Abstract:
BACKGROUND:Research imaging of brain structure and function has helped to elucidate the pathophysiology of medication overuse headache (MOH). METHODS:This is a narrative review of imaging research studies that have investigated brain structural and functional alterations associated with MOH. Studies included in this review have investigated abnormal structure and function of pain processing regions in people with MOH, functional patterns that might predispose individuals to development of MOH, similarity of brain functional patterns in patients with MOH to those found in people with addiction, brain structure that could predict headache improvement following discontinuation of the overused medication, and changes in brain structure and function after discontinuation of medication overuse. RESULTS AND CONCLUSIONS:MOH is associated with atypical structure and function of brain regions responsible for pain processing as well as brain regions that are commonly implicated in addiction. Several studies have shown "normalization" of structure and function in pain processing regions following discontinuation of the overused medication and resolution of MOH. However, some of the abnormalities in regions also implicated in addiction tend to persist following discontinuation of the overused medication, suggesting that they are a brain trait that predisposes certain individuals to medication overuse and MOH.
journal_name
Headachejournal_title
Headacheauthors
Schwedt TJ,Chong CDdoi
10.1111/head.13037subject
Has Abstractpub_date
2017-07-01 00:00:00pages
1173-1178issue
7eissn
0017-8748issn
1526-4610journal_volume
57pub_type
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