Abstract:
Background:Detection of pubertal growth peak is vital in orthodontic treatment timing and planning. Gingival crevicular fluid (GCF) contains abundant proteins from different sources and is an ideal source of biomarkers. The aim of this research is to detect candidate GCF biomarkers of pubertal growth by tandem mass tags (TMT) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) to help diagnosis and treatment planning of functional treatment. Methods:Forty subjects were recruited and were divided into pubertal and post-pubertal groups according to cervical vertebral maturation method. GCF samples were collected by paper points. GCF proteome of pubertal and post-pubertal subjects was compared by TMT labelling coupled with LC-MS/MS. Results:A total of 537 proteins were detected in GCF samples, with 183 proteins detected in GCF for the first time. These proteins were involved in processes of immune response, ion transport, and signal transduction. The GCF concentration of vitamin D binding protein (DBP) and seroserotransferrin (Tf) was significantly higher in pubertal than that in post-pubertal subjects. DBP and Tf, therefore, were considered to be candidate biomarkers of pubertal growth. This result was validated using GCF samples from new subjects (P < 0.05). Conclusion:Our results indicate that TMT labelling coupled with LC-MS/MS were proved to be a useful method for proteomic analysis of GCF with high accuracy. The expression of DBP and Tf was increased in children at circumpubertal stage and can be considered candidate biomarkers of pubertal growth.
journal_name
Eur J Orthodjournal_title
European journal of orthodonticsauthors
Wen X,Franchi L,Chen F,Gu Ydoi
10.1093/ejo/cjx082subject
Has Abstractpub_date
2018-07-27 00:00:00pages
414-422issue
4eissn
0141-5387issn
1460-2210pii
4571751journal_volume
40pub_type
杂志文章abstract::The purpose of this study was to determine whether an additional application of Fluor Protector before band cementation with glass ionomer cement reduces white spot formation compared with band cementation with glass ionomer cement. In the in vitro study, 80 premolars were divided in half, creating a control and a tes...
journal_title:European journal of orthodontics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/ejo/20.3.219
更新日期:1998-06-01 00:00:00
abstract:Background:Scientific evidence is insufficient to answer the question of whether premature birth causes altered tooth-crown dimensions. Objective:To evaluate permanent tooth-crown dimensions in prematurely born children and to compare the findings with full-term born controls. Subjects and Methods:Preterm children of...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjx021
更新日期:2017-11-30 00:00:00
abstract::Cervical column morphology was examined in 41 adult patients with a skeletal deep bite, 23 females aged 22-42 years (mean 27.9) and 18 males aged 21-44 years (mean 30.8) and compared with the cervical column morphology in an adult control group consisting of 21 subjects, 15 females, aged 23-40 years (mean 29.2 years) ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjm043
更新日期:2007-10-01 00:00:00
abstract::The effect of protruded mandibular function on the maxilla and zygoma was studied in young unilaterally condylectomized growing rats. Forty-eight-4-week-old rats were divided into two experimental and two control groups as follows: group A, 12 animals unilaterally condylectomized on the right side; the mandible was al...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/19.2.205
更新日期:1997-04-01 00:00:00
abstract::The aim of this investigation was to study symptoms of temporomandibular disorders (TMD) and headaches longitudinally in girls with Class II malocclusions receiving orthodontic treatment in comparison with subjects with untreated Class II malocclusions and girls with normal occlusion, and to evaluate the need and dema...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/22.3.283
更新日期:2000-06-01 00:00:00
abstract::The purpose of this study was to qualitatively and quantitatively assess the nickel, chromium, and ferrous levels in a population of 17 orthodontic patients undergoing treatment, compared with seven untreated individuals, employing a novel methodological approach and a new analytical technique. Salivary samples obtain...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/25.1.103
更新日期:2003-02-01 00:00:00
abstract::Tensile bond strength and bond failure location were evaluated in vitro for two types of aesthetic brackets (non-silanated ceramic, polycarbonate) and one stainless steel bracket, using bovine teeth as the substrate and diacrylate resin as the adhesive. The results show that metallic bracket had the highest bond stren...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/21.1.71
更新日期:1999-02-01 00:00:00
