Conservative oxygen therapy in mechanically ventilated patients following cardiac arrest: A retrospective nested cohort study.

Abstract:

BACKGROUND:In mechanically ventilated (MV) cardiac arrest (CA) survivors admitted to the intensive care unit (ICU) avoidance of hypoxia is considered crucial. However, avoidance of hyperoxia may also be important. A conservative approach to oxygen therapy may reduce exposure to both. METHODS:We evaluated the introduction of conservative oxygen therapy (target SpO2 88-92% using the lowest FiO2) during MV for resuscitated CA patients admitted to the ICU. RESULTS:We studied 912 arterial blood gas (ABG) datasets: 448 ABGs from 50 'conventional' and 464 ABGs from 50 'conservative' oxygen therapy patients. Compared to the conventional group, conservative group patients had significantly lower PaO2 values and FiO2 exposure (p<0.001, respectively); more received MV in a spontaneous ventilation mode (18% vs 2%; p=0.001) and more were exposed to a FiO2 of 0.21 (19 vs 0 patients, p=0.001). Additionally, according to mean PaO2, more conservative group patients were classified as normoxaemic (36 vs 16 patients, p<0.01) and fewer as hyperoxaemic (14 vs 33 patients, p<0.01). Finally, ICU length of stay was significantly shorter for conservative group patients (p=0.04). There was no difference in the proportion of survivors discharged from hospital with good neurological outcome (14/23 vs 12/22 patients, p=0.67). CONCLUSIONS:Our findings provide preliminary support for the feasibility and physiological safety of conservative oxygen therapy in patients admitted to ICU for MV support after cardiac arrest (Trial registration, NCT01684124).

journal_name

Resuscitation

journal_title

Resuscitation

authors

Eastwood GM,Tanaka A,Espinoza ED,Peck L,Young H,Mårtensson J,Zhang L,Glassford NJ,Hsiao YF,Suzuki S,Bellomo R

doi

10.1016/j.resuscitation.2015.11.026

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

108-14

eissn

0300-9572

issn

1873-1570

pii

S0300-9572(15)00901-6

journal_volume

101

pub_type

杂志文章
  • In hospital cardiac arrest: a role for automatic defibrillation.

    abstract:INTRODUCTION:Sudden cardiac death (SCD) survival decreases by 10% for each minute of delay in defibrillation, however, survival rates of 98% can be achieved when defibrillation is accomplished within 30s of collapse. Recently, a fully automated external cardioverter-defibrillator (AECD) was approved by the FDA for in-h...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2004.05.012

    authors: Cusnir H,Tongia R,Sheka KP,Kavesteen D,Segal RR,Nowakiwskyj VN,Cassera F,Scherer H,Costello D,Valerio L,Yens DP,Shani J,Hollander G

    更新日期:2004-11-01 00:00:00

  • Endothelium-dependent responses and their potential relevance to the distribution of blood flow during hemorrhagic shock.

    abstract::The endothelium releases vasoactive substances in response to several circulating hormones and to changes in shear stress of the flowing blood across the endothelial surface. Because the distribution of receptors mediating the release of endothelium-derived factors is not uniform along the vascular bed, the vascular e...

    journal_title:Resuscitation

    pub_type: 杂志文章,评审

    doi:10.1016/0300-9572(89)90019-1

    authors: Miller VM,Vanhoutte PM

    更新日期:1989-12-01 00:00:00

  • Low rates of immediate coronary angiography among young adults resuscitated from sudden cardiac arrest.

    abstract:AIM:Coronary artery disease (CAD) has recently been emphasized as a major cause of sudden cardiac arrest (SCA) in young adults. We aim to assess the rate of immediate coronary angiography performance in young patients resuscitated from SCA. METHODS:From May 2011 to May 2017, all cases of out-of-hospital SCA aged 18-40...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2019.12.005

    authors: Waldmann V,Karam N,Rischard J,Bougouin W,Sharifzadehgan A,Dumas F,Narayanan K,Sideris G,Voicu S,Gandjbakhch E,Jost D,Lamhaut L,Ludes B,Plu I,Beganton F,Wahbi K,Varenne O,Megarbane B,Algalarrondo V,Extramiana F,Lel

