Abstract:
:Cleidocranial dysplasia (CCD) is a rare, well-defined skeletal disorder with autosomal dominant inheritance and complete penetrance. Although it involves the whole skeletal system, the main clinical manifestations of CCD are malformations of the skull and clavicles, which lead to a typical appearance of the face and shoulders. Dental aspects are particularly evident and often eruption difficulties are the first indication for the patient, who does not present any other problem. It has been established that insufficiency of the RUNX-related transcription factor, the core-binding factor alpha 1 (CBFA1) protein, causes CCD. This protein is essential in skeletal development by regulating osteoblast differentiation and chondrocyte maturation. CBFA1 protein is encoded by the RUNX2 gene located on chromosome 6p21. The molecular characterization of the novel RUNX2 gene mutation c.580 + 1G > A in an Italian family (a 27-year-old female, her 54-year-old mother and 24-year-old sister) affected by the typical CCD phenotype, which was proven to alter splicing of the RUNX2 messenger RNA, underscoring the contribution of novel altered splicing mechanism to the aetiology of this disease is presented.
journal_name
Eur J Orthodjournal_title
European journal of orthodonticsauthors
Marchisella C,Rolando F,Muscarella LA,Zelante L,Bracco P,Piemontese MRdoi
10.1093/ejo/cjq107subject
Has Abstractpub_date
2011-10-01 00:00:00pages
498-502issue
5eissn
0141-5387issn
1460-2210pii
cjq107journal_volume
33pub_type
杂志文章abstract::Shared decision making between children and parents is required in orthodontics. This study compared agreement among mothers, fathers, and children regarding the oral health-related quality of life (OHRQoL) of children. A sample of 71 child patients (41 girls and 30 boys) aged 12.6 years with an orthodontic treatment ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjl058
更新日期:2007-04-01 00:00:00
abstract::A clinical trial was undertaken to assess the value of incorporating fluoride released from a commercially available bonding adhesive (Rely-a-Bond) to determine the extent of any protection provided against enamel decalcification. Fifty patients undergoing fixed appliance therapy were included in the trial. Contralate...
journal_title:European journal of orthodontics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/ejo/19.4.391
更新日期:1997-08-01 00:00:00
abstract::The aim of this laboratory-based study was to investigate the effects of different combinations of tip and torque upon friction between an orthodontic bracket and archwire using a specially made jig. Victory Twin Series upper premolar brackets (3M Unitek) were mounted on a jig, which allowed tip and torque values in t...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjn017
更新日期:2008-10-01 00:00:00
abstract::The aim of this study was to determine whether Fluor Protector, a fluoride varnish, applied to molars before orthodontic banding could prevent white spot formation. In the in vitro study 93 human premolars were used, divided in five different groups, representing different clinical situations. Each tooth was sliced in...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/12.3.316
更新日期:1990-08-01 00:00:00
abstract:Background:Orthodontic diagnostic standards generally use the cranial base as a reference and rely on samples selected by orthodontists. Objective:The purpose of this study was to provide male and female standards for a novel non-radiographic approach for orthodontic diagnosis that utilizes 3D dentofacial photogrammet...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjw055
更新日期:2017-04-01 00:00:00
abstract::The aim of this study was to test the hypothesis that there is no difference in salivary metal ion content between subjects with fixed orthodontic appliances and their same-gender sister or brother without any orthodontic appliance. This retrospective study was carried out on 28 subjects (16 females and 12 males) who ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjq181
更新日期:2012-02-01 00:00:00
abstract::The aim of this longitudinal study was to monitor patients' microbiological and clinical parameters from bracket placement up to 3 months post-treatment. Twenty-four patients (10 males and 14 females, aged 14.6 ± 1.0 years) were included in this investigation. Microbiology (sub- and supragingival), periodontal probing...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjq032
更新日期:2011-02-01 00:00:00
abstract::This retrospective study examined the occurrence of congenitally missing permanent teeth and the need for dental treatment in the Regensburg University Medical Centre of Eastern Bavaria. Using a dental administration software tool, a total of 1442 patients who presented for orthodontic treatment between 1994 and 2006 ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjq021
