Abstract：
BACKGROUND/OBJECTIVE:Chondrogenesis is an integral part of endochondral bone formation, by which the midline cranial base is developed. Reactive oxygen species (ROS) are required in chondrogenic differentiation and antioxidant enzymes regulate their levels. The aim of this study was to localize the antioxidant enzyme glutathione peroxidase 1 (Gpx1) at the spheno-occipital synchondrosis, as well as its effect on ROS challenge and its expression pattern in the course of differentiation. MATERIALS AND METHODS:Gpx1 was semiquantified in immunohistochemically stained sections of spheno-occipital synchondroses of rats. The effect of Gpx1 on ROS-induced apoptosis was investigated by manipulating the expression of Gpx1 in ATDC5 cells. The temporal pattern of Gpx1 expression was determined during chondrocyte differentiation for 21 days in vitro. RESULTS:Proliferating chondrocytes exhibited the greatest Gpx1 immunoreactivity and hypertrophic ones the lowest (P = 0.02). Cells transfected with Gpx1-siRNA had the highest apoptotic rate, while cells overexpressing Gpx1 the lowest one (P < 0.001). Gpx1 was significantly increased on days 10 (P = 0.02) and 14 (P = 0.01). CONCLUSIONS:Hypertrophic chondrocytes have the lowest Gpx1 activity in the spheno-occipital synchondrosis. Gpx1 is implicated in the ROS-induced apoptosis in chondrocytes. Its expression was not constitutive during chondrogenic differentiation.
journal_name
Eur J Orthodjournal_title
European journal of orthodonticsauthors
Koretsi V,Kirschneck C,Proff P,Römer Pdoi
10.1093/ejo/cju045subject
Has Abstractpub_date
2015-06-01 00:00:00pages
308-13issue
3eissn
0141-5387issn
1460-2210pii
cju045journal_volume
37pub_type
杂志文章abstract：:The effect of protruded mandibular function on the maxilla and zygoma was studied in young unilaterally condylectomized growing rats. Forty-eight-4-week-old rats were divided into two experimental and two control groups as follows: group A, 12 animals unilaterally condylectomized on the right side; the mandible was al...
journal_title：European journal of orthodontics
pub_type： 杂志文章
doi：10.1093/ejo/19.2.205
更新日期：1997-04-01 00:00:00
abstract：:Shared decision making between children and parents is required in orthodontics. This study compared agreement among mothers, fathers, and children regarding the oral health-related quality of life (OHRQoL) of children. A sample of 71 child patients (41 girls and 30 boys) aged 12.6 years with an orthodontic treatment ...
journal_title：European journal of orthodontics
pub_type： 杂志文章
doi：10.1093/ejo/cjl058
更新日期：2007-04-01 00:00:00
abstract：:As orthodontic appliances can corrode with time in the oral environment, the aim of this study was to compare the release of metal ions from new and recycled brackets immersed in buffers of different pH values over a 48 week period. To simulate commercial recycling, the stainless steel brackets were divided into two g...
journal_title：European journal of orthodontics
pub_type： 杂志文章
doi：10.1093/ejo/26.2.171
更新日期：2004-04-01 00:00:00
abstract：:The purpose of this study was to investigate the effect of treatment of mandibular crowding with self-ligating and conventional brackets on dental arch variables. Fifty-six patients were selected from a pool of subjects satisfying the following inclusion criteria: non-extraction treatment in the mandibular or maxillar...
journal_title：European journal of orthodontics
pub_type： 临床试验,杂志文章
doi：10.1093/ejo/cjp123
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to evaluate the cephalometric outcome of bone-anchored maxillary protraction (BAMP) in individuals with unilateral complete cleft lip and palate (UCLP). MATERIAL AND METHODS:The experimental group (EG) comprised 23 individuals (17 males and 6 females) with UCLP and a mean age of 11...
journal_title：European journal of orthodontics
pub_type： 杂志文章
doi：10.1093/ejo/cjz005
更新日期：2019-09-21 00:00:00
abstract：:This study aimed to gather statistically validated information on the changes in orthodontic variables in patients with bilateral upper lateral incisor aplasia treated with isolated orthodontic space closure. Data were collected from 25 (15 females, 10 males) consecutively treated, unselected adolescents [mean age at ...
journal_title：European journal of orthodontics
pub_type： 杂志文章
doi：10.1093/ejo/cjn100
更新日期：2009-06-01 00:00:00
abstract：:It was the aim of this study to investigate radiologically the distraction site in the gonial angle area after three different protocols of unidirectional mandibular distraction in sheep. Bilateral mandibular distraction was performed in nine sheep, and one other sheep served as a sham-operated control. In the nine ex...
journal_title：European journal of orthodontics
pub_type： 杂志文章
doi：10.1093/ejo/25.2.127
更新日期：2003-04-01 00:00:00
abstract：:Corrosion of orthodontic miniscrews or temporary anchorage devices (TADs) has been proposed as a contributor to inflammation, which in turn is a factor in the clinical success of miniscrews. The purpose of this study was to measure the electrochemical properties of orthodontic miniscrews in artificial saliva with and ...
