The neurotoxic effects of ampicillin-associated gut bacterial imbalances compared to those of orally administered propionic acid in the etiology of persistent autistic features in rat pups: effects of various dietary regimens.

Abstract:

HYPOTHESIS:A healthy gut with normal intestinal microflora is completely disrupted by oral antibiotics. The byproducts of harmful gut bacteria can interfere with brain development and may contribute to autism. Strategies to improve the gut microflora profile through dietary modification may help to alleviate gut disorders in autistic patients. METHOD:Sixty young male western albino rats were divided into six equal groups. The first group served as the control; the second group was given an oral neurotoxic dose of propionic (PPA) (250 mg/kg body weight/day) for three days. The third group received an orogastric dose of ampicillin (50 mg/kg for three weeks) with a standard diet. Groups 4, 5 and 6 were given an orogastric dose of ampicillin and fed high-carbohydrate, high-protein and high-lipid diets, respectively, for 10 weeks. Biochemical parameters related to oxidative stress were investigated in brain homogenates from each group. RESULT:The microbiology results revealed descriptive changes in the fecal microbiota of rats treated with ampicillin either alone or with the three dietary regimens. The results of PPA acid and ampicillin treatment showed significant increases in lipid peroxidation and catalase with decreases in glutathione and potassium compared with levels in the control group. A protein-rich diet was effective at restoring the glutathione level, while the carbohydrate-rich diet recovered lipid peroxidation and catalase activity. In addition, the three dietary regimens significantly increase the potassium level in the brain tissue of the test animals. Lactate dehydrogenase was remarkably elevated in all groups relative to the control. No outstanding effects were observed in glutathione S-transferase and creatine kinase. CONCLUSION:The changes observed in the measured parameters reflect the neurotoxic effects of PPA and ampicillin. Lipid peroxide and catalase activity and the levels of glutathione and potassium are satisfactory biomarkers of PPA and ampicillin neurotoxicity. Based on the effects of the three dietary regimens, a balanced diet can protect against PPA or ampicillin-induced neurotoxicity that might induce autistic traits. These outcomes will help efforts directed at controlling the prevalence of autism, a disorder that has recently been associated with PPA neurotoxicity.

journal_name

Gut Pathog

journal_title

Gut pathogens

authors

El-Ansary A,Bhat RS,Al-Daihan S,Al Dbass AM

doi

10.1186/s13099-015-0054-4

subject

Has Abstract

pub_date

2015-03-22 00:00:00

pages

7

issn

1757-4749

pii

54

journal_volume

7

pub_type

杂志文章
  • Leukocyte-subset counts in idiopathic parkinsonism provide clues to a pathogenic pathway involving small intestinal bacterial overgrowth. A surveillance study.

    abstract:UNLABELLED: BACKGROUND:Following Helicobacter pylori eradication in idiopathic parkinsonism (IP), hypokinesia improved but flexor-rigidity increased. Small intestinal bacterial-overgrowth (SIBO) is a candidate driver of the rigidity: hydrogen-breath-test-positivity is common in IP and case histories suggest that Helic...

    journal_title:Gut pathogens

    pub_type: 杂志文章

    doi:10.1186/1757-4749-4-12

    authors: Dobbs RJ,Charlett A,Dobbs SM,Weller C,A Ibrahim MA,Iguodala O,Smee C,Plant JM,Lawson AJ,Taylor D,Bjarnason I

    更新日期:2012-10-19 00:00:00

  • Bacillus coagulans GBI-30, 6086 limits the recurrence of Clostridium difficile-Induced colitis following vancomycin withdrawal in mice.

    abstract:BACKGROUND:Recently, we found that the probiotic strain Bacillus coagulans GBI-30, 6086 (GanedenBC30) improved indices of Clostridium difficile (C. difficile)-induced colitis in mice (Fitzpatrick et al., Gut Pathogens, 2011). Our goal was to determine if BC30 could also prevent the recurrence of C. difficile-induced co...

