Regulatory network changes between cell lines and their tissues of origin.

abstract：BACKGROUND:Post-translational glycosylation of the flagellin protein is relatively common among Gram-negative bacteria, and has been linked to several phenotypes, including flagellar biosynthesis and motility, biofilm formation, host immune evasion and manipulation and virulence. However to date, despite extensive phys...

journal_title：BMC genomics

authors： De Maayer P,Cowan DA

更新日期：2016-05-20 00:00:00

abstract：BACKGROUND:Escherichia coli infections known as colibacillosis constitute a considerable challenge to poultry farmers worldwide, in terms of decreased animal welfare and production economy. Colibacillosis is caused by avian pathogenic E. coli (APEC). APEC strains are extraintestinal pathogenic E. coli and have in gener...

journal_title：BMC genomics

authors： Ronco T,Stegger M,Olsen RH,Sekse C,Nordstoga AB,Pohjanvirta T,Lilje B,Lyhs U,Andersen PS,Pedersen K

更新日期：2017-01-03 00:00:00

abstract：BACKGROUND:The mosquito species Aedes aegypti is the primary vector of many arboviral diseases, including dengue and yellow fevers, that are responsible for a large worldwide health burden. The biological rhythms of mosquitoes regulate many of the physiological processes and behaviors that influence the transmission of...

journal_title：BMC genomics

authors： Leming MT,Rund SS,Behura SK,Duffield GE,O'Tousa JE

更新日期：2014-12-17 00:00:00

abstract：BACKGROUND:The AP2/ERF transcription factor, one of the largest gene families in plants, plays a crucial role in the regulation of growth and development, metabolism, and responses to biotic and abiotic stresses. Castor bean (Ricinus communis L., Euphobiaceae) is one of most important non-edible oilseed crops and its s...

journal_title：BMC genomics

authors： Xu W,Li F,Ling L,Liu A

更新日期：2013-11-13 00:00:00

abstract：BACKGROUND:Obesity affects quality of life and life expectancy and is associated with cardiovascular disorders, cancer, diabetes, reproductive disorders in women, prostate diseases in men, and congenital anomalies in children. The use of single nucleotide polymorphism (SNP) markers of diseases and drug responses (i.e.,...

journal_title：BMC genomics

authors： Arkova OV,Ponomarenko MP,Rasskazov DA,Drachkova IA,Arshinova TV,Ponomarenko PM,Savinkova LK,Kolchanov NA

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Meta-analysis of QTLs combines the results of several QTL detection studies and provides narrow confidence intervals for meta-QTLs, permitting easier positional candidate gene identification. It is usually applied to multiple mapping populations, but can be applied to one. Here, a meta-analysis of drought re...

journal_title：BMC genomics

authors： Khowaja FS,Norton GJ,Courtois B,Price AH

更新日期：2009-06-22 00:00:00

abstract：BACKGROUND:Oxidative stress is a consequence of normal and abnormal cellular metabolism and is linked to the development of human diseases. The effective functioning of the pathway responding to oxidative stress protects the cellular DNA against oxidative damage; conversely the failure of the oxidative stress response ...

journal_title：BMC genomics

authors： Sridharan S,Layek R,Datta A,Venkatraj J

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Phlebotomine sand flies (Diptera, Nematocera) are important vectors of several pathogens, including Leishmania parasites, causing serious diseases of humans and dogs. Despite their importance as disease vectors, most aspects of sand fly biology remain unknown including the molecular basis of their reproducti...

journal_title：BMC genomics

authors： Petrella V,Aceto S,Colonna V,Saccone G,Sanges R,Polanska N,Volf P,Gradoni L,Bongiorno G,Salvemini M

更新日期：2019-06-25 00:00:00

abstract：BACKGROUND:As economically relevant traits, feeding behavior and food preference domestication determine production cost and profitability. Although there are intensive research efforts on feeding behavior and food intake, little is known about food preference. Mandarin fish accept only live prey fish and refuse dead p...

journal_title：BMC genomics

authors： He S,Liang XF,Sun J,Li L,Yu Y,Huang W,Qu CM,Cao L,Bai XL,Tao YX

更新日期：2013-09-05 00:00:00

abstract：BACKGROUND:According to history, in the pre-Hispanic period, during the conquest and Inka expansion in Ecuador, many Andean families of the Cañar region would have been displaced to several places of Tawantinsuyu, including Kañaris, a Quechua-speaking community located at the highlands of the Province of Ferreñafe, Lam...

journal_title：BMC genomics

authors： Sandoval JR,Lacerda DR,Jota MMS,Robles-Ruiz P,Danos P,Paz-Y-Miño C,Wells S,Santos FR,Fujita R

