Extranodal Spread is Associated with Recurrence and Poor Survival in Stage III Cutaneous Melanoma Patients.

abstract：BACKGROUND:Melphalan (L-PAM) hyperthermic isolated limb perfusion (HILP) is currently considered the standard treatment for patients with in-transit metastases from cutaneous melanoma. We here report on the results of L-PAM and low-dose tumor necrosis factor (TNF)alpha HILP in patients with bulky disease. METHODS:Twen...

journal_title：Annals of surgical oncology

authors： Rossi CR,Foletto M,Mocellin S,Pilati P,Lise M

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:The ACOSOG Z0011 (Z11) trial demonstrated that in patients with nonpalpable axillary lymph nodes (LN) and one to two positive sentinel LN (SLN), axillary LN dissection (ALND) is unnecessary.JAMA 305:569-575, [2011], Ann Surg 264:413-42, [2016] The Z11 trial did not require preoperative axillary ultrasound (a...

journal_title：Annals of surgical oncology

authors： Harris CK,Tran HT,Lee K,Mylander C,Pack D,Rosman M,Tafra L,Umbricht CB,Andrade R,Liang W,Jackson RS

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Dysregulation of apoptosis is a key factor in carcinogenesis and tumor progression. X-linked inhibitor of apoptosis (XIAP) is the most potent member of the inhibitor of apoptosis protein (IAP) family, which directly inhibits apoptosis by binding to caspases. Antagonists of XIAP have recently been identified:...

journal_title：Annals of surgical oncology

authors： Shibata T,Noguchi T,Takeno S,Gabbert HE,Ramp U,Kawahara K

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Rad51 is a protein which plays a vital role in DNA double-strand break repair and maintenance of telomeres. However, the underlying mechanism for its action in esophageal squamous cell carcinoma (ESCC) remains unclear. PATIENTS AND METHODS:Eighty-seven patients with ESCC were enrolled in this study. Express...

journal_title：Annals of surgical oncology

authors： Chiu WC,Fang PT,Lee YC,Wang YY,Su YH,Hu SC,Chen YK,Tsui YT,Kao YH,Huang MY,Yuan SF

更新日期：2020-06-01 00:00:00

abstract：:The Chicago Consensus Working Group provides multidisciplinary recommendations for the management of colorectal cancer specifically as it relates to the management of peritoneal surface malignancy. These guidelines are developed with input from leading experts including surgical oncologists, medical oncologists, patho...

journal_title：Annals of surgical oncology

authors： Chicago Consensus Working Group.

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:We seek to determine whether laparoscopic hyperthermic intraperitoneal chemoperfusion (LS-HIPEC) improves overall survival (OS) in patients with gastric and gastroesophageal adenocarcinoma and low-volume peritoneal metastasis compared with standard of care treatment. PATIENTS AND METHODS:We reviewed data fr...

journal_title：Annals of surgical oncology

authors： Blumenthaler AN,Allen CJ,Ikoma N,Blum M,Das P,Minsky BD,Mansfield PF,Ajani JA,Badgwell BD

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:The determination of the incidence and prevalence of rare diseases is important for economists and health-care providers. Pseudomyxoma peritonei (PMP) is a rare, slow-growing abdominal cancer that represents a substantial burden on both patients and health-care systems. The incidence rate was previously appr...

journal_title：Annals of surgical oncology

authors： Patrick-Brown TDJH,Carr NJ,Swanson DM,Larsen S,Mohamed F,Flatmark K

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Metastases to internal mammary lymph nodes (IMN) may occur in patients with breast cancer and may alter treatment recommendations. The purpose of this study was to identify the frequency of IMN drainage in patients undergoing breast lymphoscintigraphy and sentinel lymph node dissection (SLND). METHODS:The c...

journal_title：Annals of surgical oncology

authors： Byrd DR,Dunnwald LK,Mankoff DA,Anderson BO,Moe RE,Yeung RS,Schubert EK,Eary JF

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND:NIMA-related kinase 2 (NEK2), an enzyme involved in the development and progression of cancer, is abnormally expressed in a wide variety of human cancers, including colorectal cancer (CRC), and is known to have roles in cell division and mitotic regulation through centrosome splitting. We investigated the cl...

journal_title：Annals of surgical oncology

authors： Takahashi Y,Iwaya T,Sawada G,Kurashige J,Matsumura T,Uchi R,Ueo H,Takano Y,Eguchi H,Sudo T,Sugimachi K,Yamamoto H,Doki Y,Mori M,Mimori K

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Hepatitis B (HBV)-associated hepatocellular carcinoma (HCC) is often associated with alpha-fetoprotein (AFP) production. Although serum AFP has been demonstrated to be a prognostic factor for patient survival, optimal cutoff levels remain unclear. METHODS:Patients with HBV-associated HCC treated by primary ...