    journal_title:Gut pathogens

    pub_type: 杂志文章

    doi:10.1186/1757-4749-4-13

    authors: Fitzpatrick LR,Small JS,Greene WH,Karpa KD,Farmer S,Keller D

    更新日期:2012-10-22 00:00:00

  • Core 2 mucin-type O-glycan inhibits EPEC or EHEC O157:H7 invasion into HT-29 epithelial cells.

    abstract:BACKGROUND:How host cell glycosylation affects EPEC or EHEC O157:H7 invasion is unclear. This study investigated whether and how O-glycans were involved in EPEC or EHEC O157:H7 invasion into HT-29 cells. RESULTS:Lectin histochemical staining confirmed stronger staining with PNA, which labeled Galβ1, 3 GalNAc (core 1 s...

    journal_title:Gut pathogens

    pub_type: 杂志文章

    doi:10.1186/s13099-015-0078-9

    authors: Ye J,Pan Q,Shang Y,Wei X,Peng Z,Chen W,Chen L,Wang R

    更新日期:2015-12-15 00:00:00

  • Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: part III - convergence toward clinical trials.

    abstract::Rapid scientific and technological advances have allowed for a more detailed understanding of the relevance of intestinal microbiota, and the entire body-wide microbiome, to human health and well-being. Rodent studies have provided suggestive evidence that probiotics (e.g. lactobacillus and bifidobacteria) can influen...

    journal_title:Gut pathogens

    pub_type: 杂志文章

    doi:10.1186/1757-4749-5-4

    authors: Bested AC,Logan AC,Selhub EM

    更新日期:2013-03-16 00:00:00

  • Antimicrobial resistances do not affect colonization parameters of intestinal E. coli in a small piglet group.

    abstract:BACKGROUND:Although antimicrobial resistance and persistence of resistant bacteria in humans and animals are major health concerns worldwide, the impact of antimicrobial resistance on bacterial intestinal colonization in healthy domestic animals has only been rarely studied. We carried out a retrospective analysis of t...

    journal_title:Gut pathogens

    pub_type: 杂志文章

    doi:10.1186/1757-4749-1-18

    authors: Schierack P,Kadlec K,Guenther S,Filter M,Schwarz S,Ewers C,Wieler LH

    更新日期:2009-10-08 00:00:00

  • Characterisation of Campylobacter jejuni genes potentially involved in phosphonate degradation.

    abstract::Potential biological roles of the Campylobacter jejuni genes cj0641, cj0774c and cj1663 were investigated. The proteins encoded by these genes showed sequence similarities to the phosphonate utilisation PhnH, K and L gene products of Escherichia coli. The genes cj0641, cj0774c and cj1663 were amplified from the pathog...

    journal_title:Gut pathogens

    pub_type: 杂志文章

    doi:10.1186/1757-4749-1-13

    authors: Hartley LE,Kaakoush NO,Ford JL,Korolik V,Mendz GL

    更新日期:2009-06-25 00:00:00

  • Detection, identification and quantification of Campylobacter jejuni, coli and lari in food matrices all at once using multiplex qPCR.

    abstract:BACKGROUND:Thermotolerant Campylobacter jejuni, coli and lari are recognized as leading food-borne pathogens causing an acute bacterial enteritis worldwide. Due to narrow spectrum of their biochemical activity, it is very complicated to distinguish between individual species. For reliable risk assessment, proper incide...

    journal_title:Gut pathogens

    pub_type: 杂志文章

    doi:10.1186/1757-4749-6-12

    authors: Vondrakova L,Pazlarova J,Demnerova K

    更新日期:2014-05-09 00:00:00

  • Adhesive threads of extraintestinal pathogenic Escherichia coli.

    abstract::The ability to adhere to host surfaces is by far the most vital step in the successful colonization by microbial pathogens. Colonization begins with the attachment of the bacterium to receptors expressed by cells forming the lining of the mucosa. Long hair like extracellular appendages called fimbriae, produced by mos...

