Abstract:
BACKGROUND:Approximately half of trauma patients develop post-traumatic depression. It is suggested that beta-blockade impairs trauma memory recollection, reducing depressive symptoms. This study investigates the effect of early beta-blockade on depression following severe traumatic injuries in patients without significant brain injury. METHODS:Patients were identified by retrospectively reviewing the trauma registry at an urban university hospital between 2007 and 2011. Severe extracranial injuries were defined as extracranial injuries with Abbreviated Injury Scale score ≥3, intracranial Abbreviated Injury Scale score <3 and an Injury Severity Score ≥16. In-hospital deaths and patients prescribed antidepressant therapy ≤1 year prior to admission were excluded. Patients were stratified into groups based on pre-admission beta-blocker status. The primary outcome was post-traumatic depression, defined as receiving antidepressants ≤1 year following trauma. RESULTS:Five hundred and ninety-six patients met the inclusion criteria with 11.4% prescribed pre-admission beta-blockade. Patients receiving beta-blockers were significantly older (57 ± 18 vs. 42 ± 17 years, p < 0.001) with lower Glasgow Coma Scale score (12 ± 3 vs. 14 ± 2, p < 0.001). The beta-blocked cohort spent significantly longer in hospital (21 ± 20 vs. 15 ± 17 days, p < 0.01) and intensive care (4 ± 7 vs. 3 ± 5 days, p = 0.01). A forward logistic regression model was applied and predicted lack of beta-blockade to be associated with increased risk of depression (OR 2.7, 95% CI 1.1-7.2, p = 0.04). After adjusting for group differences, patients lacking beta-blockers demonstrated an increased risk of depression (AOR 3.3, 95% CI 1.2-8.6, p = 0.02). CONCLUSIONS:Pre-admission beta-blockade is associated with a significantly reduced risk of depression following severe traumatic injury. Further investigation is needed to determine the beneficial effects of beta-blockade in these instances.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Ahl R,Barmparas G,Riddez L,Ley EJ,Wallin G,Ljungqvist O,Mohseni Sdoi
10.1007/s00268-017-3935-5subject
Has Abstractpub_date
2017-07-01 00:00:00pages
1801-1806issue
7eissn
0364-2313issn
1432-2323pii
10.1007/s00268-017-3935-5journal_volume
41pub_type
杂志文章abstract:BACKGROUND:Video-assisted thoracoscopic surgery (VATS) is a new area of exploration and evolution in thoracic minimal invasive surgery. The uniportal VATS approach has become popular during lung resection for small nodules and ground glass lesions. Our objective is to investigate the efficacy, availability and safety o...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-020-05781-y
更新日期:2021-01-01 00:00:00
abstract::A new endoprosthesis designed for surgical intubation of neoplastic strictures of the proximal biliary tract has been developed. The technical aspects of intubation by this endoprosthesis are discussed, and the results in the first 25 patients are given. The results suggest that this device was well tolerated. Mortali...
journal_title:World journal of surgery
pub_type: 杂志文章
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abstract:BACKGROUND:Medullary thyroid cancer (MTC) is characterized by early regional lymph node metastasis, the presence of which represents a critical obstacle to cure. At present no molecular markers have been successfully integrated into the clinical care of sporadic MTC. The present study was designed to evaluate TP53INP1 ...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-010-0395-6
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Delayed recovery of gastrointestinal (GI) motility is a common complication following surgery. TZP-101/ulimorelin is a macrocyclic peptidomimetic ghrelin receptor agonist with GI promotility effects that significantly accelerates time to recovery of GI motility compared to placebo following partial colectomy...
journal_title:World journal of surgery
pub_type: 杂志文章,多中心研究,随机对照试验
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abstract:BACKGROUND:The estimation of physiologic ability and surgical stress (E-PASS) has been used to produce a numerical estimate of expected mortality and morbidity after elective gastrointestinal surgery. The aim of this study was to validate E-PASS in a selected cohort of patients requiring liver resections (LR). METHODS...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-009-9989-2
更新日期:2009-06-01 00:00:00
abstract::A group of 105 consecutive patients with venographically proved major acute deep vein thrombosis (DVT) were randomized in an open prospective study to evaluate the comparative efficacy and safety of a fixed dose of subcutaneous low-molecular-weight heparin (LMWH) and warfarin for the prevention of recurrent venous thr...
journal_title:World journal of surgery
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1996-06-01 00:00:00
abstract::Although HLA matching can improve organ graft survival, well matched grafts fail and poorly matched ones survive. Recently evidence has been found that perinatal exposure to noninherited antigens (NIMAs) has a lifelong impact on the immune repertoire of the individual. The state of the art of the influence of NIMAs on...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
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更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Abdominal packing (AP) in damage-control laparotomy (DCL) is a lifesaving technique that controls coagulopathic hemorrhage in severely injured trauma patients. However, the impact of the duration of AP on the incidence of re-bleeding and on intra-abdominal infections in penetrating abdominal trauma is not cl...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-012-1745-3
更新日期:2012-12-01 00:00:00
abstract::In a retrospective study the clinical course of 40 patients with symptomatic persistent or recurrent parathyroid cancer was analyzed in order to assess the value of aggressive surgical intervention. Recurrence was diagnosed after a median period of 33 months (1-228 months). Twenty-two patients had locoregional disease...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/BF00353773
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND:Although the low central venous pressure (LCVP) technique is used to decrease blood loss during liver resection, its efficacy and safety during transplant procedures are still debatable. Our study aimed to assess the effects of this technique and its clinical safety for recipients undergoing liver transplant...
