Elevation of serum pancreatic secretory trypsin inhibitor following serious injury.


:Twenty-six of 31 seriously injured patients (84%) showed a marked elevation of serum pancreatic secretory trypsin inhibitor (PSTI) to more than twice the initial level within the first 2 weeks after admission. Serum PSTI rose from the second or third post-traumatic day and reached the maximum at day 5.8 on average. In uneventful cases, it returned to the level on admission within 2 weeks. The maximum serum PSTI in these patients was significantly correlated with the severity of the injury as judged at the time of admission, indicating that the elevation of serum PSTI in these patients was related to the extent of initial damage. In contrast, serum PSTI in patients with serious complications remained at high level even at 2 weeks after trauma, and it was not correlated with the initial severity of the injury.






Shibata T,Ogawa M,Takata N,Niinobu T,Uda K,Ukai T,Ohta M,Mori T




Has Abstract


1988-07-01 00:00:00














  • The resuscitation greats. Cemil Topuzlu Pasha: one of the forgotten pioneers in the history of open chest cardiac massage.

    abstract::One of the pioneers of open chest cardiac massage was Cemil Topuzlu Pasha, in Turkey. He presented his experience in open heart cardiac massage in several papers published in Ottoman and French and German. On 27 August 1903 one of his patients undergoing external urethrotomy under chloroform anaesthesia developed card...


    pub_type: 传,历史文章,杂志文章


    authors: Karatepe M,Tomatir E,Bozkurt P

    更新日期:2006-02-01 00:00:00

  • One-handed versus two-handed chest compressions in paediatric cardio-pulmonary resuscitation.

    abstract:OBJECTIVES:To determine emergency department (ED) staff preference for one- or two-handed paediatric chest compressions and to determine if there was a difference in compression rates delivered and fatigability between the techniques. METHODS:This was a randomised, cross-over observational study of paediatric CPR perf...


    pub_type: 杂志文章,随机对照试验


    authors: Peska E,Kelly AM,Kerr D,Green D

    更新日期:2006-10-01 00:00:00

  • Intracerebroventricular application of granulocyte colony-stimulating factor after cardiac arrest does not promote beneficial effects on cerebral recovery after cardiac arrest in rats.

    abstract:SUBJECT:Recent data demonstrated potent neuroprotective effects of growth hormones such as granulocyte colony-stimulating factor (G-CSF) after focal cerebral ischaemia. In order to assess possible effects of intracerebroventricular application of G-CSF on cerebral recovery after cardiac arrest (CA) in rats, neurologica...


    pub_type: 杂志文章


    authors: Popp E,Rabsahl T,Schneider A,Russ N,Spöhr F,Vogel P,Böttiger BW,Teschendorf P

    更新日期:2009-04-01 00:00:00

  • Reduced metabolic rate accompanies the hemorrhage-induced hypothermia in conscious rats.

    abstract::The mechanism for the hemorrhage-induced drop in body temperature is unknown. This study determined the alterations in cutaneous heat exchange and metabolic heat production caused by a moderate hemorrhage in conscious rats. Chronically instrumented rats were subjected to a 16 ml/kg hemorrhage, followed by a 4-h recove...


    pub_type: 杂志文章


    authors: Henderson RA,Whitehurst ME,Morgan KR,Carroll RG

    更新日期:2000-04-01 00:00:00

  • The feasibility of a regional cardiac arrest receiving system.

    abstract:BACKGROUND:Patients suffering out-of-hospital cardiac arrest (OOHCA) are generally transported to the closest ED, presumably to expedite a hospital level of care and improve the chances of return for spontaneous circulation (ROSC) or provide post-resuscitative care for patients with prehospital ROSC. As hospital-based ...


    pub_type: 杂志文章


    authors: Davis DP,Fisher R,Aguilar S,Metz M,Ochs G,McCallum-Brown L,Ramanujam P,Buono C,Vilke GM,Chan TC,Dunford JV

