Abstract:
:The role of matrix metalloproteinases (MMPs) in response to mechanical forces in orthodontic tooth movement has only been partially clarified. In the present in vivo pilot study, the presence, levels, and degree of activation of MMP-1 and -8 were measured daily for 1 month in gingival crevicular fluid (GCF) of patients treated with orthodontic fixed appliances. GCF samples were collected from five orthodontic patients and three controls from one upper or lower central incisor or from one upper canine before fixed appliance activation and every 24 hours for 1 month thereafter. The molecular forms and activation degrees of MMP-1 and -8 in GCF were analysed by Western blotting, and MMP-8 levels determined by immunofluorometric assay (IFMA).IFMA revealed, during the study period, on average 12-fold higher levels (56 +/- 50 versus 4.6 +/- 4 microg/l) of MMP-8 in orthodontic GCF than in control GCF. The MMP-8 levels in orthodontic GCF were lower than those detected in gingivitis and periodontitis GCF, but significantly higher than in control GCF. IFMA analysis was confirmed by Western blot analysis showing elevated MMP-8 levels from orthodontic GCF relative to control GCF. Forty-one per cent of total MMP-8 immunoreactivities were high-molecular weight complexes (>100 kDa), 32 per cent in the 75 kDa pro-polymorphonuclear (PMN)-MMP-8 form, 14 per cent in the 60 kDa active-PMN-MMP-8 form, and 13 per cent in the 55 kDa fibroblast-type pro-MMP-8 form. In the GCF of orthodontic patients no MMP-1 immunoreactivities were detected. MMP-8 and -1 levels in the control GCF were low and not detectable. These results demonstrate that in vivo in human GCF, elevation and partial activation of multiple species of PMN- and fibroblast-type MMP-8 reflect periodontal remodelling during orthodontic tooth movement.
journal_name
Eur J Orthodjournal_title
European journal of orthodonticsauthors
Ingman T,Apajalahti S,Mäntylä P,Savolainen P,Sorsa Tdoi
10.1093/ejo/cjh097keywords:
subject
Has Abstractpub_date
2005-04-01 00:00:00pages
202-7issue
2eissn
0141-5387issn
1460-2210pii
27/2/202journal_volume
27pub_type
杂志文章abstract::The aim of this study was to develop a valid and reproducible index of orthodontic treatment priority. After reviewing the available literature, it was felt that this could be best achieved by using two separate components to record firstly the dental health and functional indications for treatment, and secondly the a...
journal_title:European journal of orthodontics
pub_type: 杂志文章
doi:10.1093/oxfordjournals.ejo.a035999
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abstract::The aim of this study was to evaluate the effects of the headgear activator (HGA) and Herbst appliance during active treatment and retention and at follow-up in children with a skeletal Class II malocclusion. The two groups comprised 16 consecutive male patients (mean age 11.6 +/- 1.42 years) treated with a HGA and 16...
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更新日期:1997-12-01 00:00:00
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更新日期:2000-06-01 00:00:00
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journal_title:European journal of orthodontics
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更新日期:2014-02-01 00:00:00
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更新日期:2008-08-01 00:00:00
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journal_title:European journal of orthodontics
pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
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更新日期:2007-06-01 00:00:00
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更新日期:1997-02-01 00:00:00
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