Abstract:
Objective:To investigate effects of mandible advanced device (MAD) therapy for obstructive sleep apnoea-hypopnea syndrome (OSAHS) on the neuron apoptosis and acetylcholine esterase activity in frontal cortex. Materials and methods:Thirty male New Zealand white rabbits were randomly divided into three groups (n = 10 in each group): group OSAHS, group MAD, and control group. Hydrophilic polyacrylamide gel was injected into soft palate of the animals to induce OSAHS in group OSAHS and group MAD. The group MAD animals wore MAD to relief the obstructiveness. The control group was not given any treatment. Computed tomography (CT) examination of the upper airway and polysomnography (PSG) recordings were performed in supine position. All rabbits were induced to sleep in a supine position for 4 to 6 hours every day and were observed for consecutive 8 weeks. The frontal cortices of three groups were dissected and the neuron apoptosis was detected by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and flow cytometry. Acetylcholine esterase (AchE) activity in the frontal cortex was measured by spectrophotometry. Results:The group OSAHS exhibited high neuron apoptosis rate and low AchE activity than those of group MAD and control group. The blood oxygen saturation was negatively correlated with neuronal apoptosis rate and positively correlated with AchE activity. Applying MAD in OSAHS animals significantly improve the neuronal damage and function deficits by apnoea-hypoxia caused by narrowed upper airway. Conclusion:This study provided evidence that MAD therapy for OSAHS can significantly decrease neuronal apoptosis and increase AchE activity in the frontal cortex.
journal_name
Eur J Orthodjournal_title
European journal of orthodonticsauthors
Lu HY,Wang W,Zhou Z,Liu CY,Liu Y,Xiao W,Dong FS,Wang Jdoi
10.1093/ejo/cjx060subject
Has Abstractpub_date
2018-05-25 00:00:00pages
273-280issue
3eissn
0141-5387issn
1460-2210pii
4191336journal_volume
40pub_type
杂志文章abstract:BACKGROUND:Low-frequency vibrations have been proposed as a means of accelerating tooth movement and reducing orthodontic treatment times. OBJECTIVE:To determine any differences in the accuracy of dental movement in patients treated with a low-frequency vibration aligner protocol and/or by reducing the aligner replace...
journal_title:European journal of orthodontics
pub_type: 杂志文章,随机对照试验
doi:10.1093/ejo/cjy076
更新日期:2019-08-08 00:00:00
abstract::Reduced nasal airflow can be the result of enlarged adenoids, hypertrophic turbinates, severely deviated nasal septum, or even narrow nasal cavities. The question of whether the width of the nasal cavity may influence certain facial dimensions examined on the postero-anterior cephalometric X-ray was evaluated through ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/13.5.410
更新日期:1991-10-01 00:00:00
abstract::The aims of this study were to evaluate the frequency of errors in panoramic radiographs in young orthodontic patients, to register pathologic and abnormal conditions, and to compare these findings with the patient's record. A total of 1287 panoramic radiographs of children and adolescents (530 boys and 757 girls; mea...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjr035
更新日期:2012-08-01 00:00:00
abstract::In 69 individuals from a randomized epidemiological material comprising 450 adults, an intra-individual comparison of the periodontal condition of 73 mesially tipped molars (30 degrees or more to a line perpendicular to the occlusal plane) and contralateral upright molars was made. The alveolar bone level mesially and...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/14.6.449
更新日期:1992-12-01 00:00:00
abstract:Background:Orthodontic diagnostic standards generally use the cranial base as a reference and rely on samples selected by orthodontists. Objective:The purpose of this study was to provide male and female standards for a novel non-radiographic approach for orthodontic diagnosis that utilizes 3D dentofacial photogrammet...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjw055
更新日期:2017-04-01 00:00:00
abstract::Clinical outcomes in children born with a cleft lip and palate (CLP) have been an area of interest for orthodontists for a number of years. Whilst tools for measurement of these outcomes are available, there is no widely accepted measure of initial cleft severity and no known quantitative indices. Therefore, the poten...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/22.1.93
更新日期:2000-02-01 00:00:00
abstract:Background:Detection of pubertal growth peak is vital in orthodontic treatment timing and planning. Gingival crevicular fluid (GCF) contains abundant proteins from different sources and is an ideal source of biomarkers. The aim of this research is to detect candidate GCF biomarkers of pubertal growth by tandem mass tag...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjx082