    更新日期:2007-07-01 00:00:00

  • Rescue therapy with terlipressin by continuous infusion in a child with catecholamine-resistant septic shock.

    abstract::A 2-month-old female infant presented with septic shock, refractory to high doses of catecholamines. Continuous infusion of terlipressin at a rate of 10 mcg/kgh produced a significant increase in the mean arterial pressure that was evident within half and hour, so allowing a reduction in the rate of catecholamine infu...


    pub_type: 杂志文章


    authors: Zeballos G,López-Herce J,Fernández C,Brandstrup KB,Rodríguez-Núñez A

    更新日期:2006-01-01 00:00:00

  • Mortality in patients resuscitated from out-of-hospital cardiac arrest based on automated blood cell count and neutrophil lymphocyte ratio at admission.

    abstract:INTRODUCTION:The neutrophil lymphocyte ratio(NLR) is a marker of systemic inflammation. We hypothesized that admission NLR is related to mortality and that epinephrine application during resuscitation influences NLR in patients after successful resuscitation from out of hospital cardiac arrest (OHCA). METHODS:This ret...


    pub_type: 杂志文章


    authors: Weiser C,Schwameis M,Sterz F,Herkner H,Lang IM,Schwarzinger I,Spiel AO

    更新日期:2017-07-01 00:00:00

  • Feasibility of bispectral index monitoring to guide early post-resuscitation cardiac arrest triage.

    abstract:INTRODUCTION:Triage after resuscitation from cardiac arrest is hindered by reliable early estimation of brain injury. We evaluated the performance of a triage model based on early bispectral index (BIS) findings and cardiac risk classes. METHODS:Retrospective evaluation of serial patients resuscitated from cardiac arr...


    pub_type: 杂志文章


    authors: Seder DB,Dziodzio J,Smith KA,Hickey P,Bolduc B,Stone P,May T,McCrum B,Fraser GL,Riker RR

    更新日期:2014-08-01 00:00:00

  • Why, when and how do secondary-care clinicians have emergency care and treatment planning conversations? Qualitative findings from the ReSPECT Evaluation Study.

    abstract:BACKGROUND:The Recommended Summary Plan for Emergency Care and Treatment (ReSPECT) is an emergency care and treatment planning (ECTP) process, developed to offer a patient-centred approach to deciding about and recording treatment recommendations. Conversations between clinicians and patients or their representatives a...


    pub_type: 杂志文章


    authors: Eli K,Hawkes CA,Ochieng C,Huxley CJ,Baldock C,Fortune PM,Fuld J,Perkins GD,Slowther AM,Griffiths F

    更新日期:2021-01-19 00:00:00

  • Hyperoxia, hypocapnia and hypercapnia as outcome factors after cardiac arrest in children.

    abstract:PURPOSE:Arterial hyperoxia after resuscitation has been associated with increased mortality in adults. The aim of this study was to test the hypothesis that post-resuscitation hyperoxia and hypocapnia are associated with increased mortality after resuscitation in pediatric patients. METHODS:We performed a prospective ...


    pub_type: 杂志文章,多中心研究


    authors: Del Castillo J,López-Herce J,Matamoros M,Cañadas S,Rodriguez-Calvo A,Cechetti C,Rodriguez-Núñez A,Alvarez AC,Iberoamerican Pediatric Cardiac Arrest Study Network RIBEPCI.

