Abstract:
BACKGROUND:Aedes borne viral diseases, notably dengue, are increasingly reported in Cameroon with Aedes aegypti being a major vector. Data on insecticide resistance of this vector and underlying mechanisms needed for outbreak preparedness remain scarce in Cameroon. Here, we present the nationwide distribution of insecticide resistance in Ae. aegypti and investigate the potential resistance mechanisms involved. METHODS:Immature stages of Ae. aegypti were collected between March and July 2017 in 13 locations across Cameroon and reared until G1/G2/G3 generation. Larval, adult bioassays, and piperonyl butoxide (PBO) synergist assays were carried out according to World Health Organization guidelines. F1534C mutation was genotyped using allele specific polymerase chain reaction in field collected adults (Go) and the polymorphism of the sodium channel gene was assessed. The χ2 test was used to compare the mortality rate between bioassays with insecticides only and bioassays after preexposure to PBO synergist. RESULTS:Larval bioassay revealed that all the three populations tested with temephos were susceptible. Adult bioassays showed a good level of susceptibility toward both pyrethroids tested, 0.25% permethrin and 0.05% deltamethrin, with six out of 10 populations susceptible. However, two populations (Douala and Edéa) were resistant (deltamethrin [73.2-92.5% mortality], permethrin [2.6-76.3% mortality]). The resistance to 4% dichlorodiphenyltrichloroethane was observed in four out of 10 populations tested (16.8-87.1% mortality). Resistance was also reported to carbamates including 0.1% propoxur (60.8-87.1% mortality) and to 0.1% bendiocarb (82.9% mortality). All populations tested were fully susceptible to 1% fenitrothion. A partial recovery of susceptibility was observed in the pyrethroid resistant population of Douala after pre-exposed to PBO suggesting the implication of cytochrome P450 monoxygenases permethrin resistance. Genotyping and sequencing detected the F1534C kdr mutation in the two pyrethroid resistant locations of Edéa and Douala, with allelic frequency of 3.3% and 33.3% respectively. However, the high genetic diversity of the sodium channel gene supports the recent introduction of this mutation in Cameroon. CONCLUSIONS:This study revealed the contrasting resistance profiles to insecticides of Ae. aegypti populations in Cameroon suggesting that, instead of a unique nationwide control approach, a regionally adapted strategy will be needed to control this vector. The localised distribution of the F1534C kdr mutation supports this region-specific control strategy.
journal_name
Infect Dis Povertyjournal_title
Infectious diseases of povertyauthors
Yougang AP,Kamgang B,Bahun TAW,Tedjou AN,Nguiffo-Nguete D,Njiokou F,Wondji CSdoi
10.1186/s40249-020-00769-1subject
Has Abstractpub_date
2020-11-02 00:00:00pages
152issue
1eissn
2095-5162issn
2049-9957pii
10.1186/s40249-020-00769-1journal_volume
9pub_type
杂志文章abstract:BACKGROUND:As part of an ongoing program that aims to use early detection and timely treatment to improve the control of echinococcosis, especially in younger age groups, we undertook a series of active surveys among Qinghai-Tibetan children in the Qinghai Province of Northwestern China in 2011 and 2012. The significan...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-018-0455-y
更新日期:2018-07-12 00:00:00
abstract:BACKGROUND:China is facing challenges of the shifting presentation of tuberculosis (TB) from younger to elderly due to an ageing population, longer life expectancy and reactivation disease. However, the burden of elderly TB and influence factors are not yet clear. To fill the gap, we generated a cohort study to measure...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-019-0614-9
更新日期:2020-01-31 00:00:00
abstract:BACKGROUND:The prevalence of infection with Toxoplasma gondii (T. gondii) in humans has been increasing in China due to the growing number of cats in the country. Hand, foot and mouth disease (HFMD) is a serious public health issue in China and still one of the leading causes of child mortality. However, little is know...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-015-0088-3
更新日期:2015-12-10 00:00:00
abstract::The transmission of infectious diseases is a dynamic process determined by multiple factors originating from disease pathogens and/or parasites, vector species, and human populations. These factors interact with each other and demonstrate the intrinsic mechanisms of the disease transmission temporally, spatially, and ...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-017-0339-6