    更新日期:2020-02-01 00:00:00

  • Adult in-hospital cardiac arrest in Denmark.

    abstract:AIM:The aim of this study was to describe patient characteristics, event characteristics, and outcomes for patients with in-hospital cardiac arrest in Denmark. METHODS:Data was obtained from DANARREST. DANARREST is a nationwide registry that covers all in-hospital cardiac arrests in Denmark with a clinical indication ...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2019.04.046

    authors: Andersen LW,Holmberg MJ,Løfgren B,Kirkegaard H,Granfeldt A

    更新日期:2019-07-01 00:00:00

  • Prognostic value of cell-free DNA in plasma of out-of-hospital cardiac arrest survivors at ICU admission and 24h post-admission.

    abstract::Cell-free DNA has been associated with outcome in several acute conditions including two reports concerning the outcomes after cardiac arrest that found association of circulating DNA quantities at admission with mortality. The origins of cell-free DNA are primarily necrosis and apoptosis, which in cardiac arrest occu...

    journal_title:Resuscitation

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.resuscitation.2013.10.008

    authors: Gornik I,Wagner J,Gašparović V,Miličić D,Degoricija V,Skorić B,Gornik O,Lauc G

    更新日期:2014-02-01 00:00:00

  • Mechanical active compression-decompression cardiopulmonary resuscitation (ACD-CPR) versus manual CPR according to pressure of end tidal carbon dioxide (P(ET)CO2) during CPR in out-of-hospital cardiac arrest (OHCA).

    abstract:AIM:In animal and human studies, measuring the pressure of end tidal carbon dioxide (P(ET)CO2) has been shown to be a practical non-invasive method that correlates well with the pulmonary blood flow and cardiac output (CO) generated during cardiopulmonary resuscitation (CPR). This study aims to compare mechanical activ...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2009.08.006

    authors: Axelsson C,Karlsson T,Axelsson AB,Herlitz J

    更新日期:2009-10-01 00:00:00

  • The 9 ALS triads--an alphabetical checklist for advanced life support providers.

    abstract::The successful outcome of a resuscitation attempt relies frequently on the performance of many advanced life support interventions. A checklist of 27 procedures, following an alphabetical sequence, is presented as an educational memory aid for healthcare providers. ...

    journal_title:Resuscitation

    pub_type: 杂志文章,评审

    doi:10.1016/s0300-9572(00)00368-3

    authors: Kloeck WG

    更新日期:2001-07-01 00:00:00

  • Resuscitative endovascular balloon occlusion of the aorta.

    abstract::The management of non-compressible torso hemorrhage can be problematic. Current therapy requires either open or interventional radiologic control of bleeding vessels and/or organs. Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a new tool to stabilize patients in shock by achieving temporary infl...

    journal_title:Resuscitation

    pub_type: 杂志文章,评审

    doi:10.1016/j.resuscitation.2015.09.003

    authors: Qasim Z,Brenner M,Menaker J,Scalea T

    更新日期:2015-11-01 00:00:00

  • Changes in blood viscosity and plasma proteins in myocardial infarction.

    abstract::A clinical study of some biological and biochemical factors was carried out on patients with acute myocardial infarction. It was shown that: (i) the plasma viscosity was highly correlated to the clinical evolution of myocardial infarction; (ii) the variations of plasma viscosity were related to changes in the connecti...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/0300-9572(76)90041-1

    authors: Bondoli A,Marana E,Magalini SI,Sabato A,Ranieri R,Scrascia E

    更新日期:1976-01-01 00:00:00

  • The epidemiology of defibrillation in a medical school complex.

    abstract::Defibrillation is the definitive treatment for ventricular fibrillation (VF). Participation of physicians, paramedical personnel and lay people in cardiopulmonary resuscitation has significantly increased the survival from ventricular fibrillation. The number of defibrillators has increased and their primary placement...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/0300-9572(84)90037-6

    authors: Shiner SL,Gold MI

    更新日期:1984-02-01 00:00:00

  • Comparison of defibrillation efficacy between two pads placements in a pediatric porcine model of cardiac arrest.

