Abstract:
:Mechanical stress induces human periodontal ligament (PDL) cells to express an osteoblastic phenotype in vitro. Core binding factor a1 (CBFA1) is a key regulator of osteoblast differentiation. This study was designed to investigate the role of CBFA1 in alveolar bone remodelling, specifically the expression of CBFA1 messenger RNA (mRNA) in human PDL cells under mechanical stress and its up- and downstream relationships with other bone remodelling markers. Cultured human PDL cells were exposed to mechanical stress. The expressions of CBFA1 and alkaline phosphatase (ALP), osteopontin (OPN), osteoprotegrin (OPG), and receptor activator nuclear factor kappa B ligand (RANKL) were detected before and after RNA interference (RNAi) of CBFA1. The data were analysed using a t-test and one-way analysis of variance. After mechanical stress loading, CBFA1 mRNA expression was raised initially, followed by an increased expression of ALP and RANKL, decreased expression of OPG, and a change in OPN expression. After CBFA1 knock-down in human PDL cells by small hairpin (sh) RNA, the expression of ALP, OPN, OPG, and RANKL also changed. These findings suggest that in the present model system CBFA1 may play an important role in PDL-mediated bone remodelling in response to mechanical stimulation. Mechanical stress: CBFA1-ALP and OPG-PDL homeostasis may be one of the signal transduction pathways of human PDL cell differentiation under mechanical stress without exclusion of the involvement of other pathways.
journal_name
Eur J Orthodjournal_title
European journal of orthodonticsauthors
Yang Y,Yang Y,Li X,Cui L,Fu M,Rabie AB,Zhang Ddoi
10.1093/ejo/cjq010subject
Has Abstractpub_date
2010-12-01 00:00:00pages
698-705issue
6eissn
0141-5387issn
1460-2210pii
cjq010journal_volume
32pub_type
杂志文章abstract::The persistence of childlike deglutition after the replacement of deciduous teeth is described as atypical deglutition. This condition has been attributed to sucking action without nutritive purposes, use of a feeding bottle, oral respiration, and anatomical abnormalities. Among the possible anatomical alterations, th...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjq167
更新日期:2012-02-01 00:00:00
abstract::The purpose of this study was to perform a meta-analysis of articles to verify the mandibular changes produced by the Fränkel-2 (FR-2) appliance during the treatment of growing patients with Class II malocclusions when compared with untreated growing Class II subjects. The literature published from January 1966 to Jan...
journal_title:European journal of orthodontics
pub_type: 杂志文章,meta分析,评审
doi:10.1093/ejo/cjq033
更新日期:2011-02-01 00:00:00
abstract::The purpose of the present investigation was to determine the long-term prognosis of autotransplanted premolars with respect to periodontal healing. The subjects consisted of 195 patients aged 7 to 35 years, with a total of 370 autotransplanted all operated and followed with a standard technique. The observation perio...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/12.1.25
更新日期:1990-02-01 00:00:00
abstract::The objective of this study was to investigate the effects of precuring of primer coated on bracket bases on the strength of bonds between metal brackets and gold alloy. Square type III gold alloy plates were sandblasted with 30 μm silicon dioxide. After silica coating, excessive particles were removed gently with air...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjq163
更新日期:2012-02-01 00:00:00
abstract:AIM:To assess the prevalence of adjustment for confounding within statistical analysis and matching at the design stage in leading orthodontic journals and to explore potential associations between accounting for confounding and publication characteristics. MATERIALS AND METHODS:Twenty-four issues of four leading orth...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjv004
更新日期:2016-02-01 00:00:00
abstract::The aim of this study was to determine whether Fluor Protector, a fluoride varnish, applied to molars before orthodontic banding could prevent white spot formation. In the in vitro study 93 human premolars were used, divided in five different groups, representing different clinical situations. Each tooth was sliced in...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/12.3.316
更新日期:1990-08-01 00:00:00
abstract:Background/objective:To assess the validity and reliability of a series of three questionnaires for the quantification of patient perception of fixed appliance orthodontic treatment. Subjects and methods:The study was carried out at the University of Dundee with content and face validity being assessed using proformas...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjw076
更新日期:2017-08-01 00:00:00
abstract::The aims of this study were to provide a description of the craniofacial morphology of Singaporean Chinese children and to compare gender differences. Lateral cephalometric radiographs were obtained of 81 Singaporean Chinese children (31 boys and 50 girls; mean age 12.7 and 12.5 years, respectively, standard deviation...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/26.6.605
