Nicotiana attenuata Data Hub (NaDH): an integrative platform for exploring genomic, transcriptomic and metabolomic data in wild tobacco.

abstract：BACKGROUND:Though glioblastoma multiforme (GBM) is the most frequently occurring brain malignancy in adults, clinical treatment still faces challenges due to poor prognoses and tumor relapses. Recently, microRNAs (miRNAs) have been extensively used with the aim of developing accurate molecular therapies, because of the...

journal_title：BMC genomics

authors： Yerukala Sathipati S,Huang HL,Ho SY

更新日期：2016-12-22 00:00:00

abstract：BACKGROUND:Anguillicola crassus is an economically and ecologically important parasitic nematode of eels. The native range of A. crassus is in East Asia, where it infects Anguilla japonica, the Japanese eel. A. crassus was introduced into European eels, Anguilla anguilla, 30 years ago. The parasite is more pathogenic i...

journal_title：BMC genomics

authors： Heitlinger E,Bridgett S,Montazam A,Taraschewski H,Blaxter M

更新日期：2013-02-08 00:00:00

abstract：BACKGROUND:Gonadotropin releasing hormone (GnRH) is responsible for stimulation of gonadotropic hormone (GtH) in the hypothalamus-pituitary-gonadal axis (HPG). The regulatory mechanisms responsible for brain specificity make the promoter attractive for in silico analysis and reporter gene studies in zebrafish (Danio re...

journal_title：BMC genomics

authors： Torgersen J,Nourizadeh-Lillabadi R,Husebye H,Aleström P

更新日期：2002-08-21 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are a large family of endogenous, non-coding RNAs, about 22 nucleotides long, which regulate gene expression through sequence-specific base pairing with target mRNAs. Extensive studies have shown that miRNA expression in the skin changes remarkably during distinct stages of the hair cycle ...

journal_title：BMC genomics

authors： Yuan C,Wang X,Geng R,He X,Qu L,Chen Y

更新日期：2013-07-28 00:00:00

abstract：BACKGROUND:Reading disability (RD) is a common syndrome with a large genetic component. Chromosome 6 has been identified in several linkage studies as playing a significant role. A more recent study identified a peak of transmission disequilibrium to marker JA04 (G72384) on chromosome 6p22.3, suggesting that a gene is ...

journal_title：BMC genomics

authors： Londin ER,Meng H,Gruen JR

更新日期：2003-06-30 00:00:00

abstract：BACKGROUND:Chronic renal disease (CKD) is characterized by complex changes in cell metabolism leading to an increased production of oxygen radicals, that, in turn has been suggested to play a key role in numerous clinical complications of this pathological condition. Several reports have focused on the identification o...

journal_title：BMC genomics

authors： Granata S,Zaza G,Simone S,Villani G,Latorre D,Pontrelli P,Carella M,Schena FP,Grandaliano G,Pertosa G

更新日期：2009-08-21 00:00:00

abstract：BACKGROUND:The Engrailed Homology 1 (EH1) motif is a small region, believed to have evolved convergently in homeobox and forkhead containing proteins, that interacts with the Drosophila protein groucho (C. elegans unc-37, Human Transducin-like Enhancers of Split). The small size of the motif makes its reliable identifi...

journal_title：BMC genomics

authors： Copley RR

更新日期：2005-11-27 00:00:00

abstract：BACKGROUND:Rumen epithelial tissue plays an important role in nutrient absorption and rumen health. However, whether forage quality and particle size impact the rumen epithelial morphology is unclear. The current study was conducted to elucidate the effects of forage quality and forage particle size on rumen epithelial...

journal_title：BMC genomics

authors： Wang B,Wang D,Wu X,Cai J,Liu M,Huang X,Wu J,Liu J,Guan L

更新日期：2017-05-06 00:00:00

abstract：BACKGROUND:Higher crustaceans (class Malacostraca) represent the most species-rich and morphologically diverse group of non-insect arthropods and many of its members are commercially important. Although the crustacean DNA sequence information is growing exponentially, little is known about the genome organization of Ma...

journal_title：BMC genomics

authors： Koyama T,Asakawa S,Katagiri T,Shimizu A,Fagutao FF,Mavichak R,Santos MD,Fuji K,Sakamoto T,Kitakado T,Kondo H,Shimizu N,Aoki T,Hirono I

更新日期：2010-02-26 00:00:00

abstract：BACKGROUND:Crustacean moulting is a complex process involving many regulatory pathways. A holistic approach to examine differential gene expression profiles of transcripts relevant to the moulting process, across all moult cycle stages, was used in this study. Custom cDNA microarrays were constructed for Portunus pelag...

