Abstract：
BACKGROUND:Although Candida albicans remains the most common fungal isolate from clinical specimens, many studies have detected a shift towards non-albicans Candida species. Despite worrying clinical pictures associated with latter species, there is little information regarding its susceptibility patterns against currently available antifungal agents, with only a small number of strains having been studied. METHODS:We evaluated the in vitro antifungal susceptibilities of clinical isolates of C. orthopsilosis already identified by two-steps PCR-RFLP and reconfirmed by sequence analysis of entire ITS rDNA region, to six antifungal drugs. RESULTS:The resulting MIC50 and MIC90 for all strains (n=18) were in increasing order, as follows: posaconazole (0.016 & 0.063 μg/ml); itraconazole (0.031 & 0.125 μg/ml); amphotericin B (0.5 & 1 μg/ml); fluconazole (0.25 & 0.5 μg/ml) and caspofungin (4 & 8 μg/ml). A uniform pattern of the MIC ranges was seen for amphotericin B, fluconazole, itraconazole, and posaconazole, while a widest range and the highest MICs were observed for caspofungin. CONCLUSION:Although we emphasis on the careful species designation of the clinical isolates of Candida, the antifungal susceptibility patterns of these clinically important organisms may have an application in clinical and epidemiological setting and deserve the implementation of local surveillance programs to monitor.
journal_name
Iran J Public Healthjournal_title
Iranian journal of public healthauthors
Mohammadi R,Mirhendi H,Hedayati MT,Badali Hsubject
Has Abstractpub_date
2017-02-01 00:00:00pages
235-241issue
2eissn
2251-6085issn
2251-6093journal_volume
46pub_type
杂志文章abstract：BACKGROUND:Child with Down's syndrome is an individual who is suitable and eligible to receive early intervention services. This study aimed to measure the family outcome among parents of Down syndrome children, on the impact of receiving early intervention and identify the factors influencing it. METHODS:A cross sect...
journal_title：Iranian journal of public health
pub_type： 杂志文章
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abstract：Background:Congenital anomalies are important medical and public health conditions. The pattern and prevalence of birth defects may vary over time or with geographical location. We investigated the live birth prevalence and occurrence pattern of birth defects in Golestan Province, northern Iran. Methods:This cross-sec...
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journal_title：Iranian journal of public health
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journal_title：Iranian journal of public health
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journal_title：Iranian journal of public health
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更新日期：2018-04-01 00:00:00
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journal_title：Iranian journal of public health
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journal_title：Iranian journal of public health
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2017-11-01 00:00:00
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journal_title：Iranian journal of public health
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doi：
更新日期：2019-07-01 00:00:00
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journal_title：Iranian journal of public health
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更新日期：2016-01-01 00:00:00
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journal_title：Iranian journal of public health
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doi：
更新日期：2012-01-01 00:00:00
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journal_title：Iranian journal of public health
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doi：
更新日期：2012-01-01 00:00:00
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2017-01-01 00:00:00
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journal_title：Iranian journal of public health
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doi：
更新日期：2019-06-01 00:00:00
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journal_title：Iranian journal of public health
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doi：10.18502/ijph.v49i8.3897
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journal_title：Iranian journal of public health
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更新日期：2018-07-01 00:00:00
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journal_title：Iranian journal of public health
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更新日期：2018-04-01 00:00:00
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journal_title：Iranian journal of public health
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更新日期：2017-04-01 00:00:00
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journal_title：Iranian journal of public health
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journal_title：Iranian journal of public health
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pub_type： 杂志文章
doi：
更新日期：2017-09-01 00:00:00