    更新日期:2012-12-01 00:00:00

  • Resuscitation of out-of-hospital cardiac arrest by Asian primary health-care physicians.

    abstract:AIM:To assess the experience, knowledge and attitudes of local primary health-care doctors towards resuscitation in out-of-hospital cardiac arrest. METHODS:We conducted a survey of general practitioners (GPs) working in both private and public sectors. The survey consisted of 29 questions and was self-administered. R...


    pub_type: 杂志文章


    authors: Ong ME,Chan YH,Ang HY,Lim SH,Tan KL

    更新日期:2005-05-01 00:00:00

  • Performance of coronary angiography and intervention after out of hospital cardiac arrest.

    abstract:AIMS:Out of Hospital Cardiac Arrest (OHCA) is frequently attributed to coronary artery disease, thus guidelines recommend coronary angiography (CAG) for survivors of OHCA. However, the real-world application of these guidelines is unknown, and we sought to evaluate CAG practices in the contemporary OHCA population. ME...


    pub_type: 杂志文章


    authors: Kearney KE,Maynard C,Smith B,Rea TD,Beatty A,McCabe JM

    更新日期:2018-12-01 00:00:00

  • Comparing three CPR feedback devices and standard BLS in a single rescuer scenario: a randomised simulation study.

    abstract:BACKGROUND:Efficiently performed basic life support (BLS) after cardiac arrest is proven to be effective. However, cardiopulmonary resuscitation (CPR) is strenuous and rescuers' performance declines rapidly over time. Audio-visual feedback devices reporting CPR quality may prevent this decline. We aimed to investigate ...


    pub_type: 杂志文章,随机对照试验


    authors: Zapletal B,Greif R,Stumpf D,Nierscher FJ,Frantal S,Haugk M,Ruetzler K,Schlimp C,Fischer H

    更新日期:2014-04-01 00:00:00

  • Impact of first documented rhythm on cost-effectiveness of extracorporeal cardiopulmonary resuscitation.

    abstract:OBJECTIVES:Recommendations for extracorporeal cardiopulmonary resuscitation (ECPR) state that appropriate patient selection is important for the sake of efficacy and cost-effectiveness of ECPR. It is not known whether first documented rhythm plays a prominent role in economic outcomes of patients with cardiac arrest wh...


    pub_type: 杂志文章


    authors: Kawashima T,Uehara H,Miyagi N,Shimajiri M,Nakamura K,Chinen T,Hatano S,Nago C,Chiba S,Nakane H,Gima Y

    更新日期:2019-07-01 00:00:00

  • Hyperoxic ventilation at the critical haematocrit.

    abstract:OBJECTIVE:During normovolaemic haemodilution arterial O(2)-content decreases exponentially. Nevertheless, tissue oxygenation is first maintained initially by increased organ perfusion and O(2)-extraction. As soon as these compensatory mechanisms are exhausted, myocardial ischaemia and tissue hypoxia occur at an individ...


    pub_type: 杂志文章


    authors: Kemming GI,Meisner FG,Kleen M,Meier JM,Tillmanns J,Hutter JW,Wojtczyk CJ,Packert KB,Bottino D,Habler OP

    更新日期:2003-03-01 00:00:00

  • A new evaluation method for instructors of advanced cardiac life support.

    abstract::This study evaluated the ability of a specific educational program to teach instructors of advanced cardiac life support (ACLS) how to identify errors committed by team leaders of cardiac arrest simulations. The design compared experimental and control groups for differences in identification of critical performance e...


    pub_type: 杂志文章


    authors: Goldman SL,Thompson B,Whitcomb J

    更新日期:1986-11-01 00:00:00

  • Serum magnesium increases following severe hemorrhage in dogs blocked by verapamil treatment.

    abstract::The opening of voltage sensitive calcium channels is an important event in the progression of irreversible shock, allowing the entry of toxic amounts of calcium (Ca2+) into the cells. Because intracellular magnesium (Mg2+) can efflux through these same channels, changes in serum Mg2+ may reflect the patency of these c...


    pub_type: 杂志文章


    authors: Carroll RG,Iams SG,Pryor WH Jr,Allison EJ Jr

    更新日期:1990-01-01 00:00:00

  • Open-chest cardiac massage after closed-chest compression in a canine model: when to intervene.

    abstract::Open-chest cardiac massage appears beneficial in improving hemodynamics during resuscitation efforts and in improving resuscitation success. The time between cardiac arrest and the initiation of open-chest cardiac massage is crucial. It would appear that if initiation of open chest cardiac massage is delayed for more ...