abstract::The purpose of this study was to demonstrate the advantage of the finite helical axis (FHA) system in the biomechanical analysis of orthodontic tooth movement by comparing it with the rectangular coordinate (XYZ) system. Ten patients (6 females and 4 males, mean age 23 years 7 months) were selected. Maxillary canine r...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjm061
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVES:To examine the relationships between dental appearance, characteristics of the individual and their environment, and oral health-related quality of life (OHQoL) in young people over time. METHODS:A total of 374 young people (122 boys, 252 girls) aged 11-12 years from seven different XX schools were recruite...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cju076
更新日期:2015-10-01 00:00:00
abstract::Although there are numerous publications on bilateral non-compliance molar distalization appliances, there is limited information on problems such as asymmetrical unilateral Class II malocclusions. The aim of the present investigation was to examine the distalization of molars unilaterally in patients with a unilatera...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cji118
更新日期:2006-08-01 00:00:00
abstract::The aim of this study was to investigate the relationship between Turkish university students' awareness of malocclusion, their satisfaction with their personal dental appearance, and the severity of their occlusal irregularities. The sample consisted of 841 randomly selected university students, 522 (62.1 per cent) m...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjn083
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVES:Mastication is an essential function that prepares the food for swallowing and digestion and may be related to nutritional status. Thus, the aims of this study were to evaluate the masticatory parameters in overweight and obese children and the relation between bite force and anthropometric evaluation, food ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjv092
更新日期:2016-08-01 00:00:00
abstract:Background/objective:The aim of this study was to evaluate the efficacy of tooth alignment with conventional and self-ligating labial and lingual orthodontic bracket systems. Materials/methods:We tested labial brackets (0.022″ slot size) and lingual brackets (0.018″ slot size). The labial brackets were: (i) regular tw...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjy005
更新日期:2018-11-30 00:00:00
abstract::Pre-treatment, end of treatment, and post-retention study models of 30 subjects with a Class II division 2 malocclusion were assessed, after a period of at least 3 years, in order to evaluate the long-term changes in occlusion, alignment, and arch dimensions. Molar relationship correction was found to be stable after ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/21.4.377
更新日期:1999-08-01 00:00:00
abstract::This prospective study investigated the skeletal, dental, and soft-tissue effects of a mini maxillary protractor appliance in class III subjects with maxillary retrusion and mandibular protrusion and compared these changes with those of untreated, well matched control sample with normal occlusions. Twenty patients wit...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjt006
更新日期:2014-02-01 00:00:00
abstract::The aetiology of palatal canine impaction is unclear. The aim of this research was to investigate the occlusal features that could contribute to the aetiology of palatal maxillary canine impaction. The material consisted of the pre-treatment dental casts of 34 patients (27 female and seven male) with unilateral palata...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cji022
更新日期:2005-10-01 00:00:00
abstract::The aim of this investigation was to determine the pattern of repair of root resorption regarding the location and type of tissue in adolescents after application of a well-controlled force magnitude. In 16 adolescents (mean age 13.8 years), the maxillary first premolars were buccally moved with a weekly reactivated f...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/20.6.727
更新日期:1998-12-01 00:00:00
abstract::The purpose of this laboratory study was to assess the potential cleaning efficacy of nine different toothbrushes around brackets in vitro. Standard and Mini Diamond brackets were fixed on coloured teeth in a special model, coated with white titanium oxide, brushed in a machine with different manual toothbrushes (thre...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjn070
更新日期:2009-02-01 00:00:00
abstract::Corrosion of orthodontic miniscrews or temporary anchorage devices (TADs) has been proposed as a contributor to inflammation, which in turn is a factor in the clinical success of miniscrews. The purpose of this study was to measure the electrochemical properties of orthodontic miniscrews in artificial saliva with and ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjs027
