially involved in phosphonate degradation.

    abstract::Potential biological roles of the Campylobacter jejuni genes cj0641, cj0774c and cj1663 were investigated. The proteins encoded by these genes showed sequence similarities to the phosphonate utilisation PhnH, K and L gene products of Escherichia coli. The genes cj0641, cj0774c and cj1663 were amplified from the pathog...

    journal_title:Gut pathogens

    pub_type: 杂志文章


    authors: Hartley LE,Kaakoush NO,Ford JL,Korolik V,Mendz GL

    更新日期:2009-06-25 00:00:00

  • Genome characterization of a novel binary toxin-positive strain of Clostridium difficile and comparison with the epidemic 027 and 078 strains.

    abstract:BACKGROUND:Clostridium difficile is an anaerobic Gram-positive spore-forming gut pathogen that causes antibiotic-associated diarrhea worldwide. A small number of C. difficile strains express the binary toxin (CDT), which is generally found in C. difficile 027 (ST1) and/or 078 (ST11) in clinic. However, we isolated a bi...

    journal_title:Gut pathogens

    pub_type: 杂志文章


    authors: Peng Z,Liu S,Meng X,Liang W,Xu Z,Tang B,Wang Y,Duan J,Fu C,Wu B,Wu A,Li C

    更新日期:2017-08-07 00:00:00

  • Genome analysis revealed novel genotypes and recombination of the human parechoviruses prevalent in children in Eastern China.

    abstract:BACKGROUND:Human parechovirus (HPeV) is a genus of virus in the family Picornaviridae, having two species A and B. HPeVs are common infectious agents, usually causing mild diarrhea and respiratory disease in young children. RESULTS:Here, we collected and sequenced the near complete genome sequences of 17 novel HPeVs f...

    journal_title:Gut pathogens



    authors: Zhao X,Shi Y,Xia Y

    更新日期:2016-11-08 00:00:00

  • Non-therapeutic administration of a model antimicrobial growth promoter modulates intestinal immune responses.

    abstract:BACKGROUND:The development of efficacious alternatives to antimicrobial growth promoters (AGP) in livestock production is an urgent issue, but is hampered by a lack of knowledge regarding the mode of action of AGP. The belief that AGP modulate the intestinal microbiota has become prominent in the literature; however, t...

    journal_title:Gut pathogens

    pub_type: 杂志文章


    authors: Costa E,Uwiera RR,Kastelic JP,Selinger LB,Inglis GD

    更新日期:2011-09-25 00:00:00

  • Whole genome sequencing of "Faecalibaculum rodentium" ALO17, isolated from C57BL/6J laboratory mouse feces.

    abstract:BACKGROUND:Intestinal microorganisms affect host physiology, including ageing. Given the difficulty in controlling for human studies of the gut microbiome, mouse models provide an alternative avenue to study such relationships. In this study, we report on the complete genome of "Faecalibaculum rodentium" ALO17, a bacte...

    journal_title:Gut pathogens



    authors: Lim S,Chang DH,Ahn S,Kim BC

    更新日期:2016-02-12 00:00:00

  • High contiguity genome sequence of a multidrug-resistant hospital isolate of Enterobacter hormaechei.

    abstract:Background:Enterobacter hormaechei is an important emerging pathogen and a key member of the highly diverse Enterobacter cloacae complex. E. hormaechei strains can persist and spread in nosocomial environments, and often exhibit resistance to multiple clinically important antibiotics. However, the genomic regions that ...

    journal_title:Gut pathogens



    authors: Monahan LG,DeMaere MZ,Cummins ML,Djordjevic SP,Roy Chowdhury P,Darling AE

    更新日期:2019-02-13 00:00:00

  • The neurotoxic effects of ampicillin-associated gut bacterial imbalances compared to those of orally administered propionic acid in the etiology of persistent autistic features in rat pups: effects of various dietary regimens.

    abstract:HYPOTHESIS:A healthy gut with normal intestinal microflora is completely disrupted by oral antibiotics. The byproducts of harmful gut bacteria can interfere with brain development and may contribute to autism. Strategies to improve the gut microflora profile through dietary modification may help to alleviate gut disord...

