Abstract:
:To study the effects of transforming growth factor beta 2 (TGF-beta 2) on bone resorption, cultures of 17-day-old foetal mouse metatarsal long bones were used. The long bone rudiments were cultured for 5 days in medium supplemented with 10% rat serum. The effects of TGF-beta 2 were studied at concentrations of 1, 4, and 10 ng/ml. At all concentrations TGF-beta 2 caused a significant reduction in osteoclastic resorption measured as release of 45Ca from prelabelled bones. The same long bones were subsequently used for histological evaluations. Pre-osteoclasts and osteoclasts were identified as tartrate resistant acid phosphatase (TRAP) positive cells in the mineralized diaphysis, the periosteum around the diaphysis, and the perichondrium around the cartilaginous ends. The distribution of TRAP-positive cells over the three compartments showed that TGF-beta 2 inhibited the migration of TRAP-positive cells from the periosteum into the mineralized diaphysis in a dose dependent manner. In addition, TGF-beta 2 had a biphasic effect on TRAP cell differentiation, as 1 ng/ml increased, but 4 ng/ml and higher decreased TRAP cell numbers. We conclude that TGF-beta 2 is a potent regulator of osteoclastic bone resorption, by modulating both osteoclast migration and osteoclast differentiation.
journal_name
Eur J Orthodjournal_title
European journal of orthodonticsauthors
Berghuis HM,Dieudonné SC,Goei W,Veldhuijzen JPdoi
10.1093/ejo/16.2.130subject
Has Abstractpub_date
1994-04-01 00:00:00pages
130-7issue
2eissn
0141-5387issn
1460-2210journal_volume
16pub_type
杂志文章abstract::The purpose of this ex vivo study was to compare the bond strengths and modes of failure of brackets bonded with three self-etching products [Adper Prompt L-Pop (3M Espe), Futurabond NR (Voco) and Transbond Plus (3M Unitek)] and a conventional 38 per cent phosphoric acid-etching system Etch-Rite (Pulpdent Corp.) at tw...
journal_title:European journal of orthodontics
pub_type: 杂志文章,随机对照试验
doi:10.1093/ejo/cjn103
更新日期:2009-06-01 00:00:00
abstract::Pre-treatment, end of treatment, and post-retention study models of 30 subjects with a Class II division 2 malocclusion were assessed, after a period of at least 3 years, in order to evaluate the long-term changes in occlusion, alignment, and arch dimensions. Molar relationship correction was found to be stable after ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/21.4.377
更新日期:1999-08-01 00:00:00
abstract::The aim of this study was to investigate the in vivo bonding of orthodontic brackets using two resin-modified glass poly(alkenoate) cements and to compare them with a conventional light-cured diacrylate bonding agent. Twenty consecutive patients attending for bond up appointments took part in this randomized cross-mou...
journal_title:European journal of orthodontics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/ejo/23.4.403
更新日期:2001-08-01 00:00:00
abstract::The effect of protruded mandibular function on the maxilla and zygoma was studied in young unilaterally condylectomized growing rats. Forty-eight-4-week-old rats were divided into two experimental and two control groups as follows: group A, 12 animals unilaterally condylectomized on the right side; the mandible was al...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/19.2.205
更新日期:1997-04-01 00:00:00
abstract::The aim of this cross-sectional study was to determine the prevalence of malocclusions, occlusal traits, and their gender distribution in urban Iranian school children. Five hundred and two subjects (253 females and 249 males, aged 11-14 years) were examined. Molar relationship, overjet (OJ), overbite, midline deviati...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjp031
更新日期:2009-10-01 00:00:00
abstract::Various investigations have mentioned the use of a bonded maxillary expansion appliance. It was postulated that a full coverage of the occlusal surfaces by acrylic would remove interferences during the lateral displacement of the two maxillary bones and would lessen the resistance to maxillary expansion. The first obj...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/oxfordjournals.ejo.a035967
更新日期:1989-02-01 00:00:00
abstract::This study investigated the influence of changing the antero-posterior (AP) and vertical proportions of the lower face on the rankings of facial attractiveness. Four hundred and fifty-four (219 males and 235 females) native Jordanians of various ages and professions rated the attractiveness of a sequence of antero-pos...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjq028
更新日期:2011-02-01 00:00:00
abstract::The surface topography of 100 clinically used archwires of stainless steel, beta-, or nickel-titanium were investigated that had contacted either ceramic or stainless steel brackets. One group consisted of two sets: 60 wires with no treatment records accessed to bias analyses, and 40 wires for which extensive clinical...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/22.4.409
更新日期:2000-08-01 00:00:00
abstract::The aim of this study was to investigate potential occurrence of bacteremia in orthodontic patients after removal of miniscrews.The study group comprised 30 healthy subjects (17 males, 13 females) with a mean age of 24.1 years treated with self-ligating fixed appliances and mini-implant anchorage. Two 20 ml venous blo...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjs099
更新日期:2014-02-01 00:00:00
abstract::The purpose of this study was to describe condylar growth and mandibular remodelling changes associated with bionator therapy. Twenty-five patients (15 males and 10 females) between 6.9 and 11.2 years of age with Class II division 1 malocclusions were randomly allocated to either control (n = 11) or treatment (n = 14;...