    journal_title:Gut pathogens

    pub_type: 杂志文章

    doi:10.1186/1757-4749-1-22

    authors: Antão EM,Wieler LH,Ewers C

    更新日期:2009-12-10 00:00:00

  • Antibiotic resistance, serogroups, virulence genes, and phylogenetic groups of Escherichia coli isolated from yaks with diarrhea in Qinghai Plateau, China.

    abstract:BACKGROUND:Ruminants serve as one of the most important reservoirs for pathogenic Escherichia coli. Infection with E. coli, a foodborne enteropathogen, can lead to asymptomatic infections that can cause life-threatening complications in humans. Therefore, from a clinical and human health perspective, it is important to...

    journal_title:Gut pathogens

    pub_type: 杂志文章

    doi:10.1186/s13099-017-0174-0

    authors: Rehman MU,Zhang H,Iqbal MK,Mehmood K,Huang S,Nabi F,Luo H,Lan Y,Li J

    更新日期:2017-04-28 00:00:00

  • Antimicrobial resistance patterns and prevalence of class 1 and 2 integrons in Shigella flexneri and Shigella sonnei isolated in Uzbekistan.

    abstract:BACKGROUND:Shigella is a frequent cause of bacterial dysentery in the developing world. Treatment with effective antibiotics is recommended for shigellosis, but options become limited due to globally emerging resistance. One of the mechanisms for the development of resistance utilizes integrons. This study described th...

    journal_title:Gut pathogens

    pub_type: 杂志文章

    doi:10.1186/1757-4749-2-18

    authors: Madiyarov RS,Bektemirov AM,Ibadova GA,Abdukhalilova GK,Khodiev AV,Bodhidatta L,Sethabutr O,Mason CJ

    更新日期:2010-12-09 00:00:00

  • Comparison of clinical and immunological findings in gnotobiotic piglets infected with Escherichia coli O104:H4 outbreak strain and EHEC O157:H7.

    abstract:BACKGROUND:Shiga toxin (Stx) producing Escherichia coli (E. coli) (STEC) is the most frequent cause of diarrhoea-positive haemolytic uraemic syndrome (D + HUS) in humans. In 2011, a huge outbreak with an STEC O104:H4 strain in Germany highlighted the limited possibilities for causative treatment of this syndrome. The r...

    journal_title:Gut pathogens

    pub_type: 杂志文章

    doi:10.1186/s13099-017-0179-8

    authors: Wöchtl B,Gunzer F,Gerner W,Gasse H,Koch M,Bagó Z,Ganter M,Weissenböck H,Dinhopl N,Coldewey SM,von Altrock A,Waldmann KH,Saalmüller A,Zimmermann K,Steinmann J,Kehrmann J,Klein-Hitpass L,Blom J,Ehricht R,Engelmann I,

    更新日期:2017-05-25 00:00:00

  • Antimicrobial resistance and integron gene cassette arrays in commensal Escherichia coli from human and animal sources in IRI.

    abstract:BACKGROUND:The human and animal intestinal tract harbors a complex community of microbes which enables bacteria to inherit antibiotic resistance genes. The aims of this study were to investigate clonality, antimicrobial resistance, prevalence and gene cassette arrays of class I and II integrons among commensal Escheric...

    journal_title:Gut pathogens

    pub_type: 杂志文章

    doi:10.1186/s13099-016-0123-3

    authors: Kheiri R,Akhtari L

    更新日期:2016-08-30 00:00:00

  • Insights of biosurfactant producing Serratia marcescens strain W2.3 isolated from diseased tilapia fish: a draft genome analysis.

    abstract:BACKGROUND:Serratia marcescens is an opportunistic bacterial pathogen with broad range of host ranging from vertebrates, invertebrates and plants. S. marcescens strain W2.3 was isolated from a diseased tilapia fish and it was suspected to be the causal agent for the fish disease as virulence genes were found within its...

    journal_title:Gut pathogens

    pub_type: 杂志文章

    doi:10.1186/1757-4749-5-29

    authors: Chan XY,Chang CY,Hong KW,Tee KK,Yin WF,Chan KG

    更新日期:2013-10-22 00:00:00

  • The emergence of Klebsiella pneumoniae liver abscess in non-diabetic patients and the distribution of capsular types.

