Abstract:
:Despite increased international efforts to control schistosomiasis using preventive chemotherapy, several challenges still exist in reaching the target populations. Until recently, preschool-aged children had been excluded from the recommended target population for mass drug administration, i.e. primary school children aged 6-15 years. Our studies and those of others provided the evidence base for the need to treat preschool-aged children that led to recommendations by the World Health Organization to include preschool-aged children in treatment programmes in 2010. The major challenge now lies in the unavailability of a child-size formulation of the appropriate anthelmintic drug, praziquantel.The currently available formulation of praziquantel presents several problems. First, it is a large tablet, making it difficult for young children and infants to swallow it and thus requires its breaking/crushing to allow for safe uptake. Second, it is bitter so it is often mixed with a sweetener to make it palatable for young children. Third, the current formulation of 600 mg does not allow for flexible dose adjustments for this age group. Thus, there is a need to formulate a child-appropriate praziquantel tablet.This paper discusses the target product profile for paediatric praziquantel, as well as knowledge gaps pertinent to the successful control of schistosome infection and disease in preschool-aged children.
journal_name
Infect Dis Povertyjournal_title
Infectious diseases of povertyauthors
Mduluza T,Mutapi Fdoi
10.1186/s40249-017-0300-8subject
Has Abstractpub_date
2017-04-07 00:00:00pages
85issue
1eissn
2095-5162issn
2049-9957pii
10.1186/s40249-017-0300-8journal_volume
6pub_type
杂志文章,评审abstract:BACKGROUND:Aedes borne viral diseases, notably dengue, are increasingly reported in Cameroon with Aedes aegypti being a major vector. Data on insecticide resistance of this vector and underlying mechanisms needed for outbreak preparedness remain scarce in Cameroon. Here, we present the nationwide distribution of insect...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-020-00769-1
更新日期:2020-11-02 00:00:00
abstract:BACKGROUND:Zika virus, an Aedes mosquito-borne flavivirus, is fast becoming a worldwide public health concern following its suspected association with over 4000 recent cases of microcephaly among newborn infants in Brazil. DISCUSSION:Prior to its emergence in Latin America in 2015-2016, Zika was known to exist at a re...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-016-0132-y
更新日期:2016-04-19 00:00:00
abstract:BACKGROUND:Malaria is a major cause of morbidity and mortality in Northeast India. As there is limited information available on the potential influence of socio-economic variables on malaria risk, the present study was conducted to assess the influence of demographic factors, the socio-economic status, and knowledge, a...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/2049-9957-3-19
更新日期:2014-06-24 00:00:00
abstract::To further enhance dialogue and promote cross-strait cooperation in the prevention and control of parasitic diseases, this paper reviewed the progress and current challenges in the cross-strait control and research of parasitic infections, based on three cross-strait meetings on parasitological research in the last de...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/2049-9957-3-40
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:As part of an ongoing program that aims to use early detection and timely treatment to improve the control of echinococcosis, especially in younger age groups, we undertook a series of active surveys among Qinghai-Tibetan children in the Qinghai Province of Northwestern China in 2011 and 2012. The significan...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-018-0455-y
更新日期:2018-07-12 00:00:00
abstract::Mechanisms and outcomes of host-parasite interactions during malaria co-infections with gastrointestinal helminths are reasonably understood. In contrast, very little is known about such mechanisms in cases of malaria co-infections with tissue-dwelling parasites. This is lack of knowledge is exacerbated by misdiagnosi...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s40249-015-0070-0
更新日期:2015-08-29 00:00:00
abstract:BACKGROUND:Cystic echinococcosis (CE) and alveolar echinococcosis (AE) are highly endemic in Xiji County of Ningxia Hui Autonomous Region (NHAR) in China where the control campaign based on dog de-worming with praziquantel has been undertaken over preceding decades. This study is to determine the current prevalence of ...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-018-0458-8
更新日期:2018-08-09 00:00:00