journal_title:European journal of orthodontics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/ejo/26.5.515
更新日期:2004-10-01 00:00:00
abstract::The aim of the present study was to examine dentoalveolar development in subjects with an 'ideal' (normal) occlusion. The material comprised 436 study casts of 189 male and 247 female subjects of Swedish origin between the ages of 5 and 31 years with no history of orthodontic treatment. Tooth width, and arch length, w...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjn124
更新日期:2009-04-01 00:00:00
abstract::The aim of the present investigation was to examine position, occlusion, and interproximal contacts of 139 transplanted third molars in 136 patients (94 females, 42 males) with a mean age of 17.6 years at the time of transplantation. Ninety-two teeth were placed directly into favourable positions and left to erupt spo...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjn084
更新日期:2009-04-01 00:00:00
abstract:Background:Orthodontically induced external root resorption (OIRR) is a pathologic consequence of orthodontic tooth movement. However, the limitations of two-dimensional radiography suggest that cone beam computed tomography (CBCT) with its three-dimensional capabilities might be more suitable to assess OIRR. Objectiv...
journal_title:European journal of orthodontics
pub_type: 杂志文章,meta分析
doi:10.1093/ejo/cjy027
更新日期:2019-01-23 00:00:00
abstract:Objective:To investigate effects of mandible advanced device (MAD) therapy for obstructive sleep apnoea-hypopnea syndrome (OSAHS) on the neuron apoptosis and acetylcholine esterase activity in frontal cortex. Materials and methods:Thirty male New Zealand white rabbits were randomly divided into three groups (n = 10 in...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjx060
更新日期:2018-05-25 00:00:00
abstract:Objective:The aim of this in vitro study was to evaluate the progressive development of surface microdamage produced following the insertion of orthodontic miniscrews (OMs) into 1.5 mm thick porcine tibia bone using maximum insertion torque values of 12 Ncm, 18 Ncm, and 24 Ncm. Methods:Aarhus OMs (diameter 1.5 mm; len...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjx026
更新日期:2018-01-23 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the effects of premaxillary advancement with distraction osteogenesis (DO) on the skeletal, dental, and soft tissues. MATERIALS AND METHODS:A total of 21 cases with Angle class I molar relationship and negative overjet or edge-to-edge incisor relationship were included....