    abstract:BACKGROUND:Klebsiella pneumoniae is the most common pathogen of community-acquired pyogenic liver abscess in East Asia. Diabetes mellitus (DM) is a well-established risk factor for K. pneumoniae liver abscess (KPLA). However, reports regarding the emergence of KPLA in non-diabetic patients are limited. RESULTS:A total...

    journal_title:Gut pathogens

    pub_type: 杂志文章

    doi:10.1186/s13099-016-0128-y

    authors: Chuang C,Fan WC,Lin YT,Wang FD

    更新日期:2016-10-18 00:00:00

  • Non-therapeutic administration of a model antimicrobial growth promoter modulates intestinal immune responses.

    abstract:BACKGROUND:The development of efficacious alternatives to antimicrobial growth promoters (AGP) in livestock production is an urgent issue, but is hampered by a lack of knowledge regarding the mode of action of AGP. The belief that AGP modulate the intestinal microbiota has become prominent in the literature; however, t...

    journal_title:Gut pathogens

    pub_type: 杂志文章

    doi:10.1186/1757-4749-3-14

    authors: Costa E,Uwiera RR,Kastelic JP,Selinger LB,Inglis GD

    更新日期:2011-09-25 00:00:00

  • Erratum to: Genome sequencing, annotation and comparative genomic analysis of Shigella dysenteriae strain SD1D.

    abstract::[This corrects the article DOI: 10.1186/1757-4749-6-28.]. ...

    journal_title:Gut pathogens

    pub_type: 已发布勘误

    doi:10.1186/s13099-016-0120-6

    authors: Kaur G,Sathyabama S,Arora A,Verma S,Mubin N,Agrewala JN,Mayilraj S

    更新日期:2016-08-10 00:00:00

  • Exosomal miRNAs in hepatitis B virus related liver disease: a new hope for biomarker.

    abstract::The World Health Organisation, in its 2019 progress report on HIV, viral hepatitis and STDs indicates that 257 million people are afflicted with chronic HBV infections, of which, 1 million patients lose their lives every year due to HBV related chronic liver diseases including serious complications such as liver cirrh...

    journal_title:Gut pathogens

    pub_type: 杂志文章,评审

    doi:10.1186/s13099-020-00353-w

    authors: Bandopadhyay M,Bharadwaj M

    更新日期:2020-04-24 00:00:00

  • Differences in the gut microbiota of dogs (Canis lupus familiaris) fed a natural diet or a commercial feed revealed by the Illumina MiSeq platform.

    abstract:Background:Recent advances in next-generation sequencing technologies have enabled comprehensive analysis of the gut microbiota, which is closely linked to the health of the host. Consequently, several studies have explored the factors affecting gut microbiota composition. In recent years, increasing number of dog owne...

    journal_title:Gut pathogens

    pub_type: 杂志文章

    doi:10.1186/s13099-017-0218-5

    authors: Kim J,An JU,Kim W,Lee S,Cho S

    更新日期:2017-11-21 00:00:00

  • Interaction between Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium avium subspecies paratuberculosis with the enteric glia and microglial cells.

    abstract:BACKGROUND:We investigated the interaction of Mycobacterium avium subspecies paratuberculosis, M. bovis and M. tuberculosis and different glial cells (enteric glial and microglial cells) in order to evaluate the infecting ability of these microorganisms and the effects produced on these cells, such as the evaluation of...

    journal_title:Gut pathogens

    pub_type: 杂志文章

    doi:10.1186/1757-4749-3-19

    authors: Cannas S,Molicotti P,Bua A,Usai D,Sechi LA,Scanu AM,Blasi E,Zanetti S

    更新日期:2011-12-09 00:00:00

  • Gut microbiome of native Arab Kuwaitis.