journal_title：European journal of orthodontics
pub_type： 杂志文章
doi：10.1093/ejo/cjs027
更新日期：2013-08-01 00:00:00
abstract：:The aim of this prospective study was to quantify the display of the dentition through the soft tissue frame during speech using videography for different age groups. Two hundred and sixty-one subjects were initially screened and were divided into five groups: group 1 (G1) (15-19 years), G2 (20-29 years), G3 (30-39 ye...
journal_title：European journal of orthodontics
pub_type： 杂志文章
doi：10.1093/ejo/cjs084
更新日期：2013-10-01 00:00:00
abstract：:Various investigations have mentioned the use of a bonded maxillary expansion appliance. It was postulated that a full coverage of the occlusal surfaces by acrylic would remove interferences during the lateral displacement of the two maxillary bones and would lessen the resistance to maxillary expansion. The first obj...
journal_title：European journal of orthodontics
pub_type： 杂志文章
doi：10.1093/oxfordjournals.ejo.a035967
更新日期：1989-02-01 00:00:00
abstract：:The effect of contamination by dietary oil on acid etching has not been reported in the literature. If dietary oil adversely affects acid etching, then a decrease in bond strength is expected. This in vitro study investigated the bond strength of brackets bonded to tooth surfaces that had been contaminated with dietar...
journal_title：European journal of orthodontics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/ejo/19.2.109
更新日期：1997-04-01 00:00:00
abstract：:To study the effects of transforming growth factor beta 2 (TGF-beta 2) on bone resorption, cultures of 17-day-old foetal mouse metatarsal long bones were used. The long bone rudiments were cultured for 5 days in medium supplemented with 10% rat serum. The effects of TGF-beta 2 were studied at concentrations of 1, 4, a...
journal_title：European journal of orthodontics
pub_type： 杂志文章
doi：10.1093/ejo/16.2.130
更新日期：1994-04-01 00:00:00
abstract：:Mechanical stress induces human periodontal ligament (PDL) cells to express an osteoblastic phenotype in vitro. Core binding factor a1 (CBFA1) is a key regulator of osteoblast differentiation. This study was designed to investigate the role of CBFA1 in alveolar bone remodelling, specifically the expression of CBFA1 me...
journal_title：European journal of orthodontics
pub_type： 杂志文章
doi：10.1093/ejo/cjq010
更新日期：2010-12-01 00:00:00
abstract：:The aim of this study was to assess the prevalence of malocclusion and its association with socio-demographic characteristics, caries experience, and level of oral hygiene in 12- to 14-year-old schoolchildren residing in two socio-economically different districts of Tanzania. A total of 1601 children (mean age 13 year...
journal_title：European journal of orthodontics
pub_type： 杂志文章
doi：10.1093/ejo/cjn125
更新日期：2009-10-01 00:00:00
abstract：:The objective of this study was to investigate the effects of precuring of primer coated on bracket bases on the strength of bonds between metal brackets and gold alloy. Square type III gold alloy plates were sandblasted with 30 μm silicon dioxide. After silica coating, excessive particles were removed gently with air...
journal_title：European journal of orthodontics
pub_type： 杂志文章
doi：10.1093/ejo/cjq163
更新日期：2012-02-01 00:00:00
abstract：:This study investigated the prevalence of bacteraemia on removal of fixed appliances. Venous blood samples were taken before and after debonding and debanding for 30 patients (mean age 17 years 8 months) who had worn fixed appliances for an average of 19 months. Before removal of the fixed appliances, bacteraemia was ...
journal_title：European journal of orthodontics
pub_type： 杂志文章
doi：10.1093/ejo/26.4.443
更新日期：2004-08-01 00:00:00
abstract：:The Beni Solow award for the best article published in the European Journal of Orthodontics in 2014 has been won by: Karoline Dreesen, Steven Swinnen, Koenraad Devriendt, and Carine Carels from Departments of Orthodontics and Human Genetics, Katholieke Universiteit Leuven, Belgium and Department of Orthodontics and Cr...
journal_title：European journal of orthodontics
pub_type： 社论,历史文章
doi：10.1093/ejo/cjv043
更新日期：2015-08-01 00:00:00
abstract：:The objective of the present study was to evaluate the cytotoxicity and degree of monomer conversion of resin-reinforced glass ionomer cements (RGIC) over different time periods. Four RGICs: Fuji Ortho LC (FOLC), Fuji Ortho Band (FOB), Orthoglass (OGL), and Multicure Glass Ionomer (MCI) were evaluated for cytotoxicity...
journal_title：European journal of orthodontics
pub_type： 杂志文章
doi：10.1093/ejo/cjr009
更新日期：2012-06-01 00:00:00
abstract：:Unilateral tip-back mechanics are challenging because of a number of undesirable side-effects associated with their use during orthodontic treatment. The purpose of this paper is to review the differential diagnosis and treatment planning of Class II subdivision malocclusions and present a treatment strategy based on ...