更新日期：2020-09-10 00:00:00

abstract：BACKGROUND:The epithelium is the first line of defense against pathogens. Notably the epithelial cells lining the respiratory track are crucial in sensing airborne microbes and mounting an effective immune response via the expression of target genes such as cytokines and chemokines. Gene expression regulation following...

journal_title：BMC genomics

authors： Borghini L,Hibberd M,Davila S

更新日期：2018-12-27 00:00:00

abstract：BACKGROUND:Hemolymph plays key roles in honey bee molecule transport, immune defense, and in monitoring the physiological condition. There is a lack of knowledge regarding how the proteome achieves these biological missions for both the western and eastern honey bees (Apis mellifera and Apis cerana). A time-resolved pr...

journal_title：BMC genomics

authors： Feng M,Ramadan H,Han B,Fang Y,Li J

更新日期：2014-07-05 00:00:00

abstract：BACKGROUND:Understanding how plants and pathogens modulate gene expression during the host-pathogen interaction is key to uncovering the molecular mechanisms that regulate disease progression. Recent advances in sequencing technologies have provided new opportunities to decode the complexity of such interactions. In th...

journal_title：BMC genomics

authors： Dobon A,Bunting DC,Cabrera-Quio LE,Uauy C,Saunders DG

更新日期：2016-05-20 00:00:00

abstract：BACKGROUND:The sRNAs of bacterial pathogens are known to be involved in various cellular roles including environmental adaptation as well as regulation of virulence and pathogenicity. It is expected that sRNAs may also have similar functions for Burkholderia pseudomallei, a soil bacterium that can adapt to diverse envi...

journal_title：BMC genomics

authors： Khoo JS,Chai SF,Mohamed R,Nathan S,Firdaus-Raih M

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Fusarium verticillioides causes ear rot in maize (Zea mays L.) and accumulation of mycotoxins, that affect human and animal health. Currently, chemical and agronomic measures to control Fusarium ear rot are not very effective and selection of more resistant genotypes is a desirable strategy to reduce contami...

journal_title：BMC genomics

authors： Lanubile A,Ferrarini A,Maschietto V,Delledonne M,Marocco A,Bellin D

更新日期：2014-08-25 00:00:00

abstract：BACKGROUND:The problem of supervised DNA sequence classification arises in several fields of computational molecular biology. Although this problem has been extensively studied, it is still computationally challenging due to size of the datasets that modern sequencing technologies can produce. RESULTS:We introduce CLA...

journal_title：BMC genomics

authors： Ounit R,Wanamaker S,Close TJ,Lonardi S

更新日期：2015-03-25 00:00:00

abstract：BACKGROUND:DNA methylation at promoters is largely correlated with inhibition of gene expression. However, the role of DNA methylation at enhancers is not fully understood, although a crosstalk with chromatin marks is expected. Actually, there exist contradictory reports about positive and negative correlations between...

journal_title：BMC genomics

authors： Sharifi-Zarchi A,Gerovska D,Adachi K,Totonchi M,Pezeshk H,Taft RJ,Schöler HR,Chitsaz H,Sadeghi M,Baharvand H,Araúzo-Bravo MJ

更新日期：2017-12-12 00:00:00

abstract：BACKGROUND:Rhesus monkeys (Macaca mulatta) are widely-used as experimental animals in biomedical research and are closely related to other laboratory macaques, such as cynomolgus monkeys (Macaca fascicularis), and to humans, sharing a last common ancestor from about 25 million years ago. Although rhesus monkeys have be...

journal_title：BMC genomics

authors： Kim DS,Huh JW,Kim YH,Park SJ,Lee SR,Chang KT

更新日期：2010-07-12 00:00:00

abstract：BACKGROUND:Campylobacter is the leading cause of foodborne diarrhoeal illness in humans and is mostly acquired from consumption or handling of contaminated poultry meat. In the absence of effective licensed vaccines and inhibitors, selection for chickens with increased resistance to Campylobacter could potentially redu...

journal_title：BMC genomics

authors： Psifidi A,Fife M,Howell J,Matika O,van Diemen PM,Kuo R,Smith J,Hocking PM,Salmon N,Jones MA,Hume DA,Banos G,Stevens MP,Kaiser P

更新日期：2016-04-18 00:00:00

abstract：BACKGROUND:Myostatin, a muscle-specific member of the Transforming Growth Factor beta family, negatively regulates muscle development. Double-muscled (DM) cattle have a loss-of-function mutation in their myostatin gene responsible for the hypermuscular phenotype. Thus, these animals are a good model for understanding t...

journal_title：BMC genomics

authors： Cassar-Malek I,Passelaigue F,Bernard C,Léger J,Hocquette JF

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:The cotton (Gossypium spp.) fiber cell is an important unicellular model for studying cell differentiation. There is evidence suggesting that phosphorylation is a critical post-translational modification involved in regulation of a wide range of cell activities. Nevertheless, the sites of phosphorylation in ...

