Abstract：
:P561T heterozygous missense mutation in the growth hormone receptor (GHR) is a candidate genetic polymorphism (single-nucleotide polymorphism) for human mandibular growth. The purpose of this study was to assess whether this mutation affects mandibular growth during early childhood. The difference in mandibular growth between P561T heterozygous and wild-type individuals was analysed by cephalometric measurements during childhood. The subjects included 33 children with mandibular protrusion (aged 3-12 years, 16 males and 17 females) and 27 normal children (aged 3-13 years, 14 males and 13 females). Genomic DNA extracted from buccal epithelial cells was genotyped for the P561T heterozygous mutation with a molecular analysis (polymerase chain reaction--restriction fragment length polymorphism method). Two of the patients with normal occlusion and five with mandibular protrusion were heterozygous for the mutation. Chi-square analysis showed that the frequency of this mutation did not differ statistically between the normal and mandibular protrusion subjects. Multilevel model analysis of the 101 cephalograms showed that the mutation reduced the linear measurements of the mandible. These findings suggest that P561T heterozygous mutation affects mandibular growth during early childhood, and this mutation in the GHR gene is hypothesized to function as an inhibitory factor in the process of mandibular growth.
journal_name
Eur J Orthodjournal_title
European journal of orthodonticsauthors
Sasaki Y,Satoh K,Hayasaki H,Fukumoto S,Fujiwara T,Nonaka Kdoi
10.1093/ejo/cjp017subject
Has Abstractpub_date
2009-10-01 00:00:00pages
536-41issue
5eissn
0141-5387issn
1460-2210pii
cjp017journal_volume
31pub_type
杂志文章abstract：:The purpose of this study was to determine whether an additional application of Fluor Protector before band cementation with glass ionomer cement reduces white spot formation compared with band cementation with glass ionomer cement. In the in vitro study, 80 premolars were divided in half, creating a control and a tes...
journal_title：European journal of orthodontics
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1998-06-01 00:00:00
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journal_title：European journal of orthodontics
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journal_title：European journal of orthodontics
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journal_title：European journal of orthodontics
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journal_title：European journal of orthodontics
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更新日期：2014-08-01 00:00:00
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更新日期：2011-12-01 00:00:00
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journal_title：European journal of orthodontics
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journal_title：European journal of orthodontics
pub_type： 杂志文章
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