    pub_type: 杂志文章


    authors: Kern KB,Sanders AB,Ewy GA

    更新日期:1987-03-01 00:00:00

  • Chest-compression-only versus conventional cardiopulmonary resuscitation by bystanders for children with out-of-hospital cardiac arrest: A systematic review and meta-analysis.

    abstract:BACKGROUND:For children with out-of-hospital cardiac arrest, previous observational studies regarding chest-compression-only CPR (CC-CPR) versus conventional CPR yielded inconsistent results. We aimed to summarize the current evidence and compare the outcomes after CC-CPR with those after conventional CPR by bystanders...


    pub_type: 杂志文章,meta分析


    authors: Zhang X,Zhang W,Wang C,Tao W,Dou Q,Yang Y

    更新日期:2019-01-01 00:00:00

  • Microcirculatory perfusion and vascular reactivity are altered in post cardiac arrest patients, irrespective of target temperature management to 33 °C vs 36 °C.

    abstract:AIM:In previous reports both microcirculatory alterations and impaired vascular reactivity have been described in post cardiac arrest patients treated with mild therapeutic hypothermia. As of now it is unknown whether these alterations are related to the temperature management or to the cardiac arrest itself. Aim of th...


    pub_type: 杂志文章,随机对照试验


    authors: Koopmans M,Kuiper MA,Endeman H,Veenstra G,Vellinga NA,de Vos R,Boerma EC

    更新日期:2015-01-01 00:00:00

  • CaRdiac Arrest Survival Score (CRASS) - A tool to predict good neurological outcome after out-of-hospital cardiac arrest.

    abstract:AIM:The aim of this study was to develop a score to predict the outcome for patients brought to hospital following out-of-hospital cardiac arrest (OHCA). METHODS:All patients recorded in the German Resuscitation Registry (GRR) who suffered OHCA 2010-2017, who had ROSC or ongoing CPR at hospital admission were included...


    pub_type: 杂志文章


    authors: Seewald S,Wnent J,Lefering R,Fischer M,Bohn A,Jantzen T,Brenner S,Masterson S,Bein B,Scholz J,Gräsner JT

    更新日期:2020-01-01 00:00:00

  • Physicians' own preferences to the limitation and withdrawal of life-sustaining therapy.

    abstract::While limiting and forgoing therapy at the end of life is now accepted on medical, ethical, moral and legal grounds, many Americans continue to die with heroic measures being taken to prevent their death. Recent studies have demonstrated that physicians frequently attend to their patients without knowledge of their pr...


    pub_type: 杂志文章


    authors: Marik PE,Varon J,Lisbon A,Reich HS

    更新日期:1999-11-01 00:00:00

  • The opioid/anti-opioid balance in shock: a new target for therapy in resuscitation.

    abstract::Teleologically, pain is of paramount importance for survival and induces the organism to cope in an active way with aggressions from a basically hostile environment. While the activation of endogenous analgesic (opioid) systems typically occurs in conditions of surrender (pre-terminal conditions, sustained tortures, e...


    pub_type: 杂志文章,评审


    authors: Bertolini A

    更新日期:1995-08-01 00:00:00

  • Discriminating the effect of accelerated compression from accelerated decompression during high-impulse CPR in a porcine model of cardiac arrest.

    abstract:AIM OF THE STUDY:Piston based mechanical chest compression devices deliver compressions and decompressions in an accelerated pattern, resulting in superior haemodynamics compared to manual compression in animal studies. The present animal study compares haemodynamics during two different hybrid compression patterns to ...


    pub_type: 杂志文章


    authors: Tømte Ø,Sjaastad I,Wik L,Kuzovlev A,Eriksen M,Norseng PA,Sunde K

    更新日期:2010-04-01 00:00:00

  • Hospitals with more-active participation in conducting standardized in-situ mock codes have improved survival after in-hospital cardiopulmonary arrest.