journal_title：BMC genomics

authors： Ma Q,Wu M,Pei W,Li H,Li X,Zhang J,Yu J,Yu S

更新日期：2014-06-12 00:00:00

abstract：BACKGROUND:RNA sequencing (RNA-seq) and microarrays are two transcriptomics techniques aimed at the quantification of transcribed genes and their isoforms. Here we compare the latest Affymetrix HTA 2.0 microarray with Illumina 2000 RNA-seq for the analysis of patient samples - normal lung epithelium tissue and squamous...

journal_title：BMC genomics

authors： Nazarov PV,Muller A,Kaoma T,Nicot N,Maximo C,Birembaut P,Tran NL,Dittmar G,Vallar L

更新日期：2017-06-06 00:00:00

abstract：BACKGROUND:Gene expression variation is a key underlying factor influencing phenotypic variation, and can occur via cis- or trans-regulation. To understand the role of cis- and trans-regulatory variation on population divergence in chicken, we developed reciprocal crosses of two chicken breeds, White Leghorn and Cornis...

journal_title：BMC genomics

authors： Wang Q,Jia Y,Wang Y,Jiang Z,Zhou X,Zhang Z,Nie C,Li J,Yang N,Qu L

更新日期：2019-12-05 00:00:00

abstract：BACKGROUND:Intellectual Disability (ID) is among the most common global disorders, yet etiology is unknown in ~30% of patients despite clinical assessment. Whole genome sequencing (WGS) is able to interrogate the entire genome, providing potential to diagnose idiopathic patients. METHODS:We conducted WGS on eight chil...

journal_title：BMC genomics

authors： Zahir FR,Mwenifumbo JC,Chun HE,Lim EL,Van Karnebeek CDM,Couse M,Mungall KL,Lee L,Makela N,Armstrong L,Boerkoel CF,Langlois SL,McGillivray BM,Jones SJM,Friedman JM,Marra MA

更新日期：2017-05-24 00:00:00

abstract：BACKGROUND:The phytoflagellated protozoan, Euglena gracilis, has been proposed as an attractive feedstock for the accumulation of valuable compounds such as β-1,3-glucan, also known as paramylon, and wax esters. The production of wax esters proceeds under anaerobic conditions, designated as wax ester fermentation. In s...

journal_title：BMC genomics

authors： Yoshida Y,Tomiyama T,Maruta T,Tomita M,Ishikawa T,Arakawa K

更新日期：2016-03-03 00:00:00

abstract：BACKGROUND:Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias. RESULTS:In this study we have sampled over 800 unrelated individuals from the population of Spain,...

journal_title：BMC genomics

authors： Gayán J,Galan JJ,González-Pérez A,Sáez ME,Martínez-Larrad MT,Zabena C,Rivero MC,Salinas A,Ramírez-Lorca R,Morón FJ,Royo JL,Moreno-Rey C,Velasco J,Carrasco JM,Molero E,Ochoa C,Ochoa MD,Gutiérrez M,Reina M,Pascual R,

更新日期：2010-05-25 00:00:00

abstract：BACKGROUND:The objective of this research was to investigate the reproducibility of cross-species microarray hybridisation. Comparisons between same- and cross-species hybridisations were also made. Nine hybridisations between a single pig skeletal muscle RNA sample and three human cDNA nylon microarrays were completed...

journal_title：BMC genomics

authors： Moody DE,Zou Z,McIntyre L

更新日期：2002-09-27 00:00:00

abstract：BACKGROUND:Although prokaryotic gene transcription has been studied over decades, many aspects of the process remain poorly understood. Particularly, recent studies have revealed that transcriptomes in many prokaryotes are far more complex than previously thought. Genes in an operon are often alternatively and dynamica...

journal_title：BMC genomics

authors： Li S,Dong X,Su Z

更新日期：2013-07-30 00:00:00

abstract：BACKGROUND:To date several studies have sought to catalog the full suite of antibodies that humans naturally produce against single antigens or other specificities (repertoire). Here we analyze the properties of all sequenced repertoires in order to better understand the specificity of antibody responses. Specifically,...

journal_title：BMC genomics

authors： Arnaout RA

更新日期：2005-10-28 00:00:00

abstract：BACKGROUND:Deep sequencing is a powerful tool for assessing viral genetic diversity. Such experiments harness the high coverage afforded by next generation sequencing protocols by treating sequencing reads as a population sample. Distinguishing true single nucleotide variants (SNVs) from sequencing errors remains chall...

journal_title：BMC genomics

authors： McElroy K,Zagordi O,Bull R,Luciani F,Beerenwinkel N

更新日期：2013-07-24 00:00:00