Core Genes Evolve Rapidly in the Long-Term Evolution Experiment with Escherichia coli.

Abstract:

:Bacteria can evolve rapidly under positive selection owing to their vast numbers, allowing their genes to diversify by adapting to different environments. We asked whether the same genes that evolve rapidly in the long-term evolution experiment (LTEE) with Escherichia coli have also diversified extensively in nature. To make this comparison, we identified ∼2000 core genes shared among 60 E. coli strains. During the LTEE, core genes accumulated significantly more nonsynonymous mutations than flexible (i.e., noncore) genes. Furthermore, core genes under positive selection in the LTEE are more conserved in nature than the average core gene. In some cases, adaptive mutations appear to modify protein functions, rather than merely knocking them out. The LTEE conditions are novel for E. coli, at least in relation to its evolutionary history in nature. The constancy and simplicity of the environment likely favor the complete loss of some unused functions and the fine-tuning of others.

journal_name

Genome Biol Evol

authors

Maddamsetti R,Hatcher PJ,Green AG,Williams BL,Marks DS,Lenski RE

doi

10.1093/gbe/evx064

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

1072-1083

issue

4

issn

1759-6653

pii

3100447

journal_volume

9

pub_type

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