journal_title:World journal of surgery
pub_type: 杂志文章,随机对照试验
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更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Sometimes, it seems to be difficult to preserve the aberrant hepatic artery (HA) during pancreaticoduodenectomy (PD), with respect to en bloc lymph node dissection, especially in the case of aberrant right hepatic artery (RHA). Therefore, we evaluated the influence of incomplete en bloc lymph node (LN) disse...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-009-0063-x
更新日期:2009-08-01 00:00:00
abstract:AIMS:Post-operative urinary retention (POUR) is a common cause of unplanned admission following day-case surgery and has negative effects on both patient and surgical institution. We aimed to prospectively evaluate potential risk factors for the development of POUR following day-case general surgical procedures. METHO...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-018-4697-4
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Nodal involvement of papillary thyroid carcinoma (PTC) commonly occurs in the paratracheal region and the internal jugular chain. Lymph node metastasis in the parapharyngeal space (PPS) is rare. In this report, we describe our experience and surgical outcomes of patients with PPS metastasis of PTC. METHODS:...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-015-3321-0
更新日期:2016-02-01 00:00:00
abstract::Factors influencing postoperative hospital mortality and long-term survival after radical resection of stage IV gallbladder carcinoma remain unclear. The objective of this study was to identify characteristics of patients who are good candidates in terms of surgical risk and long-term survival for radical resection of...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-002-6654-4
更新日期:2003-03-01 00:00:00
abstract::Burn patients develop a number of physiologic alterations among which is a markedly increased metabolic rate. Other metabolic changes include an increased rate of glucose production and utilization, a decreased rate of lipid metabolism, and an increased rate of both protein catabolism and anabolism. These alterations ...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/BF02067118
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to report on the application of a minimally invasive technique to the radical extirpation of primary and recurrent pilonidal disease. This technique does not require specific equipments, is ordinarily performed under local anesthesia on an outpatient basis, and provides optimal cosm...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-019-05313-3
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Thymic carcinoma is reputed to carry a poor prognosis. Although few scholars have studied the prognosis of thymic carcinoma, the prognostic factors of patients after surgery are not well established. We analyze the prognostic significance of undetermined factors to predict the survival of patients after surg...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-014-2492-4
更新日期:2014-08-01 00:00:00
abstract::Upper dorsal sympathectomy is the only successful therapeutic method for idiopathic palmar hyperhidrosis (IPHH). However, the techniques for sympathetic ablation are still debated. The aim of this study was to compare prospectively two accepted methods for endoscopic sympathetic ablation: resection of T2-T3 ganglia ve...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-007-9160-x
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:A recent analysis found bradycardia during laparoscopy as a potential early warning sign of cardiac arrest. Knowledge regarding bradycardia frequency and its consequences during laparoscopy is limited. METHODS:Using the computerized record database, files of 9915 patients undergoing laparoscopic surgery, be...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-019-04935-x
更新日期:2019-06-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-018-4578-x
更新日期:2018-09-01 00:00:00
abstract::Trends are changing in the management of infants and children with indirect inguinal hernias. Advances in neonatal intensive care have resulted in the survival of many small premature infants who have a high incidence of inguinal hernia. The rate of incarceration, strangulation, and gonadal infarction in these babies ...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/BF01658863
更新日期:1989-09-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-019-05020-z
更新日期:2019-08-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/pl00013163
更新日期:1999-02-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-019-05061-4
更新日期:2019-10-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/s00268-017-3953-3
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Diabetes mellitus (DM) is a known risk factor for worse outcomes after emergency abdominal surgery (EAS). However, it is unclear if the type of diabetes treatment (insulin or oral agents) has any effect on outcomes after EAS. METHODS:Matched cohort study utilizing the ACS NSQIP database. Patients with DM un...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-016-3469-2
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Pancreaticodudenectomy (PD) is a high-risk, technically demanding operation associated with substantial perioperative morbidity and mortality. This review is intended to evaluate the perioperative outcomes of PD done in a single gastrointestinal surgery unit of a university teaching hospital. PATIENTS AND M...
journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-010-0589-y
更新日期:2010-08-01 00:00:00
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journal_title:World journal of surgery
pub_type: 杂志文章
doi:10.1007/s00268-020-05385-6
更新日期:2020-05-01 00:00:00
abstract::The combination of conventional traumatic injuries and radiation exposure has synergistic consequences, the full extent of which may take days to weeks to become apparent. Our understanding of such is derived from a variety of laboratory and clinical scenarios involving both therapeutic and accidental exposures. When ...
journal_title:World journal of surgery
pub_type: 杂志文章,评审
doi:10.1007/BF02066992
更新日期:1992-09-01 00:00:00
abstract::Jaundice in patients of advanced carcinoma of the gallbladder requires palliation for the distressing symptoms of pruritus and cholangitis. Intrahepatic segment III duct cholangiojejunostomy is a means for alleviating the obstruction with malignant porta block. The authors reviewed their experience with this procedure...
journal_title:World journal of surgery
pub_type: 杂志文章
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更新日期:1997-10-01 00:00:00