更新日期:2018-07-27 00:00:00
abstract::Corrosion of orthodontic miniscrews or temporary anchorage devices (TADs) has been proposed as a contributor to inflammation, which in turn is a factor in the clinical success of miniscrews. The purpose of this study was to measure the electrochemical properties of orthodontic miniscrews in artificial saliva with and ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjs027
更新日期:2013-08-01 00:00:00
abstract:Aim:To assess the association between tooth wear (TW) and gingival recession (GR). Materials and Methods:Two hundred and ten orthodontically treated participants (100 males) were evaluated. GR and TW were rated independently by four raters on plaster models at four time points: before treatment (T1), mean age 13.8 yea...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjx083
更新日期:2018-07-27 00:00:00
abstract::The mechanics of the quadhelix maxillary expansion appliance have been derived using the complementary (strain) energy approach, and the results checked experimentally on enlarged models. Good agreement between theory and experiment was obtained, for both the lateral stiffness and the magnitude of the molar couple ind...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/oxfordjournals.ejo.a035980
更新日期:1989-05-01 00:00:00
abstract:OBJECTIVE:This study investigated the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in the compression area during orthodontic relapse in rat molars. MATERIALS AND METHODS:Thirty Wistar rats (6 weeks old) underwent orthodontic tooth movement (OTM) of the left first maxillary molar for 21 days,...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjz046
更新日期:2020-06-23 00:00:00
abstract::Malocclusion assessment methods are based on measurements of study casts, which requires that impressions be taken. In addition to being costly and time consuming, this process can be unpleasant for children. Therefore, the aim of this study was to evaluate intra- and inter-examiner reliability of intraoral score meas...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjl064
更新日期:2007-02-01 00:00:00
abstract::The aim of this investigation was to determine the pattern of repair of root resorption regarding the location and type of tissue in adolescents after application of a well-controlled force magnitude. In 16 adolescents (mean age 13.8 years), the maxillary first premolars were buccally moved with a weekly reactivated f...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/20.6.727
更新日期:1998-12-01 00:00:00
abstract::This paper describes and illustrates an innovative versatile skull-holding device for experimental research in cephalometrics. Repositioning of the skulls was evaluated and found to be highly reproducible. ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/18.2.193
更新日期:1996-04-01 00:00:00
abstract::Orthodontic bonding with glass ionomer cement is comparatively new. The purpose of this article is to review the current literature covering both in vitro and in vivo studies of various glass ionomer cements that have been used for orthodontic bonding. The review indicates that there is little support in the literatur...
journal_title:European journal of orthodontics
pub_type: 杂志文章,评审
doi:10.1093/ejo/18.4.385
更新日期:1996-08-01 00:00:00
abstract::This study investigated whether there were differences between the debond stress and adhesive remnant index (ARI) of an adhesive cured with three different orthodontic light sources. Sixty sound premolar teeth were divided into three groups of 20. A standard pre-adjusted edgewise premolar bracket (Victory Series) was ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cji076
更新日期:2006-02-01 00:00:00
abstract::The purpose of this laboratory study was to assess the potential cleaning efficacy of nine different toothbrushes around brackets in vitro. Standard and Mini Diamond brackets were fixed on coloured teeth in a special model, coated with white titanium oxide, brushed in a machine with different manual toothbrushes (thre...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjn070
更新日期:2009-02-01 00:00:00
abstract::Unilateral tip-back mechanics are challenging because of a number of undesirable side-effects associated with their use during orthodontic treatment. The purpose of this paper is to review the differential diagnosis and treatment planning of Class II subdivision malocclusions and present a treatment strategy based on ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/19.1.93
更新日期:1997-02-01 00:00:00
abstract::The purpose of this study was to describe condylar growth and mandibular remodelling changes associated with bionator therapy. Twenty-five patients (15 males and 10 females) between 6.9 and 11.2 years of age with Class II division 1 malocclusions were randomly allocated to either control (n = 11) or treatment (n = 14;...
