Abstract:
:Cleidocranial dysplasia (CCD) is a rare, well-defined skeletal disorder with autosomal dominant inheritance and complete penetrance. Although it involves the whole skeletal system, the main clinical manifestations of CCD are malformations of the skull and clavicles, which lead to a typical appearance of the face and shoulders. Dental aspects are particularly evident and often eruption difficulties are the first indication for the patient, who does not present any other problem. It has been established that insufficiency of the RUNX-related transcription factor, the core-binding factor alpha 1 (CBFA1) protein, causes CCD. This protein is essential in skeletal development by regulating osteoblast differentiation and chondrocyte maturation. CBFA1 protein is encoded by the RUNX2 gene located on chromosome 6p21. The molecular characterization of the novel RUNX2 gene mutation c.580 + 1G > A in an Italian family (a 27-year-old female, her 54-year-old mother and 24-year-old sister) affected by the typical CCD phenotype, which was proven to alter splicing of the RUNX2 messenger RNA, underscoring the contribution of novel altered splicing mechanism to the aetiology of this disease is presented.
journal_name
Eur J Orthodjournal_title
European journal of orthodonticsauthors
Marchisella C,Rolando F,Muscarella LA,Zelante L,Bracco P,Piemontese MRdoi
10.1093/ejo/cjq107subject
Has Abstractpub_date
2011-10-01 00:00:00pages
498-502issue
5eissn
0141-5387issn
1460-2210pii
cjq107journal_volume
33pub_type
杂志文章abstract::The purpose of this study was to investigate cephalometrically, the effects of a functional appliance-headgear combination, the Elastic Bite-block (EBB). Of 50 Class II division 1 subjects who participated in this study, 30 made up the treatment group and 20 the control group. All of the selected cases exhibited mandi...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/17.5.375
更新日期:1995-10-01 00:00:00
abstract::Malocclusion assessment methods are based on measurements of study casts, which requires that impressions be taken. In addition to being costly and time consuming, this process can be unpleasant for children. Therefore, the aim of this study was to evaluate intra- and inter-examiner reliability of intraoral score meas...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjl064
更新日期:2007-02-01 00:00:00
abstract::The effect of contamination by dietary oil on acid etching has not been reported in the literature. If dietary oil adversely affects acid etching, then a decrease in bond strength is expected. This in vitro study investigated the bond strength of brackets bonded to tooth surfaces that had been contaminated with dietar...
journal_title:European journal of orthodontics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/ejo/19.2.109
更新日期:1997-04-01 00:00:00
abstract::The present study reveals new data concerning the prenatal interrelationship between maturation of teeth and basicranial bones. By using radiographs of the mid-sagittal tissue segment of 43 human craniums, the developmental relationship between a well-defined stage of the central maxillary incisor development and the ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/15.2.149
更新日期:1993-04-01 00:00:00
abstract::The aim of this study was to assess the severity of any underlying malocclusion in subjects presenting for treatment of a palatally impacted canine (PIC) using a modification of the Dental Health Component (DHC) of the Index of Treatment Need (MIOTN), which does not factor in the impacted canine. The pre-treatment stu...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjn130
更新日期:2009-08-01 00:00:00
abstract::The aetiology of palatal canine impaction is unclear. The aim of this research was to investigate the occlusal features that could contribute to the aetiology of palatal maxillary canine impaction. The material consisted of the pre-treatment dental casts of 34 patients (27 female and seven male) with unilateral palata...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cji022
更新日期:2005-10-01 00:00:00
abstract::This radiographic study analysed the changes that occurred in the airway and surrounding structures when subjects with sleep disordered breathing moved from the upright to the supine position. Radiographs of 100 dentate, Caucasian males were examined. Fifty individuals were non-apnoeic snorers and in 50 a diagnosis of...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/24.3.263
更新日期:2002-06-01 00:00:00
abstract::Unilateral tip-back mechanics are challenging because of a number of undesirable side-effects associated with their use during orthodontic treatment. The purpose of this paper is to review the differential diagnosis and treatment planning of Class II subdivision malocclusions and present a treatment strategy based on ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/19.1.93
更新日期:1997-02-01 00:00:00
abstract::Many animal experiments dealing with function-form interaction and mandibular condylar growth have utilized hyperpropulsion of the animal's mandible. Numerous hyperpropulsive appliances have been described in the literature. However, there are significant discrepancies between reported results which are most likely du...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/19.1.1
更新日期:1997-02-01 00:00:00
abstract::The purpose of this study was to describe condylar growth and mandibular remodelling changes associated with bionator therapy. Twenty-five patients (15 males and 10 females) between 6.9 and 11.2 years of age with Class II division 1 malocclusions were randomly allocated to either control (n = 11) or treatment (n = 14;...