journal_title：Annals of surgical oncology

authors： Blank S,Wang Q,Fiel MI,Luan W,Kim KW,Kadri H,Mandeli J,Hiotis SP

更新日期：2014-03-01 00:00:00

abstract：INTRODUCTION:Regional nodal status is the most powerful predictor of recurrence and survival in women with breast cancer. Lymphatic mapping and sentinel lymph node (SLN) biopsy have been found to accurately predict the regional nodal status. Preoperative lymphoscintigraphy has been used in melanoma patients to identify...

journal_title：Annals of surgical oncology

authors： Dupont EL,Kamath VJ,Ramnath EM,Shivers SC,Cox C,Berman C,Leight GS Jr,Ross MI,Blumencranz P,Reintgen DS,DOD Breast Lymphatic Mapping Trial Investigators.

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:More than 20% of patients undergoing initial breast-conserving surgery (BCS) for cancer require reoperation. To address this concern, the American Society of Breast Surgeons (ASBrS) endorsed 10 processes of care (tools) in 2015 to be considered by surgeons to de-escalate reoperations. In a planned follow-up,...

journal_title：Annals of surgical oncology

authors： Landercasper J,Borgert AJ,Fayanju OM,Cody H 3rd,Feldman S,Greenberg C,Linebarger J,Pockaj B,Wilke L

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:The biopsy method of choice for soft tissue sarcomas (STS) of the limb and limb girdle is controversial. There have been no randomized controlled trials that compare incision biopsy with Tru-cut biopsy. We present a large series, which includes an analysis of the effectiveness of Tru-cut core biopsy both in ...

journal_title：Annals of surgical oncology

authors： Hoeber I,Spillane AJ,Fisher C,Thomas JM

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Neoadjuvant chemotherapy (NAC) has been attempted as a means of improving survival of potentially resectable advanced gastric cancer (AGC). In the course of exploring the most promising NAC regimen, a superior surrogate marker reflecting overall survival (OS) is necessary. We investigated prognostic factors ...

journal_title：Annals of surgical oncology

authors： Fujitani K,Mano M,Hirao M,Kodama Y,Tsujinaka T

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Currently, reinterventions for involved margins after breast-conserving surgery remain common. The aim of this study was to assess the capability of the cavity shave margins (CSM) technique to reduce positive margin rates and reoperations compared with simple lumpectomy (SL). The impact of CSM on the various...

journal_title：Annals of surgical oncology

authors： Corsi F,Sorrentino L,Bonzini M,Bossi D,Truffi M,Amadori R,Nebuloni M,Brillat B,Mazzucchelli S

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Consensus guidelines recommend prolonged thromboprophylaxis for up to 4 weeks after major abdominopelvic cancer operations. Several factors impede widespread adoption of these guidelines. These include lack of awareness, cost, increased bleeding complications, increased incidence of heparin-induced thrombocy...

journal_title：Annals of surgical oncology

authors： Bradley CT,Brasel KJ,Miller JJ,Pappas SG

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Positive peritoneal cytology is a predictor of poor survival in patients with gastric cancer. Our aim is to more clearly define the natural history of this cohort. METHODS:Review of a prospectively maintained gastric cancer database of patients who had diagnostic laparoscopy with peritoneal washings. Clinic...

journal_title：Annals of surgical oncology

authors： Mezhir JJ,Shah MA,Jacks LM,Brennan MF,Coit DG,Strong VE

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:L-phenylalanine mustard (LPAM) has been the standard for use in regional chemotherapy (RC) for unresectable in-transit melanoma. Preclinical data demonstrated that regional temozolomide (TMZ) may be more effective. METHODS:Patients with AJCC Stage IIIB or IIIC extremity melanoma who failed previous LPAM-bas...

journal_title：Annals of surgical oncology

authors： Beasley GM,Speicher P,Augustine CK,Dolber PC,Peterson BL,Sharma K,Mosca PJ,Royal R,Ross M,Zager JS,Tyler DS

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Adrenocortical carcinoma (ACC) is a rare, aggressive disease with no apparent change in treatment or survival in the United States over the past two decades. Our objective was to determine whether treatment patterns or clinical outcomes vary by hospital case volume. METHODS:Patients with ACC were identified...

journal_title：Annals of surgical oncology

authors： Gratian L,Pura J,Dinan M,Reed S,Scheri R,Roman S,Sosa JA

更新日期：2014-10-01 00:00:00

abstract：INTRODUCTION:Lymphadenectomy and thyroidectomy is standard treatment for medullary thyroid carcinoma (MTC), but the prognostic importance of the number of lymph nodes removed (lymph node yield, LNY) and the proportion of metastatic lymph nodes resected (metastatic lymph node ratio, MLNR) is unknown. We hypothesized tha...