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjt056
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Clear aligner is an advanced orthodontic method with benefits of comfort, aesthetics, and convenience. This study aimed to compare pain perception, anxiety, and impacts on oral health-related quality of life (OHRQoL) between adult patients receiving clear aligners and fixed appliances during t...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjaa037
更新日期:2020-07-02 00:00:00
abstract:Background:Orthodontic diagnostic standards generally use the cranial base as a reference and rely on samples selected by orthodontists. Objective:The purpose of this study was to provide male and female standards for a novel non-radiographic approach for orthodontic diagnosis that utilizes 3D dentofacial photogrammet...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjw055
更新日期:2017-04-01 00:00:00
abstract::Many animal experiments dealing with function-form interaction and mandibular condylar growth have utilized hyperpropulsion of the animal's mandible. Numerous hyperpropulsive appliances have been described in the literature. However, there are significant discrepancies between reported results which are most likely du...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/19.1.1
更新日期:1997-02-01 00:00:00
abstract::The performance of 5941 stainless steel orthodontic brackets bonded with a no-mix adhesive (Right-on) in 563 patients was reviewed over a 5-year period. The effects of age and sex of the patient, treatment mechanics, operator experience, and arch location on the failure rate and mean survival time (MST) of bonded orth...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/16.3.203
更新日期:1994-06-01 00:00:00
abstract::The purpose of this study was to qualitatively and quantitatively assess the nickel, chromium, and ferrous levels in a population of 17 orthodontic patients undergoing treatment, compared with seven untreated individuals, employing a novel methodological approach and a new analytical technique. Salivary samples obtain...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/25.1.103
更新日期:2003-02-01 00:00:00
abstract::Cleidocranial dysplasia (CCD) is a rare, well-defined skeletal disorder with autosomal dominant inheritance and complete penetrance. Although it involves the whole skeletal system, the main clinical manifestations of CCD are malformations of the skull and clavicles, which lead to a typical appearance of the face and s...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjq107
更新日期:2011-10-01 00:00:00
abstract::The Beni Solow award for the best article published in the European Journal of Orthodontics in 2014 has been won by: Karoline Dreesen, Steven Swinnen, Koenraad Devriendt, and Carine Carels from Departments of Orthodontics and Human Genetics, Katholieke Universiteit Leuven, Belgium and Department of Orthodontics and Cr...
journal_title:European journal of orthodontics
pub_type: 社论,历史文章
doi:10.1093/ejo/cjv043
更新日期:2015-08-01 00:00:00
abstract::The objective of this research was to investigate the effect of applying a sustained seating force during bonding on the adhesive layer and on shear bond strength (SBS) of orthodontic brackets. Forty human premolars divided into two groups were included in the study. Stainless steel brackets were bonded to the premola...
journal_title:European journal of orthodontics
pub_type: 杂志文章,随机对照试验
doi:10.1093/ejo/cjq096
更新日期:2011-08-01 00:00:00
abstract::Non-syndromic permanent canine agenesis, or combined with agenesis, or developmental absence of other tooth types, has occasionally been described in the literature, but isolated forms are rarely observed. The purpose of the present retrospective radiographic study was to provide data on the prevalence and distributio...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjp018
更新日期:2009-08-01 00:00:00
abstract::Differential scanning calorimetry (DSC) was used to determine the transition temperature ranges (TTR) of four types of super-elastic orthodontic nickel-titanium coil springs (Sentalloy). A knowledge of the TTR provides information on the temperature at which a NiTi wire or spring can assume superelastic properties and...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/21.5.497
更新日期:1999-10-01 00:00:00
abstract::The aim of this study was to explore the complexities in constructing league tables purporting to measure orthodontic clinical outcomes. Eighteen orthodontists were invited to participate in a cost-effectiveness study. Each orthodontist was asked to provide information on 100 consecutively treated patients. The Index ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjn036
更新日期:2008-12-01 00:00:00
abstract::Class II elastics are usually employed in the treatment of excessive overbite and overjet with the Begg technique. The effect of Class II elastics on bite opening and the extent of such an effect is uncertain. This article, based on measurements of 30 cases, illustrates that the effect of the vertical component of for...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/14.4.280
更新日期:1992-08-01 00:00:00
abstract::The purpose of this study was to investigate cephalometrically, the effects of a functional appliance-headgear combination, the Elastic Bite-block (EBB). Of 50 Class II division 1 subjects who participated in this study, 30 made up the treatment group and 20 the control group. All of the selected cases exhibited mandi...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/17.5.375
更新日期:1995-10-01 00:00:00
abstract::Tensile bond strength and bond failure location were evaluated in vitro for two types of aesthetic brackets (non-silanated ceramic, polycarbonate) and one stainless steel bracket, using bovine teeth as the substrate and diacrylate resin as the adhesive. The results show that metallic bracket had the highest bond stren...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/21.1.71
更新日期:1999-02-01 00:00:00