    abstract:Background:The human gut microbiome has an important role in health and disease. There is extensive geographical variation in the composition of the gut microbiome, however, little is known about the gut microbiome composition of people from the Arabian Peninsula. In this study, we describe the gut microbiome of Arab K...

    journal_title:Gut pathogens

    pub_type: 杂志文章

    doi:10.1186/s13099-020-00351-y

    authors: Plummer E,Bulach D,Carter G,Albert MJ

    更新日期:2020-02-26 00:00:00

  • Existence of a novel qepA variant in quinolone resistant Escherichia coli from aquatic habitats of Bangladesh.

    abstract::Of 19 environmental Escherichia coli (n = 12) and Klebsiella pneumoniae (n = 7) tested for quinolone resistance-related genes qnrA, qnrB, qnrC, qnrS and qepA, four each of E. coli and K. pneumoniae possessed qnrS, and another E. coli isolate possessed a new variant of qepA. This is the first detection of qepA in envir...

    journal_title:Gut pathogens

    pub_type: 杂志文章

    doi:10.1186/s13099-017-0207-8

    authors: Rahman Z,Islam A,Rashid MU,Johura FT,Monira S,Watanabe H,Ahmed N,Camilli A,Alam M

    更新日期:2017-10-23 00:00:00

  • The complete genome sequence of Cronobacter sakazakii ATCC 29544T, a food-borne pathogen, isolated from a child's throat.

    abstract:BACKGROUND:Cronobacter sakazakii is an emerging opportunistic pathogen that is associated with rare but life-threatening cases of severe diseases: meningitis, necrotizing enterocolitis, and sepsis in premature and full-term infants. However, the pathogenesis mechanism of this pathogen remains largely unknown. To determ...

    journal_title:Gut pathogens

    pub_type:

    doi:10.1186/s13099-016-0150-0

    authors: Kim S,Kim YT,Yoon H,Lee JH,Ryu S

    更新日期:2017-01-04 00:00:00

  • Effects of Escherichia coli Nissle 1917 and Ciprofloxacin on small intestinal epithelial cell mRNA expression in the neonatal piglet model of human rotavirus infection.

    abstract::We evaluated the effects of the probiotic Escherichia coli Nissle 1917 (EcN) and the antibiotic Ciprofloxacin (Cipro) on mRNA expression of intestinal epithelial cells (IEC) in gnotobiotic (Gn) piglets colonized with a defined commensal microflora (DMF) and inoculated with human rotavirus (HRV) that infects IECs. We a...

    journal_title:Gut pathogens

    pub_type:

    doi:10.1186/s13099-016-0148-7

    authors: Paim FC,Langel SN,Fischer DD,Kandasamy S,Shao L,Alhamo MA,Huang HC,Kumar A,Rajashekara G,Saif LJ,Vlasova AN

    更新日期:2016-12-13 00:00:00

  • The murine appendiceal microbiome is altered in spontaneous colitis and its pathological progression.

    abstract:BACKGROUND:Inflammatory bowel disease (comprising ulcerative colitis and Crohn's disease) is a multifactorial disease that is extensively associated with stool microbiome changes (dysbiosis). Appendicitis and appendectomy limits subsequent colitis, clinically, and in animal models. We wanted to examine how the appendic...

    journal_title:Gut pathogens

    pub_type: 杂志文章

    doi:10.1186/1757-4749-6-25

    authors: Alkadhi S,Kunde D,Cheluvappa R,Randall-Demllo S,Eri R

    更新日期:2014-06-21 00:00:00

  • Genome characterization of a novel binary toxin-positive strain of Clostridium difficile and comparison with the epidemic 027 and 078 strains.

    abstract:BACKGROUND:Clostridium difficile is an anaerobic Gram-positive spore-forming gut pathogen that causes antibiotic-associated diarrhea worldwide. A small number of C. difficile strains express the binary toxin (CDT), which is generally found in C. difficile 027 (ST1) and/or 078 (ST11) in clinic. However, we isolated a bi...