更新日期:2013-08-01 00:00:00
abstract::The purpose of this study was to examine the mechanical behaviour of orthodontic delta retraction springs. Twelve titanium-molybdenum (0.016 × 0.022 inch) delta loops were studied. The springs were analysed by means of the finite element (FE) method and experimental tests using a platform transducer. Each spring was a...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjr062
更新日期:2013-08-01 00:00:00
abstract::The physiology of masseter muscles is known to change in response to functional demands, but the effect on the satellite cell (SC) population is not known. In this study, the hypothesis is tested that a decreased functional demand of the masseter muscle causes a reduction of SCs. To this end, twelve 5-week-old male Sp...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjs044
更新日期:2014-06-01 00:00:00
abstract::The purpose of this work was to examine whether the clinical eruption of the permanent first molars and incisors is affected by pre-term birth. The data applied to 328 prematurely born white and black children and 1804 control children who participated in the Collaborative Perinatal Project (USA) in the early 1960s an...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/25.3.293
更新日期:2003-06-01 00:00:00
abstract::The aim of this study was to review recent randomized clinical trials (RCTs) dealing with the effectiveness of various modalities of orthopaedic/orthodontic expansion of maxillary arches with crossbite and the associated 6 month post retention stability. The study selection criteria included RCTs involving subjects wi...
journal_title:European journal of orthodontics
pub_type: 杂志文章,评审
doi:10.1093/ejo/cjr140
更新日期:2013-02-01 00:00:00
abstract::Deviations in the growth of the mandibular condyle can affect both the functional occlusion and the aesthetic appearance of the face. The reasons for these growth deviations are numerous and often entail complex sequences of malfunction at the cellular level. The aim of this review is to summarize recent progress in t...
journal_title:European journal of orthodontics
pub_type: 杂志文章,评审
doi:10.1093/ejo/cjn117
更新日期:2009-02-01 00:00:00
abstract::The aim of the present study was to develop an index specifically for the measurement of treatment complexity. Input factors were directly related to complexity, and the output was a score measuring the degree of treatment complexity. The sample comprised 120 sets of dental casts, 30 for each of the four main malocclu...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjl080
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Cervical headgear (CH) is a commonly used orthodontic appliance and its dentoalveolar changes are known. However, the effects related to gender and timing have gained less attention. OBJECTIVES:To examine dimensions of dental arches among children with Class II occlusion without posterior mandibular rotatio...
journal_title:European journal of orthodontics
pub_type: 杂志文章,随机对照试验
doi:10.1093/ejo/cjy083
更新日期:2019-11-15 00:00:00
abstract::The aim of this study was to compare the effects of the Gjessing (PG) retraction spring used with and without the zygoma anchorage system (ZAS) on canine retraction. Thirty patients, with an Angle Class I or Class II malocclusion, whose upper first premolars were scheduled for extraction, were divided into two equal g...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjp167
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:There are few cost evaluation studies of orthodontic retention treatment. The aim of this study was to compare the costs in a randomized controlled trial of three retention methods during 2 years of retention treatment. MATERIALS/METHODS:To determine which alternative has the lower cost, a cost-minimization...
journal_title:European journal of orthodontics
pub_type: 杂志文章,随机对照试验
doi:10.1093/ejo/cjt070
更新日期:2014-08-01 00:00:00
abstract::The purpose of this investigation was to evaluate the effects of dental tipping and rotation immediately after surgically assisted rapid palatal expansion (SARPE). Fourteen patients (10 females, four males; mean age 25.6 years) who required a SARPE procedure were available for this study. A palatal expander appliance ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/25.4.353
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:Hyaluronic acid (HA) is a major molecular component of the articular cartilage of the temporomandibular joint (TMJ) influencing joint lubrication. Functional lateral shift of the mandible (FLSM) can lead to malocclusion. This study investigated the effects of FLSM on HA metabolism and lubrication of the TMJ ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjaa012
更新日期:2020-02-29 00:00:00