abstract:BACKGROUND:Over half the world's human populations are currently at risk from vector-borne diseases (VBDs), and the heaviest burden is borne by the world's poorest people, communities, and countries. The aim of this study was to conduct a review on VBD interventions relevant to housing and hygiene (including sanitation...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章,评审
doi:10.1186/s40249-018-0477-5
更新日期:2018-09-03 00:00:00
abstract:BACKGROUND:The data on hepatitis b virus (HBV) infection in immigrants population are scanty. The porpoise of this study was to define the demographic, virological, and clinical characteristics of subjects infected with HBV chronic infection in a cohort of immigrants living in Naples, Italy. METHODS:A screening for HB...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章,多中心研究
doi:10.1186/s40249-016-0228-4
更新日期:2017-02-09 00:00:00
abstract:BACKGROUND:Trachoma is a disease of the eye, caused by the bacteria Chlamydia trachomatis, which can lead to blindness if left untreated. Ethiopia is one of the most trachoma-affected countries in the world. The objective of this study was to determine the prevalence of and associated risk factors for active trachoma a...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-017-0358-3
更新日期:2017-10-09 00:00:00
abstract:BACKGROUND:A high epilepsy prevalence has been reported in several onchocerciasis-endemic villages along the Mbam and Sanaga river valleys in Cameroon, including Bilomo and Kelleng. We sought to determine the prevalence of epilepsy in these two villages following more than 13 years of community-directed treatment with ...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-018-0497-1
更新日期:2018-12-03 00:00:00
abstract:BACKGROUND:Malaria is a major world health issue and its continued burden is due, in part, to difficulties in the diagnosis of the illness. The World Health Organization recommends confirmatory testing using microscopy-based techniques or rapid diagnostic tests (RDT) for all cases of suspected malaria. In regions where...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-017-0251-0
更新日期:2017-04-04 00:00:00
abstract::Shenzhen is a city of 22 million people in south China that serves as a financial and trade center for East Asia. The city has extensive ties to Hubei Province, the first reported epicenter of the coronavirus disease 2019 (COVID-19) outbreak in the world. Initial predictions suggested Shenzhen would experience a high ...
journal_title:Infectious diseases of poverty
pub_type: 信件
doi:10.1186/s40249-020-00714-2
更新日期:2020-07-10 00:00:00
abstract:BACKGROUND:In order to achieve the goal of malaria elimination, the Chinese government launched the National Malaria Elimination Programme in 2010. However, as a result of increasing cross-border population movements, the risk of imported malaria cases still exists at the border areas of China, resulting in a potential...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-017-0322-2
更新日期:2017-07-06 00:00:00
abstract::Enabling innovation and access to health technologies remains a key strategy in combating infectious diseases in low- and middle-income countries (LMICs). However, a gulf between paying markets and the endemicity of such diseases has contributed to the dearth of R&D in meeting these public health needs. While the phar...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/2049-9957-1-2
更新日期:2012-10-25 00:00:00
abstract::Zambia's estimated incidence of all forms of human tuberculosis (TB) is 707/100,000. High prevalence of bovine tuberculosis (BTB) - infection with Mycobacterium bovis - in cattle and the Kafue lechwe antelopes (Kobus leche Kafuensis) has been reported in the Kafue basin. Consumption of unpasteurised milk and meat prod...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/2049-9957-2-13
更新日期:2013-07-09 00:00:00
abstract:BACKGROUND:The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to the outbreak of pneumonia in Wuhan. The virus is highly infectious. Patients with cancer might be susceptible to the viral infection because of the immunosuppressive state cause by therapies on tumors. CASE PRESENTATION:We present the c...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-020-00707-1
更新日期:2020-07-02 00:00:00
abstract:BACKGROUND:The Qinghai-Tibet Plateau (QTP) of China is an extensive pastoral and semi-pastoral area, and because of poverty and bad hygiene conditions, Brucella is highly prevalent in this region. In order to adequately prevent this disease in the QTP region it is important to determine the identity of Brucella species...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-016-0123-z
更新日期:2016-04-13 00:00:00
abstract:BACKGROUND:Given that increase in temperature may alter host-parasite relationships, the anticipated rise in temperature due to global warming might change transmission patterns of certain diseases. However, the extent to which this will happen is not well understood. METHODS:Using a host-parasite system involving Bul...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-017-0260-z