journal_title：European journal of orthodontics
pub_type： 杂志文章
doi：10.1093/ejo/19.1.93
更新日期：1997-02-01 00:00:00
abstract：:The purpose of this study was to investigate the effects of rapid maxillary expansion (RME) and semi-rapid maxillary expansion (SRME) in the mixed dentition period. The SRME group consisted of 18 patients (11 girls and 7 boys) with a mean age of 8.63 +/- 1.09 years and the RME group 17 patients (11 girls and 6 boys) w...
journal_title：European journal of orthodontics
pub_type： 杂志文章,随机对照试验
doi：10.1093/ejo/cjp057
更新日期：2010-02-01 00:00:00
abstract：:Tensile bond strength and bond failure location were evaluated in vitro for two types of aesthetic brackets (non-silanated ceramic, polycarbonate) and one stainless steel bracket, using bovine teeth as the substrate and diacrylate resin as the adhesive. The results show that metallic bracket had the highest bond stren...
journal_title：European journal of orthodontics
pub_type： 杂志文章
doi：10.1093/ejo/21.1.71
更新日期：1999-02-01 00:00:00
abstract：:The aim of this study was to determine whether Fluor Protector, a fluoride varnish, applied to molars before orthodontic banding could prevent white spot formation. In the in vitro study 93 human premolars were used, divided in five different groups, representing different clinical situations. Each tooth was sliced in...
journal_title：European journal of orthodontics
pub_type： 杂志文章
doi：10.1093/ejo/12.3.316
更新日期：1990-08-01 00:00:00
abstract：:The purpose of this work was to examine whether the clinical eruption of the permanent first molars and incisors is affected by pre-term birth. The data applied to 328 prematurely born white and black children and 1804 control children who participated in the Collaborative Perinatal Project (USA) in the early 1960s an...
journal_title：European journal of orthodontics
pub_type： 杂志文章
doi：10.1093/ejo/25.3.293
更新日期：2003-06-01 00:00:00
abstract：:The purpose of the study was to evaluate differences in dental arch morphology among an orthodontic sample of 386 untreated adult females between 17 and 68 years of age, categorized by age group (17-25 years, 26-35 years, or 35+ years) and malocclusion (Class I, Class II division 1, or Class II division 2). The result...
journal_title：European journal of orthodontics
pub_type： 杂志文章
doi：10.1093/ejo/16.1.47
更新日期：1994-02-01 00:00:00
abstract：:This study provides sex specific reference data for the incremental growth of the mandibular condyle. The results pertain to a mixed-longitudinal sample of 113 males and 108 females followed annually between 6 and 16 years of age (total of 1647 observations). Growth of condylion was evaluated using naturally stable ma...
journal_title：European journal of orthodontics
pub_type： 杂志文章
doi：10.1093/ejo/21.2.167
更新日期：1999-04-01 00:00:00
abstract：:The aim of this study was to test the hypothesis that there is no difference in salivary metal ion content between subjects with fixed orthodontic appliances and their same-gender sister or brother without any orthodontic appliance. This retrospective study was carried out on 28 subjects (16 females and 12 males) who ...
journal_title：European journal of orthodontics
pub_type： 杂志文章
doi：10.1093/ejo/cjq181
更新日期：2012-02-01 00:00:00
abstract：:Many animal experiments dealing with function-form interaction and mandibular condylar growth have utilized hyperpropulsion of the animal's mandible. Numerous hyperpropulsive appliances have been described in the literature. However, there are significant discrepancies between reported results which are most likely du...
journal_title：European journal of orthodontics
pub_type： 杂志文章
doi：10.1093/ejo/19.1.1
更新日期：1997-02-01 00:00:00
abstract：:The aim of this investigation was to compare Swedish and immigrant groups of 12- and 13-year-old boys and girls with respect to: (1) self-perceived need for and attitude to orthodontic treatment, (2) attitude to own teeth and general appearance, (3) behaviour pattern and psychosocial functioning, and (4) self-perceive...
journal_title：European journal of orthodontics
pub_type： 杂志文章
doi：10.1093/ejo/cjh070
更新日期：2005-04-01 00:00:00
abstract：:The purpose of this investigation was to evaluate the effects of dental tipping and rotation immediately after surgically assisted rapid palatal expansion (SARPE). Fourteen patients (10 females, four males; mean age 25.6 years) who required a SARPE procedure were available for this study. A palatal expander appliance ...
journal_title：European journal of orthodontics
pub_type： 杂志文章
doi：10.1093/ejo/25.4.353
更新日期：2003-08-01 00:00:00
abstract：Objective:To evaluate the transverse relationships of the first permanent molars after the correction of posterior crossbite performed during the deciduous dentition with two different treatment protocols. Materials/methods:Ninety patients (40 males and 50 females) with posterior crossbite were treated during the deci...
journal_title：European journal of orthodontics
pub_type： 杂志文章
doi：10.1093/ejo/cjw080
更新日期：2017-10-01 00:00:00
