Abstract:
:Bacteria can evolve rapidly under positive selection owing to their vast numbers, allowing their genes to diversify by adapting to different environments. We asked whether the same genes that evolve rapidly in the long-term evolution experiment (LTEE) with Escherichia coli have also diversified extensively in nature. To make this comparison, we identified ∼2000 core genes shared among 60 E. coli strains. During the LTEE, core genes accumulated significantly more nonsynonymous mutations than flexible (i.e., noncore) genes. Furthermore, core genes under positive selection in the LTEE are more conserved in nature than the average core gene. In some cases, adaptive mutations appear to modify protein functions, rather than merely knocking them out. The LTEE conditions are novel for E. coli, at least in relation to its evolutionary history in nature. The constancy and simplicity of the environment likely favor the complete loss of some unused functions and the fine-tuning of others.
journal_name
Genome Biol Evoljournal_title
Genome biology and evolutionauthors
Maddamsetti R,Hatcher PJ,Green AG,Williams BL,Marks DS,Lenski REdoi
10.1093/gbe/evx064subject
Has Abstractpub_date
2017-04-01 00:00:00pages
1072-1083issue
4issn
1759-6653pii
3100447journal_volume
9pub_type
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