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:The prevalence of infection with Toxoplasma gondii (T. gondii) in humans has been increasing in China due to the growing number of cats in the country. Hand, foot and mouth disease (HFMD) is a serious public health issue in China and still one of the leading causes of child mortality. However, little is know...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-015-0088-3
更新日期:2015-12-10 00:00:00
abstract:BACKGROUND:Avian influenza (AI) is a global public health threat. Understanding the knowledge that butchers have about it and the precautionary practices they take against it is crucial for designing future preparedness programs. This study aimed to identify the social determinants of knowledge and precautionary measur...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/2049-9957-2-10
更新日期:2013-06-05 00:00:00
abstract:BACKGROUND:The number of coronavirus disease 2019 (COVID-19) cases has rapidly increased all over the world. Specific information about immunity in non-survivors with COVID-19 is scarce. This study aimed to analyse the clinical characteristics and abnormal immunity of the confirmed COVID-19 non-survivors. METHODS:In t...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-020-00723-1
更新日期:2020-08-03 00:00:00
abstract:BACKGROUND:Strongyloidiasis is a gastrointestinal infection caused by the parasitic nematode Strongyloides stercoralis. It is estimated to infect up to 370 million people globally and is predominately found in tropical and subtropical areas of socioeconomic disadvantage. MAIN BODY:This systematic literature review ide...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-019-0555-3
更新日期:2019-06-14 00:00:00
abstract:BACKGROUND:Although preventable and curable, tuberculosis (TB) still occurs in poor or developing countries, mainly in metropolitan regions of larger cities. The disease is a serious public health problem, and is directly linked to social issues. We analyzed temporal trend variations in areas at risk for concomitant TB...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-020-00732-0
更新日期:2020-08-10 00:00:00
abstract::Ecohealth is a comprehensive approach to understanding health at its human, animal and environmental interface in a socio-ecological systems context. This approach was introduced widely in Southeast Asia (SEA) by the Canadian International Development Research Centre (IDRC) in the late 2000s. Aimed at addressing the p...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/2049-9957-4-5
更新日期:2015-01-29 00:00:00
abstract:BACKGROUND:It is one of the most infamous quotes in the history of biomedicine: "It is time to close the book on infectious diseases, and declare the war against pestilence won." Long attributed to the United States Surgeon General, Dr. William H. Stewart (1965-1969), the statement is frequently used as a foil by scien...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/2049-9957-2-3
更新日期:2013-02-18 00:00:00
abstract:BACKGROUND:Echinococcosis has a worldwide geographical distribution with endemic foci on every inhabited continent. Due to the frequent outbreaks in different parts of Pakistan in the recent past, echinococcosis is being described as a neglected tropical disease and is considered one of the most neglected parasitic dis...
journal_title:Infectious diseases of poverty
pub_type: 信件
doi:10.1186/s40249-017-0309-z
更新日期:2017-07-03 00:00:00
abstract::Schistosomiasis is an important zoonotic parasitic disease that causes serious harms to humans and animals. Surveillance and diagnosis play key roles in schistosomiasis control, however, current techniques for surveillance and diagnosis of the disease have limitations. As genome data for parasites are increasing, nove...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章,评审
doi:10.1186/s40249-016-0116-y
更新日期:2016-03-30 00:00:00
abstract:BACKGROUND:Access to clean and safe drinking water that is free from pathogenic protozoan parasites, especially Cryptosporidium parvum and Giardia lamblia that cause gastrointestinal illness in humans, is still an issue in Southeast Asia (SEA). This study is the first attempt to detect the aforementioned protozoan para...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-016-0095-z
更新日期:2016-01-13 00:00:00
abstract:BACKGROUND:The number of cumulative confirmed cases of COVID-19 in the United States has risen sharply since March 2020. A county health ranking and roadmaps program has been established to identify factors associated with disparity in mobility and mortality of COVID-19 in all counties in the United States. The risk fa...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-020-00786-0
更新日期:2021-01-04 00:00:00