    abstract:AIM:The American Heart Association (AHA) and the Institute of Medicine have published a national "call-to-action" to improve survival from in-hospital cardiopulmonary arrest (IHCA). Our aim was to determine if more-active hospital participation in standardized in-situ mock code (ISMC) training is associated with increa...


    pub_type: 杂志文章,多中心研究


    authors: Josey K,Smith ML,Kayani AS,Young G,Kasperski MD,Farrer P,Gerkin R,Theodorou A,Raschke RA

    更新日期:2018-12-01 00:00:00

  • Macrophage-specific protein perforin-2 is associated with poor neurological recovery and reduced survival after sudden cardiac arrest.

    abstract:BACKGROUND:Biomarkers involved in inflammation and stress response were implicated in patients who were successfully resuscitated from out of hospital cardiac arrest (sR-OHCA). Here we report that macrophage-expressed gene, perforin-2, an evolutionarily conserved protein with membrane attack domain, is associated with ...


    pub_type: 杂志文章


    authors: Kattel S,Bhatt H,Xu S,Gurung S,Pokharel S,Sharma UC

    更新日期:2020-10-01 00:00:00

  • Optimal in-hospital defibrillator placement.

    abstract:AIMS:To determine if mathematical optimization of in-hospital defibrillator placements can reduce in-hospital cardiac arrest-to-defibrillator distance compared to existing defibrillators in a single hospital. METHODS:We identified treated IHCAs and defibrillator placements in St. Michael's Hospital in Toronto, Canada ...


    pub_type: 杂志文章


    authors: Leung KHB,Sun CLF,Yang M,Allan KS,Wong N,Chan TCY

    更新日期:2020-06-01 00:00:00

  • Can thoracic impedance monitor the depth of chest compressions during out-of-hospital cardiopulmonary resuscitation?

    abstract:AIM:To analyze the relationship between the depth of the chest compressions and the fluctuation caused in the thoracic impedance (TI) signal in out-of-hospital cardiac arrest (OHCA). The ultimate goal was to evaluate whether it is possible to identify compressions with inadequate depth using information of the TI wavef...


    pub_type: 杂志文章


    authors: Alonso E,González-Otero D,Aramendi E,Ruiz de Gauna S,Ruiz J,Ayala U,Russell JK,Daya M

    更新日期:2014-05-01 00:00:00

  • A moderate dose of propofol and rapidly induced mild hypothermia with extracorporeal lung and heart assist (ECLHA) improve the neurological outcome after prolonged cardiac arrest in dogs.

    abstract:BACKGROUND AND PURPOSE:Propofol has been shown to protect against neuronal damage induced by brain ischaemia in small animal models. We reported previously that mild hypothermia (33 degrees C) in combination with extracorporeal lung and heart assist (ECLHA) improved the neurological outcome in dogs with cardiac arrest ...


    pub_type: 杂志文章


    authors: Ichinose K,Okamoto T,Tanimoto H,Taguchi H,Tashiro M,Sugita M,Takeya M,Terasaki H

    更新日期:2006-08-01 00:00:00

  • No difference in mortality between men and women after out-of-hospital cardiac arrest.

    abstract:AIM:Comparing the outcome after out-of-hospital cardiac arrest (OHCA) in men and women and to determine whether sex modifies the effect of targeted temperature management (TTM) at 33 or 36°C. METHODS:The TTM trial randomized 950 patients to TTM at 33 or 36°C for 24h. This predefined sub-study of the TTM trial assessed...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Winther-Jensen M,Kjaergaard J,Wanscher M,Nielsen N,Wetterslev J,Cronberg T,Erlinge D,Friberg H,Gasche Y,Horn J,Hovdenes J,Kuiper M,Pellis T,Stammet P,Wise MP,Åneman A,Hassager C

    更新日期:2015-11-01 00:00:00