    journal_title:Gut pathogens

    pub_type: 杂志文章


    authors: El-Ansary A,Bhat RS,Al-Daihan S,Al Dbass AM

    更新日期:2015-03-22 00:00:00

  • Erratum to: Genome sequencing, annotation and comparative genomic analysis of Shigella dysenteriae strain SD1D.

    abstract::[This corrects the article DOI: 10.1186/1757-4749-6-28.]. ...

    journal_title:Gut pathogens

    pub_type: 已发布勘误


    authors: Kaur G,Sathyabama S,Arora A,Verma S,Mubin N,Agrewala JN,Mayilraj S

    更新日期:2016-08-10 00:00:00

  • Antimicrobial resistance and integron gene cassette arrays in commensal Escherichia coli from human and animal sources in IRI.

    abstract:BACKGROUND:The human and animal intestinal tract harbors a complex community of microbes which enables bacteria to inherit antibiotic resistance genes. The aims of this study were to investigate clonality, antimicrobial resistance, prevalence and gene cassette arrays of class I and II integrons among commensal Escheric...

    journal_title:Gut pathogens

    pub_type: 杂志文章


    authors: Kheiri R,Akhtari L

    更新日期:2016-08-30 00:00:00

  • Adhesive threads of extraintestinal pathogenic Escherichia coli.

    abstract::The ability to adhere to host surfaces is by far the most vital step in the successful colonization by microbial pathogens. Colonization begins with the attachment of the bacterium to receptors expressed by cells forming the lining of the mucosa. Long hair like extracellular appendages called fimbriae, produced by mos...

    journal_title:Gut pathogens

    pub_type: 杂志文章


    authors: Antão EM,Wieler LH,Ewers C

    更新日期:2009-12-10 00:00:00

  • Comparison of phenotypic methods for the detection of carbapenem non-susceptible Enterobacteriaceae.

    abstract:BACKGROUND:Multidrug resistance and, in particular, carbapenem resistance is spreading worldwide at an alarming rate, comprehending a variety of bacterial species and causing both nosocomial and community acquired outbursts. Early and efficient detection of infected patients or colonized carriers are mandatory steps in...

    journal_title:Gut pathogens

    pub_type: 杂志文章


    authors: Bartolini A,Frasson I,Cavallaro A,Richter SN,Palù G

    更新日期:2014-05-19 00:00:00

  • Detection, identification and quantification of Campylobacter jejuni, coli and lari in food matrices all at once using multiplex qPCR.

    abstract:BACKGROUND:Thermotolerant Campylobacter jejuni, coli and lari are recognized as leading food-borne pathogens causing an acute bacterial enteritis worldwide. Due to narrow spectrum of their biochemical activity, it is very complicated to distinguish between individual species. For reliable risk assessment, proper incide...

    journal_title:Gut pathogens

    pub_type: 杂志文章


    authors: Vondrakova L,Pazlarova J,Demnerova K

    更新日期:2014-05-09 00:00:00

  • Draft genome sequences of two Bifidobacterium sp. from the honey bee (Apis mellifera).

    abstract:BACKGROUND:Widely considered probiotic organisms, Bifidobacteria are common inhabitants of the alimentary tract of animals including insects. Bifidobacteria identified from the honey bee are found in larval guts and throughout the alimentary tract, but attain their greatest abundance in the adult hind gut. To further u...

    journal_title:Gut pathogens

    pub_type: 杂志文章


    authors: Anderson KE,Johansson A,Sheehan TH,Mott BM,Corby-Harris V,Johnstone L,Sprissler R,Fitz W

    更新日期:2013-12-18 00:00:00

  • Core 2 mucin-type O-glycan inhibits EPEC or EHEC O157:H7 invasion into HT-29 epithelial cells.

    abstract:BACKGROUND:How host cell glycosylation affects EPEC or EHEC O157:H7 invasion is unclear. This study investigated whether and how O-glycans were involved in EPEC or EHEC O157:H7 invasion into HT-29 cells. RESULTS:Lectin histochemical staining confirmed stronger staining with PNA, which labeled Galβ1, 3 GalNAc (core 1 s...

    journal_title:Gut pathogens

    pub_type: 杂志文章


    authors: Ye J,Pan Q,Shang Y,Wei X,Peng Z,Chen W,Chen L,Wang R

    更新日期:2015-12-15 00:00:00

  • Genome sequencing, annotation and comparative genomic analysis of Shigella dysenteriae strain SD1D.