更新日期:2017-09-11 00:00:00
abstract:BACKGROUND:Leprosy can be cured, but physical disability (PD) as a result of the infection can progress in the post-release from treatment phase. This study evaluated the likelihood of, and factors associated with, the progression of the PD grade post-release from treatment among leprosy patients treated in Cáceres-MT,...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-020-00669-4
更新日期:2020-05-24 00:00:00
abstract:BACKGROUND:Before 2014 (the year of closure of the two largest needle exchange programs in Hungary, which halved the number of available syringes in the country despite increased injecting risk practices) no HIV was reportedly acquired in Hungary among people who inject drugs (PWIDs) who were not also men who had sex w...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-017-0360-9
更新日期:2017-10-11 00:00:00
abstract:BACKGROUND:Tuberculosis (TB) patients face numerous difficulties adhering to the long-term, rigorous TB treatment regimen. Findings on TB patients' treatment adherence vary across existing literature and official reports. The present study attempted to determine the actual treatment adherence of new TB patients and to ...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-016-0134-9
更新日期:2016-05-05 00:00:00
abstract:BACKGROUND:Strongyloidiasis is a gastrointestinal infection caused by the parasitic nematode Strongyloides stercoralis. It is estimated to infect up to 370 million people globally and is predominately found in tropical and subtropical areas of socioeconomic disadvantage. MAIN BODY:This systematic literature review ide...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-019-0555-3
更新日期:2019-06-14 00:00:00
abstract:BACKGROUND:Echinococcosis has a worldwide geographical distribution with endemic foci on every inhabited continent. Due to the frequent outbreaks in different parts of Pakistan in the recent past, echinococcosis is being described as a neglected tropical disease and is considered one of the most neglected parasitic dis...
journal_title:Infectious diseases of poverty
pub_type: 信件
doi:10.1186/s40249-017-0309-z
更新日期:2017-07-03 00:00:00
abstract:BACKGROUND:The development and spread of artemisinin-resistant Plasmodium falciparum malaria in Greater Mekong Subregion has created impetus for continuing global monitoring of efficacy of artemisinin-based combination therapies (ACTs). This post analyses is aimed to evaluate changes in early treatment response markers...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-019-0577-x
更新日期:2019-08-06 00:00:00
abstract:BACKGROUND:Schistosomiasis is a global snail-transmitted infectious disease of poverty. Transmission control had been achieved in China in 2015 after the control efforts for over 60 years. Currently, the remaining core regions endemic for Schistosoma japonicum are mainly located in the marshland and lake regions along ...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-017-0287-1
更新日期:2017-03-22 00:00:00
abstract:BACKGROUND:Trachoma is a disease of the eye, caused by the bacteria Chlamydia trachomatis, which can lead to blindness if left untreated. Ethiopia is one of the most trachoma-affected countries in the world. The objective of this study was to determine the prevalence of and associated risk factors for active trachoma a...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-017-0358-3
更新日期:2017-10-09 00:00:00
abstract:BACKGROUND:A recent study in the Logo and Rethy health zones in the Ituri Province in the Democratic Republic of Congo (DRC) reported that the majority of the persons with epilepsy (PWE) had not been treated with anti-epileptic medication (AEM) or had stopped treatment. Prior to the implementation of an epilepsy treatm...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-018-0498-0
更新日期:2018-12-04 00:00:00
abstract:BACKGROUND:The coronavirus disease 2019 (COVID-19) epidemic met coincidentally with massive migration before Lunar New Year in China in early 2020. This study is to investigate the relationship between the massive migration and the coronavirus disease 2019 (COVID-19) epidemic in China. METHODS:The epidemic data betwee...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-020-00722-2
更新日期:2020-08-10 00:00:00
abstract::Recently, the mortality of 240 causes in China including a subnational analysis during 1990-2013 was published in The Lancet. This comprehensive analysis will undoubtedly impact policymaking regarding public health in China. However, it is unfavourable in some degree to neglected tropical diseases, which is the subjec...