journal_title:European journal of orthodontics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/ejo/26.5.515
更新日期:2004-10-01 00:00:00
abstract::This clinical study investigated the practical value of two methods for debonding brackets attached by the adhesive Concise to acid-etched enamel surfaces. Forty-two Ultratrimm Standard metal brackets and 42 Fascination ceramic brackets were collected from juvenile patients undergoing orthodontic treatment. All metal ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/18.6.655
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:Facial asymmetry is very common in adult class III patients; however, the degree of facial asymmetry in growing class III subjects has been poorly investigated. Therefore, the aim was to assess the degree of facial asymmetry of growing class III subjects and to compare it with a sample of growing s...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjt069
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVE:To investigate the factors associated with the change in alveolar bone level of mandibular second and third molars after second molar protraction into the space of the missing first molar (L6) or second premolar (LE). METHODS:Fifty-one patients in whom space of the missing L6 or LE was treated with second mo...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjz001
更新日期:2019-09-21 00:00:00
abstract:OBJECTIVES:Loosening and loss rates of monocortical mini-implants are relatively high, therefore the following null hypothesis was tested: 'The local bone stress in mono and bicortically-anchored mini-implants is identical'. MATERIAL AND METHODS:Anisotropic Finite Element Method (FEM) models of the mandibular bone, in...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjt023
更新日期:2014-10-01 00:00:00
abstract::The purpose of this work was to examine whether the clinical eruption of the permanent first molars and incisors is affected by pre-term birth. The data applied to 328 prematurely born white and black children and 1804 control children who participated in the Collaborative Perinatal Project (USA) in the early 1960s an...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/25.3.293
更新日期:2003-06-01 00:00:00
abstract:Objective:To assess the dental, skeletal, and profile changes after functional appliances and subsequent fixed appliances treatment in order to quantify their effect and evaluate the influence of initial incisal inclination and growth pattern. Materials and methods:A retrospective cephalometric analysis was performed ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjw064
更新日期:2017-06-01 00:00:00
abstract::Many more adults are undergoing orthodontic therapy than in the past. Since adult dentitions often exhibit diminished alveolar support, it is important to recognize the related apical migration of the dental centre of resistance when applying force systems to the teeth. The force system compensations necessary to prod...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/15.1.73
更新日期:1993-02-01 00:00:00
abstract::This retrospective, cephalometric study was undertaken in an attempt to identify the aetiological features which may be associated with a Class III malocclusion in the growing child. Four-hundred-and-ninety-five lateral cephalometric radiographs (210 control and 285 Class III films) formed the basis of the study. All ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/15.5.347
更新日期:1993-10-01 00:00:00
abstract::The aim of this cross-sectional study was to determine the prevalence of malocclusions, occlusal traits, and their gender distribution in urban Iranian school children. Five hundred and two subjects (253 females and 249 males, aged 11-14 years) were examined. Molar relationship, overjet (OJ), overbite, midline deviati...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjp031
更新日期:2009-10-01 00:00:00
abstract::The purpose of this study was to examine the natural growth changes which occur between 22 and 33 years of age. The material consisted of two series of cephalograms of 74 females and 90 males with approximately 11 years between the two series. None of the subjects had orthodontic retainers when the first exposure was ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/17.6.525
更新日期:1995-12-01 00:00:00
abstract:BACKGROUND:No reliable predictive factors for treatment (Tx) success and outcome quality in Class II:1 Tx have been identified yet. OBJECTIVE:To assess the influence of pre-Tx Class II severity and skeletal maturity on outcome quality after Herbst-multibracket appliance (MBA) Tx. SUBJECTS AND METHODS:All Class II:1 p...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjaa052
更新日期:2020-09-24 00:00:00
abstract:SUMMARY:The aim of this study was to evaluate the effects of orthodontic treatment on systemic levels of the inflammatory markers, C-reactive protein (CRP), tumour necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6). The study group comprised 11 girls and 6 boys (mean age 13.1 years) treated with fixed applianc...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjp108
更新日期:2010-08-01 00:00:00
abstract::This retrospective study examined the occurrence of congenitally missing permanent teeth and the need for dental treatment in the Regensburg University Medical Centre of Eastern Bavaria. Using a dental administration software tool, a total of 1442 patients who presented for orthodontic treatment between 1994 and 2006 ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjq021
更新日期:2011-02-01 00:00:00
abstract::The purpose of the study is to determine whether the various aspects of the craniofacial complex exhibit female adolescent growth spurts. Multilevel polynomial models were used to estimate the growth curves of a mixed-longitudinal sample of 111 untreated females 10-15 years of age. To evaluate the horizontal and verti...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjs094
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:To assess intra- and inter-observer reproducibility of the evaluation of the Frӓnkel Manoeuvre (FM) on three-dimensional (3D) scans and to compare it to the assessment on two-dimensional (2D) pictures. MATERIALS/METHODS:This study included 44 individuals with a skeletal Class II malocclusion [9-1...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjz081
更新日期:2020-04-01 00:00:00
abstract::P561T heterozygous missense mutation in the growth hormone receptor (GHR) is a candidate genetic polymorphism (single-nucleotide polymorphism) for human mandibular growth. The purpose of this study was to assess whether this mutation affects mandibular growth during early childhood. The difference in mandibular growth...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjp017
更新日期:2009-10-01 00:00:00
abstract::It is well known that elastomers exhibit viscoelasticity and as such have their mechanical properties modified by temperature. Nickel titanium archwires are also affected by temperature and have been modified with specific temperature related properties for clinical use. What is less well known is the effect that othe...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/20.2.169
更新日期:1998-04-01 00:00:00
abstract:OBJECTIVES:Mechanobiology phenomena constitute a major element of the cellular and tissue response during orthodontic treatment and the implantation of a biomaterial. Better understanding these phenomena will improve the effectiveness of our treatments. The objective of this work is to validate a model of three-dimensi...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjaa017
更新日期:2020-09-11 00:00:00
abstract::The purpose of this study was to compare the effect of overjet and overbite correction in non-extraction and extraction therapy in a sample of Class II malocclusions treated with the Edgewise appliance. The subjects were 20 children treated without extraction and 20 children treated with extraction of the four first p...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/oxfordjournals.ejo.a035984
更新日期:1989-05-01 00:00:00
abstract::The aim of this investigation was to compare Swedish and immigrant groups of 12- and 13-year-old boys and girls with respect to: (1) self-perceived need for and attitude to orthodontic treatment, (2) attitude to own teeth and general appearance, (3) behaviour pattern and psychosocial functioning, and (4) self-perceive...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjh070
更新日期:2005-04-01 00:00:00