    abstract:BACKGROUND:Shigellosis is an acute form of gastroenteritis caused by the bacteria belonging to the genus Shigella. It is the most common cause of morbidity and mortality in children. Shigella belongs to the family Enterobactericeae, which is a Gram-negative and rod shaped bacterium. In the present study, we report the ...

    journal_title:Gut pathogens

    pub_type: 杂志文章


    authors: Kaur G,Sathyabama S,Arora A,Verma S,Mubin N,Agrewala JN,Mayilraj S

    更新日期:2014-07-11 00:00:00

  • Distribution of flagella secreted protein and integral membrane protein among Campylobacter jejuni isolated from Thailand.

    abstract:BACKGROUND:Campylobacter jejuni, a gram-negative bacterium, is a frequent cause of gastrointestinal food-borne illness in humans throughout the world. There are several reports that the virulence of C. jejuni might be modulated by non-flagellar proteins that are secreted through the filament. Recently, FspA (Flagella s...

    journal_title:Gut pathogens

    pub_type: 杂志文章


    authors: Pootong P,Serichantalergs O,Bodhidatta L,Poly F,Guerry P,Mason CJ

    更新日期:2011-07-12 00:00:00

  • Comparison of clinical and immunological findings in gnotobiotic piglets infected with Escherichia coli O104:H4 outbreak strain and EHEC O157:H7.

    abstract:BACKGROUND:Shiga toxin (Stx) producing Escherichia coli (E. coli) (STEC) is the most frequent cause of diarrhoea-positive haemolytic uraemic syndrome (D + HUS) in humans. In 2011, a huge outbreak with an STEC O104:H4 strain in Germany highlighted the limited possibilities for causative treatment of this syndrome. The r...

    journal_title:Gut pathogens

    pub_type: 杂志文章


    authors: Wöchtl B,Gunzer F,Gerner W,Gasse H,Koch M,Bagó Z,Ganter M,Weissenböck H,Dinhopl N,Coldewey SM,von Altrock A,Waldmann KH,Saalmüller A,Zimmermann K,Steinmann J,Kehrmann J,Klein-Hitpass L,Blom J,Ehricht R,Engelmann I,

    更新日期:2017-05-25 00:00:00

  • Single-nucleotide polymorphism typing analysis for molecular subtyping of Salmonella Tennessee isolates associated with the 2007 nationwide peanut butter outbreak in the United States.

    abstract:BACKGROUND:In 2007, a nationwide Salmonella Tennessee outbreak occurred via contaminated peanut butter. Here, we developed a single-nucleotide polymorphism (SNP)-typing method for S. Tennessee to determine the clonal subtypes of S. Tennessee that were associated with the peanut butter outbreak. METHODS AND RESULTS:One...

    journal_title:Gut pathogens

    pub_type: 杂志文章


    authors: Dong HJ,Cho S,Boxrud D,Rankin S,Downe F,Lovchik J,Gibson J,Erdman M,Saeed AM

    更新日期:2017-05-01 00:00:00

  • The impact of Rhodiola rosea on the gut microbial community of Drosophila melanogaster.

    abstract:Background:The root extract of Rhodiola rosea has historically been used in Europe and Asia as an adaptogen, and similar to ginseng and Shisandra, shown to display numerous health benefits in humans, such as decreasing fatigue and anxiety while improving mood, memory, and stamina. A similar extract in the Rhodiola fami...

    journal_title:Gut pathogens

    pub_type: 杂志文章


    authors: Labachyan KE,Kiani D,Sevrioukov EA,Schriner SE,Jafari M

    更新日期:2018-03-20 00:00:00

  • Role of TLR1, TLR2 and TLR6 in the modulation of intestinal inflammation and Candida albicans elimination.

    abstract:BACKGROUND:Toll-like receptors (TLRs) are the major pattern recognition receptors that mediate sensing of a wide range of microorganisms. TLR2 forms heterodimers with either TLR1 or TLR6, broadening its ligand diversity against pathogens. TLR1, TLR2 and TLR6 have been implicated in the recognition of Candida albicans, ...

    journal_title:Gut pathogens

    pub_type: 杂志文章


    authors: Choteau L,Vancraeyneste H,Le Roy D,Dubuquoy L,Romani L,Jouault T,Poulain D,Sendid B,Calandra T,Roger T,Jawhara S