journal_title：Annals of surgical oncology

authors： Leggett MD,Chen SL,Schneider PD,Martinez SR

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Sarcopenia, characterized by loss of skeletal muscle mass, is recognized as a prognostic factor in patients with gastric cancer. However, wide variability exists in the cutoff values of muscle mass for defining sarcopenia across previous studies, and the best cutoff values to predict survival remain unknown....

journal_title：Annals of surgical oncology

authors： Nishigori T,Tsunoda S,Obama K,Hisamori S,Hashimoto K,Itatani Y,Okada K,Sakai Y

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Accumulated evidence indicates that the incidence of early-onset breast cancer has rapidly increased in Taiwan and other Asian compared to Western countries. The mismatch repair (MMR) pathway might be one of the crucial mechanisms of predisposition to early breast cancer. In this study, we explored whether M...

journal_title：Annals of surgical oncology

authors： Hsieh YC,Cho EC,Tu SH,Wu CH,Hung CS,Hsieh MC,Su CT,Liu YR,Lee CH,Ho YS,Chiou HY

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Preoperative cutaneous lymphoscintigraphy (LS) to identify sentinel (first-tier) lymph nodes was performed in 250 consecutive melanoma patients before wide local excision only or wide local excision with sentinel node biopsy. METHODS:The location of the sentinel nodes was marked on the overlying skin in all...

journal_title：Annals of surgical oncology

authors： Uren RF,Howman-Giles RB,Thompson JF

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Intraperitoneal chemotherapy has an established role in the treatment of selected patients with colorectal peritoneal metastases. Oxaliplatin is highly suitable as a chemotherapeutic agent for hyperthermic intraperitoneal chemotherapy (HIPEC), but its use to date has been limited because of the morbidity cau...

journal_title：Annals of surgical oncology

authors： Mehta AM,Huitema AD,Burger JW,Brandt-Kerkhof AR,van den Heuvel SF,Verwaal VJ

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Cancer patients have often been reported to have impaired immune function, and the effect of treatment modalities, such as surgery, irradiation, and chemotherapy, in depressing patients' immunity has also been reported. In this investigation, the effect of treatment on the cellular immunity of esophageal can...

journal_title：Annals of surgical oncology

authors： Mafune K,Tanaka Y

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Extensive lymph node dissection (LND) is beneficial in primarily resected esophageal cancer patients. Such benefit was believed to be seen in neoadjuvant chemoradiotherapy (CRT)-treated patients, but evidence was inconsistent. We hypothesized that CRT might offset the benefit of LND in certain subgroup of pa...

journal_title：Annals of surgical oncology

authors： Chao YK,Liu HP,Hsieh MJ,Wu YC,Liu YH,Yeh CH,Chang HK,Tseng CK

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:The treatment of Wilms' tumor has undergone major advances in the past four decades. Current therapy is based on both the stage and pathology of the tumor. We have reviewed our recent experience with this tumor to assess the results of treatment on protocols that generally avoid the use of doxorubicin. METH...

journal_title：Annals of surgical oncology

authors： Shamberger RC,Macklis RM,Sallan SE

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Liver-directed therapies have been used to treat neuroendocrine liver metastases (NELM) for both symptomatic improvement and tumor growth control. We reviewed our experience with NELM to investigate the outcomes of available treatment modalities and to identify prognostic factors for survival. METHODS:We id...

journal_title：Annals of surgical oncology

authors： Fairweather M,Swanson R,Wang J,Brais LK,Dutton T,Kulke MH,Clancy TE

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:The management of state III breast cancer is challenging; it often includes multimodal treatment with systemic therapy and/or radiation therapy and surgery. Immediate breast reconstruction has not traditionally been performed in these patients. We review the results of immediate transverse rectus abdominis m...

journal_title：Annals of surgical oncology

authors： Styblo TM,Lewis MM,Carlson GW,Murray DR,Wood WC,Lawson D,Landry J,Hughes L,Nahai F,Bostwick J 3rd

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:Esophageal cancer is an aggressive cancer with poor prognosis. However, little is known about the immune response in the tumor microenvironment after neoadjuvant chemotherapy. PURPOSE:To investigate the immunological impact of neoadjuvant chemotherapy in the tumor microenvironment of esophageal squamous cel...

journal_title：Annals of surgical oncology

authors： Tsuchikawa T,Miyamoto M,Yamamura Y,Shichinohe T,Hirano S,Kondo S

更新日期：2012-05-01 00:00:00