Abstract:
:Glutamate homeostasis plays a vital role in central nitrogen metabolism and coordinates several key metabolic functions. However, its function in fungal pathogenesis and development has not been investigated in detail. In this study, we identified and characterized a glutamate synthase gene MoGLT1 in the rice blast fungus Magnaporthe oryzae that was important to glutamate homeostasis. MoGLT1 was constitutively expressed, but showed the highest expression level in appressoria. Deletion of MoGLT1 resulted in a significant reduction in conidiation and virulence. The ΔMoglt1 mutants were defective in appressorial penetration and the differentiation and spread of invasive hyphae in penetrated plant cells. The addition of exogenous glutamic acid partially rescued the defects of the ΔMoglt1 mutants in conidiation and plant infection. Assays for MoAtg8 expression and localization showed that the ΔMoglt1 mutants were defective in autophagy. The ΔMoglt1 mutants were delayed in the mobilization of glycogens and lipid bodies from conidia to developing appressoria. Taken together, our results show that glutamate synthase MoGlt1-mediated glutamate homeostasis is important for pathogenesis and development in the rice blast fungus, possibly via the regulation of autophagy.
journal_name
Mol Plant Patholjournal_title
Molecular plant pathologyauthors
Zhou W,Shi W,Xu XW,Li ZG,Yin CF,Peng JB,Pan S,Chen XL,Zhao WS,Zhang Y,Yang J,Peng YLdoi
10.1111/mpp.12541subject
Has Abstractpub_date
2018-03-01 00:00:00pages
564-578issue
3eissn
1464-6722issn
1364-3703journal_volume
19pub_type
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