journal_title：BMC genomics

authors： Kuballa AV,Holton TA,Paterson B,Elizur A

更新日期：2011-03-12 00:00:00

abstract：BACKGROUND:LEF1/TCF transcription factors and their activator β-catenin are effectors of the canonical Wnt pathway. Although Wnt/β-catenin signaling has been implicated in neurodegenerative and psychiatric disorders, its possible role in the adult brain remains enigmatic. To address this issue, we sought to identify th...

journal_title：BMC genomics

authors： Wisniewska MB,Nagalski A,Dabrowski M,Misztal K,Kuznicki J

更新日期：2012-11-17 00:00:00

abstract：BACKGROUND:The Polima (pol) system of cytoplasmic male sterility (CMS) and its fertility restoration gene Rfp have been used in hybrid breeding in Brassica napus, which has greatly improved the yield of rapeseed. However, the mechanism of the male sterility transition in pol CMS remains to be determined. RESULTS:To in...

journal_title：BMC genomics

authors： An H,Yang Z,Yi B,Wen J,Shen J,Tu J,Ma C,Fu T

更新日期：2014-04-03 00:00:00

abstract：BACKGROUND:Aging is associated with functional decline of neurons and increased incidence of both neurodegenerative and ocular disease. Photoreceptor neurons in Drosophila melanogaster provide a powerful model for studying the molecular changes involved in functional senescence of neurons since decreased visual behavio...

journal_title：BMC genomics

authors： Hall H,Medina P,Cooper DA,Escobedo SE,Rounds J,Brennan KJ,Vincent C,Miura P,Doerge R,Weake VM

更新日期：2017-11-21 00:00:00

abstract：BACKGROUND:With the development of several new technologies using synthetic biology, it is possible to engineer genetically intractable organisms including Mycoplasma mycoides subspecies capri (Mmc), by cloning the intact bacterial genome in yeast, using the host yeast's genetic tools to modify the cloned genome, and s...

journal_title：BMC genomics

authors： Chandran S,Noskov VN,Segall-Shapiro TH,Ma L,Whiteis C,Lartigue C,Jores J,Vashee S,Chuang RY

更新日期：2014-12-24 00:00:00

abstract：BACKGROUND:Cell lines are an indispensable tool in biomedical research and often used as surrogates for tissues. Although there are recognized important cellular and transcriptomic differences between cell lines and tissues, a systematic overview of the differences between the regulatory processes of a cell line and th...

journal_title：BMC genomics

authors： Lopes-Ramos CM,Paulson JN,Chen CY,Kuijjer ML,Fagny M,Platig J,Sonawane AR,DeMeo DL,Quackenbush J,Glass K

更新日期：2017-09-12 00:00:00

abstract：BACKGROUND:Genome-wide association studies show that most human traits and diseases are caused by a combination of environmental and genetic causes, with each one of these having a relatively small effect. In contrast, most therapies based on macromolecules like antibodies, antisense oligonucleotides or peptides focus ...

journal_title：BMC genomics

authors： Varela MA

更新日期：2015-07-18 00:00:00

abstract：BACKGROUND:Single-cell (sc) sequencing performs unbiased profiling of individual cells and enables evaluation of less prevalent cellular populations, often missed using bulk sequencing. However, the scale and the complexity of the sc datasets poses a great challenge in its utility and this problem is further exacerbate...

journal_title：BMC genomics

authors： Kumar N,Golhar R,Sharma KS,Holloway JL,Sarangi S,Neuhaus I,Walsh AM,Pitluk ZW

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:The question of whether bacterial species objectively exist has long divided microbiologists. A major source of contention stems from the fact that bacteria regularly engage in horizontal gene transfer (HGT), making it difficult to ascertain relatedness and draw boundaries between taxa. A natural way to defi...

journal_title：BMC genomics

authors： Wright ES,Baum DA

更新日期：2018-10-03 00:00:00

abstract：BACKGROUND:Large-scale comparison of metazoan genomes has revealed that a significant fraction of genes of the last common ancestor of Bilateria (Urbilateria) is lost in each animal lineage. This event could be one of the underlying mechanisms involved in generating metazoan diversity. However, the present functions of...

journal_title：BMC genomics

authors： Matsui T,Yamamoto T,Wyder S,Zdobnov EM,Kadowaki T

更新日期：2009-01-12 00:00:00

abstract：BACKGROUND:The only known albino gorilla, named Snowflake, was a male wild born individual from Equatorial Guinea who lived at the Barcelona Zoo for almost 40 years. He was diagnosed with non-syndromic oculocutaneous albinism, i.e. white hair, light eyes, pink skin, photophobia and reduced visual acuity. Despite previo...

journal_title：BMC genomics

authors： Prado-Martinez J,Hernando-Herraez I,Lorente-Galdos B,Dabad M,Ramirez O,Baeza-Delgado C,Morcillo-Suarez C,Alkan C,Hormozdiari F,Raineri E,Estellé J,Fernandez-Callejo M,Valles M,Ritscher L,Schöneberg T,de la Calle-Mustienes E