journal_title:Infectious diseases of poverty
pub_type: 信件
doi:10.1186/s40249-017-0237-y
更新日期:2017-02-03 00:00:00
abstract:BACKGROUND:The pandemic of the coronavirus disease 2019 (COVID-19) has caused substantial disruptions to health services in the low and middle-income countries with a high burden of other diseases, such as malaria in sub-Saharan Africa. The aim of this study is to assess the impact of COVID-19 pandemic on malaria trans...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-020-00788-y
更新日期:2021-01-07 00:00:00
abstract:BACKGROUND:In the Yunnan province of China, 18 counties in six prefectures border Myanmar. Due to its particular combination of geographic features, climate conditions, and cultural landscape, the area provides a suitable environment for the spread of insect-borne diseases such as malaria. In five identified Myanmar Sp...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-016-0175-0
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Schistosomiasis japonica is still endemic in the People's Republic of China (P.R. China) in five provinces of lake and marshland regions and in two provinces of mountainous regions. Studies elucidated that individual and community perception, attitudes towards schistosomiasis, and hygiene behaviors were cruc...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/2049-9957-3-16
更新日期:2014-05-07 00:00:00
abstract:BACKGROUND:The data on hepatitis b virus (HBV) infection in immigrants population are scanty. The porpoise of this study was to define the demographic, virological, and clinical characteristics of subjects infected with HBV chronic infection in a cohort of immigrants living in Naples, Italy. METHODS:A screening for HB...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章,多中心研究
doi:10.1186/s40249-016-0228-4
更新日期:2017-02-09 00:00:00
abstract::Ecohealth is a comprehensive approach to understanding health at its human, animal and environmental interface in a socio-ecological systems context. This approach was introduced widely in Southeast Asia (SEA) by the Canadian International Development Research Centre (IDRC) in the late 2000s. Aimed at addressing the p...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/2049-9957-4-5
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章
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abstract:BACKGROUND:There is accumulating evidence supporting the use of ivermectin as a malaria control tool. Recent findings from the repeat ivermectin mass drug administrations for control of malaria trial demonstrated a reduced incidence of malaria in villages which received repeated ivermectin mass drug administration (MDA...
journal_title:Infectious diseases of poverty
pub_type: 信件
doi:10.1186/s40249-019-0588-7
更新日期:2019-08-23 00:00:00
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-020-0629-2
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-018-0458-8
更新日期:2018-08-09 00:00:00
abstract:BACKGROUND:Although preventable and curable, tuberculosis (TB) still occurs in poor or developing countries, mainly in metropolitan regions of larger cities. The disease is a serious public health problem, and is directly linked to social issues. We analyzed temporal trend variations in areas at risk for concomitant TB...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-020-00732-0
更新日期:2020-08-10 00:00:00
abstract:BACKGROUND:The damage inflicted by the coronavirus diseases 2019 (COVID-19) pandemic upon humanity is and will continue to be considerable. Unprecedented progress made in global health over the past 20 years has reverted and economic growth has already evaporated, giving rise to a global recession, the likes of which w...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章,评审
doi:10.1186/s40249-020-00790-4
更新日期:2021-01-04 00:00:00
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章
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更新日期:2020-10-13 00:00:00
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journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-018-0472-x
更新日期:2018-08-18 00:00:00
abstract::In the past five months, success in control the national epidemic of coronavirus disease 2019 (COVID-19) has been witnessed in China. The implementation of public health measures accounts for the success which include different interventions in the early or later stages of the outbreak. It is clear that although not a...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-020-00759-3
更新日期:2020-10-12 00:00:00