Abstract：
:This study evaluated the clinical use of serum metabolomics to discriminate malignant cancers including pancreatic cancer (PC) from malignant diseases, such as biliary tract cancer (BTC), intraductal papillary mucinous carcinoma (IPMC), and various benign pancreaticobiliary diseases. Capillary electrophoresismass spectrometry was used to analyze charged metabolites. We repeatedly analyzed serum samples (n = 41) of different storage durations to identify metabolites showing high quantitative reproducibility, and subsequently analyzed all samples (n = 140). Overall, 189 metabolites were quantified and 66 metabolites had a 20% coefficient of variation and, of these, 24 metabolites showed significant differences among control, benign, and malignant groups (p < 0.05; Steel-Dwass test). Four multiple logistic regression models (MLR) were developed and one MLR model clearly discriminated all disease patients from healthy controls with an area under receiver operating characteristic curve (AUC) of 0.970 (95% confidential interval (CI), 0.946-0.994, p < 0.0001). Another model to discriminate PC from BTC and IPMC yielded AUC = 0.831 (95% CI, 0.650-1.01, p = 0.0020) with higher accuracy compared with tumor markers including carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), pancreatic cancer-associated antigen (DUPAN2) and s-pancreas-1 antigen (SPAN1). Changes in metabolomic profiles might be used to screen for malignant cancers as well as to differentiate between PC and other malignant diseases.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Itoi T,Sugimoto M,Umeda J,Sofuni A,Tsuchiya T,Tsuji S,Tanaka R,Tonozuka R,Honjo M,Moriyasu F,Kasuya K,Nagakawa Y,Abe Y,Takano K,Kawachi S,Shimazu M,Soga T,Tomita M,Sunamura Mdoi
10.3390/ijms18040767subject
Has Abstractpub_date
2017-04-04 00:00:00issue
4issn
1422-0067pii
ijms18040767journal_volume
18pub_type
杂志文章abstract：:Nonobese diabetic (NOD) mice spontaneously develop lacrimal and salivary gland autoimmunity similar to human Sjögren syndrome. In both humans and NOD mice, the early immune response that drives T-cell infiltration into lacrimal and salivary glands is poorly understood. In NOD mice, lacrimal gland autoimmunity spontane...
journal_title：International journal of molecular sciences
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更新日期：2018-10-20 00:00:00
abstract：:Epithelial cell adhesion molecule (EpCAM) is overexpressed in 55%-75% of ovarian carcinomas (OC). EpCAM might be used as a target for a treatment of disseminated OC. Designed ankyrin repeats protein (DARPin) Ec1 is a small (18 kDa) protein, which binds to EpCAM with subnanomolar affinity. We tested a hypothesis that E...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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更新日期：2020-05-07 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2017-06-29 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2020-11-08 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-06-11 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms151120382
更新日期：2014-11-06 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2018-01-11 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2016-06-29 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2019-09-11 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-10-11 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2017-12-16 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2019-06-12 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2014-04-15 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-07-30 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-09-25 00:00:00
abstract：:Spiciformin (1) is a sesquiterpene lactone with a germacrane skeleton that is found in two Tanacetum species endemic to the Canary Islands. In this study, the cytotoxicities of 1 and its acetyl derivative (2) were evaluated against human tumor cells. These sesquiterpene lactones were cytotoxic against human acute myel...
journal_title：International journal of molecular sciences
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更新日期：2020-04-16 00:00:00
abstract：:Citrus fruit are sensitive to chilling injury (CI) during cold storage, a peel disorder that causes economic losses. C-repeat binding factors (CBFs) are related to cold acclimation and tolerance in different plants. To explore the role of Citrus CBFs in fruit response to cold, an in silico study was performed, reveali...
journal_title：International journal of molecular sciences
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abstract：:The mammalian target of rapamycin (mTOR) is the central regulator of mammalian cell growth, and is essential for the formation of two structurally and functionally distinct complexes: mTORC1 and mTORC2. mTORC1 can sense multiple cues such as nutrients, energy status, growth factors and hormones to control cell growth ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2016-09-29 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-01-18 00:00:00
abstract：:Protein-protein interactions are important for the molecular understanding of the biological processes of proteins. The dimerization of bZIPs (basic leucine zipper proteins) is involved in modifying binding site specificities, altering dimer stability, and permitting a new set of specific protein-to-protein interactio...
journal_title：International journal of molecular sciences
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doi：10.3390/ijms150610005
更新日期：2014-06-04 00:00:00