更新日期：2013-05-31 00:00:00

abstract：BACKGROUND:Copy number variation (CNV) is a major component of genomic variation, yet methods to accurately type genomic CNV lag behind methods that type single nucleotide variation. High-throughput sequencing can contribute to these methods by using sequence read depth, which takes the number of reads that map to a gi...

journal_title：BMC genomics

authors： Forni D,Martin D,Abujaber R,Sharp AJ,Sironi M,Hollox EJ

更新日期：2015-11-02 00:00:00

abstract：BACKGROUND:Gibel carp is an important aquaculture species in China, and a herpesvirus, called as Carassius auratus herpesvirus (CaHV), has hampered the aquaculture development. Diverse gynogenetic clones of gibel carp have been identified or created, and some of them have been used as aquaculture varieties, but their r...

journal_title：BMC genomics

authors： Gao FX,Wang Y,Zhang QY,Mou CY,Li Z,Deng YS,Zhou L,Gui JF

更新日期：2017-07-24 00:00:00

abstract：BACKGROUND:Fistular leaves frequently appear in Allium species, and previous developmental studies have proposed that the process of fistular leaf formation involves programmed cell death. However, molecular evidence for the role of programmed cell death in the formation of fistular leaf cavities has yet to be reported...

journal_title：BMC genomics

authors： Zhu S,Tang S,Tan Z,Yu Y,Dai Q,Liu T

更新日期：2017-01-10 00:00:00

abstract：BACKGROUND:The large amount of data produced by high-throughput sequencing poses new computational challenges. In the last decade, several tools have been developed for the identification of transcription and splicing factor binding sites. RESULTS:Here, we introduce the SeAMotE (Sequence Analysis of Motifs Enrichment)...

journal_title：BMC genomics

authors： Agostini F,Cirillo D,Ponti RD,Tartaglia GG

更新日期：2014-10-23 00:00:00

abstract：BACKGROUND:Rich in genetic information and cost-effective to genotype, the Insertion-Deletion (InDel) molecular marker system is an important tool for studies in genetics, genomics and for marker-assisted breeding. Advent of next-generation sequencing (NGS) revolutionized the speed and throughput of sequence data gener...

journal_title：BMC genomics

authors： Lv Y,Liu Y,Zhao H

更新日期：2016-04-14 00:00:00

abstract：BACKGROUND:In most species of mammals, the TRB locus has the common feature of a library of TRBV genes positioned at the 5'- end of two in tandem aligned D-J-C gene clusters, each composed of a single TRBD gene, 6-7 TRBJ genes and one TRBC gene. An enhancer located at the 3'end of the last TRBC and a well-defined promo...

journal_title：BMC genomics

authors： Di Tommaso S,Antonacci R,Ciccarese S,Massari S

更新日期：2010-01-04 00:00:00

abstract：BACKGROUND:Colon cancer occurrence is increasing worldwide, making it the third most frequent cancer. Although many therapeutic options are available and quite efficient at the early stages, survival is strongly decreased when the disease has spread to other organs. The identification of molecular markers of colon canc...

journal_title：BMC genomics

authors： Durand S,Trillet K,Uguen A,Saint-Pierre A,Le Jossic-Corcos C,Corcos L

更新日期：2017-09-30 00:00:00

abstract：BACKGROUND:Fusarium verticillioides causes ear rot in maize (Zea mays L.) and accumulation of mycotoxins, that affect human and animal health. Currently, chemical and agronomic measures to control Fusarium ear rot are not very effective and selection of more resistant genotypes is a desirable strategy to reduce contami...

journal_title：BMC genomics

authors： Lanubile A,Ferrarini A,Maschietto V,Delledonne M,Marocco A,Bellin D

更新日期：2014-08-25 00:00:00

abstract：BACKGROUND:Bacteriophages are the most abundant and diverse entities in the biosphere, and this diversity is driven by constant predator-prey evolutionary dynamics and horizontal gene transfer. Phage genome sequences are under-sampled and therefore present an untapped and uncharacterized source of genetic diversity, ty...

journal_title：BMC genomics

authors： Oliveira H,Sampaio M,Melo LDR,Dias O,Pope WH,Hatfull GF,Azeredo J

更新日期：2019-05-09 00:00:00

abstract：BACKGROUND:Both male and female pigeons have the ability to produce a nutrient solution in their crop for the nourishment of their young. The production of the nutrient solution has been likened to lactation in mammals, and hence the product has been called pigeon 'milk'. It has been shown that pigeon 'milk' is essenti...

journal_title：BMC genomics

authors： Gillespie MJ,Haring VR,McColl KA,Monaghan P,Donald JA,Nicholas KR,Moore RJ,Crowley TM

更新日期：2011-09-19 00:00:00