更新日期:2004-12-01 00:00:00
abstract::The aim of this study was to identify the transverse growth pattern of the craniofacial skeleton and dentition from 7 to 15 years of age. The database for this longitudinal study comprised the postero-anterior (PA) cephalograms and dental casts at 7, 9, 11, 13 and 15 years of age of 18 untreated Class I subjects with ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/26.1.31
更新日期:2004-02-01 00:00:00
abstract::Cervical column morphology was examined in adult patients with obstructive sleep apnoea (OSA) and compared with the cervical morphology of an adult control group with neutral occlusion, normal craniofacial morphology, and no history of sleep apnoea. The sleep apnoea group consisted of 91 patients, 16 females aged 29-5...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjn028
更新日期:2008-10-01 00:00:00
abstract::This study, performed using a specially designed apparatus that included 10 aligned brackets, evaluated the frictional resistance generated by conventional stainless steel (SS) brackets (Victory Series), self-ligating Damon SL II brackets, Time Plus brackets, and low-friction ligatures (Slide) coupled with various SS,...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjm007
更新日期:2007-08-01 00:00:00
abstract::Patients with mandibular prognathism have, for a number of years, been treated by orthognathic surgery and post-surgical changes in the facial profile have been widely reported. However, little is known about the influence of gender and age on the soft tissues. The aim of this study was to investigate changes in the s...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjn025
更新日期:2008-08-01 00:00:00
abstract::The aim of this longitudinal study was to monitor patients' microbiological and clinical parameters from bracket placement up to 3 months post-treatment. Twenty-four patients (10 males and 14 females, aged 14.6 ± 1.0 years) were included in this investigation. Microbiology (sub- and supragingival), periodontal probing...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjq032
更新日期:2011-02-01 00:00:00
abstract::Class II elastics are usually employed in the treatment of excessive overbite and overjet with the Begg technique. The effect of Class II elastics on bite opening and the extent of such an effect is uncertain. This article, based on measurements of 30 cases, illustrates that the effect of the vertical component of for...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/14.4.280
更新日期:1992-08-01 00:00:00
abstract:Background and objectives:Apart from the primary effect of bite-blocks on tooth position, they may also influence the mandibular condylar growth. Our aim was to investigate their influence on the condylar morphology, with variable masticatory forces. Material and methods:Fifty-two 4-week old male rats were divided int...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjx072
更新日期:2018-05-25 00:00:00
abstract::Differential scanning calorimetry (DSC) was used to determine the transition temperature ranges (TTR) of four types of super-elastic orthodontic nickel-titanium coil springs (Sentalloy). A knowledge of the TTR provides information on the temperature at which a NiTi wire or spring can assume superelastic properties and...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/21.5.497
更新日期:1999-10-01 00:00:00
abstract::The performance of 5941 stainless steel orthodontic brackets bonded with a no-mix adhesive (Right-on) in 563 patients was reviewed over a 5-year period. The effects of age and sex of the patient, treatment mechanics, operator experience, and arch location on the failure rate and mean survival time (MST) of bonded orth...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/16.3.203
更新日期:1994-06-01 00:00:00
abstract::This clinical study investigated the practical value of two methods for debonding brackets attached by the adhesive Concise to acid-etched enamel surfaces. Forty-two Ultratrimm Standard metal brackets and 42 Fascination ceramic brackets were collected from juvenile patients undergoing orthodontic treatment. All metal ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/18.6.655
更新日期:1996-12-01 00:00:00
abstract:SUMMARY:The aim of this study was to measure lingual volume and to correlate it with and predict it from the area of the radiographic shadow of the tongue as well as with demographic and biometric characteristics. In 70 healthy subjects (35 males and 35 females) aged between 20 and 37 years, tongue volume was determine...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjp105
更新日期:2010-08-01 00:00:00
abstract::The Beni Solow award for the best article published in the European Journal of Orthodontics in 2014 has been won by: Karoline Dreesen, Steven Swinnen, Koenraad Devriendt, and Carine Carels from Departments of Orthodontics and Human Genetics, Katholieke Universiteit Leuven, Belgium and Department of Orthodontics and Cr...