journal_title:European journal of orthodontics
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-10-01 00:00:00
abstract::The purpose of this study was to evaluate the Denture Frame Analysis. This adjunctive cephalometric analysis of the lateral headfilm was introduced in Japan, but no data exist for the Caucasian population at present. One-hundred-and-six Caucasians were randomly selected and assigned to one of four groups, according to...
journal_title:European journal of orthodontics
pub_type: 杂志文章
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更新日期:1998-10-01 00:00:00
abstract:Background/objective:To assess the validity and reliability of a series of three questionnaires for the quantification of patient perception of fixed appliance orthodontic treatment. Subjects and methods:The study was carried out at the University of Dundee with content and face validity being assessed using proformas...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjw076
更新日期:2017-08-01 00:00:00
abstract::The aim of this study was to identify the craniofacial characteristics of 16 osteogenesis imperfecta (OI) patients, 10 males and 6 females, aged 7-15 years. The control group comprised 863 Chinese children from 6 to 18 years of age. Eleven cephalometric reference points and 25 variables were measured on the lateral ce...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjl035
更新日期:2007-06-01 00:00:00
abstract::The aims of this study were to investigate the effects of two surface-conditioning methods on the shear bond strength (SBS) of metal brackets bonded to three different all-ceramic materials, and to evaluate the mode of failure after debonding. Twenty feldspathic, 20 fluoro-apatite, and 20 leucite-reinforced ceramic sp...
journal_title:European journal of orthodontics
pub_type: 杂志文章,随机对照试验
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更新日期:2011-12-01 00:00:00
abstract::The aim of the present study was to examine dentoalveolar development in subjects with an 'ideal' (normal) occlusion. The material comprised 436 study casts of 189 male and 247 female subjects of Swedish origin between the ages of 5 and 31 years with no history of orthodontic treatment. Tooth width, and arch length, w...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjn124
更新日期:2009-04-01 00:00:00
abstract::The purpose of this investigation was to evaluate the effects of dental tipping and rotation immediately after surgically assisted rapid palatal expansion (SARPE). Fourteen patients (10 females, four males; mean age 25.6 years) who required a SARPE procedure were available for this study. A palatal expander appliance ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/25.4.353
更新日期:2003-08-01 00:00:00
abstract:Background:Hawley retainers (HRs) and vacuum formed retainers (VFRs) are the most commonly used removable retainers in the orthodontic practice. Patients' cooperation in wearing these appliances is affected by the levels of discomfort and oral impairment. The evidence regarding their acceptably among orthodontic patien...
journal_title:European journal of orthodontics
pub_type: 杂志文章,随机对照试验
doi:10.1093/ejo/cjx024
更新日期:2017-08-01 00:00:00
abstract:SUMMARY:The purpose of this study was to assess the short-term psychosocial impact of dental aesthetic improvement in adult subjects. Sixty-nine adult patients (61 females and 8 males, aged 21-59 years) requesting aesthetic dental improvement were prospectively and randomly recruited for the study in a private orthodon...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjp144
更新日期:2010-08-01 00:00:00
abstract::The purpose of this study was to evaluate the outcome of a scheme for provision of orthognathic surgery by examining whether patients' expectations were fulfilled as well as their opinions about the result of treatment and side-effects. Data were obtained during a pre-planned 3-year follow-up clinical examination whic...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjm081
更新日期:2008-02-01 00:00:00
abstract::P561T heterozygous missense mutation in the growth hormone receptor (GHR) is a candidate genetic polymorphism (single-nucleotide polymorphism) for human mandibular growth. The purpose of this study was to assess whether this mutation affects mandibular growth during early childhood. The difference in mandibular growth...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjp017
更新日期:2009-10-01 00:00:00
abstract::A retrospective cephalometric study was made of the hard tissue changes in a group of 90 Class III, Skeletal III children, diagnosed as suitable for treatment by orthodontic means alone. Thirty-two were treated by a combination of upper incisor proclination and headgear to an intact mandibular dentition (Group 1), whi...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/13.3.212
更新日期:1991-06-01 00:00:00