Abstract:
:(2R,3R)-2,3-Butanediol has many industrial applications, such as it is used as an antifreeze agent and low freezing point fuel. In addition, it is particularly important to provide chiral groups in drugs. In recent years, this valuable bio-based chemical has attracted increasing attention, and significant progress has been made in the development of microbial cell factories for (2R,3R)-2,3-butanediol production. This article reviews recent advances and challenges in microbial routes to (2R,3R)-2,3- butanediol production, and highlights the metabolic engineering and synthetic biological approaches used to improve titers, yields, productivities, and optical purities. Finally, a systematic and integrative strategy for developing high-performance microbial cell factories is proposed.
journal_name
Curr Top Med Chemjournal_title
Current topics in medicinal chemistryauthors
Xie NZ,Chen XR,Wang QY,Chen D,Du QS,Zhou GP,Huang RBdoi
10.2174/1568026617666170504101646subject
Has Abstractpub_date
2017-01-01 00:00:00pages
2433-2439issue
21eissn
1568-0266issn
1873-4294pii
CTMC-EPUB-83249journal_volume
17pub_type
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