    更新日期:2017-02-15 00:00:00

  • Salmonella enterica serovar Typhimurium adhesion and cytotoxicity during epithelial cell stress is reduced by Lactobacillus rhamnosus GG.

    abstract:BACKGROUND:Physiological stressors may alter susceptibility of the host intestinal epithelium to infection by enteric pathogens. In the current study, cytotoxic effect, adhesion and invasion of Salmonella enterica serovar Typhimurium (S. Typhimurium) to Caco-2 cells exposed to thermal stress (41 degrees C, 1 h) was inv...

    journal_title:Gut pathogens

    pub_type: 杂志文章


    authors: Burkholder KM,Bhunia AK

    更新日期:2009-07-09 00:00:00

  • Infectious bursal disease virus inoculation infection modifies Campylobacter jejuni-host interaction in broilers.

    abstract:Background:Campylobacter jejuni is considered as a chicken commensal. The gut microbiota and the immune status of the host may affect its colonization. Infectious bursal disease virus (IBDV) is an immunosuppressive virus of chickens, which allows secondary pathogens to invade or exacerbates their pathogenesis. To inves...

    journal_title:Gut pathogens

    pub_type: 杂志文章


    authors: Li L,Pielsticker C,Han Z,Kubasová T,Rychlik I,Kaspers B,Rautenschlein S

    更新日期:2018-03-30 00:00:00

  • Extensive inter-strain diversity among clinical isolates of Shigella flexneri with reference to its serotype, virulence traits and plasmid incompatibility types, a study from south India over a 6-year period.

    abstract:Background:Shigella has evolved as a result of acquiring extragenetic material through horizontal gene exchange. These aid in the rapid emergence of bacterial inter-strain diversity in virulence factors and serotype variants through O-antigenic switching. Plasmid incompatibility typing of isolates is insightful in unde...

    journal_title:Gut pathogens

    pub_type: 杂志文章


    authors: Das A,Mandal J

    更新日期:2019-06-14 00:00:00

  • The murine appendiceal microbiome is altered in spontaneous colitis and its pathological progression.

    abstract:BACKGROUND:Inflammatory bowel disease (comprising ulcerative colitis and Crohn's disease) is a multifactorial disease that is extensively associated with stool microbiome changes (dysbiosis). Appendicitis and appendectomy limits subsequent colitis, clinically, and in animal models. We wanted to examine how the appendic...

    journal_title:Gut pathogens

    pub_type: 杂志文章


    authors: Alkadhi S,Kunde D,Cheluvappa R,Randall-Demllo S,Eri R

    更新日期:2014-06-21 00:00:00

  • Campylobacter jejuni induces transcytosis of commensal bacteria across the intestinal epithelium through M-like cells.

    abstract:BACKGROUND:Recent epidemiological analyses have implicated acute Campylobacter enteritis as a factor that may incite or exacerbate inflammatory bowel disease (IBD) in susceptible individuals. We have demonstrated previously that C. jejuni disrupts the intestinal barrier function by rapidly inducing epithelial transloca...

    journal_title:Gut pathogens

    pub_type: 杂志文章


    authors: Kalischuk LD,Leggett F,Inglis GD

    更新日期:2010-11-01 00:00:00

  • Strain-specific probiotic properties of lactic acid bacteria and their interference with human intestinal pathogens invasion.

    abstract:BACKGROUND:One of the working mechanisms of probiotic bacteria is their ability to compete with pathogens. To define the probiotic properties of seven Lactic Acid Bacteria (LAB) strains, we tested them for survival in simulated gastro-intestinal conditions, antimicrobial activities, co-aggregative abilities, and interf...

    journal_title:Gut pathogens

    pub_type: 杂志文章


    authors: Campana R,van Hemert S,Baffone W

    更新日期:2017-03-06 00:00:00

  • Preliminary feasibility for recruiting and retaining black and white females to provide fecal samples for longitudinal research.

    abstract::As the associations between the gut microbiota and numerous health outcomes become more evident, it is important to conduct longitudinal microbiome research to advance the field beyond the identification of associations. It is also necessary to include individuals who have historically been underrepresented in biomedi...

    journal_title:Gut pathogens

    pub_type: 杂志文章


    authors: Carson TL,Little RB,Townsend S

    更新日期:2019-08-26 00:00:00