    abstract:OBJECTIVE:The placement of defibrillation pads at ideal anatomical sites is one of the major determinants of transthoracic defibrillation success. However, the optimal pads position for ventricular defibrillation is still undetermined. In the present study, we compared the effects of two different pads positions on def...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2011.12.010

    authors: Ristagno G,Yu T,Quan W,Freeman G,Li Y

    更新日期:2012-06-01 00:00:00

  • Family presence during resuscitation and invasive procedures: physicians' and nurses' attitudes working in pediatric departments in Greece.

    abstract:BACKGROUND:Family presence during resuscitation and invasive procedures (FPDRAIP) has been a frequent topic of debate among healthcare personnel worldwide. This paper determines the knowledge, experiences and views of Greek physicians and nurses on FPDRAIP and examines possible correlations and factors promoting or lim...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2011.02.011

    authors: Vavarouta A,Xanthos T,Papadimitriou L,Kouskouni E,Iacovidou N

    更新日期:2011-06-01 00:00:00

  • Incidence and outcome from adult cardiac arrest occurring in the intensive care unit: a systematic review of the literature.

    abstract:BACKGROUND:Significant amount of data on the incidence and outcome of out-of-hospital and in-hospital cardiac arrest have been published. Cardiac arrest occurring in the intensive care unit has received less attention. AIMS:To evaluate and summarize current knowledge of intensive care unit cardiac arrest including qua...

    journal_title:Resuscitation

    pub_type: 杂志文章,评审

    doi:10.1016/j.resuscitation.2013.12.027

    authors: Efendijev I,Nurmi J,Castrén M,Skrifvars MB

    更新日期:2014-04-01 00:00:00

  • Ventricular fibrillation frequency characteristics and time evolution in piglets: a developmental study.

    abstract:BACKGROUND:Derived variables of ventricular fibrillation, such as the frequency distribution by fast Fourier transformation and its evolution over time, have been used to determine the optimum timing for defibrillation. We hypothesized that these frequency variables would differ among neonatal, young child and older ch...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2004.05.001

    authors: Indik JH,Donnerstein RL,Berg MD,Samson RA,Berg RA

    更新日期:2004-10-01 00:00:00

  • Heart rate response to therapeutic hypothermia in infants with hypoxic-ischaemic encephalopathy.

    abstract:AIM OF THE STUDY:Neonatal encephalopathy (NE) of hypoxic-ischaemic origin may cause death or life-long disability which is reduced by therapeutic hypothermia (TH). Our objective was to assess HR response in infants undergoing TH after perinatal asphyxia. METHODS:We performed a retrospective case series, from a single-...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2016.06.023

    authors: Elstad M,Liu X,Thoresen M

    更新日期:2016-09-01 00:00:00

  • Evidence-based educational pathway for the integration of first aid training in school curricula.

    abstract:BACKGROUND:"Calling for help, performing first aid and providing Cardiopulmonary Resuscitation (CPR)" is part of the educational goals in secondary schools in Belgium (Flanders). However, for teachers it is not always clear at what age children can be taught which aspects of first aid. In addition, it is not clear what...

    journal_title:Resuscitation

    pub_type: 杂志文章,评审

    doi:10.1016/j.resuscitation.2015.06.008

    authors: De Buck E,Van Remoortel H,Dieltjens T,Verstraeten H,Clarysse M,Moens O,Vandekerckhove P

    更新日期:2015-09-01 00:00:00

  • Compression characteristics of CPR manikins.

    abstract::We evaluated the force-depth compression characteristics of 8 different CPR manikins during mechanical cardiopulmonary resuscitation by a thumper. The force required to compress the manikin's thorax of 1, 2, 3, 4 and 5 cm was measured. It ranged between 6.3 and 14 kp at a depth of 1 cm, 11.6-30 kp at 2 cm, 17-38 kp at...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/0300-9572(95)00874-s

    authors: Baubin MA,Gilly H,Posch A,Schinnerl A,Kroesen GA

    更新日期:1995-10-01 00:00:00

  • Should age be included as a component of track and trigger systems used to identify sick adult patients?

