Does systemic administration of casein phosphopeptides affect orthodontic movement and root resorption in rats?

Abstract:

Objectives:To assess the potential effects of casein phosphopeptides (CPPs) on orthodontically induced iatrogenic root resorption (OIIRR) and orthodontic teeth movement. Materials and methods:Forty Wistar rats (aged 11 weeks) were randomly divided into experimental group (EG; n = 20) that received a diet supplemented with CPP and control group (CG; n = 20) devoid of diet supplement. A 150 g force was applied using nickel titanium (NiTi) coil that was bonded on maxillary incisors and extended unilaterally to a maxillary first molar. At Day 28, animals in both groups were euthanized. Volumetric assessment of root resorption craters and linear measurement of maxillary first molars movement were blindly examined using a micro-computed tomography scan. Results:Nine rats were excluded from the experiment due to loss during general anesthesia or appliances' failure. Intra-operator reproducibility was high in both volumetric and linear measurements, 92.8 per cent and 98.5-97.6 per cent, respectively. The results reveal that dietary CPP has statistically insignificant effect on the overall OIIRR and orthodontic movement. Conclusions:CPP seems to have statistically insignificant effect on the volume of OIIRR and orthodontic movement in rats. A long-term study with larger sample size using a different concentration of CPP is required to clarify the dentoalveolar effect of CPP.

journal_name

Eur J Orthod

authors

Crowther L,Shen G,Almuzian M,Jones A,Walsh W,Oliver R,Petocz P,Tarraf NE,Darendeliler MA

doi

10.1093/ejo/cjw085

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

541-546

issue

5

eissn

0141-5387

issn

1460-2210

pii

2953251

journal_volume

39

pub_type

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