更新日期:2011-02-01 00:00:00
abstract::The performance of 5941 stainless steel orthodontic brackets bonded with a no-mix adhesive (Right-on) in 563 patients was reviewed over a 5-year period. The effects of age and sex of the patient, treatment mechanics, operator experience, and arch location on the failure rate and mean survival time (MST) of bonded orth...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/16.3.203
更新日期:1994-06-01 00:00:00
abstract:OBJECTIVE:This study investigated the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in the compression area during orthodontic relapse in rat molars. MATERIALS AND METHODS:Thirty Wistar rats (6 weeks old) underwent orthodontic tooth movement (OTM) of the left first maxillary molar for 21 days,...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjz046
更新日期:2020-06-23 00:00:00
abstract::The aim of the present study was to establish whether the early signs of various orofacial dysfunctions, malocclusions, or occlusal interferences can predict the development of temporomandibular dysfunction (TMD) in young adults. Forty-eight subjects referred for speech therapy and 49 controls participated in all four...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/26.4.367
更新日期:2004-08-01 00:00:00
abstract::The purpose of this study was to determine whether an additional application of Fluor Protector before band cementation with glass ionomer cement reduces white spot formation compared with band cementation with glass ionomer cement. In the in vitro study, 80 premolars were divided in half, creating a control and a tes...
journal_title:European journal of orthodontics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/ejo/20.3.219
更新日期:1998-06-01 00:00:00
abstract::The aim of this study was to develop a valid and reproducible index of orthodontic treatment priority. After reviewing the available literature, it was felt that this could be best achieved by using two separate components to record firstly the dental health and functional indications for treatment, and secondly the a...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/oxfordjournals.ejo.a035999
更新日期:1989-08-01 00:00:00
abstract::This prospective study analysed the lateral cephalometric radiographs of 59 dentate, white, Caucasian males. Thirty-five patients with proven obstructive sleep apnoea (OSA) formed the experimental group, while 24 subjects with no history of respiratory disease acted as controls. Radiographs were traced and digitized, ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/18.6.557
更新日期:1996-12-01 00:00:00
abstract:AIMS:The aim of this work was to investigate the effects of commonly used orthodontic appliances on the magnetic resonance (MR) image quality of the craniofacial region, with special interest in the soft palate and velopharyngeal wall using real-time speech imaging sequences and anatomical imaging of the temporomandibu...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cju103
更新日期:2015-12-01 00:00:00
abstract::P561T heterozygous missense mutation in the growth hormone receptor (GHR) is a candidate genetic polymorphism (single-nucleotide polymorphism) for human mandibular growth. The purpose of this study was to assess whether this mutation affects mandibular growth during early childhood. The difference in mandibular growth...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjp017
更新日期:2009-10-01 00:00:00
abstract::A logical basis for the sequence of wires chosen during orthodontic treatment with fixed appliances is presented. This utilizes a new more realistic model for the radial deflection of a segment of the archwire in which the wire is restrained by the ligatures on the misaligned tooth, contacts the inner edges of the bra...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/14.3.240
更新日期:1992-06-01 00:00:00
abstract::The aim of this in vitro study was to investigate both shear bond strength (SBS) by shear testing of indirectly bonded brackets, and the accuracy of a new transfer method, the Aptus bonding device (ABD). For comparison, the SBS of directly bonded brackets in two experimental arrangements was also measured. The precisi...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjm094
更新日期:2008-02-01 00:00:00
abstract::The purpose of this study was to investigate the effects of rapid maxillary expansion (RME) and semi-rapid maxillary expansion (SRME) in the mixed dentition period. The SRME group consisted of 18 patients (11 girls and 7 boys) with a mean age of 8.63 +/- 1.09 years and the RME group 17 patients (11 girls and 6 boys) w...