    abstract:AIM OF STUDY:Few published "track and trigger systems" used to identify sick adult patients incorporate patient age as a variable. We investigated the relationship between vital signs, patient age and in-hospital mortality and investigated the impact of patient age on the function as predictors of in-hospital mortality...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2008.03.004

    authors: Smith GB,Prytherch DR,Schmidt PE,Featherstone PI,Kellett J,Deane B,Higgins B

    更新日期:2008-08-01 00:00:00

  • International EMS systems: France.

    abstract::The EMS (Emergency Medical Service) system in France is a centrally based, two-tiered, physician-manned system. The first level is composed of BLS (Basic Life Support) fire department ambulances (called "VSAB") based at fire stations. The second level is composed of ALS (Advanced Life Support) physician staffed-ambula...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2004.04.001

    authors: Adnet F,Lapostolle F

    更新日期:2004-10-01 00:00:00

  • Unintentional variation in positive end expiratory pressure during resuscitation with a T-piece resuscitator.

    abstract:INTRODUCTION:The ability of T-piece resuscitators to deliver consistent peak inspiratory pressure (PIP) and positive end expiratory pressure (PEEP) during real and simulated neonatal resuscitation has been well described. The Neopuff (Fisher & Paykel Healthcare, Auckland, New Zealand) has been the device used for nearl...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2011.02.017

    authors: Finer NN,Rich WD

    更新日期:2011-06-01 00:00:00

  • Ivabradine but not propranolol delays the time to onset of ischaemia-induced ventricular fibrillation by preserving myocardial metabolic energy status.

    abstract:OBJECTIVE:Heart rate reduction (HRR) has shown a beneficial impact on the prevention of ventricular fibrillation, which could be explained by increased myocardial blood flow and preservation of mitochondrial structure. Here, we assessed the HRR impact on time to onset of ventricular fibrillation (TOVF) and myocardial m...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2012.07.041

    authors: Vaillant F,Dehina L,Dizerens N,Bui-Xuan B,Tabib A,Lauzier B,Chevalier P,Descotes J,Timour Q

    更新日期:2013-03-01 00:00:00

  • Should there be a change in the teaching of airway management in the medical school curriculum?

    abstract:OBJECTIVE:To evaluate the use of the Laryngeal Mask Airway (LMA), the oesophageal-tracheal combitube (ETC) and the tracheal tube (TT) by medical students, with a view to recommend changes to the medical school curriculum. METHODS:A prospective cohort study of 93 third-year medical students were taught the use of LMA, ...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2004.07.011

    authors: Tiah L,Wong E,Chen MF,Sadarangani SP

    更新日期:2005-01-01 00:00:00

  • Rescue therapy with terlipressin by continuous infusion in a child with catecholamine-resistant septic shock.

    abstract::A 2-month-old female infant presented with septic shock, refractory to high doses of catecholamines. Continuous infusion of terlipressin at a rate of 10 mcg/kgh produced a significant increase in the mean arterial pressure that was evident within half and hour, so allowing a reduction in the rate of catecholamine infu...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2005.06.016

    authors: Zeballos G,López-Herce J,Fernández C,Brandstrup KB,Rodríguez-Núñez A

    更新日期:2006-01-01 00:00:00

  • Influence of pre-course assessment using an emotionally activating stimulus with feedback: a pilot study in teaching Basic Life Support.

    abstract:BACKGROUND:Cardiopulmonary resuscitation (CPR) mastery continues to challenge medical professionals. The purpose of this study was to determine if an emotional stimulus in combination with peer or expert feedback during pre-course assessment effects future performance in a single rescuer simulated cardiac arrest. METH...

    journal_title:Resuscitation

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.resuscitation.2011.08.024

    authors: Beckers SK,Biermann H,Sopka S,Skorning M,Brokmann JC,Heussen N,Rossaint R,Younker J

    更新日期:2012-02-01 00:00:00

  • Use of double sequential external defibrillation for refractory ventricular fibrillation during out-of-hospital cardiac arrest.