journal_title:European journal of orthodontics
pub_type: 社论,历史文章
doi:10.1093/ejo/cjv043
更新日期:2015-08-01 00:00:00
abstract::This investigation was designed to repeat classic studies into the associations between head posture and growth as a single unified study using up-dated methods for gathering and analysing the data. The material comprised the cephalometric radiographs of 59 children (34 males and 25 females) recorded in natural head p...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjq131
更新日期:2012-08-01 00:00:00
abstract::The purpose of this investigation was to evaluate the effects of dental tipping and rotation immediately after surgically assisted rapid palatal expansion (SARPE). Fourteen patients (10 females, four males; mean age 25.6 years) who required a SARPE procedure were available for this study. A palatal expander appliance ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/25.4.353
更新日期:2003-08-01 00:00:00
abstract::To investigate whether orthodontic cases can fulfil gnathologic requirement, models of 10 adolescent patients (of the Department of Orthodontics at the University Dental Clinic, Graz) were mounted in an articulator at band removal and 2, 4 and 12 weeks and one year later. During this year the patients wore a gnatholog...
journal_title:European journal of orthodontics
pub_type: 杂志文章,评审
doi:10.1093/oxfordjournals.ejo.a035989
更新日期:1989-08-01 00:00:00
abstract::The aim of the present study was to examine dentoalveolar development in subjects with an 'ideal' (normal) occlusion. The material comprised 436 study casts of 189 male and 247 female subjects of Swedish origin between the ages of 5 and 31 years with no history of orthodontic treatment. Tooth width, and arch length, w...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjn124
更新日期:2009-04-01 00:00:00
abstract::Malocclusion assessment methods are based on measurements of study casts, which requires that impressions be taken. In addition to being costly and time consuming, this process can be unpleasant for children. Therefore, the aim of this study was to evaluate intra- and inter-examiner reliability of intraoral score meas...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjl064
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:High-angle Class II malocclusion is considered challenging to treat to a stable result and, although studies report treatment outcome in terms of morphology, patient satisfaction has not been addressed. The objectives of the present study were to examine patients' motives for treatment and sat...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjaa038
更新日期:2020-06-20 00:00:00
abstract::Recent studies revealed that the initial root resorption occurred in the peripheries of the necrotic periodontal ligament (PDL) and was performed by mono-nucleated non-clast macrophage- and fibroblast-like cells (Brudvik and Rygh, 1993a, b). The aim of the present transmission electron microscopic (TEM) investigation ...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/16.4.265
更新日期:1994-08-01 00:00:00
abstract::P561T heterozygous missense mutation in the growth hormone receptor (GHR) is a candidate genetic polymorphism (single-nucleotide polymorphism) for human mandibular growth. The purpose of this study was to assess whether this mutation affects mandibular growth during early childhood. The difference in mandibular growth...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjp017
更新日期:2009-10-01 00:00:00
abstract::The purpose of the study was to evaluate differences in dental arch morphology among an orthodontic sample of 386 untreated adult females between 17 and 68 years of age, categorized by age group (17-25 years, 26-35 years, or 35+ years) and malocclusion (Class I, Class II division 1, or Class II division 2). The result...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/16.1.47
更新日期:1994-02-01 00:00:00
abstract::The aim of this study was to evaluate oral sensory perception in patients with an anterior open bite (AOB) and associated tongue thrusting activity. This study was performed in the Department of Orthodontics, Government Dental Hospital, Chennai, on 30 subjects (16 females and 14 males) aged from 12 to 17 years with an...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/ejo/cjq042
更新日期:2011-04-01 00:00:00