    journal_title:Gut pathogens

    pub_type: 杂志文章

    doi:10.1186/s13099-017-0191-z

    authors: Peng Z,Liu S,Meng X,Liang W,Xu Z,Tang B,Wang Y,Duan J,Fu C,Wu B,Wu A,Li C

    更新日期:2017-08-07 00:00:00

  • The impact of Rhodiola rosea on the gut microbial community of Drosophila melanogaster.

    abstract:Background:The root extract of Rhodiola rosea has historically been used in Europe and Asia as an adaptogen, and similar to ginseng and Shisandra, shown to display numerous health benefits in humans, such as decreasing fatigue and anxiety while improving mood, memory, and stamina. A similar extract in the Rhodiola fami...

    journal_title:Gut pathogens

    pub_type: 杂志文章

    doi:10.1186/s13099-018-0239-8

    authors: Labachyan KE,Kiani D,Sevrioukov EA,Schriner SE,Jafari M

    更新日期:2018-03-20 00:00:00

  • Serologic host response to Helicobacter pylori and Campylobacter jejuni in socially housed Rhesus macaques (Macaca mulatta).

    abstract:UNLABELLED: BACKGROUND:Helicobacter pylori are successful colonizers of the human gastric mucosa. Colonization increases the risk of peptic ulcer disease and adenocarcinoma. However, potential benefits of H. pylori colonization include protection against early-onset asthma and against gastrointestinal infections. Camp...

    journal_title:Gut pathogens

    pub_type: 杂志文章

    doi:10.1186/1757-4749-4-9

    authors: Kienesberger S,Perez-Perez GI,Rivera-Correa JL,Tosado-Acevedo R,Li H,Dubois A,Gonzalez-Martinez JA,Dominguez-Bello MG,Blaser MJ

    更新日期:2012-08-24 00:00:00

  • Genome analysis revealed novel genotypes and recombination of the human parechoviruses prevalent in children in Eastern China.

    abstract:BACKGROUND:Human parechovirus (HPeV) is a genus of virus in the family Picornaviridae, having two species A and B. HPeVs are common infectious agents, usually causing mild diarrhea and respiratory disease in young children. RESULTS:Here, we collected and sequenced the near complete genome sequences of 17 novel HPeVs f...

    journal_title:Gut pathogens

    pub_type:

    doi:10.1186/s13099-016-0135-z

    authors: Zhao X,Shi Y,Xia Y

    更新日期:2016-11-08 00:00:00

  • Single-nucleotide polymorphism typing analysis for molecular subtyping of Salmonella Tennessee isolates associated with the 2007 nationwide peanut butter outbreak in the United States.

    abstract:BACKGROUND:In 2007, a nationwide Salmonella Tennessee outbreak occurred via contaminated peanut butter. Here, we developed a single-nucleotide polymorphism (SNP)-typing method for S. Tennessee to determine the clonal subtypes of S. Tennessee that were associated with the peanut butter outbreak. METHODS AND RESULTS:One...

    journal_title:Gut pathogens

    pub_type: 杂志文章

    doi:10.1186/s13099-017-0176-y

    authors: Dong HJ,Cho S,Boxrud D,Rankin S,Downe F,Lovchik J,Gibson J,Erdman M,Saeed AM

    更新日期:2017-05-01 00:00:00

  • Stool and sputum microbiome during quinolone prophylaxis of spontaneous bacterial peritonitis: an exploratory study.

    abstract:Introduction:Quinolone prophylaxis is recommended for patients with advanced cirrhosis at high risk of spontaneous bacterial peritonitis (SBP) or with prior SBP. Yet, the impact of long-term antibiotic prophylaxis on the microbiome of these patients is poorly characterized. Methods:Patients with liver cirrhosis receiv...

    journal_title:Gut pathogens

    pub_type: 杂志文章

    doi:10.1186/s13099-020-00389-y

    authors: Mücke MM,Rüschenbaum S,Mayer A,Mücke VT,Schwarzkopf KM,Zeuzem S,Kehrmann J,Scholtysik R,Lange CM

    更新日期:2020-10-30 00:00:00