    abstract:INTRODUCTION:Survival from out of hospital cardiac arrest (OHCA) is highest in victims with shockable rhythms when early CPR and rapid defibrillation are provided. However, a subset of individuals present with ventricular fibrillation (VF) that does not respond to defibrillation (refractory VF). One intervention that m...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2016.08.002

    authors: Cortez E,Krebs W,Davis J,Keseg DP,Panchal AR

    更新日期:2016-11-01 00:00:00

  • A 5-year experience with cardiopulmonary resuscitation using extracorporeal life support in non-postcardiotomy patients with cardiac arrest.

    abstract:BACKGROUND:Cardiopulmonary resuscitation (CPR) using extracorporeal life support (ECLS) system has been successfully used to support patients with in- and out-of-hospital cardiac arrest (IHCA, OHCA) when conventional measures have failed. The purpose of the current study is to report on our experience with extracorpore...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2012.07.009

    authors: Haneya A,Philipp A,Diez C,Schopka S,Bein T,Zimmermann M,Lubnow M,Luchner A,Agha A,Hilker M,Hirt S,Schmid C,Müller T

    更新日期:2012-11-01 00:00:00

  • Recommended guidelines for reporting on emergency medical dispatch when conducting research in emergency medicine: the Utstein style.

    abstract:OBJECTIVES:To establish a uniform framework describing the system and organisation of emergency medical response centres and the process of emergency medical dispatching (EMD) when reporting results from studies in emergency medicine and prehospital care. DESIGN AND RESULTS:In September 2005 a task force of 22 experts...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2008.07.007

    authors: Castrén M,Karlsten R,Lippert F,Christensen EF,Bovim E,Kvam AM,Robertson-Steel I,Overton J,Kraft T,Engerstrom L,Garcia-Castrill Riego L,Emergency Medical Dispatch expert group at the Utstein Consensus Symposium 2005.

    更新日期:2008-11-01 00:00:00

  • Elimination of glutamate using CRRT for 72 h in patients with post-cardiac arrest syndrome: A randomized clinical pilot trial.

    abstract:AIM:Glutamine and glutamate are major mediators of secondary brain cell death during post-cardiac arrest syndrome. As there is an equilibrium between brain tissue and plasma concentrations of glutamine and glutamate, their elimination from systemic circulation by extracorporeal blood purification may ultimately lead to...

    journal_title:Resuscitation

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.resuscitation.2019.09.020

    authors: Nee J,Jörres A,Krannich A,Leithner C,Schroeder T,Munk AL,Enghard P,Moore C,Steppan S,Storm C

    更新日期:2019-11-01 00:00:00

  • The value of susceptibility-weighted imaging (SWI) in patients with non-neonatal hypoxic-ischemic encephalopathy.

    abstract:OBJECTIVE:In susceptibility-weighted imaging (SWI) in the normal brain, cortical veins appear hypointense due to paramagnetic properties of deoxy-hemoglobin. Global cerebral anoxia decreases cerebral oxygen metabolism, thereby increasing oxy-hemoglobin levels in cerebral veins. We hypothesized that a lower cerebral oxy...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2014.12.024

    authors: Wagner F,Haenggi MM,Wagner B,Weck A,Weisstanner C,Grunt S,Z'Graggen WJ,Gralla J,Wiest R,Verma RK

    更新日期:2015-03-01 00:00:00

  • Traumatic pericardial effusion: impact of diagnostic and surgical approaches.

    abstract:INTRODUCTION:In trauma patients with chest injuries, traumatic pericardial effusion is an important scenario to consider because of its close linkage to cardiac injury. Even with advances in imaging, diagnosis remains a challenge and use of which surgical approach is controversial. This study reviews the treatment algo...

    journal_title:Resuscitation

    pub_type: 杂志文章

    doi:10.1016/j.resuscitation.2010.06.026

    authors: Huang YK,Lu MS,Liu KS,Liu EH,Chu JJ,Tsai FC,Lin PJ

    更新日期:2010-12-01 00:00:00