journal_title:European journal of orthodontics
pub_type: 杂志文章,随机对照试验
doi:10.1093/ejo/cjp057
更新日期:2010-02-01 00:00:00
abstract::The aim of the present study was to examine dentoalveolar development in subjects with an 'ideal' (normal) occlusion. The material comprised 436 study casts of 189 male and 247 female subjects of Swedish origin between the ages of 5 and 31 years with no history of orthodontic treatment. Tooth width, and arch length, w...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjn124
更新日期:2009-04-01 00:00:00
abstract:Background and objectives:Apart from the primary effect of bite-blocks on tooth position, they may also influence the mandibular condylar growth. Our aim was to investigate their influence on the condylar morphology, with variable masticatory forces. Material and methods:Fifty-two 4-week old male rats were divided int...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjx072
更新日期:2018-05-25 00:00:00
abstract::The long-term goal of this research is to define the dimensions of nasal airway adequacy in children. Nasal airway size and variables associated with growth were assessed in 138 healthy children aged 7-15 years. The pressure-flow technique (Warren, 1984) was used to calculate the smallest cross-sectional area of the n...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/13.4.311
更新日期:1991-08-01 00:00:00
abstract::The aim of this randomized controlled trial was to assess the effectiveness of a mandibular advancement appliance (MAA) in managing severe snoring. Twenty-eight adults with severe snoring and normal overnight oximetry were recruited from sleep disorder clinics. A maxillary placebo appliance and a MAA were worn by each...
journal_title:European journal of orthodontics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/ejo/23.2.127
更新日期:2001-04-01 00:00:00
abstract::The aim of this study was to explore the complexities in constructing league tables purporting to measure orthodontic clinical outcomes. Eighteen orthodontists were invited to participate in a cost-effectiveness study. Each orthodontist was asked to provide information on 100 consecutively treated patients. The Index ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjn036
更新日期:2008-12-01 00:00:00
abstract:Background/objective:The aim of this study was to evaluate the efficacy of tooth alignment with conventional and self-ligating labial and lingual orthodontic bracket systems. Materials/methods:We tested labial brackets (0.022″ slot size) and lingual brackets (0.018″ slot size). The labial brackets were: (i) regular tw...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjy005
更新日期:2018-11-30 00:00:00
abstract::This study investigated the changes in the initial centres of rotation (Crot) of the upper six anterior teeth in response to a horizontal load. Six upper anterior teeth were extracted, splinted as a unit, and embedded in dental stone after the roots were uniformly coated with silicone. An aluminium fixture was bonded ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjl023
更新日期:2006-10-01 00:00:00
abstract::Unilateral tip-back mechanics are challenging because of a number of undesirable side-effects associated with their use during orthodontic treatment. The purpose of this paper is to review the differential diagnosis and treatment planning of Class II subdivision malocclusions and present a treatment strategy based on ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/19.1.93
更新日期:1997-02-01 00:00:00
abstract::This retrospective, cephalometric study was undertaken in an attempt to identify the aetiological features which may be associated with a Class III malocclusion in the growing child. Four-hundred-and-ninety-five lateral cephalometric radiographs (210 control and 285 Class III films) formed the basis of the study. All ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/15.5.347
更新日期:1993-10-01 00:00:00
abstract::It has previously been shown by light (LM) and scanning electron microscopy (SEM), that after force is terminated, repair of the orthodontic root resorption lacunae occur by deposition of new cementum. The ultrastructural details of the process are not well established. Since it has been hypothesized that a new barrie...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/17.3.189
更新日期:1995-06-01 00:00:00
abstract::This study evaluated the effect of sandblasting foil mesh molar tube bases on the shear bond strength obtained when bonding to first molar teeth. Fifty-two recently extracted first molar teeth were etched with 35 per cent phosphoric acid gel for 30 seconds. Twenty-six sandblasted 'A' Company molar tube attachments and...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/21.3.311
更新日期:1999-06-01 00:00:00